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Increased high-mannose N-glycan level

MedGen UID:
1693624
Concept ID:
C5139522
Finding
Synonym: Increased high-mannose N-glycans on glycoprotein concentration
 
HPO: HP:0410357

Definition

An abnormal increase in the concentration of high-mannose N-glycans on glycoproteins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased high-mannose N-glycan level

Recent clinical studies

Etiology

Fan J, Sha J, Chang S, Zhao H, Niu X, Gu Y, Gu J, Ren S
Aging Cell 2023 Jul;22(7):e13855. Epub 2023 May 2 doi: 10.1111/acel.13855. PMID: 37132100Free PMC Article
Trbojević-Akmačić I, Vučković F, Vilaj M, Skelin A, Karssen LC, Krištić J, Jurić J, Momčilović A, Šimunović J, Mangino M, De Gregori M, Marchesini M, Dagostino C, Štambuk J, Novokmet M, Rauck R, Aulchenko YS, Primorac D, Kapural L, Buyse K, Mesotten D, Williams FMK, van Zundert J, Allegri M, Lauc G
Biochim Biophys Acta Gen Subj 2018 Oct;1862(10):2124-2133. Epub 2018 Jul 5 doi: 10.1016/j.bbagen.2018.07.003. PMID: 29981899
Terkelsen T, Haakensen VD, Saldova R, Gromov P, Hansen MK, Stöckmann H, Lingjaerde OC, Børresen-Dale AL, Papaleo E, Helland Å, Rudd PM, Gromova I
Mol Oncol 2018 Jun;12(6):972-990. Epub 2018 May 14 doi: 10.1002/1878-0261.12312. PMID: 29698574Free PMC Article
Bai L, Li Q, Li L, Lin Y, Zhao S, Wang W, Wang R, Li Y, Yuan J, Wang C, Wang Z, Fan J, Liu E
PLoS One 2016;11(3):e0146982. Epub 2016 Mar 21 doi: 10.1371/journal.pone.0146982. PMID: 26999365Free PMC Article
Inafuku S, Noda K, Amano M, Nishimura S, Ishida S
Curr Eye Res 2016 May;41(5):721-4. Epub 2015 Jul 15 doi: 10.3109/02713683.2015.1068816. PMID: 26177396

Diagnosis

Wei Y, Chen Q, Huang S, Liu Y, Li Y, Xing Y, Shi D, Xu W, Liu W, Ji Z, Wu B, Chen X, Jiang J
Adv Sci (Weinh) 2022 Sep;9(26):e2202216. Epub 2022 Jul 7 doi: 10.1002/advs.202202216. PMID: 35798319Free PMC Article
Terkelsen T, Haakensen VD, Saldova R, Gromov P, Hansen MK, Stöckmann H, Lingjaerde OC, Børresen-Dale AL, Papaleo E, Helland Å, Rudd PM, Gromova I
Mol Oncol 2018 Jun;12(6):972-990. Epub 2018 May 14 doi: 10.1002/1878-0261.12312. PMID: 29698574Free PMC Article
Jin ZC, Kitajima T, Dong W, Huang YF, Ren WW, Guan F, Chiba Y, Gao XD, Fujita M
J Biol Chem 2018 Apr 13;293(15):5572-5584. Epub 2018 Feb 23 doi: 10.1074/jbc.M117.813030. PMID: 29475941Free PMC Article
Sethi MK, Hancock WS, Fanayan S
Acc Chem Res 2016 Oct 18;49(10):2099-2106. Epub 2016 Sep 21 doi: 10.1021/acs.accounts.6b00193. PMID: 27653471
Bai L, Li Q, Li L, Lin Y, Zhao S, Wang W, Wang R, Li Y, Yuan J, Wang C, Wang Z, Fan J, Liu E
PLoS One 2016;11(3):e0146982. Epub 2016 Mar 21 doi: 10.1371/journal.pone.0146982. PMID: 26999365Free PMC Article

