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Recurrent Soft Tissue Sarcoma of the Trunk and Extremities

MedGen UID:
1714956
•Concept ID:
C5239342
•
Neoplastic Process

Definition

The reemergence of a soft tissue sarcoma of the trunk and extremities after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Soft Tissue Sarcoma of the Trunk and Extremities

Professional guidelines

PubMed

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Radiation Therapy for Treatment of Soft Tissue Sarcoma in Adults: Executive Summary of an ASTRO Clinical Practice Guideline.
Salerno KE, Alektiar KM, Baldini EH, Bedi M, Bishop AJ, Bradfield L, Chung P, DeLaney TF, Folpe A, Kane JM, Li XA, Petersen I, Powell J, Stolten M, Thorpe S, Trent JC, Voermans M, Guadagnolo BA
Pract Radiat Oncol 2021 Sep-Oct;11(5):339-351. Epub 2021 Jul 26 doi: 10.1016/j.prro.2021.04.005. PMID: 34326023
Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis.
Schneider N, Fisher C, Thway K
Ann Diagn Pathol 2016 Feb;20:52-8. Epub 2015 Dec 2 doi: 10.1016/j.anndiagpath.2015.11.002. PMID: 26732302

Recent clinical studies

Etiology

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Radiation Therapy for Treatment of Soft Tissue Sarcoma in Adults: Executive Summary of an ASTRO Clinical Practice Guideline.
Salerno KE, Alektiar KM, Baldini EH, Bedi M, Bishop AJ, Bradfield L, Chung P, DeLaney TF, Folpe A, Kane JM, Li XA, Petersen I, Powell J, Stolten M, Thorpe S, Trent JC, Voermans M, Guadagnolo BA
Pract Radiat Oncol 2021 Sep-Oct;11(5):339-351. Epub 2021 Jul 26 doi: 10.1016/j.prro.2021.04.005. PMID: 34326023
Cytopathology of myxofibrosarcoma: a study of 66 cases and literature review.
Wakely PE Jr
J Am Soc Cytopathol 2021 May-Jun;10(3):300-309. Epub 2020 Sep 19 doi: 10.1016/j.jasc.2020.09.004. PMID: 33041221
Soft tissue sarcomas.
Cormier JN, Pollock RE
CA Cancer J Clin 2004 Mar-Apr;54(2):94-109. doi: 10.3322/canjclin.54.2.94. PMID: 15061599
Cutaneous leiomyosarcoma.
Kaddu S, Beham A, Cerroni L, Humer-Fuchs U, Salmhofer W, Kerl H, Soyer HP
Am J Surg Pathol 1997 Sep;21(9):979-87. doi: 10.1097/00000478-199709000-00001. PMID: 9298873

Diagnosis

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Desmoid-type fibromatosis.
Otero S, Moskovic EC, Strauss DC, Benson C, Miah AB, Thway K, Messiou C
Clin Radiol 2015 Sep;70(9):1038-45. Epub 2015 Jul 7 doi: 10.1016/j.crad.2015.04.015. PMID: 26162574
Dermatofibrosarcoma protuberans.
Dimitropoulos VA
Dermatol Ther 2008 Nov-Dec;21(6):428-32. doi: 10.1111/j.1529-8019.2008.00242.x. PMID: 19076619
Soft tissue sarcomas.
Cormier JN, Pollock RE
CA Cancer J Clin 2004 Mar-Apr;54(2):94-109. doi: 10.3322/canjclin.54.2.94. PMID: 15061599
Dermatofibrosarcoma protuberans.
Laskin WB
CA Cancer J Clin 1992 Mar-Apr;42(2):116-25. doi: 10.3322/canjclin.42.2.116. PMID: 1540852

Therapy

Effectiveness and Safety of Trabectedin and Radiotherapy for Patients With Myxoid Liposarcoma: A Nonrandomized Clinical Trial.
Sanfilippo R, Hindi N, Cruz Jurado J, Blay JY, Lopez-Pousa A, Italiano A, Alvarez R, Gutierrez A, Rincón-Perez I, Sangalli C, Pérez Aguiar JL, Romero J, Morosi C, Sunyach MP, Fabbroni C, Romagosa C, Ranchere-Vince D, Dei Tos AP, Casali PG, Martin-Broto J, Gronchi A
JAMA Oncol 2023 May 1;9(5):656-663. doi: 10.1001/jamaoncol.2023.0056. PMID: 36995731Free PMC Article
What is the standard indication of adjuvant or neoadjuvant chemotherapy in localized soft-tissue sarcoma?
Hindi N, Martin-Broto J
Curr Opin Oncol 2021 Jul 1;33(4):329-335. doi: 10.1097/CCO.0000000000000742. PMID: 33973551
Adjuvant and neoadjuvant chemotherapy for soft tissue sarcomas: JCOG Bone and Soft Tissue Tumor Study Group.
Tanaka K, Ozaki T
Jpn J Clin Oncol 2021 Feb 8;51(2):180-184. doi: 10.1093/jjco/hyaa231. PMID: 33313851
Defining Which Patients Are at High Risk for Recurrence of Soft Tissue Sarcoma.
Spolverato G, Callegaro D, Gronchi A
Curr Treat Options Oncol 2020 May 27;21(7):56. doi: 10.1007/s11864-020-00753-9. PMID: 32462511
The Treatment and Outcomes of Extraskeletal Osteosarcoma: Institutional Experience and Review of The Literature.
Nystrom LM, Reimer NB, Reith JD, Scarborough MT, Gibbs CP Jr
Iowa Orthop J 2016;36:98-103. PMID: 27528844Free PMC Article

