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Renal lymphocytic tubulitis

MedGen UID:
1711181
•Concept ID:
C5397613
•
Disease or Syndrome
HPO: HP:0032589

Definition

Infiltration of the renal tubular epithelium by lymphocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal lymphocytic tubulitis

Professional guidelines

PubMed

Challenges Posed by the Banff Classification: Diagnosis and Treatment of Chronic Active T-Cell-Mediated Rejection.
Yamamoto I, Kawabe M, Hayashi A, Kobayashi A, Yamamoto H, Yokoo T
Nephron 2023;147 Suppl 1:74-79. Epub 2023 Mar 16 doi: 10.1159/000530158. PMID: 36928337
The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials.
Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, Duong van Huyen JP, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M
Am J Transplant 2018 Feb;18(2):293-307. Epub 2018 Jan 21 doi: 10.1111/ajt.14625. PMID: 29243394Free PMC Article
Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment.
Krishnan N, Perazella MA
Iran J Kidney Dis 2015 Jan;9(1):3-13. PMID: 25599729

Recent clinical studies

Etiology

Challenges Posed by the Banff Classification: Diagnosis and Treatment of Chronic Active T-Cell-Mediated Rejection.
Yamamoto I, Kawabe M, Hayashi A, Kobayashi A, Yamamoto H, Yokoo T
Nephron 2023;147 Suppl 1:74-79. Epub 2023 Mar 16 doi: 10.1159/000530158. PMID: 36928337
Renal Manifestations of Common Variable Immunodeficiency.
Caza TN, Hassen SI, Larsen CP
Kidney360 2020 Jun 25;1(6):491-500. Epub 2020 Apr 21 doi: 10.34067/KID.0000432020. PMID: 35368588Free PMC Article
Does tubulitis without interstitial inflammation represent borderline acute T cell mediated rejection?
Nankivell BJ, P'Ng CH, Chapman JR
Am J Transplant 2019 Jan;19(1):132-144. Epub 2018 Jun 15 doi: 10.1111/ajt.14888. PMID: 29687946
The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials.
Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, Duong van Huyen JP, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M
Am J Transplant 2018 Feb;18(2):293-307. Epub 2018 Jan 21 doi: 10.1111/ajt.14625. PMID: 29243394Free PMC Article
Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment.
Krishnan N, Perazella MA
Iran J Kidney Dis 2015 Jan;9(1):3-13. PMID: 25599729

Diagnosis

Challenges Posed by the Banff Classification: Diagnosis and Treatment of Chronic Active T-Cell-Mediated Rejection.
Yamamoto I, Kawabe M, Hayashi A, Kobayashi A, Yamamoto H, Yokoo T
Nephron 2023;147 Suppl 1:74-79. Epub 2023 Mar 16 doi: 10.1159/000530158. PMID: 36928337
Renal Manifestations of Common Variable Immunodeficiency.
Caza TN, Hassen SI, Larsen CP
Kidney360 2020 Jun 25;1(6):491-500. Epub 2020 Apr 21 doi: 10.34067/KID.0000432020. PMID: 35368588Free PMC Article
The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials.
Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, Duong van Huyen JP, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M
Am J Transplant 2018 Feb;18(2):293-307. Epub 2018 Jan 21 doi: 10.1111/ajt.14625. PMID: 29243394Free PMC Article
Transcriptional Perturbations in Graft Rejection.
Vitalone MJ, Sigdel TK, Salomonis N, Sarwal RD, Hsieh SC, Sarwal MM
Transplantation 2015 Sep;99(9):1882-93. doi: 10.1097/TP.0000000000000809. PMID: 26154388Free PMC Article
Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment.
Krishnan N, Perazella MA
Iran J Kidney Dis 2015 Jan;9(1):3-13. PMID: 25599729

