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Deuteranopia

MedGen UID:
1647334
•Concept ID:
C4551635
•
Disease or Syndrome
Synonym: DEUTERANOPIA
SNOMED CT: Deuteranopia (77479002)
 
HPO: HP:0011521
OMIM®: 303800

Definition

Complete lack of the M photopigment, which is replaced with the L photopigment. Affected individuals tend to confuse red and green. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Conditions with this feature

X-linked cone dysfunction syndrome with myopia
MedGen UID:
463611
•Concept ID:
C3159311
•
Disease or Syndrome
Bornholm eye disease consists of X-linked high myopia, amblyopia, and deuteranopia. Associated signs include optic nerve hypoplasia, reduced electroretinographic (ERG) flicker, and nonspecific retinal pigment abnormalities (Schwartz et al., 1990).
See: Condition Record
X-linked cone dysfunction syndrome with myopia

Professional guidelines

PubMed

Can Protanopia Be Correctly Diagnosed in Clinical Practice? An Evaluation of Diagnosis by Four Screening Tests.
Davison PA, Scanlon G
Optom Vis Sci 2020 Oct;97(10):852-856. doi: 10.1097/OPX.0000000000001582. PMID: 33055513
Genotype-phenotype relationships in human red/green color-vision defects: molecular and psychophysical studies.
Deeb SS, Lindsey DT, Hibiya Y, Sanocki E, Winderickx J, Teller DY, Motulsky AG
Am J Hum Genet 1992 Oct;51(4):687-700. PMID: 1415215Free PMC Article

Recent clinical studies

Etiology

Cone contrast test-HD: sensitivity and specificity in red-green dichromacy and the impact of age.
Iizuka T, Kawamorita T, Handa T, Ishikawa H
J Opt Soc Am A Opt Image Sci Vis 2023 May 1;40(5):849-858. doi: 10.1364/JOSAA.480467. PMID: 37133182
Ocular Survey in Kathmandu University Medical Students.
Shrestha P , Kaiti R , Shyangbo R , Dhakal K
Kathmandu Univ Med J (KUMJ) 2022 Apr-Jun;20(78):209-213. PMID: 37017168
Color vision deficiency among a group of students of health sciences.
Pramanik T, Khatiwada B, Pandit R
Nepal Med Coll J 2012 Dec;14(4):334-6. PMID: 24579547
Relationship between schizoaffective illness and affective disorders or schizophrenia. Morbidity risk and genetic transmission.
Mendlewicz J, Linkowski P, Wilmotte J
J Affect Disord 1980 Dec;2(4):289-302. doi: 10.1016/0165-0327(80)90030-0. PMID: 6450788
Cone pigments in human deutan colour vision defects.
Alpern M, Wake T
J Physiol 1977 Apr;266(3):595-612. doi: 10.1113/jphysiol.1977.sp011784. PMID: 301185Free PMC Article

Diagnosis

Cone contrast test-HD: sensitivity and specificity in red-green dichromacy and the impact of age.
Iizuka T, Kawamorita T, Handa T, Ishikawa H
J Opt Soc Am A Opt Image Sci Vis 2023 May 1;40(5):849-858. doi: 10.1364/JOSAA.480467. PMID: 37133182
Diagnosis of colour vision deficits using eye movements.
Taore A, Lobo G, Turnbull PR, Dakin SC
Sci Rep 2022 May 11;12(1):7734. doi: 10.1038/s41598-022-11152-5. PMID: 35562176Free PMC Article
Prevalence of congenital colour vision deficiency among Black school children in Durban, South Africa.
Mashige KP, van Staden DB
BMC Res Notes 2019 Jun 10;12(1):324. doi: 10.1186/s13104-019-4374-1. PMID: 31182158Free PMC Article
X-recessive angiopathic opticopathy.
Bastiaensen LA, Vandoninck JJ
Doc Ophthalmol 1982 Jan 29;52(3-4):227-39. doi: 10.1007/BF01675853. PMID: 7067594
Deuteranopia and the sensitivity of the red receptor.
WILLMER EN
J Physiol 1949 Aug;109(1-2):Proc, 28. PMID: 15395054

