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Focal aware clonic seizure

MedGen UID:
1719261
Concept ID:
C5397721
Disease or Syndrome
Synonyms: Focal onset aware clonic epileptic seizure; Focal onset aware clonic seizure; Focal-onset aware clonic epileptic seizure
SNOMED CT: Focal onset aware clonic epileptic seizure (1269364006); Focal onset aware clonic seizure (1269364006); Focal-onset aware clonic epileptic seizure (1269364006); Focal aware clonic seizure (1269364006)
 
HPO: HP:0032711

Definition

A type of focal clonic seizure during which awareness is fully retained throughout. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal aware clonic seizure

Professional guidelines

PubMed

Cancelloni V, Rufa A, Battisti C, De Stefano N, Mastrocinque E, Garosi G, Venezia D, Chiarotti I, Cerase A
Neurol Sci 2022 Nov;43(11):6381-6387. Epub 2022 Aug 5 doi: 10.1007/s10072-022-06299-y. PMID: 35930182Free PMC Article
Ramos-Fresnedo A, Domingo RA, McGeary RC, Sirven JI, Feyissa AM, Tatum W, Ritaccio AL, Middlebrooks EH, Grewal SS
World Neurosurg 2021 Jul;151:91-101. Epub 2021 May 5 doi: 10.1016/j.wneu.2021.04.121. PMID: 33964498
van Tienderen GS, Berthel M, Yue Z, Cook M, Liu X, Beirne S, Wallace GG
Expert Opin Drug Deliv 2018 Sep;15(9):915-925. Epub 2018 Sep 12 doi: 10.1080/17425247.2018.1517745. PMID: 30169981

Recent clinical studies

Etiology

Nascimento FA, Friedman D, Peters JM, Bensalem-Owen MK, Cendes F, Rampp S, Wirrell E, Blümcke I, Tatum W, Beniczky S
Epileptic Disord 2023 Feb;25(1):1-17. Epub 2023 Apr 17 doi: 10.1002/epd2.20045. PMID: 36938903
Marson A, Burnside G, Appleton R, Smith D, Leach JP, Sills G, Tudur-Smith C, Plumpton C, Hughes DA, Williamson P, Baker GA, Balabanova S, Taylor C, Brown R, Hindley D, Howell S, Maguire M, Mohanraj R, Smith PE; SANAD II collaborators
Lancet 2021 Apr 10;397(10282):1363-1374. doi: 10.1016/S0140-6736(21)00247-6. PMID: 33838757Free PMC Article
Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485Free PMC Article
Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M
Lancet Neurol 2020 Jan;19(1):38-48. Epub 2019 Nov 14 doi: 10.1016/S1474-4422(19)30399-0. PMID: 31734103
Roberts B
Radiol Technol 2018 Jan;89(3):279-295. PMID: 29298944

Diagnosis

Nascimento FA, Friedman D, Peters JM, Bensalem-Owen MK, Cendes F, Rampp S, Wirrell E, Blümcke I, Tatum W, Beniczky S
Epileptic Disord 2023 Feb;25(1):1-17. Epub 2023 Apr 17 doi: 10.1002/epd2.20045. PMID: 36938903
Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485Free PMC Article
Pack AM
Continuum (Minneap Minn) 2019 Apr;25(2):306-321. doi: 10.1212/CON.0000000000000707. PMID: 30921011
Roberts B
Radiol Technol 2018 Jan;89(3):279-295. PMID: 29298944
Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshé SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM
Epilepsia 2017 Apr;58(4):522-530. Epub 2017 Mar 8 doi: 10.1111/epi.13670. PMID: 28276060

Therapy

Valinčiūtė J, Jucevičiūtė N, Balnytė R, Jurkevičienė G, Gelžinienė G
Medicina (Kaunas) 2023 Jun 12;59(6) doi: 10.3390/medicina59061135. PMID: 37374339Free PMC Article
Garrido Sanabria ER, Zahid A, Britton J, Kraus GJ, López-Chiriboga AS, Zekeridou A, Flanagan EP, McKeon A, Mills JR, Pittock SJ, Dubey D
Epilepsia 2022 Mar;63(3):709-722. Epub 2022 Jan 15 doi: 10.1111/epi.17164. PMID: 35032032
Marson A, Burnside G, Appleton R, Smith D, Leach JP, Sills G, Tudur-Smith C, Plumpton C, Hughes DA, Williamson P, Baker GA, Balabanova S, Taylor C, Brown R, Hindley D, Howell S, Maguire M, Mohanraj R, Smith PE; SANAD II collaborators
Lancet 2021 Apr 10;397(10282):1363-1374. doi: 10.1016/S0140-6736(21)00247-6. PMID: 33838757Free PMC Article
Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485Free PMC Article
Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M
Lancet Neurol 2020 Jan;19(1):38-48. Epub 2019 Nov 14 doi: 10.1016/S1474-4422(19)30399-0. PMID: 31734103

