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Cutaneous Langerhans Cell Histiocytosis

MedGen UID:
1717189
•Concept ID:
C5208352
•
Neoplastic Process

Definition

Langerhans cell histiocytosis that affects the skin. It manifests with skin papules and plaques. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous Langerhans Cell Histiocytosis

Professional guidelines

PubMed

Long term follow up of topical mustine treatment for cutaneous langerhans cell histiocytosis.
Hoeger PH, Nanduri VR, Harper JI, Atherton DA, Pritchard J
Arch Dis Child 2000 Jun;82(6):483-7. doi: 10.1136/adc.82.6.483. PMID: 10833183Free PMC Article
Topical nitrogen mustard: an effective treatment for cutaneous Langerhans cell histiocytosis.
Sheehan MP, Atherton DJ, Broadbent V, Pritchard J
J Pediatr 1991 Aug;119(2):317-21. doi: 10.1016/s0022-3476(05)80752-8. PMID: 1861222

Recent clinical studies

Etiology

Cutaneous Langerhans cell histiocytosis in adults: A retrospective cohort study of adult patients presenting to a single academic cancer center between 2003 and 2017.
Bui AN, Larocca C, Giobbie-Hurder A, Jacobsen ED, LeBoeuf NR
J Am Acad Dermatol 2022 Jun;86(6):1413-1416. Epub 2021 Jun 11 doi: 10.1016/j.jaad.2021.06.016. PMID: 34119604
Excimer laser as adjuvant therapy for adult cutaneous Langerhans cell histiocytosis.
Vogel CA, Aughenbaugh W, Sharata H
Arch Dermatol 2008 Oct;144(10):1287-90. doi: 10.1001/archderm.144.10.1287. PMID: 18936391
Successful treatment of cutaneous langerhans cell histiocytosis with thalidomide.
Sander CS, Kaatz M, Elsner P
Dermatology 2004;208(2):149-52. doi: 10.1159/000076491. PMID: 15057007
Adult cutaneous Langerhans cell histiocytosis.
Conias S, Strutton G, Stephenson G
Australas J Dermatol 1998 May;39(2):106-8. doi: 10.1111/j.1440-0960.1998.tb01259.x. PMID: 9611381
Primary cutaneous Langerhans cell histiocytosis treated with photochemotherapy.
Kwon OS, Cho KH, Song KY
J Dermatol 1997 Jan;24(1):54-6. doi: 10.1111/j.1346-8138.1997.tb02740.x. PMID: 9046743

Diagnosis

Cutaneous Langerhans cell histiocytosis in adults: A retrospective cohort study of adult patients presenting to a single academic cancer center between 2003 and 2017.
Bui AN, Larocca C, Giobbie-Hurder A, Jacobsen ED, LeBoeuf NR
J Am Acad Dermatol 2022 Jun;86(6):1413-1416. Epub 2021 Jun 11 doi: 10.1016/j.jaad.2021.06.016. PMID: 34119604
Cutaneous Langerhans Cell Histiocytosis Responsive to Topical Nitrogen Mustard.
Bui AN, Puleo AE, Canales AL, Jacobsen ED, LeBoeuf NR
J Drugs Dermatol 2020 Aug 1;19(8):803-805. doi: 10.36849/JDD.2020.4943. PMID: 32845598
At the Root: Cutaneous Langerhans Cell Histiocytosis.
Maglie R, Vannucchi M, Quintarelli L, Caproni M, Massi D, Antiga E
Am J Med 2018 Aug;131(8):922-926. Epub 2018 May 2 doi: 10.1016/j.amjmed.2018.04.015. PMID: 29729245
Spontaneous resolution of cutaneous Langerhans cell histiocytosis in an infant.
Korsaga-Somé N, Miquelestorena-Standley É, Finon A, Yvert M, Sallot A, Maruani A
Eur J Dermatol 2016 Dec 1;26(6):631-632. doi: 10.1684/ejd.2016.2866. PMID: 27694068
Cutaneous Langerhans cell histiocytosis.
Gupta V, Bansal M
Indian Pediatr 2012 Jan;49(1):79. PMID: 22318116

