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Abnormal erythrocyte physiology

MedGen UID:
1670968
•Concept ID:
C4732748
•
Finding
HPO: HP:0020054

Definition

Any functional abnormality of erythrocytes (red-blood cells). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal erythrocyte physiology

Professional guidelines

PubMed

Understanding Sickle cell disease: Causes, symptoms, and treatment options.
Elendu C, Amaechi DC, Alakwe-Ojimba CE, Elendu TC, Elendu RC, Ayabazu CP, Aina TO, Aborisade O, Adenikinju JS
Medicine (Baltimore) 2023 Sep 22;102(38):e35237. doi: 10.1097/MD.0000000000035237. PMID: 37746969Free PMC Article
Insight into the complex pathophysiology of sickle cell anaemia and possible treatment.
Piccin A, Murphy C, Eakins E, Rondinelli MB, Daves M, Vecchiato C, Wolf D, Mc Mahon C, Smith OP
Eur J Haematol 2019 Apr;102(4):319-330. Epub 2019 Feb 21 doi: 10.1111/ejh.13212. PMID: 30664257
Hereditary Spherocytosis - Diagnosis, Surgical Treatment and Outcomes. A Literature Review.
Manciu S, Matei E, Trandafir B
Chirurgia (Bucur) 2017 Mar-Apr;112(2):110-116. doi: 10.21614/chirurgia.112.2.110. PMID: 28463670

Recent clinical studies

Etiology

Hereditary Spherocytosis - Diagnosis, Surgical Treatment and Outcomes. A Literature Review.
Manciu S, Matei E, Trandafir B
Chirurgia (Bucur) 2017 Mar-Apr;112(2):110-116. doi: 10.21614/chirurgia.112.2.110. PMID: 28463670
Acanthocytosis and neurological disorders.
Stevenson VL, Hardie RJ
J Neurol 2001 Feb;248(2):87-94. doi: 10.1007/s004150170241. PMID: 11284140
Drug-induced megaloblastic change.
Scott JM, Weir DG
Clin Haematol 1980 Oct;9(3):587-606. PMID: 6450011
Congenital hypoplastic anemia.
Diamond LK, Wang WC, Alter BP
Adv Pediatr 1976;22:349-78. PMID: 773132
Auto-immune hemolytic anemia.
Issitt PD
Am J Med Technol 1974 Nov;40(11):479-95. PMID: 4215323

Diagnosis

Red cell membrane disorders: structure meets function.
Risinger M, Kalfa TA
Blood 2020 Sep 10;136(11):1250-1261. doi: 10.1182/blood.2019000946. PMID: 32702754Free PMC Article
Insight into the complex pathophysiology of sickle cell anaemia and possible treatment.
Piccin A, Murphy C, Eakins E, Rondinelli MB, Daves M, Vecchiato C, Wolf D, Mc Mahon C, Smith OP
Eur J Haematol 2019 Apr;102(4):319-330. Epub 2019 Feb 21 doi: 10.1111/ejh.13212. PMID: 30664257
Phytosterolemia.
Bain BJ, Chakravorty S
Am J Hematol 2016 Jun;91(6):643. Epub 2016 Apr 24 doi: 10.1002/ajh.24343. PMID: 26927922
Hereditary spherocytosis.
Shah S, Vega R
Pediatr Rev 2004 May;25(5):168-72. doi: 10.1542/pir.25-5-168. PMID: 15121908
Hereditary spherocytosis.
Bellingham AJ, Prankerd TA
Clin Haematol 1975 Feb;4(1):139-44. PMID: 1102180

Therapy

Insight into the complex pathophysiology of sickle cell anaemia and possible treatment.
Piccin A, Murphy C, Eakins E, Rondinelli MB, Daves M, Vecchiato C, Wolf D, Mc Mahon C, Smith OP
Eur J Haematol 2019 Apr;102(4):319-330. Epub 2019 Feb 21 doi: 10.1111/ejh.13212. PMID: 30664257
Phytosterolemia.
Bain BJ, Chakravorty S
Am J Hematol 2016 Jun;91(6):643. Epub 2016 Apr 24 doi: 10.1002/ajh.24343. PMID: 26927922
Drug-induced megaloblastic change.
Scott JM, Weir DG
Clin Haematol 1980 Oct;9(3):587-606. PMID: 6450011
Hereditary spherocytosis.
Bellingham AJ, Prankerd TA
Clin Haematol 1975 Feb;4(1):139-44. PMID: 1102180
Auto-immune hemolytic anemia.
Issitt PD
Am J Med Technol 1974 Nov;40(11):479-95. PMID: 4215323

