U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HbC hemoglobin

MedGen UID:
1688191
•Concept ID:
C4759912
•
Finding
Synonyms: Haemoglobin C; HbC haemoglobin; Hemoglobin C
 
HPO: HP:0032146

Definition

Presence of an abnormal type of hemoglobin characterized by the substitution of a glutamic acid residue at position 7 following the initial methionine residue by a lysine (6GAG>6AAG). The presence of HbC can be determined by hemoglobin electrophoresis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHbC hemoglobin

Professional guidelines

PubMed

Point-of-Care Newborn Screening for Sickle Cell Disease at Selected Health Facilities in the Gambia.
Adegoke SA, Makalo L, Sallah A, Saine H, Joof S, Conteh A, Bah R, Camara Jammeh AF, Bass M, Jallow M, Nnodu OE
Hemoglobin 2024 May;48(3):169-174. Epub 2024 Jul 9 doi: 10.1080/03630269.2024.2369523. PMID: 38980121
Herbal Drug use in Sickle Cell Disease Management; Trends and Perspectives in Sub-Saharan Africa - A Systematic Review.
Okoh MP, Alli LA, Tolvanen MEE, Nwegbu MM
Curr Drug Discov Technol 2019;16(4):372-385. doi: 10.2174/1570163815666181002101611. PMID: 30277160
Hemoglobinopathies: clinical manifestations, diagnosis, and treatment.
Kohne E
Dtsch Arztebl Int 2011 Aug;108(31-32):532-40. Epub 2011 Aug 8 doi: 10.3238/arztebl.2011.0532. PMID: 21886666Free PMC Article

Recent clinical studies

Etiology

Malaria parasites and red cell variants: when a house is not a home.
Taylor SM, Fairhurst RM
Curr Opin Hematol 2014 May;21(3):193-200. doi: 10.1097/MOH.0000000000000039. PMID: 24675047Free PMC Article
Expression of hemoglobin variant migration by capillary electrophoresis relative to hemoglobin A2 improves precision.
Keren DF, Shalhoub R, Gulbranson R, Hedstrom D
Am J Clin Pathol 2012 Apr;137(4):660-4. doi: 10.1309/AJCPOF8V0JJOPSVF. PMID: 22431544
Hemoglobinopathies: clinical manifestations, diagnosis, and treatment.
Kohne E
Dtsch Arztebl Int 2011 Aug;108(31-32):532-40. Epub 2011 Aug 8 doi: 10.3238/arztebl.2011.0532. PMID: 21886666Free PMC Article
Investigation of microcytosis: a comprehensive approach.
Mach-Pascual S, Darbellay R, Pilotto PA, Beris P
Eur J Haematol 1996 Jul;57(1):54-61. doi: 10.1111/j.1600-0609.1996.tb00490.x. PMID: 8698132
Innate resistance to malaria: the intraerythrocytic cycle.
Nagel RL
Blood Cells 1990;16(2-3):321-39; discussion 340-9. PMID: 2257317

Diagnosis

Tractional Retinal Detachment Related to Hemoglobin C Trait Retinopathy: A Case Report.
Garrell-Salat X, Garcia-Arumi C, Bertolani Y, García SB, Buck P, Garcia-Arumi J
Turk J Ophthalmol 2023 Oct 19;53(5):318-321. doi: 10.4274/tjo.galenos.2023.48672. PMID: 37870045Free PMC Article
Platelet count and MCHC as independent prognostic markers for feline mammary carcinomas.
da Silva Soares E, Rocha CC, Valente FL, Dos Anjos LRA, de Oliveira FLD, de Oliveira Loures C, Rocha PT, Castro VR, Sarandy TB, Borges APB
Res Vet Sci 2023 Nov;164:105024. Epub 2023 Sep 19 doi: 10.1016/j.rvsc.2023.105024. PMID: 37827061
Hemoglobinopathies: clinical manifestations, diagnosis, and treatment.
Kohne E
Dtsch Arztebl Int 2011 Aug;108(31-32):532-40. Epub 2011 Aug 8 doi: 10.3238/arztebl.2011.0532. PMID: 21886666Free PMC Article
Neonatal screening for sickle cell disorders in Ouagadougou, Burkina Faso: a pilot study.
Kafando E, Sawadogo M, Cotton F, Vertongen F, Gulbis B
J Med Screen 2005;12(3):112-4. doi: 10.1258/0969141054855300. PMID: 16156939
Conditions associated with very low values of glycohaemoglobin measured by an HPLC method.
Camargo JL, Gross JL
J Clin Pathol 2004 Apr;57(4):346-9. doi: 10.1136/jcp.2002.007088. PMID: 15047733Free PMC Article

