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Increased complex N-glycan level

MedGen UID:
1686517
•Concept ID:
C5139517
•
Finding
Synonym: Increased concentration of complex N-glycans on glycoproteins
 
HPO: HP:0410352

Definition

An abnormal increase in the concentration of complex N-glycans on glycoproteins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased complex N-glycan level

Professional guidelines

PubMed

Pro-inflammatory IgG1 N-glycan signature correlates with primary graft dysfunction onset in COPD patients.
McQuiston A, Scott D, Nord D, Langerude L, Pelaez A, Machuca T, Mehta A, Drake RR, Christie JD, Angel P, Atkinson C
Transpl Immunol 2022 Apr;71:101491. Epub 2021 Nov 10 doi: 10.1016/j.trim.2021.101491. PMID: 34767945
Clinical utility of high-throughput glycome analysis in patients with pancreatic cancer.
Nouso K, Amano M, Ito YM, Miyahara K, Morimoto Y, Kato H, Tsutsumi K, Tomoda T, Yamamoto N, Nakamura S, Kobayashi S, Kuwaki K, Hagihara H, Onishi H, Miyake Y, Ikeda F, Shiraha H, Takaki A, Nakahara T, Nishimura S, Yamamoto K
J Gastroenterol 2013 Oct;48(10):1171-9. Epub 2013 Jan 11 doi: 10.1007/s00535-012-0732-7. PMID: 23307043

Recent clinical studies

Etiology

High-throughput N-glycan analysis in aging and inflammaging: State of the art and future directions.
Cindrić A, Pribić T, Lauc G
Semin Immunol 2024 May;73:101890. Epub 2024 Oct 9 doi: 10.1016/j.smim.2024.101890. PMID: 39383621
Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo-glycans.
Morticelli L, Rossdam C, Cajic S, Böthig D, Magdei M, Tuladhar SR, Petersen B, Fischer K, Rapp E, Korossis S, Haverich A, Schnieke A, Niemann H, Buettner FFR, Hilfiker A
Xenotransplantation 2023 Jul-Aug;30(4):e12804. Epub 2023 May 6 doi: 10.1111/xen.12804. PMID: 37148126
von Willebrand factor sialylation-A critical regulator of biological function.
Ward S, O'Sullivan JM, O'Donnell JS
J Thromb Haemost 2019 Jul;17(7):1018-1029. Epub 2019 May 30 doi: 10.1111/jth.14471. PMID: 31055873
Serum protein N-glycosylation changes in multiple myeloma.
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S
Biochim Biophys Acta Gen Subj 2019 May;1863(5):960-970. Epub 2019 Mar 5 doi: 10.1016/j.bbagen.2019.03.001. PMID: 30844485
Plasma High-Mannose and Complex/Hybrid N-Glycans Are Associated with Hypercholesterolemia in Humans and Rabbits.
Bai L, Li Q, Li L, Lin Y, Zhao S, Wang W, Wang R, Li Y, Yuan J, Wang C, Wang Z, Fan J, Liu E
PLoS One 2016;11(3):e0146982. Epub 2016 Mar 21 doi: 10.1371/journal.pone.0146982. PMID: 26999365Free PMC Article

Diagnosis

High-throughput N-glycan analysis in aging and inflammaging: State of the art and future directions.
Cindrić A, Pribić T, Lauc G
Semin Immunol 2024 May;73:101890. Epub 2024 Oct 9 doi: 10.1016/j.smim.2024.101890. PMID: 39383621
Highly-sensitive label-free deep profiling of N-glycans released from biomedically-relevant samples.
Marie AL, Ray S, Ivanov AR
Nat Commun 2023 Mar 23;14(1):1618. doi: 10.1038/s41467-023-37365-4. PMID: 36959283Free PMC Article
Site- and structure-specific characterization of the human urinary N-glycoproteome with site-determining and structure-diagnostic product ions.
Shen Y, Xiao K, Tian Z
Rapid Commun Mass Spectrom 2021 Jan 15;35(1):e8952. doi: 10.1002/rcm.8952. PMID: 32965048
Identifying N-Glycan Biomarkers in Colorectal Cancer by Mass Spectrometry.
Sethi MK, Hancock WS, Fanayan S
Acc Chem Res 2016 Oct 18;49(10):2099-2106. Epub 2016 Sep 21 doi: 10.1021/acs.accounts.6b00193. PMID: 27653471
Plasma High-Mannose and Complex/Hybrid N-Glycans Are Associated with Hypercholesterolemia in Humans and Rabbits.
Bai L, Li Q, Li L, Lin Y, Zhao S, Wang W, Wang R, Li Y, Yuan J, Wang C, Wang Z, Fan J, Liu E
PLoS One 2016;11(3):e0146982. Epub 2016 Mar 21 doi: 10.1371/journal.pone.0146982. PMID: 26999365Free PMC Article

