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Recurrent Acute Myelomonocytic Leukemia

MedGen UID:
1712090
•Concept ID:
C2861599
•
Neoplastic Process
Synonym: Relapsed Acute Myelomonocytic Leukemia

Definition

The reemergence of acute myelomonocytic leukemia after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Acute Myelomonocytic Leukemia

Professional guidelines

PubMed

Leukocytapheresis for the treatment of hyperleukocytosis secondary to acute leukemia.
Aqui N, O'Doherty U
Hematology Am Soc Hematol Educ Program 2014 Dec 5;2014(1):457-60. Epub 2014 Nov 18 doi: 10.1182/asheducation-2014.1.457. PMID: 25696894
Gemtuzumab ozogamicin: an anti-CD33 immunoconjugate for the treatment of acute myeloid leukaemia.
Stasi R
Expert Opin Biol Ther 2008 Apr;8(4):527-40. doi: 10.1517/14712598.8.4.527. PMID: 18352855
Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia.
Giles F, Estey E, O'Brien S
Cancer 2003 Nov 15;98(10):2095-104. doi: 10.1002/cncr.11791. PMID: 14601078

Recent clinical studies

Etiology

10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial.
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Acute myeloid leukemia with t(8;16)(p11.2;p13.3)/KAT6A-CREBBP in adults.
Xie W, Hu S, Xu J, Chen Z, Medeiros LJ, Tang G
Ann Hematol 2019 May;98(5):1149-1157. Epub 2019 Feb 13 doi: 10.1007/s00277-019-03637-7. PMID: 30759270
The genomic landscape of juvenile myelomonocytic leukemia.
Stieglitz E, Taylor-Weiner AN, Chang TY, Gelston LC, Wang YD, Mazor T, Esquivel E, Yu A, Seepo S, Olsen S, Rosenberg M, Archambeault SL, Abusin G, Beckman K, Brown PA, Briones M, Carcamo B, Cooper T, Dahl GV, Emanuel PD, Fluchel MN, Goyal RK, Hayashi RJ, Hitzler J, Hugge C, Liu YL, Messinger YH, Mahoney DH Jr, Monteleone P, Nemecek ER, Roehrs PA, Schore RJ, Stine KC, Takemoto CM, Toretsky JA, Costello JF, Olshen AB, Stewart C, Li Y, Ma J, Gerbing RB, Alonzo TA, Getz G, Gruber T, Golub T, Stegmaier K, Loh ML
Nat Genet 2015 Nov;47(11):1326-1333. Epub 2015 Oct 12 doi: 10.1038/ng.3400. PMID: 26457647Free PMC Article
Extramedullary Manifestations of Myeloid Neoplasms.
Wilson CS, Medeiros LJ
Am J Clin Pathol 2015 Aug;144(2):219-39. doi: 10.1309/AJCPO58YWIBUBESX. PMID: 26185307
High efficacy and safety profile of fractionated doses of Mylotarg as induction therapy in patients with relapsed acute myeloblastic leukemia: a prospective study of the alfa group.
Taksin AL, Legrand O, Raffoux E, de Revel T, Thomas X, Contentin N, Bouabdallah R, Pautas C, Turlure P, Reman O, Gardin C, Varet B, de Botton S, Pousset F, Farhat H, Chevret S, Dombret H, Castaigne S
Leukemia 2007 Jan;21(1):66-71. Epub 2006 Oct 19 doi: 10.1038/sj.leu.2404434. PMID: 17051246

Diagnosis

Progression in Myeloid Neoplasms: Beyond the Myeloblast.
Faria C, Tzankov A
Pathobiology 2024;91(1):55-75. Epub 2023 May 11 doi: 10.1159/000530940. PMID: 37232015Free PMC Article
10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial.
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Extramedullary Manifestations of Myeloid Neoplasms.
Wilson CS, Medeiros LJ
Am J Clin Pathol 2015 Aug;144(2):219-39. doi: 10.1309/AJCPO58YWIBUBESX. PMID: 26185307
Survival ensembles.
Hothorn T, Bühlmann P, Dudoit S, Molinaro A, van der Laan MJ
Biostatistics 2006 Jul;7(3):355-73. Epub 2005 Dec 12 doi: 10.1093/biostatistics/kxj011. PMID: 16344280
Acute myeloid leukemia.
Löwenberg B, Downing JR, Burnett A
N Engl J Med 1999 Sep 30;341(14):1051-62. doi: 10.1056/NEJM199909303411407. PMID: 10502596

Therapy

10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial.
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Acute myeloid leukemia with t(8;16)(p11.2;p13.3)/KAT6A-CREBBP in adults.
Xie W, Hu S, Xu J, Chen Z, Medeiros LJ, Tang G
Ann Hematol 2019 May;98(5):1149-1157. Epub 2019 Feb 13 doi: 10.1007/s00277-019-03637-7. PMID: 30759270
High efficacy and safety profile of fractionated doses of Mylotarg as induction therapy in patients with relapsed acute myeloblastic leukemia: a prospective study of the alfa group.
Taksin AL, Legrand O, Raffoux E, de Revel T, Thomas X, Contentin N, Bouabdallah R, Pautas C, Turlure P, Reman O, Gardin C, Varet B, de Botton S, Pousset F, Farhat H, Chevret S, Dombret H, Castaigne S
Leukemia 2007 Jan;21(1):66-71. Epub 2006 Oct 19 doi: 10.1038/sj.leu.2404434. PMID: 17051246
Survival ensembles.
Hothorn T, Bühlmann P, Dudoit S, Molinaro A, van der Laan MJ
Biostatistics 2006 Jul;7(3):355-73. Epub 2005 Dec 12 doi: 10.1093/biostatistics/kxj011. PMID: 16344280
Acute myeloid leukemia.
Löwenberg B, Downing JR, Burnett A
N Engl J Med 1999 Sep 30;341(14):1051-62. doi: 10.1056/NEJM199909303411407. PMID: 10502596

