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Retropharyngeal Neoplasm

MedGen UID:
1687264
•Concept ID:
C5206836
•
Neoplastic Process

Definition

A benign or malignant neoplasm that affects the retropharyngeal space. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetropharyngeal Neoplasm

Professional guidelines

PubMed

Prevalence, prognosis, and treatment implications of retropharyngeal nodes in unknown primary head and neck carcinoma.
Horowitz G, Hosni A, Yu E, Xu W, Lu L, Au M, Dixon PR, Brown D, Chepeha DB, Gilbert RW, Goldstein DP, Gullane PJ, Irish JC, Bayley A, Cho J, Giuliani M, Huang SH, Hope A, Kim J, O'Sullivan B, Ringash J, Waldron J, Weinreb I, Perez-Ordonez B, Bratman SV, de Almeida JR
Oral Oncol 2018 Jul;82:162-167. Epub 2018 Jun 1 doi: 10.1016/j.oraloncology.2018.05.023. PMID: 29909891
Evaluation and management of neck masses in children.
Meier JD, Grimmer JF
Am Fam Physician 2014 Mar 1;89(5):353-8. PMID: 24695506
Metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma: imaging criteria.
Sharma M, Bartlett E, Yu E
Expert Rev Anticancer Ther 2010 Nov;10(11):1703-6. doi: 10.1586/era.10.159. PMID: 21080798

Recent clinical studies

Etiology

Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053
Retropharyngeal abscess after chemotherapy.
Mettias B, Robertson S, Buchanan MA
BMJ Case Rep 2018 Mar 5;2018 doi: 10.1136/bcr-2017-222610. PMID: 29507016Free PMC Article
Retropharyngeal lymph node metastases in head and neck malignancies.
Coskun HH, Ferlito A, Medina JE, Robbins KT, Rodrigo JP, Strojan P, Suárez C, Takes RP, Woolgar JA, Shaha AR, de Bree R, Rinaldo A, Silver CE
Head Neck 2011 Oct;33(10):1520-9. Epub 2010 Aug 24 doi: 10.1002/hed.21526. PMID: 20737485
Craniocervical chordomas.
Harwick RD, Miller AS
Am J Surg 1979 Oct;138(4):512-6. doi: 10.1016/0002-9610(79)90410-0. PMID: 114069

Diagnosis

Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Pitfalls in the staging of cancer of thyroid.
Saindane AM
Neuroimaging Clin N Am 2013 Feb;23(1):123-45. doi: 10.1016/j.nic.2012.08.010. PMID: 23199665
Retropharyngeal and prevertebral spaces: anatomic imaging and diagnosis.
Debnam JM, Guha-Thakurta N
Otolaryngol Clin North Am 2012 Dec;45(6):1293-310. doi: 10.1016/j.otc.2012.08.004. PMID: 23153750Free PMC Article
Oral cavity and pharynx.
Yousem DM, Chalian AA
Radiol Clin North Am 1998 Sep;36(5):967-81, vii. doi: 10.1016/s0033-8389(05)70071-3. PMID: 9747196
Parapharyngeal and retropharyngeal space diseases.
Batsakis JG, Sneige N
Ann Otol Rhinol Laryngol 1989 Apr;98(4 Pt 1):320-1. doi: 10.1177/000348948909800416. PMID: 2650597

Therapy

Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053
Retropharyngeal abscess after chemotherapy.
Mettias B, Robertson S, Buchanan MA
BMJ Case Rep 2018 Mar 5;2018 doi: 10.1136/bcr-2017-222610. PMID: 29507016Free PMC Article
Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?
Samuels SE, Eisbruch A, Beitler JJ, Corry J, Bradford CR, Saba NF, van den Brekel MW, Smee R, Strojan P, Suárez C, Mendenhall WM, Takes RP, Rodrigo JP, Haigentz M Jr, Rapidis AD, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2016 Oct;273(10):2877-94. Epub 2015 Oct 13 doi: 10.1007/s00405-015-3771-x. PMID: 26463714
Hypopharyngeal carcinoma.
Hinerman RW, Amdur RJ, Mendenhall WM, Villaret DB, Robbins KT
Curr Treat Options Oncol 2002 Feb;3(1):41-9. doi: 10.1007/s11864-002-0040-1. PMID: 12057086

