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Submucous cleft palate

MedGen UID:
1645448
•Concept ID:
C4551487
•
Congenital Abnormality
Synonyms: Cleft palate, submucous; Palate cleft, submucous; Submucosal cleft palate
SNOMED CT: Submucous cleft palate (763108005)
 
HPO: HP:5201016

Definition

A cleft of the muscular portion of the palate that is covered by mucous membrane. [from HPO]

Conditions with this feature

Craniofacial microsomia 2
MedGen UID:
1830923
•Concept ID:
C5781610
•
Congenital Abnormality
Most patients with craniofacial microsomia-2 (CFM2) exhibit isolated unilateral or bilateral grade III microtia, with or without aural atresia, although some patients exhibit only minor external ear defects. Mandibular hypoplasia, micrognathia, and dental anomalies have also been observed (Quiat et al., 2023; Mao et al., 2023). For a general phenotypic description and discussion of genetic heterogeneity of craniofacial microsomia, see CFM1 (164210).
See: Condition Record
Craniofacial microsomia 2

Professional guidelines

PubMed

Adenoidectomy and persistent velopharyngeal insufficiency: Considerations, risk factors, and treatment.
Lambert EM, You P, Kacmarynski DS, Rosenberg TL
Int J Pediatr Otorhinolaryngol 2021 Oct;149:110846. Epub 2021 Jul 17 doi: 10.1016/j.ijporl.2021.110846. PMID: 34329831
Surgical management in submucous cleft palate patients.
Smarius BJA, Guillaume CHAL, Slegers J, Mink van der Molen AB, Breugem CC
Clin Oral Investig 2021 Jun;25(6):3893-3903. Epub 2021 Feb 1 doi: 10.1007/s00784-020-03719-1. PMID: 33521885Free PMC Article
Submucous cleft palate. Its incidence, natural history, and indications for treatment.
Weatherley-White RC, Sakura CY Jr, Brenner LD, Stewart JM, Ott JE
Plast Reconstr Surg 1972 Mar;49(3):297-304. PMID: 5060321

Recent clinical studies

Etiology

Discussion of Furlow Palatoplasty and Tonsillectomy for Treating Patients with Submucous Cleft Palate and Tonsilar Hypertrophy: A One-Stage Procedure.
Rossell-Perry P
J Craniofac Surg 2023 Jan-Feb 01;34(1):e78-e79. Epub 2022 Aug 9 doi: 10.1097/SCS.0000000000008870. PMID: 36608088
Submucous Cleft Palate Repair in Patients With 22q11.2 Deletion Syndrome.
Fleming J, Morrell N, Zavala H, Chinnadurai S, Roby BB
Cleft Palate Craniofac J 2021 Jan;58(1):84-89. Epub 2020 Jul 23 doi: 10.1177/1055665620942436. PMID: 32700562
WITHDRAWN: Interventions for the management of submucous cleft palate.
Nasser M, Fedorowicz Z, Newton T, Nouri M
Cochrane Database Syst Rev 2016 Jan 19;2016(1):CD006703. doi: 10.1002/14651858.CD006703.pub3. PMID: 26784399Free PMC Article
Submucous cleft palate.
Chen KT, Wu J, Noordhoff SM
Changgeng Yi Xue Za Zhi 1994 Jun;17(2):131-7. PMID: 8069735
Submucous cleft palate. Its incidence, natural history, and indications for treatment.
Weatherley-White RC, Sakura CY Jr, Brenner LD, Stewart JM, Ott JE
Plast Reconstr Surg 1972 Mar;49(3):297-304. PMID: 5060321

Diagnosis

Management of submucous cleft palate.
Dean KM, Leeper LK
Curr Opin Otolaryngol Head Neck Surg 2020 Dec;28(6):410-413. doi: 10.1097/MOO.0000000000000673. PMID: 33105231
Submucous cleft palate with bifid uvula.
Hasan A, Gardner A, Devlin M, Russell C
J Pediatr 2014 Oct;165(4):872. Epub 2014 Jun 25 doi: 10.1016/j.jpeds.2014.05.034. PMID: 24973794
Submucous cleft palate.
Whitefield S
J Tenn Dent Assoc 1989 Jan;69(1):29-30. PMID: 2622148
Submucous cleft palate.
Moss AL, Piggott RW, Jones KJ
BMJ 1988 Jul 9;297(6641):85-6. doi: 10.1136/bmj.297.6641.85. PMID: 3044501Free PMC Article
Submucous cleft palate.
Thaler S, Smith HW
Arch Otolaryngol 1968 Aug;88(2):184-9. doi: 10.1001/archotol.1968.00770010186015. PMID: 5662930

