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Renal tubular cytomegalovirus inclusions

MedGen UID:
1709470
•Concept ID:
C5397953
•
Finding
Synonyms: Renal Tubular Cytomegalovirus Inclusion; Renal Tubular Cytomegalovirus Inclusions
 
HPO: HP:0032953

Definition

Characteristic intranuclear glassy-appearing basophilic inclusions with surrounding halo (owl's eye-type inclusion) and marked increase in the size of the cell (cytomegaly), particularly in tubular epithelial cells and in endothelial cells. Often accompanied by cytopathic changes including patchy interstitial pleomorphic infiltrate with lymphocytes, plasma cells, and macrophages. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal tubular cytomegalovirus inclusions

Professional guidelines

PubMed

Cytomegalovirus Infection in Pregnancy: Prevention, Presentation, Management and Neonatal Outcomes.
Pesch MH, Saunders NA, Abdelnabi S
J Midwifery Womens Health 2021 May;66(3):397-402. Epub 2021 May 24 doi: 10.1111/jmwh.13228. PMID: 34031974
The Third International Consensus Guidelines on the Management of Cytomegalovirus in Solid-organ Transplantation.
Kotton CN, Kumar D, Caliendo AM, Huprikar S, Chou S, Danziger-Isakov L, Humar A; The Transplantation Society International CMV Consensus Group
Transplantation 2018 Jun;102(6):900-931. doi: 10.1097/TP.0000000000002191. PMID: 29596116
Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy.
Rawlinson WD, Boppana SB, Fowler KB, Kimberlin DW, Lazzarotto T, Alain S, Daly K, Doutré S, Gibson L, Giles ML, Greenlee J, Hamilton ST, Harrison GJ, Hui L, Jones CA, Palasanthiran P, Schleiss MR, Shand AW, van Zuylen WJ
Lancet Infect Dis 2017 Jun;17(6):e177-e188. Epub 2017 Mar 11 doi: 10.1016/S1473-3099(17)30143-3. PMID: 28291720

Recent clinical studies

Etiology

Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation.
Limaye AP, Babu TM, Boeckh M
Clin Microbiol Rev 2020 Dec 16;34(1) Epub 2020 Oct 28 doi: 10.1128/CMR.00043-19. PMID: 33115722Free PMC Article
Cytomegalovirus in solid organ transplant recipients-Guidelines of the American Society of Transplantation Infectious Diseases Community of Practice.
Razonable RR, Humar A
Clin Transplant 2019 Sep;33(9):e13512. Epub 2019 Mar 28 doi: 10.1111/ctr.13512. PMID: 30817026
Cytomegalovirus infection in pregnancy.
Davis NL, King CC, Kourtis AP
Birth Defects Res 2017 Mar 15;109(5):336-346. doi: 10.1002/bdra.23601. PMID: 28398680Free PMC Article
Cytomegalovirus.
Dioverti MV, Razonable RR
Microbiol Spectr 2016 Aug;4(4) doi: 10.1128/microbiolspec.DMIH2-0022-2015. PMID: 27726793
The pathogenesis of human cytomegalovirus.
Griffiths P, Baraniak I, Reeves M
J Pathol 2015 Jan;235(2):288-97. doi: 10.1002/path.4437. PMID: 25205255

Diagnosis

Cytomegalovirus in solid organ transplant recipients-Guidelines of the American Society of Transplantation Infectious Diseases Community of Practice.
Razonable RR, Humar A
Clin Transplant 2019 Sep;33(9):e13512. Epub 2019 Mar 28 doi: 10.1111/ctr.13512. PMID: 30817026
Congenital cytomegalovirus infection.
Fowler KB, Boppana SB
Semin Perinatol 2018 Apr;42(3):149-154. Epub 2018 Mar 2 doi: 10.1053/j.semperi.2018.02.002. PMID: 29503048
Cytomegalovirus infection in pregnancy.
Davis NL, King CC, Kourtis AP
Birth Defects Res 2017 Mar 15;109(5):336-346. doi: 10.1002/bdra.23601. PMID: 28398680Free PMC Article
Definitions of Cytomegalovirus Infection and Disease in Transplant Patients for Use in Clinical Trials.
Ljungman P, Boeckh M, Hirsch HH, Josephson F, Lundgren J, Nichols G, Pikis A, Razonable RR, Miller V, Griffiths PD; Disease Definitions Working Group of the Cytomegalovirus Drug Development Forum
Clin Infect Dis 2017 Jan 1;64(1):87-91. Epub 2016 Sep 28 doi: 10.1093/cid/ciw668. PMID: 27682069
Cytomegalovirus.
Dioverti MV, Razonable RR
Microbiol Spectr 2016 Aug;4(4) doi: 10.1128/microbiolspec.DMIH2-0022-2015. PMID: 27726793

Therapy

Pathogenesis of human cytomegalovirus in the immunocompromised host.
Griffiths P, Reeves M
Nat Rev Microbiol 2021 Dec;19(12):759-773. Epub 2021 Jun 24 doi: 10.1038/s41579-021-00582-z. PMID: 34168328Free PMC Article
Cytomegalovirus in solid organ transplant recipients-Guidelines of the American Society of Transplantation Infectious Diseases Community of Practice.
Razonable RR, Humar A
Clin Transplant 2019 Sep;33(9):e13512. Epub 2019 Mar 28 doi: 10.1111/ctr.13512. PMID: 30817026
Congenital cytomegalovirus infection.
Fowler KB, Boppana SB
Semin Perinatol 2018 Apr;42(3):149-154. Epub 2018 Mar 2 doi: 10.1053/j.semperi.2018.02.002. PMID: 29503048
Cytomegalovirus.
Dioverti MV, Razonable RR
Microbiol Spectr 2016 Aug;4(4) doi: 10.1128/microbiolspec.DMIH2-0022-2015. PMID: 27726793
The pathogenesis of human cytomegalovirus.
Griffiths P, Baraniak I, Reeves M
J Pathol 2015 Jan;235(2):288-97. doi: 10.1002/path.4437. PMID: 25205255

