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Increased sialylated N-glycan level

MedGen UID:
1707651
Concept ID:
C5139519
Finding
Synonym: Increased concentration of sialylated N-glycans on glycoproteins
 
HPO: HP:0410354

Definition

An abnormal increase in the concentration of sialylated N-glycans on glycoproteins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased sialylated N-glycan level

Professional guidelines

PubMed

Lim SY, Hendra C, Yeo XH, Tan XY, Ng BH, Laserna AKC, Tan SH, Chan MY, Khan SH, Chen SM, Li SFY
Glycobiology 2022 May 23;32(6):469-482. doi: 10.1093/glycob/cwab129. PMID: 34939124

Recent clinical studies

Etiology

Greto VL, Cvetko A, Štambuk T, Dempster NJ, Kifer D, Deriš H, Cindrić A, Vučković F, Falchi M, Gillies RS, Tomlinson JW, Gornik O, Sgromo B, Spector TD, Menni C, Geremia A, Arancibia-Cárcamo CV, Lauc G
Int J Obes (Lond) 2021 Jul;45(7):1521-1531. Epub 2021 May 3 doi: 10.1038/s41366-021-00816-3. PMID: 33941843Free PMC Article
Ward S, O'Sullivan JM, O'Donnell JS
J Thromb Haemost 2019 Jul;17(7):1018-1029. Epub 2019 May 30 doi: 10.1111/jth.14471. PMID: 31055873
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S
Biochim Biophys Acta Gen Subj 2019 May;1863(5):960-970. Epub 2019 Mar 5 doi: 10.1016/j.bbagen.2019.03.001. PMID: 30844485
Bai L, Li Q, Li L, Lin Y, Zhao S, Wang W, Wang R, Li Y, Yuan J, Wang C, Wang Z, Fan J, Liu E
PLoS One 2016;11(3):e0146982. Epub 2016 Mar 21 doi: 10.1371/journal.pone.0146982. PMID: 26999365Free PMC Article
Shilova N, Huflejt ME, Vuskovic M, Obukhova P, Navakouski M, Khasbiullina N, Pazynina G, Galanina O, Bazhenov A, Bovin N
Top Curr Chem 2015;366:169-81. doi: 10.1007/128_2013_469. PMID: 24037491

Diagnosis

Marie AL, Ray S, Ivanov AR
Nat Commun 2023 Mar 23;14(1):1618. doi: 10.1038/s41467-023-37365-4. PMID: 36959283Free PMC Article
Jin W, Wang C, Yang M, Wei M, Huang L, Wang Z
Anal Chem 2019 Aug 20;91(16):10492-10500. Epub 2019 Jul 31 doi: 10.1021/acs.analchem.9b01393. PMID: 31329418
Sethi MK, Hancock WS, Fanayan S
Acc Chem Res 2016 Oct 18;49(10):2099-2106. Epub 2016 Sep 21 doi: 10.1021/acs.accounts.6b00193. PMID: 27653471
Bai L, Li Q, Li L, Lin Y, Zhao S, Wang W, Wang R, Li Y, Yuan J, Wang C, Wang Z, Fan J, Liu E
PLoS One 2016;11(3):e0146982. Epub 2016 Mar 21 doi: 10.1371/journal.pone.0146982. PMID: 26999365Free PMC Article
Shilova N, Huflejt ME, Vuskovic M, Obukhova P, Navakouski M, Khasbiullina N, Pazynina G, Galanina O, Bazhenov A, Bovin N
Top Curr Chem 2015;366:169-81. doi: 10.1007/128_2013_469. PMID: 24037491

