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Submucous cleft palate

MedGen UID:
1645448
Concept ID:
C4551487
Congenital Abnormality
Synonyms: Cleft palate, submucous; Palate cleft, submucous; Submucosal cleft palate
SNOMED CT: Submucous cleft palate (763108005)
 
HPO: HP:5201016

Definition

A cleft of the muscular portion of the palate that is covered by mucous membrane. [from HPO]

Conditions with this feature

Craniofacial microsomia 2
MedGen UID:
1830923
Concept ID:
C5781610
Congenital Abnormality
Most patients with craniofacial microsomia-2 (CFM2) exhibit isolated unilateral or bilateral grade III microtia, with or without aural atresia, although some patients exhibit only minor external ear defects. Mandibular hypoplasia, micrognathia, and dental anomalies have also been observed (Quiat et al., 2023; Mao et al., 2023). For a general phenotypic description and discussion of genetic heterogeneity of craniofacial microsomia, see CFM1 (164210).

Professional guidelines

PubMed

Lambert EM, You P, Kacmarynski DS, Rosenberg TL
Int J Pediatr Otorhinolaryngol 2021 Oct;149:110846. Epub 2021 Jul 17 doi: 10.1016/j.ijporl.2021.110846. PMID: 34329831
Smarius BJA, Guillaume CHAL, Slegers J, Mink van der Molen AB, Breugem CC
Clin Oral Investig 2021 Jun;25(6):3893-3903. Epub 2021 Feb 1 doi: 10.1007/s00784-020-03719-1. PMID: 33521885Free PMC Article
Gosain AK, Conley SF, Marks S, Larson DL
Plast Reconstr Surg 1996 Jun;97(7):1497-509. doi: 10.1097/00006534-199606000-00032. PMID: 8643740

Recent clinical studies

Etiology

Martin SV, Swan MC
Br Dent J 2023 Jun;234(12):937-942. Epub 2023 Jun 23 doi: 10.1038/s41415-023-6000-9. PMID: 37349450
Smarius BJA, Guillaume CHAL, Slegers J, Mink van der Molen AB, Breugem CC
Clin Oral Investig 2021 Jun;25(6):3893-3903. Epub 2021 Feb 1 doi: 10.1007/s00784-020-03719-1. PMID: 33521885Free PMC Article
Nasser M, Fedorowicz Z, Newton T, Nouri M
Cochrane Database Syst Rev 2016 Jan 19;2016(1):CD006703. doi: 10.1002/14651858.CD006703.pub3. PMID: 26784399Free PMC Article
Reiter R, Brosch S, Wefel H, Schlömer G, Haase S
Int J Pediatr Otorhinolaryngol 2011 Jan;75(1):85-8. Epub 2010 Nov 26 doi: 10.1016/j.ijporl.2010.10.015. PMID: 21112097
Chen KT, Wu J, Noordhoff SM
Changgeng Yi Xue Za Zhi 1994 Jun;17(2):131-7. PMID: 8069735

Diagnosis

Smarius BJA, Guillaume CHAL, Slegers J, Mink van der Molen AB, Breugem CC
Clin Oral Investig 2021 Jun;25(6):3893-3903. Epub 2021 Feb 1 doi: 10.1007/s00784-020-03719-1. PMID: 33521885Free PMC Article
Dean KM, Leeper LK
Curr Opin Otolaryngol Head Neck Surg 2020 Dec;28(6):410-413. doi: 10.1097/MOO.0000000000000673. PMID: 33105231
Chen KT, Wu J, Noordhoff SM
Changgeng Yi Xue Za Zhi 1994 Jun;17(2):131-7. PMID: 8069735
Moss AL, Piggott RW, Jones KJ
BMJ 1988 Jul 9;297(6641):85-6. doi: 10.1136/bmj.297.6641.85. PMID: 3044501Free PMC Article
Abyholm FE
Scand J Plast Reconstr Surg 1976;10(3):209-12. doi: 10.3109/02844317609012970. PMID: 1053450