Therapy

Simulating a colour-blind ophthalmologist for diagnosing and staging diabetic retinopathy.
AlRyalat SA, Muhtaseb R, Alshammari T
Eye (Lond) 2021 Aug;35(8):2229-2232. Epub 2020 Oct 26 doi: 10.1038/s41433-020-01232-z. PMID: 33106610Free PMC Article
A tunable digital ishihara plate for pre-school aged children.
Gambino O, Minafo E, Pirrone R, Ardizzone E
Annu Int Conf IEEE Eng Med Biol Soc 2016 Aug;2016:5628-5631. doi: 10.1109/EMBC.2016.7592003. PMID: 28269531
Retinal microscotomas revealed with adaptive-optics microflashes.
Makous W, Carroll J, Wolfing JI, Lin J, Christie N, Williams DR
Invest Ophthalmol Vis Sci 2006 Sep;47(9):4160-7. doi: 10.1167/iovs.05-1195. PMID: 16936137
Prevalence of colour blindness in young Jordanians.
Al-Aqtum MT, Al-Qawasmeh MH
Ophthalmologica 2001 Jan-Feb;215(1):39-42. doi: 10.1159/000050824. PMID: 11125268
N-hexane maculopathy in industrial workers.
Raitta C, Seppäläinen AN, Huuskonen MS
Albrecht Von Graefes Arch Klin Exp Ophthalmol 1978 Dec 15;209(2):99-110. doi: 10.1007/BF00407843. PMID: 311172

Prognosis

Social Perception of Facial Color Appearance for Human Trichromatic Versus Dichromatic Color Vision.
Thorstenson CA, Pazda AD, Elliot AJ
Pers Soc Psychol Bull 2020 Jan;46(1):51-63. Epub 2019 Apr 13 doi: 10.1177/0146167219841641. PMID: 30982423
Myopia and Late-Onset Progressive Cone Dystrophy Associate to LVAVA/MVAVA Exon 3 Interchange Haplotypes of Opsin Genes on Chromosome X.
Orosz O, Rajta I, Vajas A, Takács L, Csutak A, Fodor M, Kolozsvári B, Resch M, Sényi K, Lesch B, Szabó V, Berta A, Balogh I, Losonczy G
Invest Ophthalmol Vis Sci 2017 Mar 1;58(3):1834-1842. doi: 10.1167/iovs.16-21405. PMID: 28358949
Protanomaly without darkened red is deuteranopia with rods.
Shevell SK, Sun Y, Neitz M
Vision Res 2008 Nov;48(26):2599-603. Epub 2008 Apr 18 doi: 10.1016/j.visres.2008.03.001. PMID: 18423511Free PMC Article
Novel form of a single X-linked visual pigment gene in a unique dichromatic color-vision defect.
Hayashi T, Kubo A, Takeuchi T, Gekka T, Goto-Omoto S, Kitahara K
Vis Neurosci 2006 May-Aug;23(3-4):411-7. doi: 10.1017/S0952523806233029. PMID: 16961974
Retinal microscotomas revealed with adaptive-optics microflashes.
Makous W, Carroll J, Wolfing JI, Lin J, Christie N, Williams DR
Invest Ophthalmol Vis Sci 2006 Sep;47(9):4160-7. doi: 10.1167/iovs.05-1195. PMID: 16936137

Clinical prediction guides

Cone contrast test-HD: sensitivity and specificity in red-green dichromacy and the impact of age.
Iizuka T, Kawamorita T, Handa T, Ishikawa H
J Opt Soc Am A Opt Image Sci Vis 2023 May 1;40(5):849-858. doi: 10.1364/JOSAA.480467. PMID: 37133182
Social Perception of Facial Color Appearance for Human Trichromatic Versus Dichromatic Color Vision.
Thorstenson CA, Pazda AD, Elliot AJ
Pers Soc Psychol Bull 2020 Jan;46(1):51-63. Epub 2019 Apr 13 doi: 10.1177/0146167219841641. PMID: 30982423
Color vision deficiency among a group of students of health sciences.
Pramanik T, Khatiwada B, Pandit R
Nepal Med Coll J 2012 Dec;14(4):334-6. PMID: 24579547
Protanomaly without darkened red is deuteranopia with rods.
Shevell SK, Sun Y, Neitz M
Vision Res 2008 Nov;48(26):2599-603. Epub 2008 Apr 18 doi: 10.1016/j.visres.2008.03.001. PMID: 18423511Free PMC Article
X-linked high myopia associated with cone dysfunction.
Young TL, Deeb SS, Ronan SM, Dewan AT, Alvear AB, Scavello GS, Paluru PC, Brott MS, Hayashi T, Holleschau AM, Benegas N, Schwartz M, Atwood LD, Oetting WS, Rosenberg T, Motulsky AG, King RA
Arch Ophthalmol 2004 Jun;122(6):897-908. doi: 10.1001/archopht.122.6.897. PMID: 15197065

Supplemental Content

Table of contents

    Clinical resources

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    Related information

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