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Warm Antibody Autoimmune Hemolytic Anemia

MedGen UID:
1685970
•Concept ID:
C5206690
•
Disease or Syndrome

Definition

The most common form of autoimmune hemolytic anemia, in which the autoantibodies react with red blood cells at temperatures greater than or equal to 37 degrees Celsius. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWarm Antibody Autoimmune Hemolytic Anemia

Professional guidelines

PubMed

Current approaches for the treatment of autoimmune hemolytic anemia.
Jaime-Pérez JC, Rodríguez-Martínez M, Gómez-de-León A, Tarín-Arzaga L, Gómez-Almaguer D
Arch Immunol Ther Exp (Warsz) 2013 Oct;61(5):385-95. Epub 2013 May 21 doi: 10.1007/s00005-013-0232-3. PMID: 23689532
Treatment of autoimmune hemolytic anemias.
Petz LD
Curr Opin Hematol 2001 Nov;8(6):411-6. doi: 10.1097/00062752-200111000-00016. PMID: 11604584
Efficacy of intravenous immunoglobulin in the treatment of autoimmune hemolytic anemia: results in 73 patients.
Flores G, Cunningham-Rundles C, Newland AC, Bussel JB
Am J Hematol 1993 Dec;44(4):237-42. doi: 10.1002/ajh.2830440404. PMID: 8237993

Recent clinical studies

Etiology

Fostamatinib for warm antibody autoimmune hemolytic anemia: Phase 3, randomized, double-blind, placebo-controlled, global study (FORWARD).
Kuter DJ, Piatek C, Röth A, Siddiqui A, Numerof RP, Dummer W; FORWARD study group
Am J Hematol 2024 Jan;99(1):79-87. Epub 2023 Nov 6 doi: 10.1002/ajh.27144. PMID: 37929318
A Retrospective Study of the Combination of Rituximab, Cyclophosphamide and Dexamethasone for the Treatment of Relapsed/Refractory Warm Antibody Autoimmune Hemolytic Anemia.
Piatek CI, Bocian H, Algaze S, Weitz IC, O'Connell C, Liebman HA
Acta Haematol 2020;143(3):244-249. Epub 2019 Oct 30 doi: 10.1159/000501538. PMID: 31665725
Post-Babesiosis Warm Autoimmune Hemolytic Anemia.
Woolley AE, Montgomery MW, Savage WJ, Achebe MO, Dunford K, Villeda S, Maguire JH, Marty FM
N Engl J Med 2017 Mar 9;376(10):939-946. doi: 10.1056/NEJMoa1612165. PMID: 28273010
Efficacy and safety of rituximab in adults' warm antibody autoimmune haemolytic anemia: retrospective analysis of 27 cases.
Bussone G, Ribeiro E, Dechartres A, Viallard JF, Bonnotte B, Fain O, Godeau B, Michel M
Am J Hematol 2009 Mar;84(3):153-7. doi: 10.1002/ajh.21341. PMID: 19123460
Combined cold- and warm-antibody autoimmune hemolytic anemia--review of the literature and a case report.
Hsu HC, Lin CK, Chau WK, Hu HY, Liu SM
Gaoxiong Yi Xue Ke Xue Za Zhi 1989 Jun;5(6):350-6. PMID: 2506364

Diagnosis

Autoimmune hemolytic anemia in a patient with myelodysplastic syndrome: Responding to 5-azacitidine therapy.
Kaur J, Tuler S, Dasanu CA
J Oncol Pharm Pract 2021 Oct;27(7):1775-1778. Epub 2021 Jan 14 doi: 10.1177/1078155220987616. PMID: 33446051
Severe warm-antibody autoimmune hemolytic anemia due to multicentric Castleman disease: Responding to rituximab.
Iskandar A, Hwang A, Dasanu CA
J Oncol Pharm Pract 2019 Dec;25(8):2016-2018. Epub 2018 Nov 28 doi: 10.1177/1078155218816775. PMID: 30486744
Post-Babesiosis Warm Autoimmune Hemolytic Anemia.
Woolley AE, Montgomery MW, Savage WJ, Achebe MO, Dunford K, Villeda S, Maguire JH, Marty FM
N Engl J Med 2017 Mar 9;376(10):939-946. doi: 10.1056/NEJMoa1612165. PMID: 28273010
Warm antibody autoimmune hemolytic anemia.
Kalfa TA
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):690-697. doi: 10.1182/asheducation-2016.1.690. PMID: 27913548Free PMC Article
Refractory autoimmune hemolytic anemia in a patient with DiGeorge syndrome treated successfully with plasma exchange: a case report and review of the literature.
Damlaj M, Séguin C
Int J Hematol 2014 Nov;100(5):494-7. Epub 2014 Jul 31 doi: 10.1007/s12185-014-1648-1. PMID: 25079091

