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Refractory Sarcoma

MedGen UID:
1655780
•Concept ID:
C4724971
•
Neoplastic Process

Definition

A sarcoma that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Efficacy and Safety of Fruquintinib-Based Treatment in Patients with Refractory Bone and Soft Tissue Sarcoma after Developing Resistance to Several TKIs: A Multicenter Retrospective Study.
Yang C, Li B, Dong S, Xu J, Sun X, Liang X, Liu K, Sun K, Yang Y, Ji T, Ye Z, Xie L, Tang X
Orthop Surg 2024 Oct;16(10):2380-2390. Epub 2024 Jul 18 doi: 10.1111/os.14163. PMID: 39030807Free PMC Article
Drug-eluting bead transarterial chemoembolization in the treatment for unresectable soft tissue sarcoma refractory to systemic chemotherapy: a preliminary evaluation of efficacy and safety.
Ni JY, Sun HL, Chen YT, Luo JH, Wang WD, Jiang XY, Chen D, Xu LF
J Cancer Res Clin Oncol 2018 Jan;144(1):157-163. Epub 2017 Oct 9 doi: 10.1007/s00432-017-2530-3. PMID: 28993945
A retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments.
Wagner MJ, Amodu LI, Duh MS, Korves C, Solleza F, Manson SC, Diaz J, Neary MP, Demetri GD
BMC Cancer 2015 Mar 25;15:175. doi: 10.1186/s12885-015-1182-4. PMID: 25885530Free PMC Article

Recent clinical studies

Etiology

Efficacy and Safety of Fruquintinib-Based Treatment in Patients with Refractory Bone and Soft Tissue Sarcoma after Developing Resistance to Several TKIs: A Multicenter Retrospective Study.
Yang C, Li B, Dong S, Xu J, Sun X, Liang X, Liu K, Sun K, Yang Y, Ji T, Ye Z, Xie L, Tang X
Orthop Surg 2024 Oct;16(10):2380-2390. Epub 2024 Jul 18 doi: 10.1111/os.14163. PMID: 39030807Free PMC Article
Vincristine, Irinotecan, and Temozolomide as a Salvage Regimen for Relapsed or Refractory Sarcoma in Children and Young Adults.
Ju HY, Park M, Lee JA, Park HJ, Park SY, Kim JH, Kang HG, Yang HC, Park BK
Cancer Res Treat 2022 Apr;54(2):563-571. Epub 2021 Jun 14 doi: 10.4143/crt.2021.178. PMID: 34126703Free PMC Article
Sustained clinico-radiologic response to anti-cytotoxic T lymphocyte antigen 4 antibody therapy in metastatic myxoid liposarcoma.
Dasanu CA
J Oncol Pharm Pract 2017 Oct;23(7):549-551. Epub 2016 Aug 10 doi: 10.1177/1078155216664202. PMID: 27511215
Phase II study of cixutumumab in combination with temsirolimus in pediatric patients and young adults with recurrent or refractory sarcoma: a report from the Children's Oncology Group.
Wagner LM, Fouladi M, Ahmed A, Krailo MD, Weigel B, DuBois SG, Doyle LA, Chen H, Blaney SM
Pediatr Blood Cancer 2015 Mar;62(3):440-4. Epub 2014 Nov 28 doi: 10.1002/pbc.25334. PMID: 25446280Free PMC Article
Ifosfamide, carboplatin, and etoposide (ICE) reinduction chemotherapy in a large cohort of children and adolescents with recurrent/refractory sarcoma: the Children's Cancer Group (CCG) experience.
Van Winkle P, Angiolillo A, Krailo M, Cheung YK, Anderson B, Davenport V, Reaman G, Cairo MS
Pediatr Blood Cancer 2005 Apr;44(4):338-47. doi: 10.1002/pbc.20227. PMID: 15503297

