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Decreased sialylated N-glycan level

MedGen UID:
1705465
Concept ID:
C5139520
Finding
Synonym: Decreased concentration of sialylated N-glycans on glycoproteins
 
HPO: HP:0410355

Definition

An abnormal decrease in the concentration of sialylated N-glycans on glycoproteins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased sialylated N-glycan level

Professional guidelines

PubMed

Lim SY, Hendra C, Yeo XH, Tan XY, Ng BH, Laserna AKC, Tan SH, Chan MY, Khan SH, Chen SM, Li SFY
Glycobiology 2022 May 23;32(6):469-482. doi: 10.1093/glycob/cwab129. PMID: 34939124

Recent clinical studies

Etiology

Lim SY, Hendra C, Yeo XH, Tan XY, Ng BH, Laserna AKC, Tan SH, Chan MY, Khan SH, Chen SM, Li SFY
Glycobiology 2022 May 23;32(6):469-482. doi: 10.1093/glycob/cwab129. PMID: 34939124
Greto VL, Cvetko A, Štambuk T, Dempster NJ, Kifer D, Deriš H, Cindrić A, Vučković F, Falchi M, Gillies RS, Tomlinson JW, Gornik O, Sgromo B, Spector TD, Menni C, Geremia A, Arancibia-Cárcamo CV, Lauc G
Int J Obes (Lond) 2021 Jul;45(7):1521-1531. Epub 2021 May 3 doi: 10.1038/s41366-021-00816-3. PMID: 33941843Free PMC Article
Komaromy A, Reider B, Jarvas G, Guttman A
Clin Chim Acta 2020 Jul;506:204-213. Epub 2020 Mar 31 doi: 10.1016/j.cca.2020.03.041. PMID: 32243984
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S
Biochim Biophys Acta Gen Subj 2019 May;1863(5):960-970. Epub 2019 Mar 5 doi: 10.1016/j.bbagen.2019.03.001. PMID: 30844485
Mittermayr S, Lê GN, Clarke C, Millán Martín S, Larkin AM, O'Gorman P, Bones J
J Proteome Res 2017 Feb 3;16(2):748-762. Epub 2016 Dec 12 doi: 10.1021/acs.jproteome.6b00768. PMID: 27936757

Diagnosis

Xu M, Jin H, Ge W, Zhao L, Liu Z, Guo Z, Wu Z, Chen J, Mao C, Zhang X, Liu CF, Yang S
ACS Chem Neurosci 2023 Sep 20;14(18):3507-3517. Epub 2023 Sep 7 doi: 10.1021/acschemneuro.3c00404. PMID: 37677068
Beimdiek J, Janciauskiene S, Wrenger S, Volland S, Rozy A, Fuge J, Olejnicka B, Pink I, Illig T, Popov A, Chorostowska J, Buettner FFR, Welte T
Respir Res 2022 Dec 13;23(1):343. doi: 10.1186/s12931-022-02272-7. PMID: 36514048Free PMC Article
Lim SY, Hendra C, Yeo XH, Tan XY, Ng BH, Laserna AKC, Tan SH, Chan MY, Khan SH, Chen SM, Li SFY
Glycobiology 2022 May 23;32(6):469-482. doi: 10.1093/glycob/cwab129. PMID: 34939124
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S
Biochim Biophys Acta Gen Subj 2019 May;1863(5):960-970. Epub 2019 Mar 5 doi: 10.1016/j.bbagen.2019.03.001. PMID: 30844485
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article

Therapy

Zhang Y, Fan C, Zhang L, Ma X
Prog Mol Biol Transl Sci 2019;163:471-485. Epub 2019 Mar 25 doi: 10.1016/bs.pmbts.2019.03.004. PMID: 31030759
Chen J, Fang M, Zhao YP, Yi CH, Ji J, Cheng C, Wang MM, Gu X, Sun QS, Chen XL, Gao CF
PLoS One 2015;10(6):e0127022. Epub 2015 Jun 15 doi: 10.1371/journal.pone.0127022. PMID: 26075387Free PMC Article
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article

Prognosis

Wojcik I, Wuhrer M, Heeringa P, Stegeman CA, Rutgers A, Falck D
Front Immunol 2023;14:1214945. Epub 2023 Sep 29 doi: 10.3389/fimmu.2023.1214945. PMID: 37841251Free PMC Article
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S
Biochim Biophys Acta Gen Subj 2019 May;1863(5):960-970. Epub 2019 Mar 5 doi: 10.1016/j.bbagen.2019.03.001. PMID: 30844485
Clerc F, Novokmet M, Dotz V, Reiding KR, de Haan N, Kammeijer GSM, Dalebout H, Bladergroen MR, Vukovic F, Rapp E; IBD-BIOM Consortium, Targan SR, Barron G, Manetti N, Latiano A, McGovern DPB, Annese V, Lauc G, Wuhrer M
Gastroenterology 2018 Sep;155(3):829-843. Epub 2018 May 21 doi: 10.1053/j.gastro.2018.05.030. PMID: 29792883
Kemna MJ, Plomp R, van Paassen P, Koeleman CAM, Jansen BC, Damoiseaux JGMC, Cohen Tervaert JW, Wuhrer M
EBioMedicine 2017 Mar;17:108-118. Epub 2017 Jan 28 doi: 10.1016/j.ebiom.2017.01.033. PMID: 28169190Free PMC Article
Kodar K, Stadlmann J, Klaamas K, Sergeyev B, Kurtenkov O
Glycoconj J 2012 Jan;29(1):57-66. Epub 2011 Dec 17 doi: 10.1007/s10719-011-9364-z. PMID: 22179780

Clinical prediction guides

Greto VL, Cvetko A, Štambuk T, Dempster NJ, Kifer D, Deriš H, Cindrić A, Vučković F, Falchi M, Gillies RS, Tomlinson JW, Gornik O, Sgromo B, Spector TD, Menni C, Geremia A, Arancibia-Cárcamo CV, Lauc G
Int J Obes (Lond) 2021 Jul;45(7):1521-1531. Epub 2021 May 3 doi: 10.1038/s41366-021-00816-3. PMID: 33941843Free PMC Article
Ząbczyńska M, Link-Lenczowski P, Novokmet M, Martin T, Turek-Jabrocka R, Trofimiuk-Müldner M, Pocheć E
Biochim Biophys Acta Gen Subj 2020 Mar;1864(3):129464. Epub 2019 Oct 26 doi: 10.1016/j.bbagen.2019.129464. PMID: 31669586
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S
Biochim Biophys Acta Gen Subj 2019 May;1863(5):960-970. Epub 2019 Mar 5 doi: 10.1016/j.bbagen.2019.03.001. PMID: 30844485
Clerc F, Novokmet M, Dotz V, Reiding KR, de Haan N, Kammeijer GSM, Dalebout H, Bladergroen MR, Vukovic F, Rapp E; IBD-BIOM Consortium, Targan SR, Barron G, Manetti N, Latiano A, McGovern DPB, Annese V, Lauc G, Wuhrer M
Gastroenterology 2018 Sep;155(3):829-843. Epub 2018 May 21 doi: 10.1053/j.gastro.2018.05.030. PMID: 29792883
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article

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