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Myopenia

MedGen UID:
1707315
•Concept ID:
C5206946
•
Pathologic Function

Definition

A condition characterized by a clinically relevant degree of muscle wasting that is associated either with impaired functional capacity and/or with increased risk of morbidity or mortality. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyopenia

Professional guidelines

PubMed

Review article: Evidence-based dietary management of inflammatory bowel disease.
Gibson PR, Yao CK, Halmos EP
Aliment Pharmacol Ther 2024 Nov;60(9):1215-1233. Epub 2024 Aug 20 doi: 10.1111/apt.18214. PMID: 39164974
Diagnosis and Treatment of Sarcopenic Dysphagia: A Scoping Review.
Wakabayashi H, Kishima M, Itoda M, Fujishima I, Kunieda K, Ohno T, Shigematsu T, Oshima F, Mori T, Ogawa N, Nishioka S, Yamada M, Ogawa S; Japanese Working Group on Sarcopenic Dysphagia
Dysphagia 2021 Jun;36(3):523-531. Epub 2021 Feb 23 doi: 10.1007/s00455-021-10266-8. PMID: 33620563
Low muscle mass at initiation of anti-TNF therapy for inflammatory bowel disease is associated with early treatment failure: a retrospective analysis.
Holt DQ, Varma P, Strauss BJG, Rajadurai AS, Moore GT
Eur J Clin Nutr 2017 Jun;71(6):773-777. Epub 2017 Feb 22 doi: 10.1038/ejcn.2017.10. PMID: 28225051

Recent clinical studies

Etiology

AI-based CT Body Composition Identifies Myosteatosis as Key Mortality Predictor in Asymptomatic Adults.
Nachit M, Horsmans Y, Summers RM, Leclercq IA, Pickhardt PJ
Radiology 2023 Jun;307(5):e222008. Epub 2023 May 16 doi: 10.1148/radiol.222008. PMID: 37191484Free PMC Article
Myopenic obesity determined by visceral fat area strongly predicts long-term mortality in cirrhosis.
Feng H, Wang X, Zhao T, Mao L, Hui Y, Fan X, Lin L, Zhao W, Jiang K, Wang B, Yu Q, Zhang J, Sun C
Clin Nutr 2021 Apr;40(4):1983-1989. Epub 2020 Sep 17 doi: 10.1016/j.clnu.2020.09.016. PMID: 32977996
Muscular Atrophy in Cardiovascular Disease.
Sisto IR, Hauck M, Plentz RDM
Adv Exp Med Biol 2018;1088:369-391. doi: 10.1007/978-981-13-1435-3_17. PMID: 30390261
Nutritional supplements in support of resistance exercise to counter age-related sarcopenia.
Phillips SM
Adv Nutr 2015 Jul;6(4):452-60. Epub 2015 Jul 15 doi: 10.3945/an.115.008367. PMID: 26178029Free PMC Article
Sarcopenia and nutrition.
Laviano A, Gori C, Rianda S
Adv Food Nutr Res 2014;71:101-36. doi: 10.1016/B978-0-12-800270-4.00003-1. PMID: 24484940