Diagnosis

A study protocol for an open-label, single-arm, single-center phase I clinical study on tolerability, safety, and efficacy of dalpiciclib combined with apatinib in the treatment of patients with advanced or metastatic sarcoma.
Huang H, Zhang H, Cao B
Thorac Cancer 2024 Feb;15(5):427-433. Epub 2024 Jan 11 doi: 10.1111/1759-7714.15208. PMID: 38211967Free PMC Article
Vincristine, Irinotecan, and Temozolomide as a Salvage Regimen for Relapsed or Refractory Sarcoma in Children and Young Adults.
Ju HY, Park M, Lee JA, Park HJ, Park SY, Kim JH, Kang HG, Yang HC, Park BK
Cancer Res Treat 2022 Apr;54(2):563-571. Epub 2021 Jun 14 doi: 10.4143/crt.2021.178. PMID: 34126703Free PMC Article
Hand-foot skin reaction predicts treatment outcome of pazopanib in patients with metastatic soft tissue sarcoma: A multicenter study in the Asian population.
Huang PW, Chou WC, Shen WC, Hung CY, Huang KG, Su YL, Lu CH, Liu CT, Chang YS, Liau CT
Asia Pac J Clin Oncol 2018 Aug;14(4):353-360. Epub 2018 Jun 13 doi: 10.1111/ajco.13029. PMID: 29900662

Therapy

Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma.
D'Angelo SP, Richards AL, Conley AP, Woo HJ, Dickson MA, Gounder M, Kelly C, Keohan ML, Movva S, Thornton K, Rosenbaum E, Chi P, Nacev B, Chan JE, Slotkin EK, Kiesler H, Adamson T, Ling L, Rao P, Patel S, Livingston JA, Singer S, Agaram NP, Antonescu CR, Koff A, Erinjeri JP, Hwang S, Qin LX, Donoghue MTA, Tap WD
Nat Commun 2022 Jun 16;13(1):3477. doi: 10.1038/s41467-022-30874-8. PMID: 35710741Free PMC Article
Vincristine, Irinotecan, and Temozolomide as a Salvage Regimen for Relapsed or Refractory Sarcoma in Children and Young Adults.
Ju HY, Park M, Lee JA, Park HJ, Park SY, Kim JH, Kang HG, Yang HC, Park BK
Cancer Res Treat 2022 Apr;54(2):563-571. Epub 2021 Jun 14 doi: 10.4143/crt.2021.178. PMID: 34126703Free PMC Article
Canadian consensus on TRK-inhibitor therapy for NTRK fusion-positive sarcoma.
Simmons C, Deyell RJ, MacNeill AJ, Vera-Badillo FE, Smrke A, Abdul Razak AR, Banerji S, McLeod D, Noujaim J
Int J Cancer 2021 Nov 1;149(9):1691-1704. Epub 2021 Aug 4 doi: 10.1002/ijc.33723. PMID: 34213775
Phase 1 clinical trials for sarcomas: the cutting edge.
Subbiah V, Kurzrock R
Curr Opin Oncol 2011 Jul;23(4):352-60. doi: 10.1097/CCO.0b013e3283477a94. PMID: 21519259
Systemic hyperthermia and ICE chemotherapy for sarcoma patients: rationale and clinical status.
Wiedemann GJ, Robins HI, Katschinski DM, Mentzel M, D'Oleire F, Kutz M, Wagner T
Anticancer Res 1997 Jul-Aug;17(4B):2899-902. PMID: 9329558