Prognosis

A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection.
Hughes BL, Clifton RG, Rouse DJ, Saade GR, Dinsmoor MJ, Reddy UM, Pass R, Allard D, Mallett G, Fette LM, Gyamfi-Bannerman C, Varner MW, Goodnight WH, Tita ATN, Costantine MM, Swamy GK, Gibbs RS, Chien EK, Chauhan SP, El-Sayed YY, Casey BM, Parry S, Simhan HN, Napolitano PG, Macones GA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network
N Engl J Med 2021 Jul 29;385(5):436-444. doi: 10.1056/NEJMoa1913569. PMID: 34320288Free PMC Article
Posttransplant cyclophosphamide is associated with increased cytomegalovirus infection: a CIBMTR analysis.
Goldsmith SR, Abid MB, Auletta JJ, Bashey A, Beitinjaneh A, Castillo P, Chemaly RF, Chen M, Ciurea S, Dandoy CE, Díaz MÁ, Fuchs E, Ganguly S, Kanakry CG, Kanakry JA, Kim S, Komanduri KV, Krem MM, Lazarus HM, Liu H, Ljungman P, Masiarz R, Mulroney C, Nathan S, Nishihori T, Page KM, Perales MA, Taplitz R, Romee R, Riches M
Blood 2021 Jun 10;137(23):3291-3305. doi: 10.1182/blood.2020009362. PMID: 33657221Free PMC Article
Effect of Preemptive Therapy vs Antiviral Prophylaxis on Cytomegalovirus Disease in Seronegative Liver Transplant Recipients With Seropositive Donors: A Randomized Clinical Trial.
Singh N, Winston DJ, Razonable RR, Lyon GM, Silveira FP, Wagener MM, Stevens-Ayers T, Edmison B, Boeckh M, Limaye AP
JAMA 2020 Apr 14;323(14):1378-1387. doi: 10.1001/jama.2020.3138. PMID: 32286644Free PMC Article
Infections in pregnancy.
Keighley CL, Skrzypek HJ, Wilson A, Bonning MA, Gilbert GL
Med J Aust 2019 Aug;211(3):134-141. Epub 2019 Jul 4 doi: 10.5694/mja2.50261. PMID: 31271467
Congenital Cytomegalovirus infection: advances and challenges in diagnosis, prevention and treatment.
Marsico C, Kimberlin DW
Ital J Pediatr 2017 Apr 17;43(1):38. doi: 10.1186/s13052-017-0358-8. PMID: 28416012Free PMC Article

Clinical prediction guides

Letermovir Prophylaxis for Cytomegalovirus Infection in Children After Hematopoietic Cell Transplantation.
Richert-Przygonska M, Jaremek K, Debski R, Konieczek J, Lecka M, Dziedzic M, Bogiel T, Styczynski J, Czyzewski K
Anticancer Res 2022 Jul;42(7):3607-3612. doi: 10.21873/anticanres.15848. PMID: 35790275
Outcome and management of newborns with congenital cytomegalovirus infection.
Nicloux M, Peterman L, Parodi M, Magny JF
Arch Pediatr 2020 Apr;27(3):160-165. Epub 2020 Feb 29 doi: 10.1016/j.arcped.2020.01.006. PMID: 32127242
The etiology of lenticulostriate vasculopathy and the role of congenital infections.
Cantey JB, Sisman J
Early Hum Dev 2015 Jul;91(7):427-30. Epub 2015 May 7 doi: 10.1016/j.earlhumdev.2015.04.005. PMID: 25960415
Cytomegalovirus infection in liver transplant recipients: updates on clinical management.
Marcelin JR, Beam E, Razonable RR
World J Gastroenterol 2014 Aug 21;20(31):10658-67. doi: 10.3748/wjg.v20.i31.10658. PMID: 25152570Free PMC Article
Cytomegalovirus pneumonia.
Klotman ME, Hamilton JD
Semin Respir Infect 1987 Jun;2(2):95-103. PMID: 2827281

Recent systematic reviews

Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis.
Rybak-Krzyszkowska M, Górecka J, Huras H, Massalska-Wolska M, Staśkiewicz M, Gach A, Kondracka A, Staniczek J, Górczewski W, Borowski D, Jaczyńska R, Grzesiak M, Krzeszowski W
Viruses 2023 Oct 24;15(11) doi: 10.3390/v15112142. PMID: 38005820Free PMC Article
Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
Triggers of Guillain-Barré Syndrome: Campylobacter jejuni Predominates.
Finsterer J
Int J Mol Sci 2022 Nov 17;23(22) doi: 10.3390/ijms232214222. PMID: 36430700Free PMC Article
Estimation of the worldwide seroprevalence of cytomegalovirus: A systematic review and meta-analysis.
Zuhair M, Smit GSA, Wallis G, Jabbar F, Smith C, Devleesschauwer B, Griffiths P
Rev Med Virol 2019 May;29(3):e2034. Epub 2019 Jan 31 doi: 10.1002/rmv.2034. PMID: 30706584
Tonsillitis.
Georgalas CC, Tolley NS, Narula PA
BMJ Clin Evid 2014 Jul 22;2014 PMID: 25051184Free PMC Article

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