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Tubular microcystic change

MedGen UID:
1719066
•Concept ID:
C5397960
•
Finding
HPO: HP:0032962

Definition

Dilated renal tubules (over twice the diameter of a normal proximal tubule) containing eosinophilic amorphous material. This feature is generally accompanied by scalloping of the cast profile. The epithelium lining the microcyst is generally flattened and does not reveal brush border. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTubular microcystic change

Professional guidelines

PubMed

APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis.
Zee J, McNulty MT, Hodgin JB, Zhdanova O, Hingorani S, Jefferson JA, Gibson KL, Trachtman H, Fornoni A, Dell KM, Reich HN, Bagnasco S, Greenbaum LA, Lafayette RA, Gipson DS, Brown E, Kretzler M, Appel G, Sambandam KK, Tuttle KR, Chen D, Atkinson MA, Hogan MC, Kaskel FJ, Meyers KE, O'Toole J, Srivastava T, Sethna CB, Hladunewich MA, Lin JJ, Nast CC, Derebail VK, Patel J, Vento S, Holzman LB, Athavale AM, Adler SG, Lemley KV, Lieske JC, Hogan JJ, Gadegbeku CA, Fervenza FC, Wang CS, Matar RB, Singer P, Kopp JB, Barisoni L, Sampson MG
Pediatr Nephrol 2021 Sep;36(9):2747-2757. Epub 2021 Mar 1 doi: 10.1007/s00467-021-04990-4. PMID: 33646395Free PMC Article

Recent clinical studies

Etiology

APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis.
Zee J, McNulty MT, Hodgin JB, Zhdanova O, Hingorani S, Jefferson JA, Gibson KL, Trachtman H, Fornoni A, Dell KM, Reich HN, Bagnasco S, Greenbaum LA, Lafayette RA, Gipson DS, Brown E, Kretzler M, Appel G, Sambandam KK, Tuttle KR, Chen D, Atkinson MA, Hogan MC, Kaskel FJ, Meyers KE, O'Toole J, Srivastava T, Sethna CB, Hladunewich MA, Lin JJ, Nast CC, Derebail VK, Patel J, Vento S, Holzman LB, Athavale AM, Adler SG, Lemley KV, Lieske JC, Hogan JJ, Gadegbeku CA, Fervenza FC, Wang CS, Matar RB, Singer P, Kopp JB, Barisoni L, Sampson MG
Pediatr Nephrol 2021 Sep;36(9):2747-2757. Epub 2021 Mar 1 doi: 10.1007/s00467-021-04990-4. PMID: 33646395Free PMC Article
Focal Segmental Glomerulosclerosis.
Rosenberg AZ, Kopp JB
Clin J Am Soc Nephrol 2017 Mar 7;12(3):502-517. Epub 2017 Feb 27 doi: 10.2215/CJN.05960616. PMID: 28242845Free PMC Article
Histopathologic findings associated with APOL1 risk variants in chronic kidney disease.
Larsen CP, Beggs ML, Saeed M, Ambruzs JM, Cossey LN, Messias NC, Walker PD, Freedman BI
Mod Pathol 2015 Jan;28(1):95-102. Epub 2014 Aug 1 doi: 10.1038/modpathol.2014.92. PMID: 25081748Free PMC Article
A 20-year history of childhood HIV-associated nephropathy.
Ray PE, Xu L, Rakusan T, Liu XH
Pediatr Nephrol 2004 Oct;19(10):1075-92. Epub 2004 Aug 5 doi: 10.1007/s00467-004-1558-1. PMID: 15300477
Renal ultrastructural markers in AIDS-associated nephropathy.
Chander P, Soni A, Suri A, Bhagwat R, Yoo J, Treser G
Am J Pathol 1987 Mar;126(3):513-26. PMID: 3548410Free PMC Article

Diagnosis

APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis.
Zee J, McNulty MT, Hodgin JB, Zhdanova O, Hingorani S, Jefferson JA, Gibson KL, Trachtman H, Fornoni A, Dell KM, Reich HN, Bagnasco S, Greenbaum LA, Lafayette RA, Gipson DS, Brown E, Kretzler M, Appel G, Sambandam KK, Tuttle KR, Chen D, Atkinson MA, Hogan MC, Kaskel FJ, Meyers KE, O'Toole J, Srivastava T, Sethna CB, Hladunewich MA, Lin JJ, Nast CC, Derebail VK, Patel J, Vento S, Holzman LB, Athavale AM, Adler SG, Lemley KV, Lieske JC, Hogan JJ, Gadegbeku CA, Fervenza FC, Wang CS, Matar RB, Singer P, Kopp JB, Barisoni L, Sampson MG
Pediatr Nephrol 2021 Sep;36(9):2747-2757. Epub 2021 Mar 1 doi: 10.1007/s00467-021-04990-4. PMID: 33646395Free PMC Article
Napsin A is a highly sensitive marker for nephrogenic adenoma: an immunohistochemical study with a specificity test in genitourinary tumors.
Sharifai N, Abro B, Chen JF, Zhao M, He H, Cao D
Hum Pathol 2020 Aug;102:23-32. Epub 2020 Jun 17 doi: 10.1016/j.humpath.2020.05.007. PMID: 32561332
HIV-associated nephropathy (HIVAN): a short review of different authors.
Banu SG, Banu SS, Saleh FM
Mymensingh Med J 2013 Jul;22(3):613-7. PMID: 23982561
A 20-year history of childhood HIV-associated nephropathy.
Ray PE, Xu L, Rakusan T, Liu XH
Pediatr Nephrol 2004 Oct;19(10):1075-92. Epub 2004 Aug 5 doi: 10.1007/s00467-004-1558-1. PMID: 15300477
Pathology of HIV-associated nephropathy: a detailed morphologic and comparative study.
D'Agati V, Suh JI, Carbone L, Cheng JT, Appel G
Kidney Int 1989 Jun;35(6):1358-70. doi: 10.1038/ki.1989.135. PMID: 2770114