Prognosis

Efficacy and Safety of Fruquintinib-Based Treatment in Patients with Refractory Bone and Soft Tissue Sarcoma after Developing Resistance to Several TKIs: A Multicenter Retrospective Study.
Yang C, Li B, Dong S, Xu J, Sun X, Liang X, Liu K, Sun K, Yang Y, Ji T, Ye Z, Xie L, Tang X
Orthop Surg 2024 Oct;16(10):2380-2390. Epub 2024 Jul 18 doi: 10.1111/os.14163. PMID: 39030807Free PMC Article
Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma.
D'Angelo SP, Richards AL, Conley AP, Woo HJ, Dickson MA, Gounder M, Kelly C, Keohan ML, Movva S, Thornton K, Rosenbaum E, Chi P, Nacev B, Chan JE, Slotkin EK, Kiesler H, Adamson T, Ling L, Rao P, Patel S, Livingston JA, Singer S, Agaram NP, Antonescu CR, Koff A, Erinjeri JP, Hwang S, Qin LX, Donoghue MTA, Tap WD
Nat Commun 2022 Jun 16;13(1):3477. doi: 10.1038/s41467-022-30874-8. PMID: 35710741Free PMC Article
Vincristine, Irinotecan, and Temozolomide as a Salvage Regimen for Relapsed or Refractory Sarcoma in Children and Young Adults.
Ju HY, Park M, Lee JA, Park HJ, Park SY, Kim JH, Kang HG, Yang HC, Park BK
Cancer Res Treat 2022 Apr;54(2):563-571. Epub 2021 Jun 14 doi: 10.4143/crt.2021.178. PMID: 34126703Free PMC Article
Drug-eluting bead transarterial chemoembolization in the treatment for unresectable soft tissue sarcoma refractory to systemic chemotherapy: a preliminary evaluation of efficacy and safety.
Ni JY, Sun HL, Chen YT, Luo JH, Wang WD, Jiang XY, Chen D, Xu LF
J Cancer Res Clin Oncol 2018 Jan;144(1):157-163. Epub 2017 Oct 9 doi: 10.1007/s00432-017-2530-3. PMID: 28993945
Phase 1 clinical trials for sarcomas: the cutting edge.
Subbiah V, Kurzrock R
Curr Opin Oncol 2011 Jul;23(4):352-60. doi: 10.1097/CCO.0b013e3283477a94. PMID: 21519259

Clinical prediction guides

Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma.
D'Angelo SP, Richards AL, Conley AP, Woo HJ, Dickson MA, Gounder M, Kelly C, Keohan ML, Movva S, Thornton K, Rosenbaum E, Chi P, Nacev B, Chan JE, Slotkin EK, Kiesler H, Adamson T, Ling L, Rao P, Patel S, Livingston JA, Singer S, Agaram NP, Antonescu CR, Koff A, Erinjeri JP, Hwang S, Qin LX, Donoghue MTA, Tap WD
Nat Commun 2022 Jun 16;13(1):3477. doi: 10.1038/s41467-022-30874-8. PMID: 35710741Free PMC Article
Phase 1/2 study of immunotherapy with dendritic cells pulsed with autologous tumor lysate in patients with refractory bone and soft tissue sarcoma.
Miwa S, Nishida H, Tanzawa Y, Takeuchi A, Hayashi K, Yamamoto N, Mizukoshi E, Nakamoto Y, Kaneko S, Tsuchiya H
Cancer 2017 May 1;123(9):1576-1584. Epub 2017 Feb 27 doi: 10.1002/cncr.30606. PMID: 28241093
Intra-arterial intervention chemotherapy for sarcoma and cancerous ulcer via an implanted pump.
Liu C, Cui Q, Guo J, Li D, Zeng Y
Pathol Oncol Res 2014 Apr;20(2):229-34. Epub 2014 Jan 21 doi: 10.1007/s12253-013-9673-6. PMID: 24446082
Phase 1 clinical trials for sarcomas: the cutting edge.
Subbiah V, Kurzrock R
Curr Opin Oncol 2011 Jul;23(4):352-60. doi: 10.1097/CCO.0b013e3283477a94. PMID: 21519259
Ifosfamide, carboplatin and etoposide (ICE) combined with 41.8 degrees C whole body hyperthermia in patients with refractory sarcoma.
Wiedemann GJ, Robins HI, Gutsche S, Mentzel M, Deeken M, Katschinski DM, Eleftheriadis S, Crahé R, Weiss C, Storer B, Wagner T
Eur J Cancer 1996 May;32A(5):888-92. doi: 10.1016/0959-8049(95)00622-2. PMID: 9081372

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