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Locally Advanced Unresectable Sarcoma

MedGen UID:
1654511
Concept ID:
C4727284
Neoplastic Process

Definition

A sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Dominguez DA, Sampath S, Agulnik M, Liang Y, Nguyen B, Trisal V, Melstrom LG, Lewis AG, Paz IB, Roberts RF, Tseng WW
Curr Oncol 2023 Apr 29;30(5):4618-4631. doi: 10.3390/curroncol30050349. PMID: 37232807Free PMC Article
Rust DJ, Kwinta BD, Geskin LJ, Samie FH, Remotti F, Yoon SS
J Surg Oncol 2023 Jul;128(1):87-96. Epub 2023 Mar 31 doi: 10.1002/jso.27258. PMID: 36999599
Naito Y, Nishida T, Doi T
Gastric Cancer 2023 May;26(3):339-351. Epub 2023 Mar 13 doi: 10.1007/s10120-023-01381-6. PMID: 36913072Free PMC Article

Recent clinical studies

Etiology

Pautier P, Italiano A, Piperno-Neumann S, Chevreau C, Penel N, Firmin N, Boudou-Rouquette P, Bertucci F, Lebrun-Ly V, Ray-Coquard I, Kalbacher E, Bompas E, Collard O, Isambert N, Guillemet C, Rios M, Le Cesne A, Balleyguier C, Archambaud B, Duffaud F; French Sarcoma Group
N Engl J Med 2024 Sep 5;391(9):789-799. doi: 10.1056/NEJMoa2403394. PMID: 39231341
Naito Y, Nishida T, Doi T
Gastric Cancer 2023 May;26(3):339-351. Epub 2023 Mar 13 doi: 10.1007/s10120-023-01381-6. PMID: 36913072Free PMC Article
Pautier P, Italiano A, Piperno-Neumann S, Chevreau C, Penel N, Firmin N, Boudou-Rouquette P, Bertucci F, Balleyguier C, Lebrun-Ly V, Ray-Coquard I, Kalbacher E, Bardet A, Bompas E, Collard O, Isambert N, Guillemet C, Rios M, Archambaud B, Duffaud F; French Sarcoma Group
Lancet Oncol 2022 Aug;23(8):1044-1054. Epub 2022 Jul 11 doi: 10.1016/S1470-2045(22)00380-1. PMID: 35835135
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Judson I, Verweij J, Gelderblom H, Hartmann JT, Schöffski P, Blay JY, Kerst JM, Sufliarsky J, Whelan J, Hohenberger P, Krarup-Hansen A, Alcindor T, Marreaud S, Litière S, Hermans C, Fisher C, Hogendoorn PC, dei Tos AP, van der Graaf WT; European Organisation and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Lancet Oncol 2014 Apr;15(4):415-23. Epub 2014 Mar 5 doi: 10.1016/S1470-2045(14)70063-4. PMID: 24618336

Diagnosis

Qu G, Zhang C, Tian Z, Yao W
Curr Treat Options Oncol 2024 Oct;25(10):1289-1296. Epub 2024 Sep 20 doi: 10.1007/s11864-024-01262-9. PMID: 39302575
Hassan A, Pestana RC, Parkes A
Curr Treat Options Oncol 2021 Feb 27;22(4):33. doi: 10.1007/s11864-021-00830-7. PMID: 33641042
Iwasaki T, Yamamoto H, Oda Y
Curr Treat Options Oncol 2019 Mar 14;20(4):29. doi: 10.1007/s11864-019-0628-3. PMID: 30874910
Mavrogenis AF, Rossi G, Palmerini E, Errani C, Rimondi E, Ruggieri P, Soucacos PN, Papagelopoulos PJ
J BUON 2012 Jul-Sep;17(3):436-45. PMID: 23033278
Kornik RI, Muchard LK, Teng JM
Pediatr Dermatol 2012 Nov-Dec;29(6):707-13. Epub 2012 Jul 11 doi: 10.1111/j.1525-1470.2012.01767.x. PMID: 22780227