Prognosis

Spur-Cell Hemolytic Anemia.
Patel A, Tillman BF
N Engl J Med 2022 Jan 27;386(4):e6. doi: 10.1056/NEJMicm2101673. PMID: 35081282
A Review of Complement Activation in SLE.
Weinstein A, Alexander RV, Zack DJ
Curr Rheumatol Rep 2021 Feb 10;23(3):16. doi: 10.1007/s11926-021-00984-1. PMID: 33569681Free PMC Article
Spur-Cell Anemia.
Keyserling K, Koprowski S
N Engl J Med 2018 Aug 23;379(8):774. doi: 10.1056/NEJMicm1714572. PMID: 30134135
Diabetic nephropathy and anaemia.
Ritz E, Haxsen V
Eur J Clin Invest 2005 Dec;35 Suppl 3:66-74. doi: 10.1111/j.1365-2362.2005.01544.x. PMID: 16281961
Congenital hypoplastic anemia.
Diamond LK, Wang WC, Alter BP
Adv Pediatr 1976;22:349-78. PMID: 773132

Clinical prediction guides

Learning more and spending less with neglected laboratory parameters: the paradigmatic case of red blood cell distribution width.
Lippi G, Mattiuzzi C, Cervellin G
Acta Biomed 2016 Jan 16;87(3):323-328. PMID: 28112703Free PMC Article
The proteomics and interactomics of human erythrocytes.
Goodman SR, Daescu O, Kakhniashvili DG, Zivanic M
Exp Biol Med (Maywood) 2013 May;238(5):509-18. doi: 10.1177/1535370213488474. PMID: 23856902
Measuring single-cell density.
Grover WH, Bryan AK, Diez-Silva M, Suresh S, Higgins JM, Manalis SR
Proc Natl Acad Sci U S A 2011 Jul 5;108(27):10992-6. Epub 2011 Jun 20 doi: 10.1073/pnas.1104651108. PMID: 21690360Free PMC Article
Sickle red cell-endothelium interactions.
Kaul DK, Finnegan E, Barabino GA
Microcirculation 2009 Jan;16(1):97-111. doi: 10.1080/10739680802279394. PMID: 18720225Free PMC Article
Diabetic nephropathy and anaemia.
Ritz E, Haxsen V
Eur J Clin Invest 2005 Dec;35 Suppl 3:66-74. doi: 10.1111/j.1365-2362.2005.01544.x. PMID: 16281961

Recent systematic reviews

Prevalence of Cardiovascular Complications in Malaria: A Systematic Review and Meta-Analysis.
Holm AE, Gomes LC, Marinho CRF, Silvestre OM, Vestergaard LS, Biering-Sørensen T, Brainin P
Am J Trop Med Hyg 2021 Mar 15;104(5):1643-1650. doi: 10.4269/ajtmh.20-1414. PMID: 33724926Free PMC Article
Relationship between polyunsaturated fatty acid and eating disorders: Systematic review and meta-analysis.
Satogami K, Tseng PT, Su KP, Takahashi S, Ukai S, Li DJ, Chen TY, Lin PY, Chen YW, Matsuoka YJ
Prostaglandins Leukot Essent Fatty Acids 2019 Mar;142:11-19. Epub 2019 Jan 11 doi: 10.1016/j.plefa.2019.01.001. PMID: 30773209
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2018 Oct 19;10(10):CD003426. doi: 10.1002/14651858.CD003426.pub6. PMID: 30338520Free PMC Article
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Nagalla S, Ballas SK
Cochrane Database Syst Rev 2016 Mar 4;3:CD003426. doi: 10.1002/14651858.CD003426.pub5. PMID: 26942338
Computational microscopic imaging for malaria parasite detection: a systematic review.
Das DK, Mukherjee R, Chakraborty C
J Microsc 2015 Oct;260(1):1-19. Epub 2015 Jun 5 doi: 10.1111/jmi.12270. PMID: 26047029

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