Prognosis

Somatic SETBP1 mutations in myeloid neoplasms.
Makishima H
Int J Hematol 2017 Jun;105(6):732-742. Epub 2017 Apr 26 doi: 10.1007/s12185-017-2241-1. PMID: 28447248
The genomic landscape of juvenile myelomonocytic leukemia.
Stieglitz E, Taylor-Weiner AN, Chang TY, Gelston LC, Wang YD, Mazor T, Esquivel E, Yu A, Seepo S, Olsen S, Rosenberg M, Archambeault SL, Abusin G, Beckman K, Brown PA, Briones M, Carcamo B, Cooper T, Dahl GV, Emanuel PD, Fluchel MN, Goyal RK, Hayashi RJ, Hitzler J, Hugge C, Liu YL, Messinger YH, Mahoney DH Jr, Monteleone P, Nemecek ER, Roehrs PA, Schore RJ, Stine KC, Takemoto CM, Toretsky JA, Costello JF, Olshen AB, Stewart C, Li Y, Ma J, Gerbing RB, Alonzo TA, Getz G, Gruber T, Golub T, Stegmaier K, Loh ML
Nat Genet 2015 Nov;47(11):1326-1333. Epub 2015 Oct 12 doi: 10.1038/ng.3400. PMID: 26457647Free PMC Article
High efficacy and safety profile of fractionated doses of Mylotarg as induction therapy in patients with relapsed acute myeloblastic leukemia: a prospective study of the alfa group.
Taksin AL, Legrand O, Raffoux E, de Revel T, Thomas X, Contentin N, Bouabdallah R, Pautas C, Turlure P, Reman O, Gardin C, Varet B, de Botton S, Pousset F, Farhat H, Chevret S, Dombret H, Castaigne S
Leukemia 2007 Jan;21(1):66-71. Epub 2006 Oct 19 doi: 10.1038/sj.leu.2404434. PMID: 17051246
Survival ensembles.
Hothorn T, Bühlmann P, Dudoit S, Molinaro A, van der Laan MJ
Biostatistics 2006 Jul;7(3):355-73. Epub 2005 Dec 12 doi: 10.1093/biostatistics/kxj011. PMID: 16344280
Acute myeloid leukemia.
Löwenberg B, Downing JR, Burnett A
N Engl J Med 1999 Sep 30;341(14):1051-62. doi: 10.1056/NEJM199909303411407. PMID: 10502596

Clinical prediction guides

Acute myeloid leukemia with t(8;16)(p11.2;p13.3)/KAT6A-CREBBP in adults.
Xie W, Hu S, Xu J, Chen Z, Medeiros LJ, Tang G
Ann Hematol 2019 May;98(5):1149-1157. Epub 2019 Feb 13 doi: 10.1007/s00277-019-03637-7. PMID: 30759270
The genomic landscape of juvenile myelomonocytic leukemia.
Stieglitz E, Taylor-Weiner AN, Chang TY, Gelston LC, Wang YD, Mazor T, Esquivel E, Yu A, Seepo S, Olsen S, Rosenberg M, Archambeault SL, Abusin G, Beckman K, Brown PA, Briones M, Carcamo B, Cooper T, Dahl GV, Emanuel PD, Fluchel MN, Goyal RK, Hayashi RJ, Hitzler J, Hugge C, Liu YL, Messinger YH, Mahoney DH Jr, Monteleone P, Nemecek ER, Roehrs PA, Schore RJ, Stine KC, Takemoto CM, Toretsky JA, Costello JF, Olshen AB, Stewart C, Li Y, Ma J, Gerbing RB, Alonzo TA, Getz G, Gruber T, Golub T, Stegmaier K, Loh ML
Nat Genet 2015 Nov;47(11):1326-1333. Epub 2015 Oct 12 doi: 10.1038/ng.3400. PMID: 26457647Free PMC Article
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.
Jankowska AM, Makishima H, Tiu RV, Szpurka H, Huang Y, Traina F, Visconte V, Sugimoto Y, Prince C, O'Keefe C, Hsi ED, List A, Sekeres MA, Rao A, McDevitt MA, Maciejewski JP
Blood 2011 Oct 6;118(14):3932-41. Epub 2011 Aug 9 doi: 10.1182/blood-2010-10-311019. PMID: 21828135Free PMC Article
High efficacy and safety profile of fractionated doses of Mylotarg as induction therapy in patients with relapsed acute myeloblastic leukemia: a prospective study of the alfa group.
Taksin AL, Legrand O, Raffoux E, de Revel T, Thomas X, Contentin N, Bouabdallah R, Pautas C, Turlure P, Reman O, Gardin C, Varet B, de Botton S, Pousset F, Farhat H, Chevret S, Dombret H, Castaigne S
Leukemia 2007 Jan;21(1):66-71. Epub 2006 Oct 19 doi: 10.1038/sj.leu.2404434. PMID: 17051246
Survival ensembles.
Hothorn T, Bühlmann P, Dudoit S, Molinaro A, van der Laan MJ
Biostatistics 2006 Jul;7(3):355-73. Epub 2005 Dec 12 doi: 10.1093/biostatistics/kxj011. PMID: 16344280

Recent systematic reviews

Myeloid neoplasms with t(12;22)(p13;q12)/MN1-EVT6: a systematic review of 12 cases.
Shao H, Cen J, Chen S, Qiu H, Pan J
Ann Hematol 2018 Mar;97(3):417-424. Epub 2017 Dec 22 doi: 10.1007/s00277-017-3208-2. PMID: 29273914

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