Therapy

Nasser M, Fedorowicz Z, Newton T, Nouri M
Cochrane Database Syst Rev 2016 Jan 19;2016(1):CD006703. doi: 10.1002/14651858.CD006703.pub3. PMID: 26784399Free PMC Article
Reiter R, Brosch S, Wefel H, Schlömer G, Haase S
Int J Pediatr Otorhinolaryngol 2011 Jan;75(1):85-8. Epub 2010 Nov 26 doi: 10.1016/j.ijporl.2010.10.015. PMID: 21112097
Nasser M, Fedorowicz Z, Newton JT, Nouri M
Cochrane Database Syst Rev 2008 Jan 23;(1):CD006703. doi: 10.1002/14651858.CD006703.pub2. PMID: 18254111
Conley SF, Gosain AK, Marks SM, Larson DL
Am J Otolaryngol 1997 Jan-Feb;18(1):38-46. doi: 10.1016/s0196-0709(97)90047-8. PMID: 9006676
Shapiro RS
Laryngoscope 1982 Feb;92(2):135-9. doi: 10.1002/lary.1982.92.2.135. PMID: 7162308

Prognosis

Cao C, Xu X, Yin H, Zheng Q, Xu C, Shi B
Cleft Palate Craniofac J 2023 Oct;60(10):1260-1266. Epub 2022 May 9 doi: 10.1177/10556656221100125. PMID: 35532048
Kwinter A, Dworschak-Stokan A, Paradis J, Husein M
Int J Pediatr Otorhinolaryngol 2018 Dec;115:77-81. Epub 2018 Sep 22 doi: 10.1016/j.ijporl.2018.09.022. PMID: 30368399
Ha KM, Cleland H, Greensmith A, Chong D, Macgill K, Verhoeven A, Hutson JM
J Craniofac Surg 2013 May;24(3):878-85. doi: 10.1097/SCS.0b013e31827fef4b. PMID: 23714901
ten Dam E, van der Heijden P, Korsten-Meijer AG, Goorhuis-Brouwer SM, van der Laan BF
Int J Pediatr Otorhinolaryngol 2013 Jun;77(6):1019-24. Epub 2013 Apr 30 doi: 10.1016/j.ijporl.2013.03.036. PMID: 23642488
Reiter R, Brosch S, Wefel H, Schlömer G, Haase S
Int J Pediatr Otorhinolaryngol 2011 Jan;75(1):85-8. Epub 2010 Nov 26 doi: 10.1016/j.ijporl.2010.10.015. PMID: 21112097

Clinical prediction guides

Martin SV, Swan MC
Br Dent J 2023 Jun;234(12):937-942. Epub 2023 Jun 23 doi: 10.1038/s41415-023-6000-9. PMID: 37349450
Bruce MK, Zhang C, Vodovotz L, Irgebay Z, Maliha S, Pfaff M, Ford M, Goldstein JA, Losee JE
Ann Plast Surg 2022 May 1;88(3 Suppl 3):S152-S155. doi: 10.1097/SAP.0000000000003198. PMID: 35513313
Kwinter A, Dworschak-Stokan A, Paradis J, Husein M
Int J Pediatr Otorhinolaryngol 2018 Dec;115:77-81. Epub 2018 Sep 22 doi: 10.1016/j.ijporl.2018.09.022. PMID: 30368399
Reiter R, Brosch S, Lüdeke M, Fischbein E, Rinckleb A, Haase S, Schwandt A, Pickhard A, Maier C, Högel J, Vogel W
Cleft Palate Craniofac J 2015 Jan;52(1):115-20. doi: 10.1597/13-016. PMID: 24437586
François-Fiquet C, Wavreille O, Poli Merol ML, Doco-Fenzy M
Br J Oral Maxillofac Surg 2012 Oct;50(7):e109-12. Epub 2011 Dec 6 doi: 10.1016/j.bjoms.2011.11.009. PMID: 22153181

Recent systematic reviews

Boyce JO, Kilpatrick N, Morgan AT
Child Care Health Dev 2018 Nov;44(6):818-831. Epub 2018 Aug 22 doi: 10.1111/cch.12613. PMID: 30136310
Nasser M, Fedorowicz Z, Newton T, Nouri M
Cochrane Database Syst Rev 2016 Jan 19;2016(1):CD006703. doi: 10.1002/14651858.CD006703.pub3. PMID: 26784399Free PMC Article
Gilleard O, Sell D, Ghanem AM, Tavsanoglu Y, Birch M, Sommerlad B
Cleft Palate Craniofac J 2014 Nov;51(6):686-95. doi: 10.1597/13-046. PMID: 25368910
Nasser M, Fedorowicz Z, Newton JT, Nouri M
Cochrane Database Syst Rev 2008 Jan 23;(1):CD006703. doi: 10.1002/14651858.CD006703.pub2. PMID: 18254111

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