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Grade 1 Encephalopathy, CTCAE

MedGen UID:
1644282
•Concept ID:
C4685119
•
Finding

Definition

Mild symptoms [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 1 Encephalopathy, CTCAE

Professional guidelines

PubMed

Characteristics and management of tumor treating fields-related dermatological complications in patients with glioblastoma.
Yang C, Zhang Q, Ma C, Huang Y, Ding HX, Lu JW, Wang J, Li X, Zhong YH, Li ZQ
Medicine (Baltimore) 2023 May 19;102(20):e33830. doi: 10.1097/MD.0000000000033830. PMID: 37335714Free PMC Article
Applications of the Grading Scales for the Detection of Ototoxicity in Children after Treatment of Neuroblastoma and Extracranial Germinal Tumor.
Polski B, Sosnowska-Sienkiewicz P, Szydłowski J, Januszkiewicz-Lewandowska D
Audiol Neurootol 2023;28(1):32-42. Epub 2022 Oct 3 doi: 10.1159/000526403. PMID: 36191558
Response to trametinib treatment in progressive pediatric low-grade glioma patients.
Selt F, van Tilburg CM, Bison B, Sievers P, Harting I, Ecker J, Pajtler KW, Sahm F, Bahr A, Simon M, Jones DTW, Well L, Mautner VF, Capper D, Hernáiz Driever P, Gnekow A, Pfister SM, Witt O, Milde T
J Neurooncol 2020 Sep;149(3):499-510. Epub 2020 Oct 7 doi: 10.1007/s11060-020-03640-3. PMID: 33026636Free PMC Article

Recent clinical studies

Etiology

Marizomib for patients with newly diagnosed glioblastoma: A randomized phase 3 trial.
Roth P, Gorlia T, Reijneveld JC, de Vos F, Idbaih A, Frenel JS, Le Rhun E, Sepulveda JM, Perry J, Masucci GL, Freres P, Hirte H, Seidel C, Walenkamp A, Lukacova S, Meijnders P, Blais A, Ducray F, Verschaeve V, Nicholas G, Balana C, Bota DA, Preusser M, Nuyens S, Dhermain F, van den Bent M, O'Callaghan CJ, Vanlancker M, Mason W, Weller M
Neuro Oncol 2024 Sep 5;26(9):1670-1682. doi: 10.1093/neuonc/noae053. PMID: 38502052Free PMC Article
Review of Safety Data for Adenovirus 5 as a Delivery Vector for Intratumoral Cancer Gene Therapy.
Sheldon Y, Yoo BC, Kmiec E, Petrelli N, Tiesi G, Warner S
Hum Gene Ther 2023 Apr;34(7-8):314-324. doi: 10.1089/hum.2022.228. PMID: 36851898
Cyberknife(®) hypofractionated stereotactic radiosurgery (CK-hSRS) as salvage treatment for brain metastases.
Telentschak S, Ruess D, Grau S, Goldbrunner R, von Spreckelsen N, Jablonska K, Treuer H, Kocher M, Ruge M
J Cancer Res Clin Oncol 2021 Sep;147(9):2765-2773. Epub 2021 Feb 26 doi: 10.1007/s00432-021-03564-z. PMID: 33638006Free PMC Article
Optimizing bevacizumab dosing in glioblastoma: less is more.
Ajlan A, Thomas P, Albakr A, Nagpal S, Recht L
J Neurooncol 2017 Oct;135(1):99-105. Epub 2017 Jun 30 doi: 10.1007/s11060-017-2553-2. PMID: 28667595
Cranial irradiation in adults diagnosed with acute myelogenous leukemia presenting with hyperleukocytosis and neurologic dysfunction.
Ferro A, Jabbour SK, Taunk NK, Aisner J, Cohler A, Somalya S, Goyal S
Leuk Lymphoma 2014 Jan;55(1):105-9. Epub 2013 Jun 4 doi: 10.3109/10428194.2013.797088. PMID: 23734620Free PMC Article