Therapy

Fostamatinib for warm antibody autoimmune hemolytic anemia: Phase 3, randomized, double-blind, placebo-controlled, global study (FORWARD).
Kuter DJ, Piatek C, Röth A, Siddiqui A, Numerof RP, Dummer W; FORWARD study group
Am J Hematol 2024 Jan;99(1):79-87. Epub 2023 Nov 6 doi: 10.1002/ajh.27144. PMID: 37929318
Fostamatinib for the treatment of warm antibody autoimmune hemolytic anemia: Phase 2, multicenter, open-label study.
Kuter DJ, Rogers KA, Boxer MA, Choi M, Agajanian R, Arnold DM, Broome CM, Field JJ, Murakhovskaya I, Numerof R, Tong S
Am J Hematol 2022 Jun 1;97(6):691-699. Epub 2022 Mar 3 doi: 10.1002/ajh.26508. PMID: 35179251Free PMC Article
Severe warm-antibody autoimmune hemolytic anemia due to multicentric Castleman disease: Responding to rituximab.
Iskandar A, Hwang A, Dasanu CA
J Oncol Pharm Pract 2019 Dec;25(8):2016-2018. Epub 2018 Nov 28 doi: 10.1177/1078155218816775. PMID: 30486744
Post-Babesiosis Warm Autoimmune Hemolytic Anemia.
Woolley AE, Montgomery MW, Savage WJ, Achebe MO, Dunford K, Villeda S, Maguire JH, Marty FM
N Engl J Med 2017 Mar 9;376(10):939-946. doi: 10.1056/NEJMoa1612165. PMID: 28273010
The role of rituximab in adults with warm antibody autoimmune hemolytic anemia.
Dierickx D, Kentos A, Delannoy A
Blood 2015 May 21;125(21):3223-9. Epub 2015 Mar 31 doi: 10.1182/blood-2015-01-588392. PMID: 25827833

Prognosis

A Retrospective Study of the Combination of Rituximab, Cyclophosphamide and Dexamethasone for the Treatment of Relapsed/Refractory Warm Antibody Autoimmune Hemolytic Anemia.
Piatek CI, Bocian H, Algaze S, Weitz IC, O'Connell C, Liebman HA
Acta Haematol 2020;143(3):244-249. Epub 2019 Oct 30 doi: 10.1159/000501538. PMID: 31665725
Autoimmune hemolytic anemia associated with the use of immune checkpoint inhibitors for cancer: 68 cases from the Food and Drug Administration database and review.
Tanios GE, Doley PB, Munker R
Eur J Haematol 2019 Feb;102(2):157-162. Epub 2018 Nov 29 doi: 10.1111/ejh.13187. PMID: 30347480
The role of rituximab in adults with warm antibody autoimmune hemolytic anemia.
Dierickx D, Kentos A, Delannoy A
Blood 2015 May 21;125(21):3223-9. Epub 2015 Mar 31 doi: 10.1182/blood-2015-01-588392. PMID: 25827833
Efficacy of intravenous immunoglobulin in the treatment of autoimmune hemolytic anemia: results in 73 patients.
Flores G, Cunningham-Rundles C, Newland AC, Bussel JB
Am J Hematol 1993 Dec;44(4):237-42. doi: 10.1002/ajh.2830440404. PMID: 8237993

Clinical prediction guides

Autoimmune hemolytic anemia in a patient with myelodysplastic syndrome: Responding to 5-azacitidine therapy.
Kaur J, Tuler S, Dasanu CA
J Oncol Pharm Pract 2021 Oct;27(7):1775-1778. Epub 2021 Jan 14 doi: 10.1177/1078155220987616. PMID: 33446051
Autoimmune hemolytic anemia associated with the use of immune checkpoint inhibitors for cancer: 68 cases from the Food and Drug Administration database and review.
Tanios GE, Doley PB, Munker R
Eur J Haematol 2019 Feb;102(2):157-162. Epub 2018 Nov 29 doi: 10.1111/ejh.13187. PMID: 30347480
Post-Babesiosis Warm Autoimmune Hemolytic Anemia.
Woolley AE, Montgomery MW, Savage WJ, Achebe MO, Dunford K, Villeda S, Maguire JH, Marty FM
N Engl J Med 2017 Mar 9;376(10):939-946. doi: 10.1056/NEJMoa1612165. PMID: 28273010
Induction of heme oxygenase-1 and ferritin in the kidney in warm antibody hemolytic anemia.
Fervenza FC, Croatt AJ, Bittar CM, Rosenthal DW, Lager DJ, Leung N, Zeldenrust SR, Nath KA
Am J Kidney Dis 2008 Nov;52(5):972-7. Epub 2008 Sep 21 doi: 10.1053/j.ajkd.2008.07.012. PMID: 18805612Free PMC Article
B-cell depletion with rituximab as treatment for immune hemolytic anemia and chronic thrombocytopenia.
Zaja F, Iacona I, Masolini P, Russo D, Sperotto A, Prosdocimo S, Patriarca F, de Vita S, Regazzi M, Baccarani M, Fanin R
Haematologica 2002 Feb;87(2):189-95. PMID: 11836170

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