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Locally Advanced Unresectable Digestive System Neuroendocrine Neoplasm

MedGen UID:
1679073
•Concept ID:
C4764040
•
Neoplastic Process
Synonym: Locally Advanced Unresectable Gastroenteropancreatic Neuroendocrine Neoplasm

Definition

A digestive system neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Digestive System Neuroendocrine Neoplasm

Professional guidelines

PubMed

Management of Locally Advanced and Unresectable Small Bowel Neuroendocrine Tumours.
Koea J; Commonwealth Neuroendocrine Tumour Research Collaborative (CommNETs) Surgical Section
World J Surg 2021 Jan;45(1):219-224. Epub 2020 Aug 28 doi: 10.1007/s00268-020-05740-7. PMID: 32860138
Understanding the Management and Treatment of Well-Differentiated Pancreatic Neuroendocrine Tumors: A Clinician's Guide to a Complex Illness.
Li D, Rock A, Kessler J, Ballena R, Hyder S, Mo C, Chang S, Singh G
JCO Oncol Pract 2020 Nov;16(11):720-728. Epub 2020 Oct 21 doi: 10.1200/JCOOP.20.00010. PMID: 33085933

Recent clinical studies

Etiology

Combining Hepatic Percutaneous Perfusion with Ipilimumab plus Nivolumab in advanced uveal melanoma (CHOPIN): study protocol for a phase Ib/randomized phase II trial.
Tong TML, van der Kooij MK, Speetjens FM, van Erkel AR, van der Meer RW, Lutjeboer J, van Persijn van Meerten EL, Martini CH, Zoethout RWM, Tijl FGJ, Blank CU, Burgmans MC, Kapiteijn E
Trials 2022 Feb 13;23(1):137. doi: 10.1186/s13063-022-06036-y. PMID: 35152908Free PMC Article
Mutation-targeted therapy with sunitinib or everolimus in patients with advanced low-grade or intermediate-grade neuroendocrine tumours of the gastrointestinal tract and pancreas with or without cytoreductive surgery: protocol for a phase II clinical trial.
Neychev V, Steinberg SM, Cottle-Delisle C, Merkel R, Nilubol N, Yao J, Meltzer P, Pacak K, Marx S, Kebebew E
BMJ Open 2015 May 19;5(5):e008248. doi: 10.1136/bmjopen-2015-008248. PMID: 25991462Free PMC Article

Diagnosis

Understanding the Management and Treatment of Well-Differentiated Pancreatic Neuroendocrine Tumors: A Clinician's Guide to a Complex Illness.
Li D, Rock A, Kessler J, Ballena R, Hyder S, Mo C, Chang S, Singh G
JCO Oncol Pract 2020 Nov;16(11):720-728. Epub 2020 Oct 21 doi: 10.1200/JCOOP.20.00010. PMID: 33085933
Surgical Principles in the Management of Small Bowel Neuroendocrine Tumors.
Gangi A, Anaya DA
Curr Treat Options Oncol 2020 Aug 29;21(11):88. doi: 10.1007/s11864-020-00784-2. PMID: 32862334
Transplantation and Debulking Procedures for Neuroendocrine Tumors.
Frilling A, Al-Nahhas A, Clift AK
Front Horm Res 2015;44:164-76. Epub 2015 Aug 14 doi: 10.1159/000382145. PMID: 26303711

Therapy

Combining Hepatic Percutaneous Perfusion with Ipilimumab plus Nivolumab in advanced uveal melanoma (CHOPIN): study protocol for a phase Ib/randomized phase II trial.
Tong TML, van der Kooij MK, Speetjens FM, van Erkel AR, van der Meer RW, Lutjeboer J, van Persijn van Meerten EL, Martini CH, Zoethout RWM, Tijl FGJ, Blank CU, Burgmans MC, Kapiteijn E
Trials 2022 Feb 13;23(1):137. doi: 10.1186/s13063-022-06036-y. PMID: 35152908Free PMC Article
Surgical Principles in the Management of Small Bowel Neuroendocrine Tumors.
Gangi A, Anaya DA
Curr Treat Options Oncol 2020 Aug 29;21(11):88. doi: 10.1007/s11864-020-00784-2. PMID: 32862334
Mutation-targeted therapy with sunitinib or everolimus in patients with advanced low-grade or intermediate-grade neuroendocrine tumours of the gastrointestinal tract and pancreas with or without cytoreductive surgery: protocol for a phase II clinical trial.
Neychev V, Steinberg SM, Cottle-Delisle C, Merkel R, Nilubol N, Yao J, Meltzer P, Pacak K, Marx S, Kebebew E
BMJ Open 2015 May 19;5(5):e008248. doi: 10.1136/bmjopen-2015-008248. PMID: 25991462Free PMC Article

Prognosis

Transplantation and Debulking Procedures for Neuroendocrine Tumors.
Frilling A, Al-Nahhas A, Clift AK
Front Horm Res 2015;44:164-76. Epub 2015 Aug 14 doi: 10.1159/000382145. PMID: 26303711

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