Prognosis

Histology-Tailored Approach to Soft Tissue Sarcoma.
Gervais MK, Basile G, Dulude JP, Mottard S, Gronchi A
Ann Surg Oncol 2024 Nov;31(12):7915-7929. Epub 2024 Aug 22 doi: 10.1245/s10434-024-15981-8. PMID: 39174839
The Treatment and Outcomes of Extraskeletal Osteosarcoma: Institutional Experience and Review of The Literature.
Nystrom LM, Reimer NB, Reith JD, Scarborough MT, Gibbs CP Jr
Iowa Orthop J 2016;36:98-103. PMID: 27528844Free PMC Article
Soft tissue sarcomas.
Cormier JN, Pollock RE
CA Cancer J Clin 2004 Mar-Apr;54(2):94-109. doi: 10.3322/canjclin.54.2.94. PMID: 15061599
Cutaneous leiomyosarcoma.
Kaddu S, Beham A, Cerroni L, Humer-Fuchs U, Salmhofer W, Kerl H, Soyer HP
Am J Surg Pathol 1997 Sep;21(9):979-87. doi: 10.1097/00000478-199709000-00001. PMID: 9298873
Dermatofibrosarcoma protuberans.
Laskin WB
CA Cancer J Clin 1992 Mar-Apr;42(2):116-25. doi: 10.3322/canjclin.42.2.116. PMID: 1540852

Clinical prediction guides

Effectiveness and Safety of Trabectedin and Radiotherapy for Patients With Myxoid Liposarcoma: A Nonrandomized Clinical Trial.
Sanfilippo R, Hindi N, Cruz Jurado J, Blay JY, Lopez-Pousa A, Italiano A, Alvarez R, Gutierrez A, Rincón-Perez I, Sangalli C, Pérez Aguiar JL, Romero J, Morosi C, Sunyach MP, Fabbroni C, Romagosa C, Ranchere-Vince D, Dei Tos AP, Casali PG, Martin-Broto J, Gronchi A
JAMA Oncol 2023 May 1;9(5):656-663. doi: 10.1001/jamaoncol.2023.0056. PMID: 36995731Free PMC Article
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
What is the standard indication of adjuvant or neoadjuvant chemotherapy in localized soft-tissue sarcoma?
Hindi N, Martin-Broto J
Curr Opin Oncol 2021 Jul 1;33(4):329-335. doi: 10.1097/CCO.0000000000000742. PMID: 33973551
Defining Which Patients Are at High Risk for Recurrence of Soft Tissue Sarcoma.
Spolverato G, Callegaro D, Gronchi A
Curr Treat Options Oncol 2020 May 27;21(7):56. doi: 10.1007/s11864-020-00753-9. PMID: 32462511
Cutaneous leiomyosarcoma.
Kaddu S, Beham A, Cerroni L, Humer-Fuchs U, Salmhofer W, Kerl H, Soyer HP
Am J Surg Pathol 1997 Sep;21(9):979-87. doi: 10.1097/00000478-199709000-00001. PMID: 9298873

Recent systematic reviews

Low-Grade Fibromyxoid Sarcoma of the Distal Upper Extremity: A Systematic Review.
Kim M, Policherla RK, Linhares SM, Hui-Chou HG
Hand (N Y) 2024 Jul;19(5):701-708. Epub 2023 Jan 24 doi: 10.1177/15589447221150523. PMID: 36692100Free PMC Article
A systematic review of undifferentiated pleomorphic sarcoma of the chest wall.
Bennett C, Bharadwaj S, Arndt A, Chawla A
Chin Clin Oncol 2023 Dec;12(6):66. Epub 2023 Nov 28 doi: 10.21037/cco-23-71. PMID: 38073309
Leiomyosarcoma in the extremities and trunk wall: systematic review and meta-analysis of the oncological outcomes.
Kannan S, Chong HH, Chew B, Ferguson JD, Galloway E, McCulloch T, Rankin KS, Ashford RU
World J Surg Oncol 2022 Apr 18;20(1):124. doi: 10.1186/s12957-022-02584-4. PMID: 35436892Free PMC Article
A Meta-Analysis of the Association Between Radiation Therapy and Survival for Surgically Resected Soft-Tissue Sarcoma.
Qu X, Lubitz CC, Rickard J, Bergeron SG, Wasif N
Am J Clin Oncol 2018 Apr;41(4):348-356. doi: 10.1097/COC.0000000000000274. PMID: 26886948
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081

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