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Recurrent Endometrial Dedifferentiated Carcinoma

MedGen UID:
1714847
•Concept ID:
C5237053
•
Neoplastic Process

Definition

The reemergence of endometrial dedifferentiated carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Endometrial Dedifferentiated Carcinoma

Professional guidelines

PubMed

Uterine Carcinosarcomas - Diagnosis and Management.
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231
Prognostic factors and changing trends in the treatment of Stage I endometrial cancer: a clinical and histopathological study of 182 patients.
Aalders JG, vd Syde R, Poppema S, Szabo BG, Janssens J
Int J Radiat Oncol Biol Phys 1984 Nov;10(11):2083-8. doi: 10.1016/0360-3016(84)90206-2. PMID: 6490433

Recent clinical studies

Etiology

COMPARISON OF CLINICOPATHOLOGICAL AND SURVIVAL ANALYSIS OF ENDOMETRIAL DEDIFFERENTIATED, UNDIFFERENTIATED CARCINOMAS AND CARCINOSARCOMAS.
Hassan U, Asrar I, Maqbool H, Hussain M, Hameed M, Loya A
J Ayub Med Coll Abbottabad 2024 Jul-Sep;36(3):596-605. doi: 10.55519/JAMC-03-13746. PMID: 39623842
Molecular Classification Outperforms Histologic Classification in Prognostication of High-grade Endometrial Carcinomas With Undifferentiated and Sarcomatous Components.
Hammer PM, Wang A, Vermij L, Zdravkovic S, Heilbroner L, Ryan E, Geisick RLP, Charu V, Longacre TA, Suarez CJ, Ho C, Jenkins TM, Mills AM, Bosse T, Howitt BE
Am J Surg Pathol 2024 Aug 1;48(8):953-964. Epub 2024 May 23 doi: 10.1097/PAS.0000000000002250. PMID: 38780000
Endometrial Carcinomas With Subclonal Loss of Mismatch Repair Proteins: A Clinicopathologic and Genomic Study.
Mendoza RP, Wang P, Schulte JJ, Tjota MY, Jani I, Martinez AC, Haridas R, Wanjari P, Steinhardt G, Brown N, Betz BL, Chapel DB, Kertowidjojo E, Yamada SD, Bennett JA
Am J Surg Pathol 2023 May 1;47(5):589-598. Epub 2023 Mar 3 doi: 10.1097/PAS.0000000000002031. PMID: 36866757
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Uterine Carcinosarcomas - Diagnosis and Management.
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231

Diagnosis

COMPARISON OF CLINICOPATHOLOGICAL AND SURVIVAL ANALYSIS OF ENDOMETRIAL DEDIFFERENTIATED, UNDIFFERENTIATED CARCINOMAS AND CARCINOSARCOMAS.
Hassan U, Asrar I, Maqbool H, Hussain M, Hameed M, Loya A
J Ayub Med Coll Abbottabad 2024 Jul-Sep;36(3):596-605. doi: 10.55519/JAMC-03-13746. PMID: 39623842
Yolk Sac Differentiation in Endometrial Carcinoma: Incidence and Clinicopathologic Features of Somatically Derived Yolk Sac Tumors Versus Carcinomas With Nonspecific Immunoexpression of Yolk Sac Markers.
Mills AM, Jenkins TM, Dibbern ME, Atkins KA, Ring KL
Am J Surg Pathol 2024 Jul 1;48(7):790-802. Epub 2024 Apr 23 doi: 10.1097/PAS.0000000000002230. PMID: 38651612
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Uterine Carcinosarcomas - Diagnosis and Management.
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231
Uterine carcinosarcoma: A review of the literature.
Cantrell LA, Blank SV, Duska LR
Gynecol Oncol 2015 Jun;137(3):581-8. Epub 2015 Mar 21 doi: 10.1016/j.ygyno.2015.03.041. PMID: 25805398

Therapy

Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Prognostic factors and changing trends in the treatment of Stage I endometrial cancer: a clinical and histopathological study of 182 patients.
Aalders JG, vd Syde R, Poppema S, Szabo BG, Janssens J
Int J Radiat Oncol Biol Phys 1984 Nov;10(11):2083-8. doi: 10.1016/0360-3016(84)90206-2. PMID: 6490433
Cytoplasmic progesterone and estradiol receptors in normal, hyperplastic, and carcinomatous endometria: therapeutic implications.
Ehrlich CE, Young PC, Cleary RE
Am J Obstet Gynecol 1981 Nov 1;141(5):539-46. doi: 10.1016/s0002-9378(15)33275-0. PMID: 6457531

