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Benign Parapharyngeal Neoplasm

MedGen UID:
1686401
•Concept ID:
C5206834
•
Neoplastic Process

Definition

A neoplasm that arises from the parapharyngeal space and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Parapharyngeal Neoplasm

Professional guidelines

PubMed

Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Contemporary management of primary parapharyngeal space tumors.
López F, Suárez C, Vander Poorten V, Mäkitie A, Nixon IJ, Strojan P, Hanna EY, Rodrigo JP, de Bree R, Quer M, Takes RP, Bradford CR, Shaha AR, Sanabria A, Rinaldo A, Ferlito A
Head Neck 2019 Feb;41(2):522-535. Epub 2018 Dec 14 doi: 10.1002/hed.25439. PMID: 30549361
Contemporary evaluation and management of parapharyngeal space neoplasms.
Eisele DW, Richmon JD
J Laryngol Otol 2013 Jun;127(6):550-5. Epub 2013 Apr 10 doi: 10.1017/S0022215113000686. PMID: 23575439

Recent clinical studies

Etiology

Primary neoplasms of the parapharyngeal space: diagnostic and therapeutic pearls and pitfalls.
Bulut OC, Giger R, Alwagdani A, Aldabal N, Stenzinger A, Heimgartner S, Nisa L, Borner U
Eur Arch Otorhinolaryngol 2021 Dec;278(12):4933-4941. Epub 2021 Mar 19 doi: 10.1007/s00405-021-06718-4. PMID: 33740083Free PMC Article
Parapharyngeal space primary tumours.
Grilli G, Suarez V, Muñoz MG, Costales M, Llorente JL
Acta Otorrinolaringol Esp (Engl Ed) 2017 May-Jun;68(3):138-144. doi: 10.1016/j.otorri.2016.06.003. PMID: 27663220
Parapharyngeal space benign tumours: our experience.
Cassoni A, Terenzi V, Della Monaca M, Bartoli D, Battisti A, Rajabtork Zadeh O, Valentini V
J Craniomaxillofac Surg 2014 Mar;42(2):101-5. Epub 2013 May 17 doi: 10.1016/j.jcms.2013.03.002. PMID: 23684528
Contemporary evaluation and management of parapharyngeal space neoplasms.
Eisele DW, Richmon JD
J Laryngol Otol 2013 Jun;127(6):550-5. Epub 2013 Apr 10 doi: 10.1017/S0022215113000686. PMID: 23575439
Parapharyngeal space neoplasms.
Hughes KV 3rd, Olsen KD, McCaffrey TV
Head Neck 1995 Mar-Apr;17(2):124-30. doi: 10.1002/hed.2880170209. PMID: 7558809

Diagnosis

Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Contemporary management of primary parapharyngeal space tumors.
López F, Suárez C, Vander Poorten V, Mäkitie A, Nixon IJ, Strojan P, Hanna EY, Rodrigo JP, de Bree R, Quer M, Takes RP, Bradford CR, Shaha AR, Sanabria A, Rinaldo A, Ferlito A
Head Neck 2019 Feb;41(2):522-535. Epub 2018 Dec 14 doi: 10.1002/hed.25439. PMID: 30549361
Parapharyngeal space primary tumours.
Grilli G, Suarez V, Muñoz MG, Costales M, Llorente JL
Acta Otorrinolaringol Esp (Engl Ed) 2017 May-Jun;68(3):138-144. doi: 10.1016/j.otorri.2016.06.003. PMID: 27663220
Oral cavity and pharynx.
Yousem DM, Chalian AA
Radiol Clin North Am 1998 Sep;36(5):967-81, vii. doi: 10.1016/s0033-8389(05)70071-3. PMID: 9747196
The combined CT-sialogram.
Som PM, Biller HF
Radiology 1980 May;135(2):387-90. doi: 10.1148/radiology.135.2.7367632. PMID: 7367632

Therapy

Endoscopy-Assisted Transoral Approach to Resect Parapharyngeal Space Tumors: A Systematic Review and Meta-Analysis.
Chen H, He Z, Li G, Liu C, Zhang D, Huang D, Xie C, Jiang W, Qiu Y, Zhang X, Liu Y
Laryngoscope 2021 Oct;131(10):2246-2253. Epub 2021 Feb 22 doi: 10.1002/lary.29458. PMID: 33616215
Management of a prestyloid parapharyngeal first branchial cleft cyst from puncture to surgical excision and how a routine procedure can turn into an emergency.
Fiedler LS
BMJ Case Rep 2021 Jan 12;14(1) doi: 10.1136/bcr-2020-238727. PMID: 33436361Free PMC Article
Inflammatory pseudotumor in head and neck.
Segawa Y, Yasumatsu R, Shiratsuchi H, Tamae A, Noda T, Yamamoto H, Komune S
Auris Nasus Larynx 2014 Jun;41(3):321-4. Epub 2013 Dec 17 doi: 10.1016/j.anl.2013.11.002. PMID: 24359703
Primary parapharyngeal and skull base synovial sarcoma in a 13-year-old boy with neurofibromatosis radiologically misdiagnosed as a benign lesion.
Zahir ST, Sharahjin NS, Dadgarnia MH
BMJ Case Rep 2013 Jun 3;2013 doi: 10.1136/bcr-2013-009649. PMID: 23737583Free PMC Article
Robotic skull base surgery: preclinical investigations to human clinical application.
O'Malley BW Jr, Weinstein GS
Arch Otolaryngol Head Neck Surg 2007 Dec;133(12):1215-9. doi: 10.1001/archotol.133.12.1215. PMID: 18086962