Therapy

Does tubulitis without interstitial inflammation represent borderline acute T cell mediated rejection?
Nankivell BJ, P'Ng CH, Chapman JR
Am J Transplant 2019 Jan;19(1):132-144. Epub 2018 Jun 15 doi: 10.1111/ajt.14888. PMID: 29687946
The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials.
Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, Duong van Huyen JP, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M
Am J Transplant 2018 Feb;18(2):293-307. Epub 2018 Jan 21 doi: 10.1111/ajt.14625. PMID: 29243394Free PMC Article
Transcriptional Perturbations in Graft Rejection.
Vitalone MJ, Sigdel TK, Salomonis N, Sarwal RD, Hsieh SC, Sarwal MM
Transplantation 2015 Sep;99(9):1882-93. doi: 10.1097/TP.0000000000000809. PMID: 26154388Free PMC Article
Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment.
Krishnan N, Perazella MA
Iran J Kidney Dis 2015 Jan;9(1):3-13. PMID: 25599729
Tubulitis after renal transplantation: demonstration of an association between CD103+ T cells, transforming growth factor beta1 expression and rejection grade.
Robertson H, Wong WK, Talbot D, Burt AD, Kirby JA
Transplantation 2001 Jan 27;71(2):306-13. doi: 10.1097/00007890-200101270-00024. PMID: 11213078

Prognosis

Comparative Histological Subtyping of Immune Cell Infiltrates in MPO-ANCA and PR3-ANCA Glomerulonephritis.
Hakroush S, Tampe D, Ströbel P, Korsten P, Tampe B
Front Immunol 2021;12:737708. Epub 2021 Oct 21 doi: 10.3389/fimmu.2021.737708. PMID: 34759920Free PMC Article
The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials.
Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D, Nankivell BJ, Halloran PF, Colvin RB, Akalin E, Alachkar N, Bagnasco S, Bouatou Y, Becker JU, Cornell LD, Duong van Huyen JP, Gibson IW, Kraus ES, Mannon RB, Naesens M, Nickeleit V, Nickerson P, Segev DL, Singh HK, Stegall M, Randhawa P, Racusen L, Solez K, Mengel M
Am J Transplant 2018 Feb;18(2):293-307. Epub 2018 Jan 21 doi: 10.1111/ajt.14625. PMID: 29243394Free PMC Article
Transcriptional Perturbations in Graft Rejection.
Vitalone MJ, Sigdel TK, Salomonis N, Sarwal RD, Hsieh SC, Sarwal MM
Transplantation 2015 Sep;99(9):1882-93. doi: 10.1097/TP.0000000000000809. PMID: 26154388Free PMC Article
Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment.
Krishnan N, Perazella MA
Iran J Kidney Dis 2015 Jan;9(1):3-13. PMID: 25599729
Acute tubulointerstitial nephritis: phenotype of infiltrating cells and prognostic impact of tubulitis.
Iványi B, Hamilton-Dutoit SJ, Hansen HE, Olsen S
Virchows Arch 1996 Apr;428(1):5-12. doi: 10.1007/BF00192921. PMID: 8646369

Clinical prediction guides

Challenges Posed by the Banff Classification: Diagnosis and Treatment of Chronic Active T-Cell-Mediated Rejection.
Yamamoto I, Kawabe M, Hayashi A, Kobayashi A, Yamamoto H, Yokoo T
Nephron 2023;147 Suppl 1:74-79. Epub 2023 Mar 16 doi: 10.1159/000530158. PMID: 36928337
Comparative Histological Subtyping of Immune Cell Infiltrates in MPO-ANCA and PR3-ANCA Glomerulonephritis.
Hakroush S, Tampe D, Ströbel P, Korsten P, Tampe B
Front Immunol 2021;12:737708. Epub 2021 Oct 21 doi: 10.3389/fimmu.2021.737708. PMID: 34759920Free PMC Article
Does tubulitis without interstitial inflammation represent borderline acute T cell mediated rejection?
Nankivell BJ, P'Ng CH, Chapman JR
Am J Transplant 2019 Jan;19(1):132-144. Epub 2018 Jun 15 doi: 10.1111/ajt.14888. PMID: 29687946
Transcriptional Perturbations in Graft Rejection.
Vitalone MJ, Sigdel TK, Salomonis N, Sarwal RD, Hsieh SC, Sarwal MM
Transplantation 2015 Sep;99(9):1882-93. doi: 10.1097/TP.0000000000000809. PMID: 26154388Free PMC Article
Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment.
Krishnan N, Perazella MA
Iran J Kidney Dis 2015 Jan;9(1):3-13. PMID: 25599729

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