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Renal interstitial neutrophil infiltration

MedGen UID:
1716314
•Concept ID:
C5397609
•
Finding
HPO: HP:0032584

Definition

Increased numbers of neutrophils in the interstitial tissues of the kidney. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal interstitial neutrophil infiltration

Professional guidelines

PubMed

Nesfatin-1 treatment preserves antioxidant status and attenuates renal fibrosis in rats with unilateral ureteral obstruction.
Tezcan N, Özdemir-Kumral ZN, Özkan Yenal N, Çilingir-Kaya ÖT, Virlan AT, Özbeyli D, Çetinel Ş, Yeğen BÇ, Koç M
Nephrol Dial Transplant 2022 Jun 23;37(7):1238-1248. doi: 10.1093/ndt/gfac053. PMID: 35218196

Recent clinical studies

Etiology

DNase I targeted degradation of neutrophil extracellular traps to reduce the damage on IgAV rat.
Chen XQ, Tu L, Tang Q, Zou JS, Yun X, Qin YH
PLoS One 2023;18(10):e0291592. Epub 2023 Oct 31 doi: 10.1371/journal.pone.0291592. PMID: 37906560Free PMC Article
The Role of Urinary Angiotensinogen in Kidney Interstitial Inflammation and Renal Prognosis.
Dou Y, Song D, Wang C, Liu D, Cheng G, Xiao J, Zhao Z
Iran J Kidney Dis 2019 Nov;13(6):372-379. PMID: 31880583
Interstitial Immunostaining and Renal Outcomes in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis.
Geetha D, Sethi S, De Vriese AS, Specks U, Kallenberg CGM, Lim N, Spiera R, St Clair EW, Merkel PA, Seo P, Monach PA, Lepori N, Fessler BJ, Langford CA, Hoffman GS, Sharma R, Stone JH, Fervenza FC; RAVE-ITN Research Group
Am J Nephrol 2017;46(3):231-238. Epub 2017 Sep 8 doi: 10.1159/000480443. PMID: 28881339Free PMC Article
Clinicopathologic characteristics and outcomes of renal thrombotic microangiopathy in anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis.
Chen SF, Wang H, Huang YM, Li ZY, Wang SX, Yu F, Zhao MH, Chen M
Clin J Am Soc Nephrol 2015 May 7;10(5):750-8. Epub 2015 Mar 6 doi: 10.2215/CJN.07910814. PMID: 25749534Free PMC Article
Pathology of ANCA-associated vasculitis.
Ferrario F, Vanzati A, Pagni F
Clin Exp Nephrol 2013 Oct;17(5):652-658. Epub 2012 Nov 23 doi: 10.1007/s10157-012-0701-8. PMID: 23180037

Diagnosis

Interstitial nephritis without glomerulonephritis in ANCA-associated vasculitis: a case series and literature review.
He X, Wen Y, Hu R, Wu H, Ye W, Yue C, Qin Y, Xia P, Chen L
Clin Rheumatol 2022 Nov;41(11):3551-3563. Epub 2022 Jun 27 doi: 10.1007/s10067-022-06264-2. PMID: 35759125Free PMC Article
Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive Review.
Martínez-Valenzuela L, Draibe J, Fulladosa X, Gomà M, Gómez F, Antón P, Cruzado JM, Torras J
Int J Mol Sci 2021 Feb 26;22(5) doi: 10.3390/ijms22052326. PMID: 33652638Free PMC Article
The Role of Urinary Angiotensinogen in Kidney Interstitial Inflammation and Renal Prognosis.
Dou Y, Song D, Wang C, Liu D, Cheng G, Xiao J, Zhao Z
Iran J Kidney Dis 2019 Nov;13(6):372-379. PMID: 31880583
Clinicopathologic characteristics and outcomes of renal thrombotic microangiopathy in anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis.
Chen SF, Wang H, Huang YM, Li ZY, Wang SX, Yu F, Zhao MH, Chen M
Clin J Am Soc Nephrol 2015 May 7;10(5):750-8. Epub 2015 Mar 6 doi: 10.2215/CJN.07910814. PMID: 25749534Free PMC Article
Pathology of ANCA-associated vasculitis.
Ferrario F, Vanzati A, Pagni F
Clin Exp Nephrol 2013 Oct;17(5):652-658. Epub 2012 Nov 23 doi: 10.1007/s10157-012-0701-8. PMID: 23180037