Therapy

Intravelar veloplasty in submucous cleft palate without lateral relaxing incision or nasal mucosal incision.
Sung KP, Lee SH
Int J Pediatr Otorhinolaryngol 2023 Jul;170:111575. Epub 2023 Apr 24 doi: 10.1016/j.ijporl.2023.111575. PMID: 37178521
WITHDRAWN: Interventions for the management of submucous cleft palate.
Nasser M, Fedorowicz Z, Newton T, Nouri M
Cochrane Database Syst Rev 2016 Jan 19;2016(1):CD006703. doi: 10.1002/14651858.CD006703.pub3. PMID: 26784399Free PMC Article
Identification and assessment of velopharyngeal inadequacy.
Conley SF, Gosain AK, Marks SM, Larson DL
Am J Otolaryngol 1997 Jan-Feb;18(1):38-46. doi: 10.1016/s0196-0709(97)90047-8. PMID: 9006676
Partial adenoidectomy.
Shapiro RS
Laryngoscope 1982 Feb;92(2):135-9. doi: 10.1002/lary.1982.92.2.135. PMID: 7162308
Hypernasal speech following adenotonsillectomy.
Croft CB, Shprintzen RJ, Ruben RJ
Otolaryngol Head Neck Surg 1981 Mar-Apr;89(2):179-88. doi: 10.1177/019459988108900208. PMID: 6787510

Prognosis

Cephalometric Soft Tissue Morphology of Adults With Unoperated Submucous Cleft Palate.
Cao C, Xu X, Yin H, Zheng Q, Xu C, Shi B
Cleft Palate Craniofac J 2023 Oct;60(10):1260-1266. Epub 2022 May 9 doi: 10.1177/10556656221100125. PMID: 35532048
Association between symptomatic submucous cleft palate and otologic disease: A retrospective review.
Kwinter A, Dworschak-Stokan A, Paradis J, Husein M
Int J Pediatr Otorhinolaryngol 2018 Dec;115:77-81. Epub 2018 Sep 22 doi: 10.1016/j.ijporl.2018.09.022. PMID: 30368399
Neonatal palatal cysts and their morphology in cleft lip and palate.
Richard BM, Qiu CX, Ferguson MW
Br J Plast Surg 2000 Oct;53(7):555-8. doi: 10.1054/bjps.2000.3410. PMID: 11000069
Velopharyngeal insufficiency after adenoidectomy: an 8-year review.
Witzel MA, Rich RH, Margar-Bacal F, Cox C
Int J Pediatr Otorhinolaryngol 1986 Feb;11(1):15-20. doi: 10.1016/s0165-5876(86)80023-4. PMID: 3710697
Cineradiographic assessment of combined island flap pushback and pharyngeal flap in the surgical management of submucous cleft palate.
Hoopes JE, Dellon AL, Fabrikant JI, Soliman AH
Br J Plast Surg 1970 Jan;23(1):39-44. doi: 10.1016/s0007-1226(70)80007-8. PMID: 5413495

Clinical prediction guides

An essential overview of orofacial clefting.
Martin SV, Swan MC
Br Dent J 2023 Jun;234(12):937-942. Epub 2023 Jun 23 doi: 10.1038/s41415-023-6000-9. PMID: 37349450
Cephalometric Soft Tissue Morphology of Adults With Unoperated Submucous Cleft Palate.
Cao C, Xu X, Yin H, Zheng Q, Xu C, Shi B
Cleft Palate Craniofac J 2023 Oct;60(10):1260-1266. Epub 2022 May 9 doi: 10.1177/10556656221100125. PMID: 35532048
Revision Pharyngoplasty in Cleft Palate and Velopharyngeal Insufficiency: Management and Outcomes.
Bruce MK, Zhang C, Vodovotz L, Irgebay Z, Maliha S, Pfaff M, Ford M, Goldstein JA, Losee JE
Ann Plast Surg 2022 May 1;88(3 Suppl 3):S152-S155. doi: 10.1097/SAP.0000000000003198. PMID: 35513313
Association between symptomatic submucous cleft palate and otologic disease: A retrospective review.
Kwinter A, Dworschak-Stokan A, Paradis J, Husein M
Int J Pediatr Otorhinolaryngol 2018 Dec;115:77-81. Epub 2018 Sep 22 doi: 10.1016/j.ijporl.2018.09.022. PMID: 30368399
Neonatal palatal cysts and their morphology in cleft lip and palate.
Richard BM, Qiu CX, Ferguson MW
Br J Plast Surg 2000 Oct;53(7):555-8. doi: 10.1054/bjps.2000.3410. PMID: 11000069

Recent systematic reviews

Speech and language characteristics in individuals with nonsyndromic submucous cleft palate-A systematic review.
Boyce JO, Kilpatrick N, Morgan AT
Child Care Health Dev 2018 Nov;44(6):818-831. Epub 2018 Aug 22 doi: 10.1111/cch.12613. PMID: 30136310
WITHDRAWN: Interventions for the management of submucous cleft palate.
Nasser M, Fedorowicz Z, Newton T, Nouri M
Cochrane Database Syst Rev 2016 Jan 19;2016(1):CD006703. doi: 10.1002/14651858.CD006703.pub3. PMID: 26784399Free PMC Article
Submucous cleft palate: a systematic review of surgical management based on perceptual and instrumental analysis.
Gilleard O, Sell D, Ghanem AM, Tavsanoglu Y, Birch M, Sommerlad B
Cleft Palate Craniofac J 2014 Nov;51(6):686-95. doi: 10.1597/13-046. PMID: 25368910
Interventions for the management of submucous cleft palate.
Nasser M, Fedorowicz Z, Newton JT, Nouri M
Cochrane Database Syst Rev 2008 Jan 23;(1):CD006703. doi: 10.1002/14651858.CD006703.pub2. PMID: 18254111

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