Prognosis

Valinčiūtė J, Jucevičiūtė N, Balnytė R, Jurkevičienė G, Gelžinienė G
Medicina (Kaunas) 2023 Jun 12;59(6) doi: 10.3390/medicina59061135. PMID: 37374339Free PMC Article
Bayat A, de Valles-Ibáñez G, Pendziwiat M, Knaus A, Alt K, Biamino E, Bley A, Calvert S, Carney P, Caro-Llopis A, Ceulemans B, Cousin J, Davis S, des Portes V, Edery P, England E, Ferreira C, Freeman J, Gener B, Gorce M, Heron D, Hildebrand MS, Jezela-Stanek A, Jouk PS, Keren B, Kloth K, Kluger G, Kuhn M, Lemke JR, Li H, Martinez F, Maxton C, Mefford HC, Merla G, Mierzewska H, Muir A, Monfort S, Nicolai J, Norman J, O'Grady G, Oleksy B, Orellana C, Orec LE, Peinhardt C, Pronicka E, Rosello M, Santos-Simarro F, Schwaibold EMC, Stegmann APA, Stumpel CT, Szczepanik E, Terczyńska I, Thevenon J, Tzschach A, Van Bogaert P, Vittorini R, Walsh S, Weckhuysen S, Weissman B, Wolfe L, Reymond A, De Nittis P, Poduri A, Olson H, Striano P, Lesca G, Scheffer IE, Møller RS, Sadleir LG
Epilepsia 2022 Apr;63(4):974-991. Epub 2022 Feb 18 doi: 10.1111/epi.17173. PMID: 35179230
Garrido Sanabria ER, Zahid A, Britton J, Kraus GJ, López-Chiriboga AS, Zekeridou A, Flanagan EP, McKeon A, Mills JR, Pittock SJ, Dubey D
Epilepsia 2022 Mar;63(3):709-722. Epub 2022 Jan 15 doi: 10.1111/epi.17164. PMID: 35032032
Goyal P, Malhotra A, Almast J, Sapire J, Gupta S, Mangla M, Mangla R
J Neuroimaging 2019 May;29(3):287-308. Epub 2019 Mar 28 doi: 10.1111/jon.12614. PMID: 30920080
Ferro JM, Canhão P, Aguiar de Sousa D
Presse Med 2016 Dec;45(12 Pt 2):e429-e450. Epub 2016 Nov 2 doi: 10.1016/j.lpm.2016.10.007. PMID: 27816347

Clinical prediction guides

Saemaldahr R, Ilyas M
Sensors (Basel) 2023 Jul 21;23(14) doi: 10.3390/s23146578. PMID: 37514873Free PMC Article
Valinčiūtė J, Jucevičiūtė N, Balnytė R, Jurkevičienė G, Gelžinienė G
Medicina (Kaunas) 2023 Jun 12;59(6) doi: 10.3390/medicina59061135. PMID: 37374339Free PMC Article
Bayat A, de Valles-Ibáñez G, Pendziwiat M, Knaus A, Alt K, Biamino E, Bley A, Calvert S, Carney P, Caro-Llopis A, Ceulemans B, Cousin J, Davis S, des Portes V, Edery P, England E, Ferreira C, Freeman J, Gener B, Gorce M, Heron D, Hildebrand MS, Jezela-Stanek A, Jouk PS, Keren B, Kloth K, Kluger G, Kuhn M, Lemke JR, Li H, Martinez F, Maxton C, Mefford HC, Merla G, Mierzewska H, Muir A, Monfort S, Nicolai J, Norman J, O'Grady G, Oleksy B, Orellana C, Orec LE, Peinhardt C, Pronicka E, Rosello M, Santos-Simarro F, Schwaibold EMC, Stegmann APA, Stumpel CT, Szczepanik E, Terczyńska I, Thevenon J, Tzschach A, Van Bogaert P, Vittorini R, Walsh S, Weckhuysen S, Weissman B, Wolfe L, Reymond A, De Nittis P, Poduri A, Olson H, Striano P, Lesca G, Scheffer IE, Møller RS, Sadleir LG
Epilepsia 2022 Apr;63(4):974-991. Epub 2022 Feb 18 doi: 10.1111/epi.17173. PMID: 35179230
Fisher RS, Bonner AM
Neurodiagn J 2018;58(1):1-10. doi: 10.1080/21646821.2018.1428455. PMID: 29562876
Avanzini G
Ann N Y Acad Sci 2003 Nov;999:95-102. doi: 10.1196/annals.1284.008. PMID: 14681120

Recent systematic reviews

Paprocka J, Kaminiów K, Yetkin O, Tekturk P, Baykan B, Leiz S, Kluger G, Striano P
Seizure 2024 Mar;116:14-23. Epub 2022 Dec 8 doi: 10.1016/j.seizure.2022.12.001. PMID: 36526544
Pepin C, Brochu K, Lessard-Bonaventure P, Nguyen DK, Martineau L
J Clin Neurophysiol 2023 Sep 1;40(6):507-515. Epub 2023 Mar 15 doi: 10.1097/WNP.0000000000000975. PMID: 36930208
Qin SK, Yang ZX, Guan ZW, Zhang JH, Ping X, Lu Y, Pei L
PLoS One 2022;17(12):e0278907. Epub 2022 Dec 15 doi: 10.1371/journal.pone.0278907. PMID: 36520790Free PMC Article
Selvarajah A, Zulfiqar-Ali Q, Marques P, Rong M, Andrade DM
Seizure 2021 Apr;87:39-45. Epub 2021 Feb 22 doi: 10.1016/j.seizure.2021.02.025. PMID: 33677403
Cutillo G, Tolba H, Hirsch LJ
Epilepsy Behav 2021 Apr;117:107815. Epub 2021 Feb 26 doi: 10.1016/j.yebeh.2021.107815. PMID: 33640562

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