Therapy

Cutaneous Langerhans Cell Histiocytosis Responsive to Topical Nitrogen Mustard.
Bui AN, Puleo AE, Canales AL, Jacobsen ED, LeBoeuf NR
J Drugs Dermatol 2020 Aug 1;19(8):803-805. doi: 10.36849/JDD.2020.4943. PMID: 32845598
Cutaneous Langerhans cell histiocytosis presenting with hypopigmented lesions: Report of two cases and review of literature.
Mori S, Adar T, Kazlouskaya V, Alexander JB, Heilman E, Glick SA
Pediatr Dermatol 2018 Jul;35(4):502-506. Epub 2018 Apr 25 doi: 10.1111/pde.13509. PMID: 29691886
An infant with self-healing cutaneous Langerhans cell histiocytosis followed by isolated thymic relapse.
Hatakeyama N, Hori T, Yamamoto M, Sogawa I, Inazawa N, Tsutsumi H, Suzuki N
Pediatr Blood Cancer 2009 Aug;53(2):229-31. doi: 10.1002/pbc.22026. PMID: 19343774
Adult cutaneous Langerhans cell histiocytosis.
Conias S, Strutton G, Stephenson G
Australas J Dermatol 1998 May;39(2):106-8. doi: 10.1111/j.1440-0960.1998.tb01259.x. PMID: 9611381
Primary cutaneous Langerhans cell histiocytosis treated with photochemotherapy.
Kwon OS, Cho KH, Song KY
J Dermatol 1997 Jan;24(1):54-6. doi: 10.1111/j.1346-8138.1997.tb02740.x. PMID: 9046743

Prognosis

Cutaneous Langerhans cell histiocytosis: study of Asian children shows good overall prognosis.
Ng SS, Koh MJ, Tay YK
Acta Paediatr 2013 Nov;102(11):e514-8. Epub 2013 Sep 2 doi: 10.1111/apa.12376. PMID: 23909818
Purely cutaneous Langerhans' cell histiocytosis in an adult woman.
Campanati A, Simonetti O, Marconi B, Giuliodori K, Ganzetti G, Brandozzi G, Bernardini ML, Ranaldi R, Offidani A
Acta Derm Venereol 2009;89(3):299-301. doi: 10.2340/00015555-0614. PMID: 19479131
Excimer laser as adjuvant therapy for adult cutaneous Langerhans cell histiocytosis.
Vogel CA, Aughenbaugh W, Sharata H
Arch Dermatol 2008 Oct;144(10):1287-90. doi: 10.1001/archderm.144.10.1287. PMID: 18936391
Adult cutaneous Langerhans cell histiocytosis.
Conias S, Strutton G, Stephenson G
Australas J Dermatol 1998 May;39(2):106-8. doi: 10.1111/j.1440-0960.1998.tb01259.x. PMID: 9611381
Primary cutaneous Langerhans cell histiocytosis treated with photochemotherapy.
Kwon OS, Cho KH, Song KY
J Dermatol 1997 Jan;24(1):54-6. doi: 10.1111/j.1346-8138.1997.tb02740.x. PMID: 9046743

Clinical prediction guides

Congenital Unilesional Cutaneous Langerhans Cell Histiocytosis: A Case Report.
Ungari M, Caresana G, Tanzi G, Drera B, Frittoli MC, Gusolfino MD, Ferrero G, Varotti E, Manotti L, Trombatore M, Bertoni R
Am J Dermatopathol 2021 Mar 1;43(3):e38-e42. doi: 10.1097/DAD.0000000000001770. PMID: 32769549
Cutaneous manifestations of Erdheim-Chester disease (ECD): Clinical, pathological, and molecular features in a monocentric series of 40 patients.
Chasset F, Barete S, Charlotte F, Cohen-Aubart F, Arnaud L, Le Pelletier F, Emile JF, Francès C, Amoura Z, Haroche J
J Am Acad Dermatol 2016 Mar;74(3):513-20. Epub 2016 Jan 16 doi: 10.1016/j.jaad.2015.11.007. PMID: 26785805
Neonatal and early infantile cutaneous langerhans cell histiocytosis: comparison of self-regressive and non-self-regressive forms.
Battistella M, Fraitag S, Teillac DH, Brousse N, de Prost Y, Bodemer C
Arch Dermatol 2010 Feb;146(2):149-56. doi: 10.1001/archdermatol.2009.360. PMID: 20157025
Topical nitrogen mustard: an effective treatment for cutaneous Langerhans cell histiocytosis.
Sheehan MP, Atherton DJ, Broadbent V, Pritchard J
J Pediatr 1991 Aug;119(2):317-21. doi: 10.1016/s0022-3476(05)80752-8. PMID: 1861222

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