Therapy

Wei Y, Chen Q, Huang S, Liu Y, Li Y, Xing Y, Shi D, Xu W, Liu W, Ji Z, Wu B, Chen X, Jiang J
Adv Sci (Weinh) 2022 Sep;9(26):e2202216. Epub 2022 Jul 7 doi: 10.1002/advs.202202216. PMID: 35798319Free PMC Article
Bai L, Li Q, Li L, Lin Y, Zhao S, Wang W, Wang R, Li Y, Yuan J, Wang C, Wang Z, Fan J, Liu E
PLoS One 2016;11(3):e0146982. Epub 2016 Mar 21 doi: 10.1371/journal.pone.0146982. PMID: 26999365Free PMC Article

Prognosis

Rudman N, Kifer D, Kaur S, Simunović V, Cvetko A, Pociot F, Morahan G, Gornik O
Diabetologia 2022 Aug;65(8):1315-1327. Epub 2022 May 27 doi: 10.1007/s00125-022-05703-8. PMID: 35622127Free PMC Article
Heijs B, Holst-Bernal S, de Graaff MA, Briaire-de Bruijn IH, Rodriguez-Girondo M, van de Sande MAJ, Wuhrer M, McDonnell LA, Bovée JVMG
Lab Invest 2020 Sep;100(9):1252-1261. Epub 2020 Apr 27 doi: 10.1038/s41374-020-0435-2. PMID: 32341520
Terkelsen T, Haakensen VD, Saldova R, Gromov P, Hansen MK, Stöckmann H, Lingjaerde OC, Børresen-Dale AL, Papaleo E, Helland Å, Rudd PM, Gromova I
Mol Oncol 2018 Jun;12(6):972-990. Epub 2018 May 14 doi: 10.1002/1878-0261.12312. PMID: 29698574Free PMC Article
Sethi MK, Hancock WS, Fanayan S
Acc Chem Res 2016 Oct 18;49(10):2099-2106. Epub 2016 Sep 21 doi: 10.1021/acs.accounts.6b00193. PMID: 27653471
Schwedler C, Kaup M, Weiz S, Hoppe M, Braicu EI, Sehouli J, Hoppe B, Tauber R, Berger M, Blanchard V
Anal Bioanal Chem 2014 Nov;406(28):7185-93. Epub 2014 Sep 19 doi: 10.1007/s00216-014-8168-y. PMID: 25234305

Clinical prediction guides

Trbojević-Akmačić I, Vučković F, Vilaj M, Skelin A, Karssen LC, Krištić J, Jurić J, Momčilović A, Šimunović J, Mangino M, De Gregori M, Marchesini M, Dagostino C, Štambuk J, Novokmet M, Rauck R, Aulchenko YS, Primorac D, Kapural L, Buyse K, Mesotten D, Williams FMK, van Zundert J, Allegri M, Lauc G
Biochim Biophys Acta Gen Subj 2018 Oct;1862(10):2124-2133. Epub 2018 Jul 5 doi: 10.1016/j.bbagen.2018.07.003. PMID: 29981899
Terkelsen T, Haakensen VD, Saldova R, Gromov P, Hansen MK, Stöckmann H, Lingjaerde OC, Børresen-Dale AL, Papaleo E, Helland Å, Rudd PM, Gromova I
Mol Oncol 2018 Jun;12(6):972-990. Epub 2018 May 14 doi: 10.1002/1878-0261.12312. PMID: 29698574Free PMC Article
Sethi MK, Hancock WS, Fanayan S
Acc Chem Res 2016 Oct 18;49(10):2099-2106. Epub 2016 Sep 21 doi: 10.1021/acs.accounts.6b00193. PMID: 27653471
Rouwendal GJ, van der Lee MM, Meyer S, Reiding KR, Schouten J, de Roo G, Egging DF, Leusen JH, Boross P, Wuhrer M, Verheijden GF, Dokter WH, Timmers M, Ubink R
MAbs 2016;8(1):74-86. Epub 2015 Oct 6 doi: 10.1080/19420862.2015.1102812. PMID: 26440530Free PMC Article
Urita A, Matsuhashi T, Onodera T, Nakagawa H, Hato M, Amano M, Seito N, Minami A, Nishimura S, Iwasaki N
Arthritis Rheum 2011 Nov;63(11):3428-38. doi: 10.1002/art.30584. PMID: 21834068

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