Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Locally Advanced Pancreatic Neuroendocrine Tumor

MedGen UID:: 1713714
•Concept ID:: C5238461
•: Neoplastic Process

Definition

A pancreatic neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLocally Advanced Pancreatic Neuroendocrine Tumor

Neoplasm by Special Category
- Metastatic neoplasm
  - Metastatic malignant neoplasm
    - Locally Advanced Malignant Neoplasm
      - Locally Advanced Malignant Digestive System Neoplasm
        Locally Advanced Digestive System Neuroendocrine Neoplasm
        Locally Advanced Pancreatic Neuroendocrine Tumor

Professional guidelines

PubMed

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.

Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807 Free PMC Article

Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management.

Ma ZY, Gong YF, Zhuang HK, Zhou ZX, Huang SZ, Zou YP, Huang BW, Sun ZH, Zhang CZ, Tang YQ, Hou BH
World J Gastroenterol 2020 May 21;26(19):2305-2322. doi: 10.3748/wjg.v26.i19.2305. PMID: 32476795 Free PMC Article

Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances.

Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916 Free PMC Article

See all (63)

Recent clinical studies

Etiology

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.

Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807 Free PMC Article

Evaluation of Outcomes Following Surgery for Locally Advanced Pancreatic Neuroendocrine Tumors.

Titan AL, Norton JA, Fisher AT, Foster DS, Harris EJ, Worhunsky DJ, Worth PJ, Dua MM, Visser BC, Poultsides GA, Longaker MT, Jensen RT
JAMA Netw Open 2020 Nov 2;3(11):e2024318. doi: 10.1001/jamanetworkopen.2020.24318. PMID: 33146734 Free PMC Article

Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management.

Everolimus.

Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763

Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances.

Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916 Free PMC Article

See all (200)

Diagnosis

Gastroenteropancreatic Neuroendocrine Tumors.

Fernandes CJ, Leung G, Eads JR, Katona BW
Gastroenterol Clin North Am 2022 Sep;51(3):625-647. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.002. PMID: 36153114

Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management.

Gastroenteropancreatic Neuroendocrine Tumors.

Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930

Zollinger-Ellison syndrome: recent advances and controversies.

Ito T, Igarashi H, Jensen RT
Curr Opin Gastroenterol 2013 Nov;29(6):650-61. doi: 10.1097/MOG.0b013e328365efb1. PMID: 24100728 Free PMC Article

Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances.

Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916 Free PMC Article

See all (178)

Therapy

Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial.

Pant S, Wainberg ZA, Weekes CD, Furqan M, Kasi PM, Devoe CE, Leal AD, Chung V, Basturk O, VanWyk H, Tavares AM, Seenappa LM, Perry JR, Kheoh T, McNeil LK, Welkowsky E, DeMuth PC, Haqq CM, O'Reilly EM
Nat Med 2024 Feb;30(2):531-542. Epub 2024 Jan 9 doi: 10.1038/s41591-023-02760-3. PMID: 38195752 Free PMC Article

Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management.

Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair-Deficient Cancer: Results From the Phase II KEYNOTE-158 Study.

Marabelle A, Le DT, Ascierto PA, Di Giacomo AM, De Jesus-Acosta A, Delord JP, Geva R, Gottfried M, Penel N, Hansen AR, Piha-Paul SA, Doi T, Gao B, Chung HC, Lopez-Martin J, Bang YJ, Frommer RS, Shah M, Ghori R, Joe AK, Pruitt SK, Diaz LA Jr
J Clin Oncol 2020 Jan 1;38(1):1-10. Epub 2019 Nov 4 doi: 10.1200/JCO.19.02105. PMID: 31682550 Free PMC Article

Gastroenteropancreatic Neuroendocrine Tumors.

Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930

Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances.

Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916 Free PMC Article

See all (132)

Prognosis

Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management.

Prognostic and predictive factors on overall survival and surgical outcomes in pancreatic neuroendocrine tumors: recent advances and controversies.

Lee L, Ito T, Jensen RT
Expert Rev Anticancer Ther 2019 Dec;19(12):1029-1050. Epub 2019 Nov 27 doi: 10.1080/14737140.2019.1693893. PMID: 31738624 Free PMC Article

Gastroenteropancreatic Neuroendocrine Tumors.

Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930

Zollinger-Ellison syndrome: recent advances and controversies.

Ito T, Igarashi H, Jensen RT
Curr Opin Gastroenterol 2013 Nov;29(6):650-61. doi: 10.1097/MOG.0b013e328365efb1. PMID: 24100728 Free PMC Article

Therapy of metastatic pancreatic neuroendocrine tumors (pNETs): recent insights and advances.

Ito T, Igarashi H, Jensen RT
J Gastroenterol 2012 Sep;47(9):941-60. Epub 2012 Aug 11 doi: 10.1007/s00535-012-0642-8. PMID: 22886480 Free PMC Article

See all (186)

Clinical prediction guides

Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial.

EUS-guided intra-tumoral therapies.

Marc B, Monino L, Rimbas M
Best Pract Res Clin Gastroenterol 2022 Sep-Dec;60-61:101817. Epub 2022 Dec 14 doi: 10.1016/j.bpg.2022.101817. PMID: 36577536

Evaluation of Outcomes Following Surgery for Locally Advanced Pancreatic Neuroendocrine Tumors.

Prognostic and predictive factors on overall survival and surgical outcomes in pancreatic neuroendocrine tumors: recent advances and controversies.

Lee L, Ito T, Jensen RT
Expert Rev Anticancer Ther 2019 Dec;19(12):1029-1050. Epub 2019 Nov 27 doi: 10.1080/14737140.2019.1693893. PMID: 31738624 Free PMC Article

Gastroenteropancreatic Neuroendocrine Tumors.

Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930

See all (102)

Recent systematic reviews

Efficacy and safety of temozolomide-based regimens in advanced pancreatic neuroendocrine tumors: a systematic review and meta-analysis.

Taherifard E, Bakhtiar M, Mahnoor M, Ahmed R, Cavalcante L, Zhang J, Saeed A
BMC Cancer 2024 Feb 12;24(1):192. doi: 10.1186/s12885-024-11926-2. PMID: 38347461 Free PMC Article

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.

Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615

Should platinum-based chemotherapy be preferred for germline BReast CAncer genes (BRCA) 1 and 2-mutated pancreatic ductal adenocarcinoma (PDAC) patients? A systematic review and meta-analysis.

Rebelatto TF, Falavigna M, Pozzari M, Spada F, Cella CA, Laffi A, Pellicori S, Fazio N
Cancer Treat Rev 2019 Nov;80:101895. Epub 2019 Sep 6 doi: 10.1016/j.ctrv.2019.101895. PMID: 31542591

Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.

Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354

Metastases of pancreatic adenocarcinoma: A systematic review of literature and a new functional concept.

Cannistrà M, Ruggiero M, Zullo A, Serafini S, Grande R, Nardo B
Int J Surg 2015 Sep;21 Suppl 1:S15-21. Epub 2015 Jun 26 doi: 10.1016/j.ijsu.2015.04.093. PMID: 26123383

See all (7)

MedGen

National Center for Biotechnology Information

Send to:

Locally Advanced Pancreatic Neuroendocrine Tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity