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Panniculitis and localized lipodystrophy

MedGen UID:
1678538
Concept ID:
C5190785
Disease or Syndrome
Synonyms: panniculitis and localized lipodystrophy; Panniculitis induced localized lipodystrophy; panniculitis-induced localised lipodystrophy; panniculitis-induced localized lipodystrophy; Panniculitis-induced localized lipodystrophy
SNOMED CT: Panniculitis induced localized lipodystrophy (783014007)
 
Monarch Initiative: MONDO:0019555
Orphanet: ORPHA90159

Definition

A rare acquired localised lipodystrophy disorder characterised by the eruption of tender occasionally painful, erythematous nodules and plaques, which enlarge radially and resolve into lipoatrophic lesions, often located in the upper and lower limbs. Histologically lesions are characterised by lipophagic lobular panniculitis and absence of vasculitis. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPanniculitis and localized lipodystrophy

Recent clinical studies

Etiology

Suzon B, Goulabchand R, Louis-Sidney F, Maria A, Najjari R, Chauvet E, Le Quellec A, Bessis D, Guilpain P
Autoimmun Rev 2023 Apr;22(4):103284. Epub 2023 Feb 1 doi: 10.1016/j.autrev.2023.103284. PMID: 36736986
Nolis T
J Hum Genet 2014 Jan;59(1):16-23. Epub 2013 Oct 24 doi: 10.1038/jhg.2013.107. PMID: 24152769
Serrão VV, Feio AB
Dermatol Online J 2008 Jul 15;14(7):15. PMID: 18718199
Bingham A, Mamyrova G, Rother KI, Oral E, Cochran E, Premkumar A, Kleiner D, James-Newton L, Targoff IN, Pandey JP, Carrick DM, Sebring N, O'Hanlon TP, Ruiz-Hidalgo M, Turner M, Gordon LB, Laborda J, Bauer SR, Blackshear PJ, Imundo L, Miller FW, Rider LG; Childhood Myositis Heterogeneity Study Group
Medicine (Baltimore) 2008 Mar;87(2):70-86. doi: 10.1097/MD.0b013e31816bc604. PMID: 18344805Free PMC Article
Pope E, Janson A, Khambalia A, Feldman B
J Am Acad Dermatol 2006 Dec;55(6):947-50. Epub 2006 Jun 13 doi: 10.1016/j.jaad.2006.05.005. PMID: 17097389

Diagnosis

Langkilde A, Andersen O, Henriksen JH, Langberg H, Petersen J, Eugen-Olsen J
Clin Physiol Funct Imaging 2015 Mar;35(2):110-9. Epub 2014 Feb 4 doi: 10.1111/cpf.12134. PMID: 24494803
Nolis T
J Hum Genet 2014 Jan;59(1):16-23. Epub 2013 Oct 24 doi: 10.1038/jhg.2013.107. PMID: 24152769
Serrão VV, Feio AB
Dermatol Online J 2008 Jul 15;14(7):15. PMID: 18718199
Garg A
Am J Med 2000 Feb;108(2):143-52. doi: 10.1016/s0002-9343(99)00414-3. PMID: 11126308
Winkelmann RK
Arch Dermatol 1983 Apr;119(4):336-44. PMID: 6340615

Therapy

Resende L, Noites A, Amorim M
J Cosmet Dermatol 2022 Oct;21(10):4122-4132. Epub 2022 Aug 9 doi: 10.1111/jocd.15265. PMID: 35869825
Langkilde A, Andersen O, Henriksen JH, Langberg H, Petersen J, Eugen-Olsen J
Clin Physiol Funct Imaging 2015 Mar;35(2):110-9. Epub 2014 Feb 4 doi: 10.1111/cpf.12134. PMID: 24494803
Weise G, Hupp M, Kerstan A, Buttmann M
J Clin Neurosci 2012 Sep;19(9):1312-3. Epub 2012 Jun 20 doi: 10.1016/j.jocn.2011.11.026. PMID: 22721889
Rubio Fernández D, Rodríguez Del Canto C, Marcos Galán V, Falcón N, Edreira H, Sevane Fernández L, Francoli Martínez P, Sánchez-De la Rosa R
Adv Ther 2012 Mar;29(3):267-75. Epub 2012 Feb 28 doi: 10.1007/s12325-012-0005-0. PMID: 22382874
Soós N, Shakery K, Mrowietz U
Am J Clin Dermatol 2004;5(5):357-9. doi: 10.2165/00128071-200405050-00009. PMID: 15554737

