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Advanced Sarcoma of the Extremity

MedGen UID:
1670157
•Concept ID:
C4744309
•
Neoplastic Process
Synonym: Advanced Extremity Sarcoma

Definition

A sarcoma of the soft tissues or bones of the upper or lower extremity that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Sarcoma of the Extremity

Professional guidelines

PubMed

Advances in treatment of alveolar soft part sarcoma: an updated review.
Fujiwara T, Kunisada T, Nakata E, Nishida K, Yanai H, Nakamura T, Tanaka K, Ozaki T
Jpn J Clin Oncol 2023 Nov 5;53(11):1009-1018. doi: 10.1093/jjco/hyad102. PMID: 37626447Free PMC Article
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Soft-tissue sarcoma in adults: An update on the current state of histiotype-specific management in an era of personalized medicine.
Gamboa AC, Gronchi A, Cardona K
CA Cancer J Clin 2020 May;70(3):200-229. Epub 2020 Apr 10 doi: 10.3322/caac.21605. PMID: 32275330

Recent clinical studies

Etiology

The history of resection prosthesis.
Crimì A, Joyce DM, Binitie O, Ruggieri P, Letson GD
Int Orthop 2023 Mar;47(3):873-883. Epub 2023 Jan 18 doi: 10.1007/s00264-023-05698-w. PMID: 36651984
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Pathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial.
Weiss AR, Chen YL, Scharschmidt TJ, Chi YY, Tian J, Black JO, Davis JL, Fanburg-Smith JC, Zambrano E, Anderson J, Arens R, Binitie O, Choy E, Davis JW, Hayes-Jordan A, Kao SC, Kayton ML, Kessel S, Lim R, Meyer WH, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Schlapkohl M, Shulkin BL, Smith EA, Sorger JI, Terezakis S, Hawkins DS, Spunt SL, Wang D
Lancet Oncol 2020 Aug;21(8):1110-1122. Epub 2020 Jul 20 doi: 10.1016/S1470-2045(20)30325-9. PMID: 32702309Free PMC Article
Limb Salvage and Reconstruction Options in Osteosarcoma.
Grinberg SZ, Posta A, Weber KL, Wilson RJ
Adv Exp Med Biol 2020;1257:13-29. doi: 10.1007/978-3-030-43032-0_2. PMID: 32483727
Radiotherapy in soft-tissue sarcoma of the extremities.
Correa R, Gómez-Millán J, Lobato M, Fernández A, Ordoñez R, Castro C, Lupiañez Y, Medina JA
Clin Transl Oncol 2018 Sep;20(9):1127-1135. Epub 2018 Feb 23 doi: 10.1007/s12094-018-1848-x. PMID: 29476322

Diagnosis

Advances in treatment of alveolar soft part sarcoma: an updated review.
Fujiwara T, Kunisada T, Nakata E, Nishida K, Yanai H, Nakamura T, Tanaka K, Ozaki T
Jpn J Clin Oncol 2023 Nov 5;53(11):1009-1018. doi: 10.1093/jjco/hyad102. PMID: 37626447Free PMC Article
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Tumor-Like Conditions of the Hand and Upper Extremity.
Sherman CE, Murray PM
J Hand Surg Am 2017 Dec;42(12):1009-1017. Epub 2017 Oct 28 doi: 10.1016/j.jhsa.2017.09.012. PMID: 29089162
Soft-tissue sarcoma.
Gilbert NF, Cannon CP, Lin PP, Lewis VO
J Am Acad Orthop Surg 2009 Jan;17(1):40-7. doi: 10.5435/00124635-200901000-00006. PMID: 19136426
Osteosarcoma.
Jaffe N
Pediatr Rev 1991 May;12(11):333-43. PMID: 2062744

Therapy

Desmoid tumors: diagnostic and therapeutic considerations.
Brener-Chaoul M, Cervantes-Gutiérrez Ó, Padilla-Longoria R, Martín-Téllez KS
Gac Med Mex 2020;156(5):439-445. doi: 10.24875/GMM.M20000440. PMID: 33372933
A review of retroperitoneal liposarcoma genomics.
Tyler R, Wanigasooriya K, Taniere P, Almond M, Ford S, Desai A, Beggs A
Cancer Treat Rev 2020 Jun;86:102013. Epub 2020 Mar 28 doi: 10.1016/j.ctrv.2020.102013. PMID: 32278233
Radiotherapy in soft-tissue sarcoma of the extremities.
Correa R, Gómez-Millán J, Lobato M, Fernández A, Ordoñez R, Castro C, Lupiañez Y, Medina JA
Clin Transl Oncol 2018 Sep;20(9):1127-1135. Epub 2018 Feb 23 doi: 10.1007/s12094-018-1848-x. PMID: 29476322
Radiotherapy for soft tissue sarcoma: 50 years of change and improvement.
Wang D, Abrams RA
Am Soc Clin Oncol Educ Book 2014:244-51. doi: 10.14694/EdBook_AM.2014.34.244. PMID: 24857082
Osteosarcoma.
Jaffe N
Pediatr Rev 1991 May;12(11):333-43. PMID: 2062744