Diagnosis

Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis.
Gonzalez-Ponce F, Gamez-Nava JI, Gomez-Ramirez EE, Ramirez-Villafaña M, Jacobo-Cuevas H, Rodriguez-Jimenez NA, Olivas-Flores EM, Esparza-Guerrero Y, Martelli-García A, Santiago-Garcia AP, Nava-Valdivia CA, Martinez-Hernandez A, Gonzalez-Vazquez SA, Celis A, Cabrera-Pivaral CE, Totsuka-Sutto S, Cardona-Muñoz EG, Gonzalez-Lopez L
J Immunol Res 2022;2022:7258152. Epub 2022 May 10 doi: 10.1155/2022/7258152. PMID: 35592686Free PMC Article
Diagnosis and Treatment of Sarcopenic Dysphagia: A Scoping Review.
Wakabayashi H, Kishima M, Itoda M, Fujishima I, Kunieda K, Ohno T, Shigematsu T, Oshima F, Mori T, Ogawa N, Nishioka S, Yamada M, Ogawa S; Japanese Working Group on Sarcopenic Dysphagia
Dysphagia 2021 Jun;36(3):523-531. Epub 2021 Feb 23 doi: 10.1007/s00455-021-10266-8. PMID: 33620563
Myopenia and precision (P4) medicine.
Morley JE, Anker SD
J Cachexia Sarcopenia Muscle 2017 Dec;8(6):857-863. Epub 2017 Sep 24 doi: 10.1002/jcsm.12231. PMID: 28944582Free PMC Article
Sarcopenia and the analysis of body composition.
Ribeiro SM, Kehayias JJ
Adv Nutr 2014 May;5(3):260-7. Epub 2014 May 14 doi: 10.3945/an.113.005256. PMID: 24829472Free PMC Article
Sarcopenia and nutrition.
Laviano A, Gori C, Rianda S
Adv Food Nutr Res 2014;71:101-36. doi: 10.1016/B978-0-12-800270-4.00003-1. PMID: 24484940

Therapy

Systematic review of sarcopenia in inflammatory bowel disease.
Fatani H, Olaru A, Stevenson R, Alharazi W, Jafer A, Atherton P, Brook M, Moran G
Clin Nutr 2023 Aug;42(8):1276-1291. Epub 2023 Jun 2 doi: 10.1016/j.clnu.2023.05.002. PMID: 37352818
The effect of biological agent on body composition in patients with Crohn's disease.
Choi EJ, Baek DH, Lee HS, Song GA, Kim TO, Park YE, Lee CM; Busan Ulsan Gyeongnam Intestinal Study Group Society (BIGS), Lee JH
BMC Gastroenterol 2023 Mar 30;23(1):100. doi: 10.1186/s12876-023-02742-2. PMID: 36997863Free PMC Article
Impact of myopenia and myosteatosis on postoperative outcome and recurrence in Crohn's disease.
Pozios I, Kaufmann D, Boubaris K, Seeliger H, Weixler B, Stroux A, Kamphues C, Margonis GA, Kreis ME, Beyer K, Seifarth C, Lauscher JC
Int J Colorectal Dis 2022 Apr;37(4):791-804. Epub 2022 Feb 14 doi: 10.1007/s00384-022-04104-y. PMID: 35156133Free PMC Article
Nutritional supplements in support of resistance exercise to counter age-related sarcopenia.
Phillips SM
Adv Nutr 2015 Jul;6(4):452-60. Epub 2015 Jul 15 doi: 10.3945/an.115.008367. PMID: 26178029Free PMC Article
Sarcopenia and nutrition.
Laviano A, Gori C, Rianda S
Adv Food Nutr Res 2014;71:101-36. doi: 10.1016/B978-0-12-800270-4.00003-1. PMID: 24484940

Prognosis

AI-based CT Body Composition Identifies Myosteatosis as Key Mortality Predictor in Asymptomatic Adults.
Nachit M, Horsmans Y, Summers RM, Leclercq IA, Pickhardt PJ
Radiology 2023 Jun;307(5):e222008. Epub 2023 May 16 doi: 10.1148/radiol.222008. PMID: 37191484Free PMC Article
Impact of myopenia and myosteatosis on postoperative outcome and recurrence in Crohn's disease.
Pozios I, Kaufmann D, Boubaris K, Seeliger H, Weixler B, Stroux A, Kamphues C, Margonis GA, Kreis ME, Beyer K, Seifarth C, Lauscher JC
Int J Colorectal Dis 2022 Apr;37(4):791-804. Epub 2022 Feb 14 doi: 10.1007/s00384-022-04104-y. PMID: 35156133Free PMC Article
Nutrition interventions to treat low muscle mass in cancer.
Prado CM, Purcell SA, Laviano A
J Cachexia Sarcopenia Muscle 2020 Apr;11(2):366-380. Epub 2020 Jan 8 doi: 10.1002/jcsm.12525. PMID: 31916411Free PMC Article
Muscular Atrophy in Cardiovascular Disease.
Sisto IR, Hauck M, Plentz RDM
Adv Exp Med Biol 2018;1088:369-391. doi: 10.1007/978-981-13-1435-3_17. PMID: 30390261
Myopenia and precision (P4) medicine.
Morley JE, Anker SD
J Cachexia Sarcopenia Muscle 2017 Dec;8(6):857-863. Epub 2017 Sep 24 doi: 10.1002/jcsm.12231. PMID: 28944582Free PMC Article

