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Ileal Neuroendocrine Tumor G2

MedGen UID:
1690289
Concept ID:
C5205251
Neoplastic Process
Synonym: Ileal NET G2

Definition

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the ileum. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIleal Neuroendocrine Tumor G2

Professional guidelines

PubMed

Frilling A, Clift AK, Frampton AE, Bomanji J, Kaemmerer D, Al-Nahhas A, Alsafi A, Kidd M, Modlin IM, Hoersch D, Baum RP
Int J Med Sci 2021;18(10):2166-2175. Epub 2021 Mar 19 doi: 10.7150/ijms.51740. PMID: 33859524Free PMC Article
Koch W, Auernhammer CJ, Geisler J, Spitzweg C, Cyran CC, Ilhan H, Bartenstein P, Haug AR
Mol Imaging 2014;13:1-10. PMID: 24824963

Recent clinical studies

Etiology

Costanzo A, Canziani M, Ferrari CC, Bertocchi V, Cutaia S, Bucci EO, Uslenghi E, Ferretti A, De Luca M, Ceriani F
Medicine (Baltimore) 2022 Jun 17;101(24):e29464. doi: 10.1097/MD.0000000000029464. PMID: 35713456Free PMC Article
Feola T, Puliani G, Sesti F, Modica R, Centello R, Minotta R, Cannavale G, Di Meglio S, Di Vito V, Lauretta R, Appetecchia M, Colao A, Lenzi A, Isidori AM, Faggiano A, Giannetta E
J Endocrinol Invest 2022 Apr;45(4):849-857. Epub 2022 Jan 18 doi: 10.1007/s40618-021-01715-0. PMID: 35040099
Altieri B, Barrea L, Modica R, Bottiglieri F, de Cicco F, Muscogiuri G, Circelli L, Savarese G, Di Somma C, Savastano S, Colao A, Faggiano A
Endocrine 2022 Feb;75(2):623-634. Epub 2021 Sep 17 doi: 10.1007/s12020-021-02869-w. PMID: 34533768
Rossi RE, Elli L, Branchi F, Conte D, Massironi S
Digestion 2021;102(5):722-730. Epub 2020 Dec 23 doi: 10.1159/000511850. PMID: 33361694
Imperiale A, Rust E, Gabriel S, Detour J, Goichot B, Duclos B, Kurtz JE, Bachellier P, Namer IJ, Taïeb D
J Nucl Med 2014 Mar;55(3):367-72. Epub 2013 Dec 16 doi: 10.2967/jnumed.113.126896. PMID: 24343986

Diagnosis

Romano E, Polici M, Marasco M, Lerose F, Dell'Unto E, Nardacci S, Zerunian M, Iannicelli E, Rinzivillo M, Laghi A, Annibale B, Panzuto F, Caruso D
Nutrients 2024 Jul 11;16(14) doi: 10.3390/nu16142224. PMID: 39064666Free PMC Article
Feola T, Puliani G, Sesti F, Modica R, Centello R, Minotta R, Cannavale G, Di Meglio S, Di Vito V, Lauretta R, Appetecchia M, Colao A, Lenzi A, Isidori AM, Faggiano A, Giannetta E
J Endocrinol Invest 2022 Apr;45(4):849-857. Epub 2022 Jan 18 doi: 10.1007/s40618-021-01715-0. PMID: 35040099
Kasajima A, Konukiewitz B, Schlitter AM, Weichert W, Klöppel G
Virchows Arch 2022 Feb;480(2):359-368. Epub 2021 Sep 9 doi: 10.1007/s00428-021-03202-6. PMID: 34499237Free PMC Article
Rossi RE, Elli L, Branchi F, Conte D, Massironi S
Digestion 2021;102(5):722-730. Epub 2020 Dec 23 doi: 10.1159/000511850. PMID: 33361694
Deroose CM, Hindié E, Kebebew E, Goichot B, Pacak K, Taïeb D, Imperiale A
J Nucl Med 2016 Dec;57(12):1949-1956. Epub 2016 Nov 3 doi: 10.2967/jnumed.116.179234. PMID: 27811124Free PMC Article