Therapy

Zhang Y, Fan C, Zhang L, Ma X
Prog Mol Biol Transl Sci 2019;163:471-485. Epub 2019 Mar 25 doi: 10.1016/bs.pmbts.2019.03.004. PMID: 31030759
Teare JM, Kates DS, Shah A, Garger S
Drug Des Devel Ther 2019;13:941-948. Epub 2019 Mar 22 doi: 10.2147/DDDT.S188171. PMID: 30962676Free PMC Article
Bai L, Li Q, Li L, Lin Y, Zhao S, Wang W, Wang R, Li Y, Yuan J, Wang C, Wang Z, Fan J, Liu E
PLoS One 2016;11(3):e0146982. Epub 2016 Mar 21 doi: 10.1371/journal.pone.0146982. PMID: 26999365Free PMC Article
Chen J, Fang M, Zhao YP, Yi CH, Ji J, Cheng C, Wang MM, Gu X, Sun QS, Chen XL, Gao CF
PLoS One 2015;10(6):e0127022. Epub 2015 Jun 15 doi: 10.1371/journal.pone.0127022. PMID: 26075387Free PMC Article
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article

Prognosis

Vreeker GCM, Hanna-Sawires RG, Mohammed Y, Bladergroen MR, Nicolardi S, Dotz V, Nouta J, Bonsing BA, Mesker WE, van der Burgt YEM, Wuhrer M, Tollenaar RAEM
Cancer Med 2020 Nov;9(22):8519-8529. Epub 2020 Sep 8 doi: 10.1002/cam4.3439. PMID: 32898301Free PMC Article
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S
Biochim Biophys Acta Gen Subj 2019 May;1863(5):960-970. Epub 2019 Mar 5 doi: 10.1016/j.bbagen.2019.03.001. PMID: 30844485
Costa J, Streich L, Pinto S, Pronto-Laborinho A, Nimtz M, Conradt HS, de Carvalho M
Mol Neurobiol 2019 Aug;56(8):5729-5739. Epub 2019 Jan 23 doi: 10.1007/s12035-019-1482-9. PMID: 30674035
Ma X, Dong W, Su Z, Zhao L, Miao Y, Li N, Zhou H, Jia L
Cell Death Dis 2016 Dec 29;7(12):e2561. doi: 10.1038/cddis.2016.427. PMID: 28032858Free PMC Article
Sethi MK, Hancock WS, Fanayan S
Acc Chem Res 2016 Oct 18;49(10):2099-2106. Epub 2016 Sep 21 doi: 10.1021/acs.accounts.6b00193. PMID: 27653471

Clinical prediction guides

Greto VL, Cvetko A, Štambuk T, Dempster NJ, Kifer D, Deriš H, Cindrić A, Vučković F, Falchi M, Gillies RS, Tomlinson JW, Gornik O, Sgromo B, Spector TD, Menni C, Geremia A, Arancibia-Cárcamo CV, Lauc G
Int J Obes (Lond) 2021 Jul;45(7):1521-1531. Epub 2021 May 3 doi: 10.1038/s41366-021-00816-3. PMID: 33941843Free PMC Article
Vreeker GCM, Hanna-Sawires RG, Mohammed Y, Bladergroen MR, Nicolardi S, Dotz V, Nouta J, Bonsing BA, Mesker WE, van der Burgt YEM, Wuhrer M, Tollenaar RAEM
Cancer Med 2020 Nov;9(22):8519-8529. Epub 2020 Sep 8 doi: 10.1002/cam4.3439. PMID: 32898301Free PMC Article
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S
Biochim Biophys Acta Gen Subj 2019 May;1863(5):960-970. Epub 2019 Mar 5 doi: 10.1016/j.bbagen.2019.03.001. PMID: 30844485
Sethi MK, Hancock WS, Fanayan S
Acc Chem Res 2016 Oct 18;49(10):2099-2106. Epub 2016 Sep 21 doi: 10.1021/acs.accounts.6b00193. PMID: 27653471
Shilova N, Huflejt ME, Vuskovic M, Obukhova P, Navakouski M, Khasbiullina N, Pazynina G, Galanina O, Bazhenov A, Bovin N
Top Curr Chem 2015;366:169-81. doi: 10.1007/128_2013_469. PMID: 24037491

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