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Advanced Endometrial Carcinoma

MedGen UID:
1699444
•Concept ID:
C5204617
•
Neoplastic Process

Definition

An endometrial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Treatment options for advanced endometrial carcinoma.
Dizon DS
Gynecol Oncol 2010 May;117(2):373-81. Epub 2010 Mar 12 doi: 10.1016/j.ygyno.2010.02.007. PMID: 20223510
Treatment of advanced endometrial carcinoma with tamoxifen.
Swenerton KD, White GW, Boyes DA
N Engl J Med 1979 Jul 12;301(2):105. doi: 10.1056/NEJM197907123010211. PMID: 449932
Treatment of advanced endometrial carcinoma with a progestational agent.
Peck JG, Boyes DA
Am J Obstet Gynecol 1969 Jan 1;103(1):90-1. doi: 10.1016/s0002-9378(16)34347-2. PMID: 4178207

Recent clinical studies

Etiology

Lunchbox trial: A randomized phase III trial of cisplatin and irradiation followed by carboplatin and paclitaxel versus sandwich therapy of carboplatin and paclitaxel followed by irradiation then carboplatin and paclitaxel for advanced endometrial carcinoma.
Barlin JN, Mahar B, Ata A, Cormier B, Michelin D, Salani R, Backes F, Levinson K, Cantrell LA, Weinberg L, Wagreich A, Savage D, Gasson C, Denniston K, Martin J, McElrath T, Timmins PF
Gynecol Oncol 2024 Jan;180:63-69. Epub 2023 Dec 5 doi: 10.1016/j.ygyno.2023.11.012. PMID: 38052110
Clinical relevance of circulating ESR1 mutations during endocrine therapy for advanced hormone-dependent endometrial carcinoma.
Drouyer A, Beaussire L, Jorda P, Leheurteur M, Guillemet C, Berghian A, Georgescu D, Di Fiore F, Perdrix A, Clatot F
BMC Cancer 2023 Nov 3;23(1):1061. doi: 10.1186/s12885-023-11559-x. PMID: 37924026Free PMC Article
Adjuvant chemoradiation associated with improved outcomes in patients with microsatellite instability-high advanced endometrial carcinoma.
McEachron J, Zhou N, Spencer C, Chatterton C, Shanahan L, Katz J, Naegele S, Singhal PK, Lee YC
Int J Gynecol Cancer 2021 Feb;31(2):203-208. Epub 2020 Aug 17 doi: 10.1136/ijgc-2020-001709. PMID: 32817172
Lenvatinib plus pembrolizumab in patients with advanced endometrial cancer: an interim analysis of a multicentre, open-label, single-arm, phase 2 trial.
Makker V, Rasco D, Vogelzang NJ, Brose MS, Cohn AL, Mier J, Di Simone C, Hyman DM, Stepan DE, Dutcus CE, Schmidt EV, Guo M, Sachdev P, Shumaker R, Aghajanian C, Taylor M
Lancet Oncol 2019 May;20(5):711-718. Epub 2019 Mar 25 doi: 10.1016/S1470-2045(19)30020-8. PMID: 30922731Free PMC Article
Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study.
Fiorica JV, Brunetto VL, Hanjani P, Lentz SS, Mannel R, Andersen W; Gynecologic Oncology Group study
Gynecol Oncol 2004 Jan;92(1):10-4. doi: 10.1016/j.ygyno.2003.11.008. PMID: 14751131

Diagnosis

Pembrolizumab plus lenvatinib combination therapy for advanced endometrial carcinoma.
Walker CA, Spirtos AN, Miller DS
Expert Rev Anticancer Ther 2023 Apr;23(4):361-368. Epub 2023 Mar 28 doi: 10.1080/14737140.2023.2194634. PMID: 36944439
Evaluation of the efficiency and safety of adjuvant chemotherapy alone for patients with advanced endometrial carcinoma: A protocol for systematic review and meta-analysis.
Guo J, Li S, Wu Y
Medicine (Baltimore) 2022 Jul 15;101(28):e29156. doi: 10.1097/MD.0000000000029156. PMID: 35839048Free PMC Article
The prognostic role of preoperative serum CA125 levels in patients with advanced endometrial carcinoma.
Modarres-Gilani M, Vaezi M, Shariat M, Zamani N, Nourizadeh R
Cancer Biomark 2017 Aug 23;20(2):135-141. doi: 10.3233/CBM-160529. PMID: 28800309
Clinical evaluation of women with PMB. Is it always necessary an endometrial biopsy to be performed? A review of the literature.
Dimitraki M, Tsikouras P, Bouchlariotou S, Dafopoulos A, Liberis V, Maroulis G, Teichmann AT
Arch Gynecol Obstet 2011 Feb;283(2):261-6. Epub 2010 Aug 4 doi: 10.1007/s00404-010-1601-3. PMID: 20683604Free PMC Article
Treatment options for advanced endometrial carcinoma.
Dizon DS
Gynecol Oncol 2010 May;117(2):373-81. Epub 2010 Mar 12 doi: 10.1016/j.ygyno.2010.02.007. PMID: 20223510

