Increased susceptibility to EBV-associated B-cell lymphoproliferative disorders

MedGen UID:: 1693349
•Concept ID:: C5232495
•: Finding

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIncreased susceptibility to EBV-associated B-cell lymphoproliferative disorders

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Increased susceptibility to EBV-associated B-cell lymphoproliferative disorders

Recent clinical studies

Etiology

Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation.

Moshous D, Martin E, Carpentier W, Lim A, Callebaut I, Canioni D, Hauck F, Majewski J, Schwartzentruber J, Nitschke P, Sirvent N, Frange P, Picard C, Blanche S, Revy P, Fischer A, Latour S, Jabado N, de Villartay JP
J Allergy Clin Immunol 2013 Jun;131(6):1594-603. Epub 2013 Mar 21 doi: 10.1016/j.jaci.2013.01.042. PMID: 23522482

Cyclosporin A renders target cells resistant to immune cytolysis.

Hudnall SD
Eur J Immunol 1991 Jan;21(1):221-6. doi: 10.1002/eji.1830210133. PMID: 1846819

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Diagnosis

Novel Mutations in RASGRP1 are Associated with Immunodeficiency, Immune Dysregulation, and EBV-Induced Lymphoma.

Somekh I, Marquardt B, Liu Y, Rohlfs M, Hollizeck S, Karakukcu M, Unal E, Yilmaz E, Patiroglu T, Cansever M, Frizinsky S, Vishnvenska-Dai V, Rechavi E, Stauber T, Simon AJ, Lev A, Klein C, Kotlarz D, Somech R
J Clin Immunol 2018 Aug;38(6):699-710. Epub 2018 Jul 20 doi: 10.1007/s10875-018-0533-8. PMID: 30030704

Clinical aspects on Epstein-Barr virus infection.

Andersson JP
Scand J Infect Dis Suppl 1991;80:94-104. PMID: 1666450

Enhanced destruction of lymphoid cell lines by peripheral blood leukocytes taken from patients with acute infectious mononucleosis.

Hutt LM, Huang YT, Dascomb HE, Pagano JS
J Immunol 1975 Jul;115(1):243-8. PMID: 168255

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Prognosis

CircEAF2 counteracts Epstein-Barr virus-positive diffuse large B-cell lymphoma progression via miR-BART19-3p/APC/β-catenin axis.

Zhao CX, Yan ZX, Wen JJ, Fu D, Xu PP, Wang L, Cheng S, Hu JD, Zhao WL
Mol Cancer 2021 Dec 1;20(1):153. doi: 10.1186/s12943-021-01458-9. PMID: 34852843 Free PMC Article

Phenotypic and functional analysis of Fas (CD95) expression in primary central nervous system lymphoma of patients with acquired immunodeficiency syndrome.

Baiocchi RA, Khatri VP, Lindemann MJ, Ross ME, Papoff G, Caprio AJ, Caprio TV, Fenstermaker R, Ruberti G, Bernstein ZP, Caligiuri MA
Blood 1997 Sep 1;90(5):1737-46. PMID: 9292506

Clinical aspects on Epstein-Barr virus infection.

Andersson JP
Scand J Infect Dis Suppl 1991;80:94-104. PMID: 1666450

See all (3)