Prognosis

Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Comprehensive Analyses of Intraoral Benign and Malignant Nerve Sheath Tumors: The Rare Disease Entities Revisited.
Song Y, Hu J, Wu Y, Wang D, Wang Y, Zhang P, Jiang H, Yang J, Cheng J
J Craniofac Surg 2019 Jun;30(4):e317-e327. doi: 10.1097/SCS.0000000000005231. PMID: 30845091
Parapharyngeal space benign tumours: our experience.
Cassoni A, Terenzi V, Della Monaca M, Bartoli D, Battisti A, Rajabtork Zadeh O, Valentini V
J Craniomaxillofac Surg 2014 Mar;42(2):101-5. Epub 2013 May 17 doi: 10.1016/j.jcms.2013.03.002. PMID: 23684528
Parapharyngeal space neoplasms.
Hughes KV 3rd, Olsen KD, McCaffrey TV
Head Neck 1995 Mar-Apr;17(2):124-30. doi: 10.1002/hed.2880170209. PMID: 7558809
The parapharyngeal space.
Maran AG, Mackenzie IJ, Murray JA
J Laryngol Otol 1984 Apr;98(4):371-80. doi: 10.1017/s0022215100146766. PMID: 6325567

Clinical prediction guides

Management of Parapharyngeal Space Tumors: Clinical Experience with a Large Sample and Review of the Literature.
Jiang C, Wang W, Chen S, Liu Y
Curr Oncol 2023 Jan 11;30(1):1020-1031. doi: 10.3390/curroncol30010078. PMID: 36661727Free PMC Article
Endoscopy-Aided Combined Intraoral and Cervical Approach for a Huge Parapharyngeal Benign Tumor.
Tsunoda A, Kishimoto S, Tou M, Anzai T, Matsumoto F, Oba S, Ikeda K
Ear Nose Throat J 2021 Dec;100(10_suppl):1041S-1044S. Epub 2020 Jun 18 doi: 10.1177/0145561320935834. PMID: 32551957
Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Parapharyngeal space tumors: a serial case study.
Lien KH, Young CK, Chin SC, Liao CT, Huang SF
J Int Med Res 2019 Aug;47(8):4004-4013. Epub 2019 Jul 29 doi: 10.1177/0300060519862659. PMID: 31353995Free PMC Article
Contemporary evaluation and management of parapharyngeal space neoplasms.
Eisele DW, Richmon JD
J Laryngol Otol 2013 Jun;127(6):550-5. Epub 2013 Apr 10 doi: 10.1017/S0022215113000686. PMID: 23575439

Recent systematic reviews

Head and neck lipoblastoma in children: A case report and systematic review.
Tyra J, Mierzwińska-Dolny P, Fishman AJ, Mierzwiński J
Int J Pediatr Otorhinolaryngol 2023 Oct;173:111699. Epub 2023 Aug 16 doi: 10.1016/j.ijporl.2023.111699. PMID: 37597314
Endoscopy-Assisted Transoral Approach to Resect Parapharyngeal Space Tumors: A Systematic Review and Meta-Analysis.
Chen H, He Z, Li G, Liu C, Zhang D, Huang D, Xie C, Jiang W, Qiu Y, Zhang X, Liu Y
Laryngoscope 2021 Oct;131(10):2246-2253. Epub 2021 Feb 22 doi: 10.1002/lary.29458. PMID: 33616215
Histopathologic classification of parapharyngeal space tumors: a case series and review of the literature.
Locketz GD, Horowitz G, Abu-Ghanem S, Wasserzug O, Abergel A, Yehuda M, Fliss DM
Eur Arch Otorhinolaryngol 2016 Mar;273(3):727-34. Epub 2015 Feb 24 doi: 10.1007/s00405-015-3545-5. PMID: 25708410
Management of tumors arising from the parapharyngeal space: A systematic review of 1,293 cases reported over 25 years.
Kuet ML, Kasbekar AV, Masterson L, Jani P
Laryngoscope 2015 Jun;125(6):1372-81. Epub 2014 Dec 2 doi: 10.1002/lary.25077. PMID: 25448637
A systematic review of 1143 parapharyngeal space tumors reported over 20 years.
Riffat F, Dwivedi RC, Palme C, Fish B, Jani P
Oral Oncol 2014 May;50(5):421-30. Epub 2014 Feb 28 doi: 10.1016/j.oraloncology.2014.02.007. PMID: 24589290

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