Therapy

DNase I targeted degradation of neutrophil extracellular traps to reduce the damage on IgAV rat.
Chen XQ, Tu L, Tang Q, Zou JS, Yun X, Qin YH
PLoS One 2023;18(10):e0291592. Epub 2023 Oct 31 doi: 10.1371/journal.pone.0291592. PMID: 37906560Free PMC Article
Interstitial nephritis without glomerulonephritis in ANCA-associated vasculitis: a case series and literature review.
He X, Wen Y, Hu R, Wu H, Ye W, Yue C, Qin Y, Xia P, Chen L
Clin Rheumatol 2022 Nov;41(11):3551-3563. Epub 2022 Jun 27 doi: 10.1007/s10067-022-06264-2. PMID: 35759125Free PMC Article
Interstitial eosinophilic infiltration in diabetic nephropathy is indicative of poor prognosis, with no therapy benefit from steroid.
Wu WY, Zhou XJ, Sun PP, Yu XJ, Wang SX, Qu L, Zhang F, Ma YY, Lv JC, Liu G, Yang L
J Diabetes 2020 Dec;12(12):881-894. Epub 2020 Aug 13 doi: 10.1111/1753-0407.13077. PMID: 32506614
Interstitial Immunostaining and Renal Outcomes in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis.
Geetha D, Sethi S, De Vriese AS, Specks U, Kallenberg CGM, Lim N, Spiera R, St Clair EW, Merkel PA, Seo P, Monach PA, Lepori N, Fessler BJ, Langford CA, Hoffman GS, Sharma R, Stone JH, Fervenza FC; RAVE-ITN Research Group
Am J Nephrol 2017;46(3):231-238. Epub 2017 Sep 8 doi: 10.1159/000480443. PMID: 28881339Free PMC Article
Clinicopathologic characteristics and outcomes of renal thrombotic microangiopathy in anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis.
Chen SF, Wang H, Huang YM, Li ZY, Wang SX, Yu F, Zhao MH, Chen M
Clin J Am Soc Nephrol 2015 May 7;10(5):750-8. Epub 2015 Mar 6 doi: 10.2215/CJN.07910814. PMID: 25749534Free PMC Article

Prognosis

Interstitial eosinophilic infiltration in diabetic nephropathy is indicative of poor prognosis, with no therapy benefit from steroid.
Wu WY, Zhou XJ, Sun PP, Yu XJ, Wang SX, Qu L, Zhang F, Ma YY, Lv JC, Liu G, Yang L
J Diabetes 2020 Dec;12(12):881-894. Epub 2020 Aug 13 doi: 10.1111/1753-0407.13077. PMID: 32506614
The Role of Urinary Angiotensinogen in Kidney Interstitial Inflammation and Renal Prognosis.
Dou Y, Song D, Wang C, Liu D, Cheng G, Xiao J, Zhao Z
Iran J Kidney Dis 2019 Nov;13(6):372-379. PMID: 31880583
Interstitial Immunostaining and Renal Outcomes in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis.
Geetha D, Sethi S, De Vriese AS, Specks U, Kallenberg CGM, Lim N, Spiera R, St Clair EW, Merkel PA, Seo P, Monach PA, Lepori N, Fessler BJ, Langford CA, Hoffman GS, Sharma R, Stone JH, Fervenza FC; RAVE-ITN Research Group
Am J Nephrol 2017;46(3):231-238. Epub 2017 Sep 8 doi: 10.1159/000480443. PMID: 28881339Free PMC Article
Clinicopathologic characteristics and outcomes of renal thrombotic microangiopathy in anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis.
Chen SF, Wang H, Huang YM, Li ZY, Wang SX, Yu F, Zhao MH, Chen M
Clin J Am Soc Nephrol 2015 May 7;10(5):750-8. Epub 2015 Mar 6 doi: 10.2215/CJN.07910814. PMID: 25749534Free PMC Article
Pathology of ANCA-associated vasculitis.
Ferrario F, Vanzati A, Pagni F
Clin Exp Nephrol 2013 Oct;17(5):652-658. Epub 2012 Nov 23 doi: 10.1007/s10157-012-0701-8. PMID: 23180037

Clinical prediction guides

DNase I targeted degradation of neutrophil extracellular traps to reduce the damage on IgAV rat.
Chen XQ, Tu L, Tang Q, Zou JS, Yun X, Qin YH
PLoS One 2023;18(10):e0291592. Epub 2023 Oct 31 doi: 10.1371/journal.pone.0291592. PMID: 37906560Free PMC Article
Clinicopathological factors for tubulointerstitial injury in lupus nephritis.
Lan-Ting H, You-Ming C, Li-Xin W, Chen W, Xiao-Yan Z, Hong-Yan H
Clin Rheumatol 2020 May;39(5):1617-1626. Epub 2020 Jan 4 doi: 10.1007/s10067-019-04909-3. PMID: 31902029
The Role of Urinary Angiotensinogen in Kidney Interstitial Inflammation and Renal Prognosis.
Dou Y, Song D, Wang C, Liu D, Cheng G, Xiao J, Zhao Z
Iran J Kidney Dis 2019 Nov;13(6):372-379. PMID: 31880583
Interstitial Immunostaining and Renal Outcomes in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis.
Geetha D, Sethi S, De Vriese AS, Specks U, Kallenberg CGM, Lim N, Spiera R, St Clair EW, Merkel PA, Seo P, Monach PA, Lepori N, Fessler BJ, Langford CA, Hoffman GS, Sharma R, Stone JH, Fervenza FC; RAVE-ITN Research Group
Am J Nephrol 2017;46(3):231-238. Epub 2017 Sep 8 doi: 10.1159/000480443. PMID: 28881339Free PMC Article
Pathology of ANCA-associated vasculitis.
Ferrario F, Vanzati A, Pagni F
Clin Exp Nephrol 2013 Oct;17(5):652-658. Epub 2012 Nov 23 doi: 10.1007/s10157-012-0701-8. PMID: 23180037

Recent systematic reviews

Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive Review.
Martínez-Valenzuela L, Draibe J, Fulladosa X, Gomà M, Gómez F, Antón P, Cruzado JM, Torras J
Int J Mol Sci 2021 Feb 26;22(5) doi: 10.3390/ijms22052326. PMID: 33652638Free PMC Article

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