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Locally Advanced Sarcoma

MedGen UID:
1656514
•Concept ID:
C4727005
•
Neoplastic Process

Definition

Sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Sarcoma treatment in the era of molecular medicine.
Grünewald TG, Alonso M, Avnet S, Banito A, Burdach S, Cidre-Aranaz F, Di Pompo G, Distel M, Dorado-Garcia H, Garcia-Castro J, González-González L, Grigoriadis AE, Kasan M, Koelsche C, Krumbholz M, Lecanda F, Lemma S, Longo DL, Madrigal-Esquivel C, Morales-Molina Á, Musa J, Ohmura S, Ory B, Pereira-Silva M, Perut F, Rodriguez R, Seeling C, Al Shaaili N, Shaabani S, Shiavone K, Sinha S, Tomazou EM, Trautmann M, Vela M, Versleijen-Jonkers YM, Visgauss J, Zalacain M, Schober SJ, Lissat A, English WR, Baldini N, Heymann D
EMBO Mol Med 2020 Nov 6;12(11):e11131. Epub 2020 Oct 13 doi: 10.15252/emmm.201911131. PMID: 33047515Free PMC Article
Myeloid Sarcoma: Presentation, Diagnosis, and Treatment.
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811
Management of Gastrointestinal Stromal Tumors.
Keung EZ, Raut CP
Surg Clin North Am 2017 Apr;97(2):437-452. doi: 10.1016/j.suc.2016.12.001. PMID: 28325196

Recent clinical studies

Etiology

What Is the Implant Survivorship and Functional Outcome After Total Humeral Replacement in Patients with Primary Bone Tumors?
Schneider KN, Bröking JN, Gosheger G, Lübben T, Hardes J, Schorn D, Smolle MA, Theil C, Andreou D
Clin Orthop Relat Res 2021 Aug 1;479(8):1754-1764. doi: 10.1097/CORR.0000000000001677. PMID: 33595237Free PMC Article
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Myoglobin does not predict local toxicity in isolated limb perfusion.
Nyström Wendt A, Mattsson J, Olofsson Bagge R
Int J Hyperthermia 2017 Sep;33(6):679-683. Epub 2017 Apr 10 doi: 10.1080/02656736.2017.1309082. PMID: 28540796

Diagnosis

Deep venous thrombosis of the extremity diagnosed by color Doppler ultrasonography after isolated limb perfusion.
Eroğlu A, Ozcan H, Eryavuz Y, Kocağlu H, Demirci S, Aytac SK
Tumori 2001 May-Jun;87(3):187-90. doi: 10.1177/030089160108700314. PMID: 11504375

Therapy

Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Myoglobin does not predict local toxicity in isolated limb perfusion.
Nyström Wendt A, Mattsson J, Olofsson Bagge R
Int J Hyperthermia 2017 Sep;33(6):679-683. Epub 2017 Apr 10 doi: 10.1080/02656736.2017.1309082. PMID: 28540796
Long-term locoregional vascular morbidity after isolated limb perfusion and external-beam radiotherapy for soft tissue sarcoma of the extremity.
Hoven-Gondrie ML, Thijssens KM, Van den Dungen JJ, Loonstra J, van Ginkel RJ, Hoekstra HJ
Ann Surg Oncol 2007 Jul;14(7):2105-12. Epub 2007 Apr 25 doi: 10.1245/s10434-007-9365-0. PMID: 17457649Free PMC Article
Deep venous thrombosis of the extremity diagnosed by color Doppler ultrasonography after isolated limb perfusion.
Eroğlu A, Ozcan H, Eryavuz Y, Kocağlu H, Demirci S, Aytac SK
Tumori 2001 May-Jun;87(3):187-90. doi: 10.1177/030089160108700314. PMID: 11504375

Prognosis

Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Myoglobin does not predict local toxicity in isolated limb perfusion.
Nyström Wendt A, Mattsson J, Olofsson Bagge R
Int J Hyperthermia 2017 Sep;33(6):679-683. Epub 2017 Apr 10 doi: 10.1080/02656736.2017.1309082. PMID: 28540796
Deep venous thrombosis of the extremity diagnosed by color Doppler ultrasonography after isolated limb perfusion.
Eroğlu A, Ozcan H, Eryavuz Y, Kocağlu H, Demirci S, Aytac SK
Tumori 2001 May-Jun;87(3):187-90. doi: 10.1177/030089160108700314. PMID: 11504375

Clinical prediction guides

What Is the Implant Survivorship and Functional Outcome After Total Humeral Replacement in Patients with Primary Bone Tumors?
Schneider KN, Bröking JN, Gosheger G, Lübben T, Hardes J, Schorn D, Smolle MA, Theil C, Andreou D
Clin Orthop Relat Res 2021 Aug 1;479(8):1754-1764. doi: 10.1097/CORR.0000000000001677. PMID: 33595237Free PMC Article
Myoglobin does not predict local toxicity in isolated limb perfusion.
Nyström Wendt A, Mattsson J, Olofsson Bagge R
Int J Hyperthermia 2017 Sep;33(6):679-683. Epub 2017 Apr 10 doi: 10.1080/02656736.2017.1309082. PMID: 28540796
Deep venous thrombosis of the extremity diagnosed by color Doppler ultrasonography after isolated limb perfusion.
Eroğlu A, Ozcan H, Eryavuz Y, Kocağlu H, Demirci S, Aytac SK
Tumori 2001 May-Jun;87(3):187-90. doi: 10.1177/030089160108700314. PMID: 11504375

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