Prognosis

Imaging of Anaplastic Thyroid Carcinoma.
Ahmed S, Ghazarian MP, Cabanillas ME, Zafereo ME, Williams MD, Vu T, Schomer DF, Debnam JM
AJNR Am J Neuroradiol 2018 Mar;39(3):547-551. Epub 2017 Dec 14 doi: 10.3174/ajnr.A5487. PMID: 29242360Free PMC Article
Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?
Samuels SE, Eisbruch A, Beitler JJ, Corry J, Bradford CR, Saba NF, van den Brekel MW, Smee R, Strojan P, Suárez C, Mendenhall WM, Takes RP, Rodrigo JP, Haigentz M Jr, Rapidis AD, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2016 Oct;273(10):2877-94. Epub 2015 Oct 13 doi: 10.1007/s00405-015-3771-x. PMID: 26463714
Giant cervico-mediastinal solitary fibrous tumor.
Schreiber A, Lombardi D, Missale F, Farina D, Lorenzi L, Nicolai P
Eur Arch Otorhinolaryngol 2014 Jun;271(6):1833-8. Epub 2014 Mar 8 doi: 10.1007/s00405-014-2943-4. PMID: 24609642
Retropharyngeal lymph node metastases in head and neck malignancies.
Coskun HH, Ferlito A, Medina JE, Robbins KT, Rodrigo JP, Strojan P, Suárez C, Takes RP, Woolgar JA, Shaha AR, de Bree R, Rinaldo A, Silver CE
Head Neck 2011 Oct;33(10):1520-9. Epub 2010 Aug 24 doi: 10.1002/hed.21526. PMID: 20737485
Craniocervical chordomas.
Harwick RD, Miller AS
Am J Surg 1979 Oct;138(4):512-6. doi: 10.1016/0002-9610(79)90410-0. PMID: 114069

Clinical prediction guides

Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053
Hybrid PET/MRI in major cancers: a scoping review.
Morsing A, Hildebrandt MG, Vilstrup MH, Wallenius SE, Gerke O, Petersen H, Johansen A, Andersen TL, Høilund-Carlsen PF
Eur J Nucl Med Mol Imaging 2019 Sep;46(10):2138-2151. Epub 2019 Jul 2 doi: 10.1007/s00259-019-04402-8. PMID: 31267161
Prevalence, prognosis, and treatment implications of retropharyngeal nodes in unknown primary head and neck carcinoma.
Horowitz G, Hosni A, Yu E, Xu W, Lu L, Au M, Dixon PR, Brown D, Chepeha DB, Gilbert RW, Goldstein DP, Gullane PJ, Irish JC, Bayley A, Cho J, Giuliani M, Huang SH, Hope A, Kim J, O'Sullivan B, Ringash J, Waldron J, Weinreb I, Perez-Ordonez B, Bratman SV, de Almeida JR
Oral Oncol 2018 Jul;82:162-167. Epub 2018 Jun 1 doi: 10.1016/j.oraloncology.2018.05.023. PMID: 29909891
Stridor in childhood.
McBride JT
J Fam Pract 1984 Dec;19(6):782-90. PMID: 6502082

Recent systematic reviews

Performance of axial diameter on MR imaging for identification of retropharyngeal lymph node metastases in head and neck cancer: a systematic review and meta-analysis.
Baba A, Kurokawa R, Kurokawa M, Rivera-de Choudens R, Srinivasan A
Neuroradiology 2023 Sep;65(9):1363-1369. Epub 2023 Jul 31 doi: 10.1007/s00234-023-03205-x. PMID: 37522935
Retropharyngeal lymph node metastasis in oral cancer. Systematic review and survival analysis.
Abdelrahman A, McGoldrick D, Aggarwal A, Idle MR, Praveen P, Martin T, Parmar S
Br J Oral Maxillofac Surg 2022 Jun;60(5):563-569. Epub 2021 Jun 10 doi: 10.1016/j.bjoms.2021.06.001. PMID: 35337688
Metastatic thyroid carcinoma to the parapharyngeal and retropharyngeal spaces: Systematic review with seven newly reported cases describing an uncommon presentation of a common disease.
Sandler ML, Xing MH, Levy JC, Chai RL, Khorsandi AS, Gonzalez-Velazquez C, Urken ML
Head Neck 2021 Apr;43(4):1331-1344. Epub 2020 Dec 9 doi: 10.1002/hed.26572. PMID: 33295689
Hybrid PET/MRI in major cancers: a scoping review.
Morsing A, Hildebrandt MG, Vilstrup MH, Wallenius SE, Gerke O, Petersen H, Johansen A, Andersen TL, Høilund-Carlsen PF
Eur J Nucl Med Mol Imaging 2019 Sep;46(10):2138-2151. Epub 2019 Jul 2 doi: 10.1007/s00259-019-04402-8. PMID: 31267161
Management of retropharyngeal node metastases from thyroid carcinoma.
Hartl DM, Leboulleux S, Vélayoudom-Céphise FL, Mirghani H, Déandréis D, Schlumberger M
World J Surg 2015 May;39(5):1274-81. doi: 10.1007/s00268-015-2947-2. PMID: 25585526

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