Prognosis

COMPARISON OF CLINICOPATHOLOGICAL AND SURVIVAL ANALYSIS OF ENDOMETRIAL DEDIFFERENTIATED, UNDIFFERENTIATED CARCINOMAS AND CARCINOSARCOMAS.
Hassan U, Asrar I, Maqbool H, Hussain M, Hameed M, Loya A
J Ayub Med Coll Abbottabad 2024 Jul-Sep;36(3):596-605. doi: 10.55519/JAMC-03-13746. PMID: 39623842
Molecular Classification Outperforms Histologic Classification in Prognostication of High-grade Endometrial Carcinomas With Undifferentiated and Sarcomatous Components.
Hammer PM, Wang A, Vermij L, Zdravkovic S, Heilbroner L, Ryan E, Geisick RLP, Charu V, Longacre TA, Suarez CJ, Ho C, Jenkins TM, Mills AM, Bosse T, Howitt BE
Am J Surg Pathol 2024 Aug 1;48(8):953-964. Epub 2024 May 23 doi: 10.1097/PAS.0000000000002250. PMID: 38780000
Yolk Sac Differentiation in Endometrial Carcinoma: Incidence and Clinicopathologic Features of Somatically Derived Yolk Sac Tumors Versus Carcinomas With Nonspecific Immunoexpression of Yolk Sac Markers.
Mills AM, Jenkins TM, Dibbern ME, Atkins KA, Ring KL
Am J Surg Pathol 2024 Jul 1;48(7):790-802. Epub 2024 Apr 23 doi: 10.1097/PAS.0000000000002230. PMID: 38651612
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Uterine Carcinosarcomas - Diagnosis and Management.
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231

Clinical prediction guides

Molecular Classification Outperforms Histologic Classification in Prognostication of High-grade Endometrial Carcinomas With Undifferentiated and Sarcomatous Components.
Hammer PM, Wang A, Vermij L, Zdravkovic S, Heilbroner L, Ryan E, Geisick RLP, Charu V, Longacre TA, Suarez CJ, Ho C, Jenkins TM, Mills AM, Bosse T, Howitt BE
Am J Surg Pathol 2024 Aug 1;48(8):953-964. Epub 2024 May 23 doi: 10.1097/PAS.0000000000002250. PMID: 38780000
ARID1A, BRG1, and INI1 deficiency in undifferentiated and dedifferentiated endometrial carcinoma: a clinicopathologic, immunohistochemical, and next-generation sequencing analysis of a case series from a single institution.
Korentzelos D, Elishaev E, Zhao C, Jones MW, Soong TR, Lesnock J, Orellana T, Zeccola A, Diamantopoulos LN, Wald AI, Bhargava R
Hum Pathol 2022 Dec;130:65-78. Epub 2022 Oct 14 doi: 10.1016/j.humpath.2022.10.003. PMID: 36252860
Prognostic impact of histological review of high-grade endometrial carcinomas in a large Danish cohort.
Boennelycke M, Peters EEM, Léon-Castillo A, Smit VTHBM, Bosse T, Christensen IJ, Ørtoft G, Høgdall C, Høgdall E
Virchows Arch 2021 Sep;479(3):507-514. Epub 2021 Jun 11 doi: 10.1007/s00428-021-03133-2. PMID: 34117532
Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma.
El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA
Am J Surg Pathol 2021 Mar 1;45(3):374-383. doi: 10.1097/PAS.0000000000001643. PMID: 33565764
Loss of ARID1B and SMARCB1 expression are specific for the diagnosis of dedifferentiated/undifferentiated carcinoma in tumours of the upper gynaecological tract and cervix.
Kang EY, Tessier-Cloutier B, Duggan MA, Stewart CJR, Lee CH, Köbel M
Histopathology 2021 Aug;79(2):160-167. Epub 2021 Jun 2 doi: 10.1111/his.14333. PMID: 33432679

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