Prognosis

Suzon B, Goulabchand R, Louis-Sidney F, Maria A, Najjari R, Chauvet E, Le Quellec A, Bessis D, Guilpain P
Autoimmun Rev 2023 Apr;22(4):103284. Epub 2023 Feb 1 doi: 10.1016/j.autrev.2023.103284. PMID: 36736986
Garg A
J Clin Endocrinol Metab 2011 Nov;96(11):3313-25. Epub 2011 Aug 24 doi: 10.1210/jc.2011-1159. PMID: 21865368Free PMC Article
Serrão VV, Feio AB
Dermatol Online J 2008 Jul 15;14(7):15. PMID: 18718199
Bingham A, Mamyrova G, Rother KI, Oral E, Cochran E, Premkumar A, Kleiner D, James-Newton L, Targoff IN, Pandey JP, Carrick DM, Sebring N, O'Hanlon TP, Ruiz-Hidalgo M, Turner M, Gordon LB, Laborda J, Bauer SR, Blackshear PJ, Imundo L, Miller FW, Rider LG; Childhood Myositis Heterogeneity Study Group
Medicine (Baltimore) 2008 Mar;87(2):70-86. doi: 10.1097/MD.0b013e31816bc604. PMID: 18344805Free PMC Article
Pope E, Janson A, Khambalia A, Feldman B
J Am Acad Dermatol 2006 Dec;55(6):947-50. Epub 2006 Jun 13 doi: 10.1016/j.jaad.2006.05.005. PMID: 17097389

Clinical prediction guides

Suzon B, Goulabchand R, Louis-Sidney F, Maria A, Najjari R, Chauvet E, Le Quellec A, Bessis D, Guilpain P
Autoimmun Rev 2023 Apr;22(4):103284. Epub 2023 Feb 1 doi: 10.1016/j.autrev.2023.103284. PMID: 36736986
Nolis T
J Hum Genet 2014 Jan;59(1):16-23. Epub 2013 Oct 24 doi: 10.1038/jhg.2013.107. PMID: 24152769
Bingham A, Mamyrova G, Rother KI, Oral E, Cochran E, Premkumar A, Kleiner D, James-Newton L, Targoff IN, Pandey JP, Carrick DM, Sebring N, O'Hanlon TP, Ruiz-Hidalgo M, Turner M, Gordon LB, Laborda J, Bauer SR, Blackshear PJ, Imundo L, Miller FW, Rider LG; Childhood Myositis Heterogeneity Study Group
Medicine (Baltimore) 2008 Mar;87(2):70-86. doi: 10.1097/MD.0b013e31816bc604. PMID: 18344805Free PMC Article
Pope E, Janson A, Khambalia A, Feldman B
J Am Acad Dermatol 2006 Dec;55(6):947-50. Epub 2006 Jun 13 doi: 10.1016/j.jaad.2006.05.005. PMID: 17097389
Peters MS, Winkelmann RK
Arch Dermatol 1980 Dec;116(12):1363-8. PMID: 7458364

Recent systematic reviews

Suzon B, Goulabchand R, Louis-Sidney F, Maria A, Najjari R, Chauvet E, Le Quellec A, Bessis D, Guilpain P
Autoimmun Rev 2023 Apr;22(4):103284. Epub 2023 Feb 1 doi: 10.1016/j.autrev.2023.103284. PMID: 36736986
Resende L, Noites A, Amorim M
J Cosmet Dermatol 2022 Oct;21(10):4122-4132. Epub 2022 Aug 9 doi: 10.1111/jocd.15265. PMID: 35869825

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