Clinical prediction guides

AI-based CT Body Composition Identifies Myosteatosis as Key Mortality Predictor in Asymptomatic Adults.
Nachit M, Horsmans Y, Summers RM, Leclercq IA, Pickhardt PJ
Radiology 2023 Jun;307(5):e222008. Epub 2023 May 16 doi: 10.1148/radiol.222008. PMID: 37191484Free PMC Article
The effect of biological agent on body composition in patients with Crohn's disease.
Choi EJ, Baek DH, Lee HS, Song GA, Kim TO, Park YE, Lee CM; Busan Ulsan Gyeongnam Intestinal Study Group Society (BIGS), Lee JH
BMC Gastroenterol 2023 Mar 30;23(1):100. doi: 10.1186/s12876-023-02742-2. PMID: 36997863Free PMC Article
Myopenic obesity determined by visceral fat area strongly predicts long-term mortality in cirrhosis.
Feng H, Wang X, Zhao T, Mao L, Hui Y, Fan X, Lin L, Zhao W, Jiang K, Wang B, Yu Q, Zhang J, Sun C
Clin Nutr 2021 Apr;40(4):1983-1989. Epub 2020 Sep 17 doi: 10.1016/j.clnu.2020.09.016. PMID: 32977996
Cancer cachexia and myopenia - Update on management strategies and the direction of future research for optimizing body composition in cancer - A narrative review.
Pring ET, Malietzis G, Kennedy RH, Athanasiou T, Jenkins JT
Cancer Treat Rev 2018 Nov;70:245-254. Epub 2018 Oct 6 doi: 10.1016/j.ctrv.2018.10.002. PMID: 30321741
Myopenia and precision (P4) medicine.
Morley JE, Anker SD
J Cachexia Sarcopenia Muscle 2017 Dec;8(6):857-863. Epub 2017 Sep 24 doi: 10.1002/jcsm.12231. PMID: 28944582Free PMC Article

Recent systematic reviews

Systematic review of sarcopenia in inflammatory bowel disease.
Fatani H, Olaru A, Stevenson R, Alharazi W, Jafer A, Atherton P, Brook M, Moran G
Clin Nutr 2023 Aug;42(8):1276-1291. Epub 2023 Jun 2 doi: 10.1016/j.clnu.2023.05.002. PMID: 37352818
Evaluation of different tools for body composition assessment in colorectal cancer - a systematic review.
Monaco-Ferreira DV, Magro DO, Coy CSR
Arq Gastroenterol 2022 Apr-Jun;59(2):296-303. doi: 10.1590/S0004-2803.202202000-52. PMID: 35830044
Body Composition and Dose-limiting Toxicity in Colorectal Cancer Chemotherapy Treatment; a Systematic Review of the Literature. Could Muscle Mass be the New Body Surface Area in Chemotherapy Dosing?
Drami I, Pring ET, Gould L, Malietzis G, Naghibi M, Athanasiou T, Glynne-Jones R, Jenkins JT
Clin Oncol (R Coll Radiol) 2021 Dec;33(12):e540-e552. Epub 2021 Jun 17 doi: 10.1016/j.clon.2021.05.011. PMID: 34147322

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