Therapy

Frilling A, Clift AK, Frampton AE, Bomanji J, Kaemmerer D, Al-Nahhas A, Alsafi A, Kidd M, Modlin IM, Hoersch D, Baum RP
Int J Med Sci 2021;18(10):2166-2175. Epub 2021 Mar 19 doi: 10.7150/ijms.51740. PMID: 33859524Free PMC Article
Del Prete M, Di Sarno A, Modica R, Lassandro F, Giorgio A, Bianco A, Muto M, Gasperi M, Del Prete F, Colao A, Montesarchio V, Faggiano A; ENETS Centre of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples (Italy)
J Endocrinol Invest 2017 Dec;40(12):1373-1380. Epub 2017 Jun 30 doi: 10.1007/s40618-017-0723-x. PMID: 28667452
Andersson E, Arvidsson Y, Swärd C, Hofving T, Wängberg B, Kristiansson E, Nilsson O
Mod Pathol 2016 Jun;29(6):616-29. Epub 2016 Mar 11 doi: 10.1038/modpathol.2016.48. PMID: 26965582
Panzuto F, Campana D, Fazio N, Brizzi MP, Boninsegna L, Nori F, Di Meglio G, Capurso G, Scarpa A, Dogliotti L, De Braud F, Tomassetti P, Delle Fave G, Falconi M
Neuroendocrinology 2012;96(1):32-40. Epub 2011 Dec 28 doi: 10.1159/000334038. PMID: 22205326
Sierra ML, Agazzi A, Bodei L, Pacifici M, Aricò D, De Cicco C, Quarna J, Sansovini M, De Simone M, Paganelli G
Cancer Biother Radiopharm 2009 Dec;24(6):659-65. doi: 10.1089/cbr.2009.0641. PMID: 20025545

Prognosis

Costanzo A, Canziani M, Ferrari CC, Bertocchi V, Cutaia S, Bucci EO, Uslenghi E, Ferretti A, De Luca M, Ceriani F
Medicine (Baltimore) 2022 Jun 17;101(24):e29464. doi: 10.1097/MD.0000000000029464. PMID: 35713456Free PMC Article
Feola T, Puliani G, Sesti F, Modica R, Centello R, Minotta R, Cannavale G, Di Meglio S, Di Vito V, Lauretta R, Appetecchia M, Colao A, Lenzi A, Isidori AM, Faggiano A, Giannetta E
J Endocrinol Invest 2022 Apr;45(4):849-857. Epub 2022 Jan 18 doi: 10.1007/s40618-021-01715-0. PMID: 35040099
Altieri B, Barrea L, Modica R, Bottiglieri F, de Cicco F, Muscogiuri G, Circelli L, Savarese G, Di Somma C, Savastano S, Colao A, Faggiano A
Endocrine 2022 Feb;75(2):623-634. Epub 2021 Sep 17 doi: 10.1007/s12020-021-02869-w. PMID: 34533768
Borga C, Dal Pozzo CA, Trevellin E, Bergamo F, Murgioni S, Milanetto AC, Pasquali C, Cillo U, Munari G, Martini C, De Carlo E, Zagonel V, Guzzardo V, Pennelli G, Dei Tos AP, Vettor R, Fassan M
Endocr Relat Cancer 2021 Jun 10;28(7):449-456. doi: 10.1530/ERC-21-0052. PMID: 33974555
Frilling A, Clift AK, Frampton AE, Bomanji J, Kaemmerer D, Al-Nahhas A, Alsafi A, Kidd M, Modlin IM, Hoersch D, Baum RP
Int J Med Sci 2021;18(10):2166-2175. Epub 2021 Mar 19 doi: 10.7150/ijms.51740. PMID: 33859524Free PMC Article

Clinical prediction guides

Frilling A, Clift AK, Frampton AE, Bomanji J, Kaemmerer D, Al-Nahhas A, Alsafi A, Kidd M, Modlin IM, Hoersch D, Baum RP
Int J Med Sci 2021;18(10):2166-2175. Epub 2021 Mar 19 doi: 10.7150/ijms.51740. PMID: 33859524Free PMC Article
Rossi RE, Elli L, Branchi F, Conte D, Massironi S
Digestion 2021;102(5):722-730. Epub 2020 Dec 23 doi: 10.1159/000511850. PMID: 33361694
Milione M, Maisonneuve P, Pellegrinelli A, Pusceddu S, Centonze G, Dominoni F, Brambilla C, Rubino M, Faggiano A, Buzzoni R, Concas L, Giacomelli L, Coppa J, Mazzaferro V, de Braud F
Endocrine 2017 Sep;57(3):512-517. Epub 2016 Nov 30 doi: 10.1007/s12020-016-1180-6. PMID: 27905048
Andersson E, Arvidsson Y, Swärd C, Hofving T, Wängberg B, Kristiansson E, Nilsson O
Mod Pathol 2016 Jun;29(6):616-29. Epub 2016 Mar 11 doi: 10.1038/modpathol.2016.48. PMID: 26965582
Esposito C, Escolino M, Till H, Bertozzi M, Riccipetitoni G, Settimi A, Varlet F
Surg Endosc 2016 Nov;30(11):4917-4923. Epub 2016 Mar 4 doi: 10.1007/s00464-016-4832-y. PMID: 26944727

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