Prognosis

A review of retroperitoneal liposarcoma genomics.
Tyler R, Wanigasooriya K, Taniere P, Almond M, Ford S, Desai A, Beggs A
Cancer Treat Rev 2020 Jun;86:102013. Epub 2020 Mar 28 doi: 10.1016/j.ctrv.2020.102013. PMID: 32278233
Soft-tissue sarcoma in adults: An update on the current state of histiotype-specific management in an era of personalized medicine.
Gamboa AC, Gronchi A, Cardona K
CA Cancer J Clin 2020 May;70(3):200-229. Epub 2020 Apr 10 doi: 10.3322/caac.21605. PMID: 32275330
Diagnosis and Management of Rhabdomyosarcoma in Children and Adolescents: ICMR Consensus Document.
Panda SP, Chinnaswamy G, Vora T, Prasad M, Bansal D, Kapoor G, Radhakrishnan V, Agarwala S, Laskar S, Arora B, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 May;84(5):393-402. Epub 2017 Apr 5 doi: 10.1007/s12098-017-2315-3. PMID: 28378141
Soft-tissue sarcoma.
Gilbert NF, Cannon CP, Lin PP, Lewis VO
J Am Acad Orthop Surg 2009 Jan;17(1):40-7. doi: 10.5435/00124635-200901000-00006. PMID: 19136426
Osteosarcoma.
Jaffe N
Pediatr Rev 1991 May;12(11):333-43. PMID: 2062744

Clinical prediction guides

A League of Its Own? Established and Emerging Therapies in Undifferentiated Pleomorphic Sarcoma.
Graves L, Jeck WR, Grilley-Olson JE
Curr Treat Options Oncol 2023 Mar;24(3):212-228. Epub 2023 Feb 2 doi: 10.1007/s11864-023-01054-7. PMID: 36729198
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Pathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial.
Weiss AR, Chen YL, Scharschmidt TJ, Chi YY, Tian J, Black JO, Davis JL, Fanburg-Smith JC, Zambrano E, Anderson J, Arens R, Binitie O, Choy E, Davis JW, Hayes-Jordan A, Kao SC, Kayton ML, Kessel S, Lim R, Meyer WH, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Schlapkohl M, Shulkin BL, Smith EA, Sorger JI, Terezakis S, Hawkins DS, Spunt SL, Wang D
Lancet Oncol 2020 Aug;21(8):1110-1122. Epub 2020 Jul 20 doi: 10.1016/S1470-2045(20)30325-9. PMID: 32702309Free PMC Article
Leiomyosarcoma: Prognostic outline of a rare head and neck malignancy.
Saluja TS, Iyer J, Singh SK
Oral Oncol 2019 Aug;95:100-105. Epub 2019 Jun 13 doi: 10.1016/j.oraloncology.2019.06.010. PMID: 31345375
Management of vascular involvement in extremity soft tissue sarcoma.
Mahendra A, Gortzak Y, Ferguson PC, Deheshi BM, Lindsay TF, Wunder JS
Recent Results Cancer Res 2009;179:285-99. doi: 10.1007/978-3-540-77960-5_18. PMID: 19230547

Recent systematic reviews

Molecular characteristics and systemic treatment options of liposarcoma: A systematic review.
Zhou XP, Xing JP, Sun LB, Tian SQ, Luo R, Liu WH, Song XY, Gao SH
Biomed Pharmacother 2024 Sep;178:117204. Epub 2024 Jul 26 doi: 10.1016/j.biopha.2024.117204. PMID: 39067161
Isolated Limb Perfusion and Infusion for Extremity Soft Tissue Sarcoma: A Contemporary Systematic Review and Meta-Analysis.
Neuwirth MG, Song Y, Sinnamon AJ, Fraker DL, Zager JS, Karakousis GC
Ann Surg Oncol 2017 Dec;24(13):3803-3810. Epub 2017 Oct 11 doi: 10.1245/s10434-017-6109-7. PMID: 29022281
Pediatric lower extremity sarcoma reconstruction: A review of limb salvage procedures and outcomes.
Piper M, Irwin C, Sbitany H
J Plast Reconstr Aesthet Surg 2016 Jan;69(1):91-6. Epub 2015 Sep 5 doi: 10.1016/j.bjps.2015.08.035. PMID: 26601876
Outcomes of isolated limb perfusion in the treatment of extremity soft tissue sarcoma: a systematic review.
Bhangu A, Broom L, Nepogodiev D, Gourevitch D, Desai A
Eur J Surg Oncol 2013 Apr;39(4):311-9. Epub 2013 Jan 23 doi: 10.1016/j.ejso.2012.12.018. PMID: 23351681
Hyperthermic isolated limb perfusion for extremity soft tissue sarcomas: systematic review of clinical efficacy and quality assessment of reported trials.
Trabulsi NH, Patakfalvi L, Nassif MO, Turcotte RE, Nichols A, Meguerditchian AN
J Surg Oncol 2012 Dec;106(8):921-8. Epub 2012 Jul 17 doi: 10.1002/jso.23200. PMID: 22806575

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