Therapy

HIVAN associated tubular pathology with reference to ER stress, mitochondrial changes, and autophagy.
Katuri A, Bryant JL, Patel D, Patel V, Andhavarapu S, Asemu G, Davis H, Makar TK
Exp Mol Pathol 2019 Feb;106:139-148. Epub 2018 Dec 31 doi: 10.1016/j.yexmp.2018.12.009. PMID: 30605635
Focal Segmental Glomerulosclerosis.
Rosenberg AZ, Kopp JB
Clin J Am Soc Nephrol 2017 Mar 7;12(3):502-517. Epub 2017 Feb 27 doi: 10.2215/CJN.05960616. PMID: 28242845Free PMC Article
Collapsing glomerulopathy in 19 patients with systemic lupus erythematosus or lupus-like disease.
Salvatore SP, Barisoni LM, Herzenberg AM, Chander PN, Nickeleit V, Seshan SV
Clin J Am Soc Nephrol 2012 Jun;7(6):914-25. Epub 2012 Mar 29 doi: 10.2215/CJN.11751111. PMID: 22461531
Zonal distribution of glomerular collapse in renal allografts: possible role of vascular changes.
Nadasdy T, Allen C, Zand MS
Hum Pathol 2002 Apr;33(4):437-41. doi: 10.1053/hupa.2002.124333. PMID: 12055680

Prognosis

Focal Segmental Glomerulosclerosis.
Rosenberg AZ, Kopp JB
Clin J Am Soc Nephrol 2017 Mar 7;12(3):502-517. Epub 2017 Feb 27 doi: 10.2215/CJN.05960616. PMID: 28242845Free PMC Article
HIV-associated nephropathy (HIVAN): a short review of different authors.
Banu SG, Banu SS, Saleh FM
Mymensingh Med J 2013 Jul;22(3):613-7. PMID: 23982561
Collapsing glomerulopathy in 19 patients with systemic lupus erythematosus or lupus-like disease.
Salvatore SP, Barisoni LM, Herzenberg AM, Chander PN, Nickeleit V, Seshan SV
Clin J Am Soc Nephrol 2012 Jun;7(6):914-25. Epub 2012 Mar 29 doi: 10.2215/CJN.11751111. PMID: 22461531
Collapsing glomerulopathy--a new pattern of renal injury.
Laurinavicius A, Rennke HG
Semin Diagn Pathol 2002 Aug;19(3):106-15. PMID: 12180632
Collapsing glomerulopathy in HIV and non-HIV patients: a clinicopathological and follow-up study.
Laurinavicius A, Hurwitz S, Rennke HG
Kidney Int 1999 Dec;56(6):2203-13. doi: 10.1046/j.1523-1755.1999.00769.x. PMID: 10594796

Clinical prediction guides

Napsin A is a highly sensitive marker for nephrogenic adenoma: an immunohistochemical study with a specificity test in genitourinary tumors.
Sharifai N, Abro B, Chen JF, Zhao M, He H, Cao D
Hum Pathol 2020 Aug;102:23-32. Epub 2020 Jun 17 doi: 10.1016/j.humpath.2020.05.007. PMID: 32561332
Collapsing glomerulopathy--a new pattern of renal injury.
Laurinavicius A, Rennke HG
Semin Diagn Pathol 2002 Aug;19(3):106-15. PMID: 12180632
Collapsing glomerulopathy in HIV and non-HIV patients: a clinicopathological and follow-up study.
Laurinavicius A, Hurwitz S, Rennke HG
Kidney Int 1999 Dec;56(6):2203-13. doi: 10.1046/j.1523-1755.1999.00769.x. PMID: 10594796
Pathology of HIV-associated nephropathy: a detailed morphologic and comparative study.
D'Agati V, Suh JI, Carbone L, Cheng JT, Appel G
Kidney Int 1989 Jun;35(6):1358-70. doi: 10.1038/ki.1989.135. PMID: 2770114
Renal ultrastructural markers in AIDS-associated nephropathy.
Chander P, Soni A, Suri A, Bhagwat R, Yoo J, Treser G
Am J Pathol 1987 Mar;126(3):513-26. PMID: 3548410Free PMC Article

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