Therapy

Pro-inflammatory IgG1 N-glycan signature correlates with primary graft dysfunction onset in COPD patients.
McQuiston A, Scott D, Nord D, Langerude L, Pelaez A, Machuca T, Mehta A, Drake RR, Christie JD, Angel P, Atkinson C
Transpl Immunol 2022 Apr;71:101491. Epub 2021 Nov 10 doi: 10.1016/j.trim.2021.101491. PMID: 34767945
Glycosylation-dependent antitumor therapeutic monoclonal antibodies.
Zhang Y, Fan C, Zhang L, Ma X
Prog Mol Biol Transl Sci 2019;163:471-485. Epub 2019 Mar 25 doi: 10.1016/bs.pmbts.2019.03.004. PMID: 31030759
Plasma High-Mannose and Complex/Hybrid N-Glycans Are Associated with Hypercholesterolemia in Humans and Rabbits.
Bai L, Li Q, Li L, Lin Y, Zhao S, Wang W, Wang R, Li Y, Yuan J, Wang C, Wang Z, Fan J, Liu E
PLoS One 2016;11(3):e0146982. Epub 2016 Mar 21 doi: 10.1371/journal.pone.0146982. PMID: 26999365Free PMC Article
Altered glycosylation of complexed native IgG molecules is associated with disease activity of systemic lupus erythematosus.
Sjöwall C, Zapf J, von Löhneysen S, Magorivska I, Biermann M, Janko C, Winkler S, Bilyy R, Schett G, Herrmann M, Muñoz LE
Lupus 2015 May;24(6):569-81. Epub 2014 Nov 11 doi: 10.1177/0961203314558861. PMID: 25389233
Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors.
Croci DO, Cerliani JP, Dalotto-Moreno T, Méndez-Huergo SP, Mascanfroni ID, Dergan-Dylon S, Toscano MA, Caramelo JJ, García-Vallejo JJ, Ouyang J, Mesri EA, Junttila MR, Bais C, Shipp MA, Salatino M, Rabinovich GA
Cell 2014 Feb 13;156(4):744-58. doi: 10.1016/j.cell.2014.01.043. PMID: 24529377

Prognosis

High-throughput N-glycan analysis in aging and inflammaging: State of the art and future directions.
Cindrić A, Pribić T, Lauc G
Semin Immunol 2024 May;73:101890. Epub 2024 Oct 9 doi: 10.1016/j.smim.2024.101890. PMID: 39383621
Pro-inflammatory IgG1 N-glycan signature correlates with primary graft dysfunction onset in COPD patients.
McQuiston A, Scott D, Nord D, Langerude L, Pelaez A, Machuca T, Mehta A, Drake RR, Christie JD, Angel P, Atkinson C
Transpl Immunol 2022 Apr;71:101491. Epub 2021 Nov 10 doi: 10.1016/j.trim.2021.101491. PMID: 34767945
Serum protein N-glycosylation changes in multiple myeloma.
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S
Biochim Biophys Acta Gen Subj 2019 May;1863(5):960-970. Epub 2019 Mar 5 doi: 10.1016/j.bbagen.2019.03.001. PMID: 30844485
N-glycan signatures identified in tumor interstitial fluid and serum of breast cancer patients: association with tumor biology and clinical outcome.
Terkelsen T, Haakensen VD, Saldova R, Gromov P, Hansen MK, Stöckmann H, Lingjaerde OC, Børresen-Dale AL, Papaleo E, Helland Å, Rudd PM, Gromova I
Mol Oncol 2018 Jun;12(6):972-990. Epub 2018 May 14 doi: 10.1002/1878-0261.12312. PMID: 29698574Free PMC Article
Identifying N-Glycan Biomarkers in Colorectal Cancer by Mass Spectrometry.
Sethi MK, Hancock WS, Fanayan S
Acc Chem Res 2016 Oct 18;49(10):2099-2106. Epub 2016 Sep 21 doi: 10.1021/acs.accounts.6b00193. PMID: 27653471

Clinical prediction guides

High-throughput N-glycan analysis in aging and inflammaging: State of the art and future directions.
Cindrić A, Pribić T, Lauc G
Semin Immunol 2024 May;73:101890. Epub 2024 Oct 9 doi: 10.1016/j.smim.2024.101890. PMID: 39383621
Increased levels of acidic free-N-glycans, including multi-antennary and fucosylated structures, in the urine of cancer patients.
Hanzawa K, Tanaka-Okamoto M, Murakami H, Suzuki N, Mukai M, Takahashi H, Omori T, Ikezawa K, Ohkawa K, Ohue M, Natsuka S, Miyamoto Y
PLoS One 2022;17(4):e0266927. Epub 2022 Apr 12 doi: 10.1371/journal.pone.0266927. PMID: 35413075Free PMC Article
Serum protein N-glycosylation changes in multiple myeloma.
Zhang Z, Westhrin M, Bondt A, Wuhrer M, Standal T, Holst S
Biochim Biophys Acta Gen Subj 2019 May;1863(5):960-970. Epub 2019 Mar 5 doi: 10.1016/j.bbagen.2019.03.001. PMID: 30844485
Identifying N-Glycan Biomarkers in Colorectal Cancer by Mass Spectrometry.
Sethi MK, Hancock WS, Fanayan S
Acc Chem Res 2016 Oct 18;49(10):2099-2106. Epub 2016 Sep 21 doi: 10.1021/acs.accounts.6b00193. PMID: 27653471
Intramolecular N-glycan/polypeptide interactions observed at multiple N-glycan remodeling steps through [(13)C,(15)N]-N-acetylglucosamine labeling of immunoglobulin G1.
Barb AW
Biochemistry 2015 Jan 20;54(2):313-22. Epub 2014 Dec 31 doi: 10.1021/bi501380t. PMID: 25551295Free PMC Article

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