Definition

A chordoma that does not respond to treatment. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRefractory Chordoma

Disorder by Site
- Connective and Soft Tissue Disorder
  - Connective tissue disorder
    - Bone Neoplasm
      - Bone cancer
        Chordoma
        Refractory Chordoma
        Refractory Dedifferentiated Chordoma

Professional guidelines

PubMed

Chordoma: Genetics and Contemporary Management.

Desai R, Pelargos PE, Dunn IF
Int J Mol Sci 2024 May 28;25(11) doi: 10.3390/ijms25115877. PMID: 38892063 Free PMC Article

Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.

Ailon T, Torabi R, Fisher CG, Rhines LD, Clarke MJ, Bettegowda C, Boriani S, Yamada YJ, Kawahara N, Varga PP, Shin JH, Saghal A, Gokaslan ZL
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S193-S198. doi: 10.1097/BRS.0000000000001812. PMID: 27753782 Free PMC Article

Immunotherapy as a Potential Treatment for Chordoma: a Review.

Patel SS, Schwab JH
Curr Oncol Rep 2016 Sep;18(9):55. doi: 10.1007/s11912-016-0543-8. PMID: 27475804

See all (4)

Recent clinical studies

Diagnosis

Response to erlotinib in a patient with treatment refractory chordoma.

Singhal N, Kotasek D, Parnis FX
Anticancer Drugs 2009 Nov;20(10):953-5. doi: 10.1097/CAD.0b013e328330c7f0. PMID: 19730087

See all (1)

Therapy

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma.

Gröschel S, Hübschmann D, Raimondi F, Horak P, Warsow G, Fröhlich M, Klink B, Gieldon L, Hutter B, Kleinheinz K, Bonekamp D, Marschal O, Chudasama P, Mika J, Groth M, Uhrig S, Krämer S, Heining C, Heilig CE, Richter D, Reisinger E, Pfütze K, Eils R, Wolf S, von Kalle C, Brandts C, Scholl C, Weichert W, Richter S, Bauer S, Penzel R, Schröck E, Stenzinger A, Schlenk RF, Brors B, Russell RB, Glimm H, Schlesner M, Fröhling S
Nat Commun 2019 Apr 9;10(1):1635. doi: 10.1038/s41467-019-09633-9. PMID: 30967556 Free PMC Article

Response to erlotinib in a patient with treatment refractory chordoma.

Singhal N, Kotasek D, Parnis FX
Anticancer Drugs 2009 Nov;20(10):953-5. doi: 10.1097/CAD.0b013e328330c7f0. PMID: 19730087

See all (2)

Prognosis

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma.

Gröschel S, Hübschmann D, Raimondi F, Horak P, Warsow G, Fröhlich M, Klink B, Gieldon L, Hutter B, Kleinheinz K, Bonekamp D, Marschal O, Chudasama P, Mika J, Groth M, Uhrig S, Krämer S, Heining C, Heilig CE, Richter D, Reisinger E, Pfütze K, Eils R, Wolf S, von Kalle C, Brandts C, Scholl C, Weichert W, Richter S, Bauer S, Penzel R, Schröck E, Stenzinger A, Schlenk RF, Brors B, Russell RB, Glimm H, Schlesner M, Fröhling S
Nat Commun 2019 Apr 9;10(1):1635. doi: 10.1038/s41467-019-09633-9. PMID: 30967556 Free PMC Article

See all (1)

Clinical prediction guides

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma.

Gröschel S, Hübschmann D, Raimondi F, Horak P, Warsow G, Fröhlich M, Klink B, Gieldon L, Hutter B, Kleinheinz K, Bonekamp D, Marschal O, Chudasama P, Mika J, Groth M, Uhrig S, Krämer S, Heining C, Heilig CE, Richter D, Reisinger E, Pfütze K, Eils R, Wolf S, von Kalle C, Brandts C, Scholl C, Weichert W, Richter S, Bauer S, Penzel R, Schröck E, Stenzinger A, Schlenk RF, Brors B, Russell RB, Glimm H, Schlesner M, Fröhling S
Nat Commun 2019 Apr 9;10(1):1635. doi: 10.1038/s41467-019-09633-9. PMID: 30967556 Free PMC Article

See all (1)

MedGen

National Center for Biotechnology Information

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Refractory Chordoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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Table of contents

Practice guidelines

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