Therapy

Insights Into Colorectal Cancer Screening: A Multidatabase Cohort Study of Over 1.5 Million Taiwanese.
Hsiao BY, Chiang CJ, Yang YW, Lin LJ, Hsieh PC, Hsu TH, Lee WC
Am J Prev Med 2024 Sep;67(3):339-349. Epub 2024 Apr 30 doi: 10.1016/j.amepre.2024.04.012. PMID: 38697323
Most adults with severe HbSC disease are not treated with hydroxyurea.
Ghunney WK, Asare EV, Ayete-Nyampong JB, Oppong SA, Rodeghier M, DeBaun MR, Olayemi E
Blood Adv 2023 Jul 11;7(13):3312-3319. doi: 10.1182/bloodadvances.2022009049. PMID: 36799926Free PMC Article
Herbal Drug use in Sickle Cell Disease Management; Trends and Perspectives in Sub-Saharan Africa - A Systematic Review.
Okoh MP, Alli LA, Tolvanen MEE, Nwegbu MM
Curr Drug Discov Technol 2019;16(4):372-385. doi: 10.2174/1570163815666181002101611. PMID: 30277160
Hemoglobinopathies: clinical manifestations, diagnosis, and treatment.
Kohne E
Dtsch Arztebl Int 2011 Aug;108(31-32):532-40. Epub 2011 Aug 8 doi: 10.3238/arztebl.2011.0532. PMID: 21886666Free PMC Article
Maternal anaemia in Abidjan--Its influence on placenta and newborns.
Reinhardt MC
Helv Paediatr Acta Suppl 1978 Dec;(41):43-63. PMID: 215575

Prognosis

Sickle Cell Hemoglobin Genotypes Affect Malaria Parasite Growth and Correlate with Exosomal miR-451a and let-7i-5p Levels.
Oxendine Harp K, Bashi A, Botchway F, Addo-Gyan D, Tetteh-Tsifoanya M, Lamptey A, Djameh G, Iqbal SA, Lekpor C, Banerjee S, Wilson MD, Dei-Adomakoh Y, Adjei AA, Stiles JK, Driss A
Int J Mol Sci 2023 Apr 19;24(8) doi: 10.3390/ijms24087546. PMID: 37108709Free PMC Article
G6PD and HBB polymorphisms in the Senegalese population: prevalence, correlation with clinical malaria.
Thiam F, Diop G, Coulonges C, Derbois C, Mbengue B, Thiam A, Nguer CM, Zagury JF, Deleuze JF, Dieye A
PeerJ 2022;10:e13487. Epub 2022 Jul 5 doi: 10.7717/peerj.13487. PMID: 35811813Free PMC Article
Prediction of anemia and estimation of hemoglobin concentration using a smartphone camera.
Suner S, Rayner J, Ozturan IU, Hogan G, Meehan CP, Chambers AB, Baird J, Jay GD
PLoS One 2021;16(7):e0253495. Epub 2021 Jul 14 doi: 10.1371/journal.pone.0253495. PMID: 34260592Free PMC Article
Cation Homeostasis in Red Cells From Patients With Sickle Cell Disease Heterologous for HbS and HbC (HbSC Genotype).
Hannemann A, Rees DC, Tewari S, Gibson JS
EBioMedicine 2015 Nov;2(11):1669-76. Epub 2015 Sep 18 doi: 10.1016/j.ebiom.2015.09.026. PMID: 26870793Free PMC Article
A potential determinant of enhanced crystallization of Hbc: spectroscopic and functional evidence of an alteration in the central cavity of oxyHbC.
Hirsch RE, Rybicki AC, Fataliev NA, Lin MJ, Friedman JM, Nagel RL
Br J Haematol 1997 Sep;98(3):583-8. doi: 10.1046/j.1365-2141.1997.2483062.x. PMID: 9332311

Clinical prediction guides

Prediction of anemia and estimation of hemoglobin concentration using a smartphone camera.
Suner S, Rayner J, Ozturan IU, Hogan G, Meehan CP, Chambers AB, Baird J, Jay GD
PLoS One 2021;16(7):e0253495. Epub 2021 Jul 14 doi: 10.1371/journal.pone.0253495. PMID: 34260592Free PMC Article
A potential determinant of enhanced crystallization of Hbc: spectroscopic and functional evidence of an alteration in the central cavity of oxyHbC.
Hirsch RE, Rybicki AC, Fataliev NA, Lin MJ, Friedman JM, Nagel RL
Br J Haematol 1997 Sep;98(3):583-8. doi: 10.1046/j.1365-2141.1997.2483062.x. PMID: 9332311
Conjunctival vessel abnormalities in sickle cell diseases: the influence of age and genotype.
Siqueira WC, Figueiredo MS, Cruz AA, Costa FF, Zago MA
Acta Ophthalmol (Copenh) 1990 Oct;68(5):515-8. doi: 10.1111/j.1755-3768.1990.tb04779.x. PMID: 2275343
Innate resistance to malaria: the intraerythrocytic cycle.
Nagel RL
Blood Cells 1990;16(2-3):321-39; discussion 340-9. PMID: 2257317
Hereditary haemoglobin disorders in Brazil.
Zago MA, Costa FF
Trans R Soc Trop Med Hyg 1985;79(3):385-8. doi: 10.1016/0035-9203(85)90389-x. PMID: 3898485

Recent systematic reviews

Thrombosis risk with haemoglobin C trait and haemoglobin C disease: A systematic review.
Jacobs JW, Sharma D, Stephens LD, Figueroa Villalba CA, Rinder HM, Woo JS, Wheeler AP, Gerberi D, Goel R, Tormey CA, Booth GS, Bloch EM, Adkins BD
Br J Haematol 2024 Apr;204(4):1500-1506. Epub 2024 Jan 30 doi: 10.1111/bjh.19313. PMID: 38291731
Herbal Drug use in Sickle Cell Disease Management; Trends and Perspectives in Sub-Saharan Africa - A Systematic Review.
Okoh MP, Alli LA, Tolvanen MEE, Nwegbu MM
Curr Drug Discov Technol 2019;16(4):372-385. doi: 10.2174/1570163815666181002101611. PMID: 30277160

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...