Therapy

Pautier P, Italiano A, Piperno-Neumann S, Chevreau C, Penel N, Firmin N, Boudou-Rouquette P, Bertucci F, Lebrun-Ly V, Ray-Coquard I, Kalbacher E, Bompas E, Collard O, Isambert N, Guillemet C, Rios M, Le Cesne A, Balleyguier C, Archambaud B, Duffaud F; French Sarcoma Group
N Engl J Med 2024 Sep 5;391(9):789-799. doi: 10.1056/NEJMoa2403394. PMID: 39231341
Naito Y, Nishida T, Doi T
Gastric Cancer 2023 May;26(3):339-351. Epub 2023 Mar 13 doi: 10.1007/s10120-023-01381-6. PMID: 36913072Free PMC Article
Pautier P, Italiano A, Piperno-Neumann S, Chevreau C, Penel N, Firmin N, Boudou-Rouquette P, Bertucci F, Balleyguier C, Lebrun-Ly V, Ray-Coquard I, Kalbacher E, Bardet A, Bompas E, Collard O, Isambert N, Guillemet C, Rios M, Archambaud B, Duffaud F; French Sarcoma Group
Lancet Oncol 2022 Aug;23(8):1044-1054. Epub 2022 Jul 11 doi: 10.1016/S1470-2045(22)00380-1. PMID: 35835135
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Judson I, Verweij J, Gelderblom H, Hartmann JT, Schöffski P, Blay JY, Kerst JM, Sufliarsky J, Whelan J, Hohenberger P, Krarup-Hansen A, Alcindor T, Marreaud S, Litière S, Hermans C, Fisher C, Hogendoorn PC, dei Tos AP, van der Graaf WT; European Organisation and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Lancet Oncol 2014 Apr;15(4):415-23. Epub 2014 Mar 5 doi: 10.1016/S1470-2045(14)70063-4. PMID: 24618336

Prognosis

Naito Y, Nishida T, Doi T
Gastric Cancer 2023 May;26(3):339-351. Epub 2023 Mar 13 doi: 10.1007/s10120-023-01381-6. PMID: 36913072Free PMC Article
Wetterwald L, Riggi N, Kyriazoglou A, Dei Tos G, Dei Tos A, Digklia A
Expert Rev Anticancer Ther 2023 Mar;23(3):235-242. Epub 2023 Feb 27 doi: 10.1080/14737140.2023.2183846. PMID: 36811446
Pautier P, Italiano A, Piperno-Neumann S, Chevreau C, Penel N, Firmin N, Boudou-Rouquette P, Bertucci F, Balleyguier C, Lebrun-Ly V, Ray-Coquard I, Kalbacher E, Bardet A, Bompas E, Collard O, Isambert N, Guillemet C, Rios M, Archambaud B, Duffaud F; French Sarcoma Group
Lancet Oncol 2022 Aug;23(8):1044-1054. Epub 2022 Jul 11 doi: 10.1016/S1470-2045(22)00380-1. PMID: 35835135
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Seddon B, Strauss SJ, Whelan J, Leahy M, Woll PJ, Cowie F, Rothermundt C, Wood Z, Benson C, Ali N, Marples M, Veal GJ, Jamieson D, Küver K, Tirabosco R, Forsyth S, Nash S, Dehbi HM, Beare S
Lancet Oncol 2017 Oct;18(10):1397-1410. Epub 2017 Sep 4 doi: 10.1016/S1470-2045(17)30622-8. PMID: 28882536Free PMC Article

Clinical prediction guides

Bui NQ, Nemat-Gorgani N, Subramanian A, Torres IA, Lohman M, Sears TJ, van de Rijn M, Charville GW, Becker HC, Wang DS, Hwang GL, Ganjoo KN, Moding EJ
Clin Cancer Res 2023 Jul 14;29(14):2612-2620. doi: 10.1158/1078-0432.CCR-23-0250. PMID: 37130154
Nakamura T, Asanuma K, Hagi T, Sudo A
Drug Des Devel Ther 2020;14:4215-4220. Epub 2020 Oct 12 doi: 10.2147/DDDT.S275526. PMID: 33116409Free PMC Article
Tap WD, Wagner AJ, Schöffski P, Martin-Broto J, Krarup-Hansen A, Ganjoo KN, Yen CC, Abdul Razak AR, Spira A, Kawai A, Le Cesne A, Van Tine BA, Naito Y, Park SH, Fedenko A, Pápai Z, Soldatenkova V, Shahir A, Mo G, Wright J, Jones RL; ANNOUNCE Investigators
JAMA 2020 Apr 7;323(13):1266-1276. doi: 10.1001/jama.2020.1707. PMID: 32259228Free PMC Article
Probst U, Fuhrmann I, Beyer L, Wiggermann P
Technol Cancer Res Treat 2018 Jan 1;17:1533033818785329. doi: 10.1177/1533033818785329. PMID: 29986632Free PMC Article
Mavrogenis AF, Rossi G, Rimondi E, Calabrò T, Papagelopoulos PJ, Ruggieri P
Eur J Orthop Surg Traumatol 2014 Dec;24(8):1351-6. Epub 2013 Sep 6 doi: 10.1007/s00590-013-1312-0. PMID: 24062055

Recent systematic reviews

Dong M, Liu R, Zhang Q, Luo H, Wang D, Wang Y, Chen J, Ou Y, Wang X
Radiat Oncol 2022 Oct 25;17(1):172. doi: 10.1186/s13014-022-02089-0. PMID: 36284346Free PMC Article
Navarrete-Dechent C, Mori S, Barker CA, Dickson MA, Nehal KS
JAMA Dermatol 2019 Mar 1;155(3):361-369. doi: 10.1001/jamadermatol.2018.4940. PMID: 30601909Free PMC Article

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