Therapy

A Phase Ib/II Study of Lenvatinib and Pembrolizumab in Advanced Endometrial Carcinoma (Study 111/KEYNOTE-146): Long-Term Efficacy and Safety Update.
Makker V, Aghajanian C, Cohn AL, Romeo M, Bratos R, Brose MS, Messing M, Dutta L, Dutcus CE, Huang J, Schmidt EV, Orlowski R, Taylor MH
J Clin Oncol 2023 Feb 10;41(5):974-979. Epub 2023 Jan 6 doi: 10.1200/JCO.22.01021. PMID: 36608305Free PMC Article
New Approved Use for Keytruda.
Aschenbrenner DS
Am J Nurs 2022 Jul 1;122(7):26-27. doi: 10.1097/01.NAJ.0000842244.43543.52. PMID: 35736598
Lenvatinib Plus Pembrolizumab in Patients With Advanced Endometrial Cancer.
Makker V, Taylor MH, Aghajanian C, Oaknin A, Mier J, Cohn AL, Romeo M, Bratos R, Brose MS, DiSimone C, Messing M, Stepan DE, Dutcus CE, Wu J, Schmidt EV, Orlowski R, Sachdev P, Shumaker R, Casado Herraez A
J Clin Oncol 2020 Sep 10;38(26):2981-2992. Epub 2020 Mar 13 doi: 10.1200/JCO.19.02627. PMID: 32167863Free PMC Article
Lenvatinib plus pembrolizumab in patients with advanced endometrial cancer: an interim analysis of a multicentre, open-label, single-arm, phase 2 trial.
Makker V, Rasco D, Vogelzang NJ, Brose MS, Cohn AL, Mier J, Di Simone C, Hyman DM, Stepan DE, Dutcus CE, Schmidt EV, Guo M, Sachdev P, Shumaker R, Aghajanian C, Taylor M
Lancet Oncol 2019 May;20(5):711-718. Epub 2019 Mar 25 doi: 10.1016/S1470-2045(19)30020-8. PMID: 30922731Free PMC Article
Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study.
Fiorica JV, Brunetto VL, Hanjani P, Lentz SS, Mannel R, Andersen W; Gynecologic Oncology Group study
Gynecol Oncol 2004 Jan;92(1):10-4. doi: 10.1016/j.ygyno.2003.11.008. PMID: 14751131

Prognosis

RNA-Binding Protein MEX3A Interacting with DVL3 Stabilizes Wnt/β-Catenin Signaling in Endometrial Carcinoma.
Yang P, Zhang P, Zhang S
Int J Mol Sci 2022 Dec 29;24(1) doi: 10.3390/ijms24010592. PMID: 36614043Free PMC Article
Endometrial Cancer-Infiltrating Mesenchymal Stem Cells Exhibit Immunosuppressive Effects.
Wang KH, Chang YH, Harnod T, Ding DC
Cell Transplant 2022 Jan-Dec;31:9636897221104452. doi: 10.1177/09636897221104452. PMID: 35712817Free PMC Article
Treatment options for advanced endometrial carcinoma.
Dizon DS
Gynecol Oncol 2010 May;117(2):373-81. Epub 2010 Mar 12 doi: 10.1016/j.ygyno.2010.02.007. PMID: 20223510
Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study.
Fiorica JV, Brunetto VL, Hanjani P, Lentz SS, Mannel R, Andersen W; Gynecologic Oncology Group study
Gynecol Oncol 2004 Jan;92(1):10-4. doi: 10.1016/j.ygyno.2003.11.008. PMID: 14751131
Spontaneous regression of advanced endometrial carcinoma.
Beller U, Beckman EM, Twombly GH
Gynecol Oncol 1984 Mar;17(3):381-5. doi: 10.1016/0090-8258(84)90225-7. PMID: 6706237

Clinical prediction guides

A phase 2 trial of zanidatamab in HER2-overexpressed advanced endometrial carcinoma and carcinosarcoma (ZW25-IST-2).
Lumish M, Chui MH, Zhou Q, Iasonos A, Sarasohn D, Cohen S, Friedman C, Grisham R, Konner J, Kyi C, Rubinstein M, Troso-Sandoval T, Aghajanian C, Makker V
Gynecol Oncol 2024 Mar;182:75-81. Epub 2024 Jan 22 doi: 10.1016/j.ygyno.2023.12.028. PMID: 38262242Free PMC Article
Evaluation of potential biomarkers for lenvatinib plus pembrolizumab among patients with advanced endometrial cancer: results from Study 111/KEYNOTE-146.
Makker V, Taylor MH, Aghajanian C, Cohn AL, Brose MS, Simone CD, Cao ZA, Suttner L, Loboda A, Cristescu R, Jelinic P, Orlowski R, Dutta L, Matsui J, Dutcus CE, Minoshima Y, Messing MJ
J Immunother Cancer 2024 Jan 19;12(1) doi: 10.1136/jitc-2023-007929. PMID: 38242717Free PMC Article
Lunchbox trial: A randomized phase III trial of cisplatin and irradiation followed by carboplatin and paclitaxel versus sandwich therapy of carboplatin and paclitaxel followed by irradiation then carboplatin and paclitaxel for advanced endometrial carcinoma.
Barlin JN, Mahar B, Ata A, Cormier B, Michelin D, Salani R, Backes F, Levinson K, Cantrell LA, Weinberg L, Wagreich A, Savage D, Gasson C, Denniston K, Martin J, McElrath T, Timmins PF
Gynecol Oncol 2024 Jan;180:63-69. Epub 2023 Dec 5 doi: 10.1016/j.ygyno.2023.11.012. PMID: 38052110
Endometrial Cancer-Infiltrating Mesenchymal Stem Cells Exhibit Immunosuppressive Effects.
Wang KH, Chang YH, Harnod T, Ding DC
Cell Transplant 2022 Jan-Dec;31:9636897221104452. doi: 10.1177/09636897221104452. PMID: 35712817Free PMC Article
Clinical evaluation of women with PMB. Is it always necessary an endometrial biopsy to be performed? A review of the literature.
Dimitraki M, Tsikouras P, Bouchlariotou S, Dafopoulos A, Liberis V, Maroulis G, Teichmann AT
Arch Gynecol Obstet 2011 Feb;283(2):261-6. Epub 2010 Aug 4 doi: 10.1007/s00404-010-1601-3. PMID: 20683604Free PMC Article

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