Diagnosis

Marizomib for patients with newly diagnosed glioblastoma: A randomized phase 3 trial.
Roth P, Gorlia T, Reijneveld JC, de Vos F, Idbaih A, Frenel JS, Le Rhun E, Sepulveda JM, Perry J, Masucci GL, Freres P, Hirte H, Seidel C, Walenkamp A, Lukacova S, Meijnders P, Blais A, Ducray F, Verschaeve V, Nicholas G, Balana C, Bota DA, Preusser M, Nuyens S, Dhermain F, van den Bent M, O'Callaghan CJ, Vanlancker M, Mason W, Weller M
Neuro Oncol 2024 Sep 5;26(9):1670-1682. doi: 10.1093/neuonc/noae053. PMID: 38502052Free PMC Article
REGOMA-OSS: a large, Italian, multicenter, prospective, observational study evaluating the efficacy and safety of regorafenib in patients with recurrent glioblastoma.
Caccese M, Desideri I, Villani V, Simonelli M, Buglione M, Chiesa S, Franceschi E, Gaviani P, Stasi I, Caserta C, Brugnara S, Lolli I, Bennicelli E, Bini P, Cuccu AS, Scoccianti S, Padovan M, Gori S, Bonetti A, Giordano P, Pellerino A, Gregucci F, Riva N, Cinieri S, Internò V, Santoni M, Pernice G, Dealis C, Stievano L, Paiar F, Magni G, De Salvo GL, Zagonel V, Lombardi G
ESMO Open 2024 Apr;9(4):102943. Epub 2024 Mar 15 doi: 10.1016/j.esmoop.2024.102943. PMID: 38492275Free PMC Article
Analysis of safety and efficacy of proton radiotherapy for IDH-mutated glioma WHO grade 2 and 3.
Eichkorn T, Lischalk JW, Hörner-Rieber J, Deng M, Meixner E, Krämer A, Hoegen P, Sandrini E, Regnery S, Held T, Harrabi S, Jungk C, Herfarth K, Debus J, König L
J Neurooncol 2023 May;162(3):489-501. Epub 2023 Jan 4 doi: 10.1007/s11060-022-04217-y. PMID: 36598613Free PMC Article
Optimizing Clinical Screening for Chemotherapy-Induced Peripheral Neuropathy.
McCrary JM, Goldstein D, Trinh T, Timmins HC, Li T, Friedlander M, Bosco A, Harrison M, Maier N, O'Neill S, Park SB
J Pain Symptom Manage 2019 Dec;58(6):1023-1032. Epub 2019 Jul 30 doi: 10.1016/j.jpainsymman.2019.07.021. PMID: 31374367
Cranial irradiation in adults diagnosed with acute myelogenous leukemia presenting with hyperleukocytosis and neurologic dysfunction.
Ferro A, Jabbour SK, Taunk NK, Aisner J, Cohler A, Somalya S, Goyal S
Leuk Lymphoma 2014 Jan;55(1):105-9. Epub 2013 Jun 4 doi: 10.3109/10428194.2013.797088. PMID: 23734620Free PMC Article

Therapy

Marizomib for patients with newly diagnosed glioblastoma: A randomized phase 3 trial.
Roth P, Gorlia T, Reijneveld JC, de Vos F, Idbaih A, Frenel JS, Le Rhun E, Sepulveda JM, Perry J, Masucci GL, Freres P, Hirte H, Seidel C, Walenkamp A, Lukacova S, Meijnders P, Blais A, Ducray F, Verschaeve V, Nicholas G, Balana C, Bota DA, Preusser M, Nuyens S, Dhermain F, van den Bent M, O'Callaghan CJ, Vanlancker M, Mason W, Weller M
Neuro Oncol 2024 Sep 5;26(9):1670-1682. doi: 10.1093/neuonc/noae053. PMID: 38502052Free PMC Article
Surgically targeted radiation therapy (STaRT) for recurrent brain metastases: Initial clinical experience.
Kutuk T, Tolakanahalli R, Chaswal V, Yarlagadda S, Herrera R, Appel H, La Rosa A, Mishra V, Wieczorek DJJ, McDermott MW, Siomin V, Mehta MP, Odia Y, Gutierrez AN, Kotecha R
Brachytherapy 2023 Nov-Dec;22(6):872-881. Epub 2023 Sep 16 doi: 10.1016/j.brachy.2023.08.002. PMID: 37722990
Patient-Reported Outcome Measures in Chemotherapy-Induced Peripheral Neurotoxicity: Defining Minimal and Clinically Important Changes.
Li T, Timmins HC, Trinh T, Mizrahi D, Harrison M, Horvath LG, Grimison P, Friedlander M, Kiernan MC, King MT, Rutherford C, Goldstein D, Park SB
J Natl Compr Canc Netw 2023 Feb;21(2):125-132.e3. doi: 10.6004/jnccn.2022.7074. PMID: 36791763
Proton therapy with a fixed beamline for skull-base chordomas and chondrosarcomas: outcomes and toxicity.
Gordon K, Gulidov I, Koryakin S, Smyk D, Makeenkova T, Gogolin D, Lepilina O, Golovanova O, Semenov A, Dujenko S, Medvedeva K, Mardynsky Y
Radiat Oncol 2021 Dec 20;16(1):238. doi: 10.1186/s13014-021-01961-9. PMID: 34930352Free PMC Article
Optimizing bevacizumab dosing in glioblastoma: less is more.
Ajlan A, Thomas P, Albakr A, Nagpal S, Recht L
J Neurooncol 2017 Oct;135(1):99-105. Epub 2017 Jun 30 doi: 10.1007/s11060-017-2553-2. PMID: 28667595

Prognosis

Defining the role of surgery for patients with multiple brain metastases.
Ersoy TF, Brainman D, Coras R, Berger B, Weissinger F, Grote A, Simon M
J Neurooncol 2024 Sep;169(2):317-328. Epub 2024 Jun 25 doi: 10.1007/s11060-024-04739-7. PMID: 38916848Free PMC Article
Marizomib for patients with newly diagnosed glioblastoma: A randomized phase 3 trial.
Roth P, Gorlia T, Reijneveld JC, de Vos F, Idbaih A, Frenel JS, Le Rhun E, Sepulveda JM, Perry J, Masucci GL, Freres P, Hirte H, Seidel C, Walenkamp A, Lukacova S, Meijnders P, Blais A, Ducray F, Verschaeve V, Nicholas G, Balana C, Bota DA, Preusser M, Nuyens S, Dhermain F, van den Bent M, O'Callaghan CJ, Vanlancker M, Mason W, Weller M
Neuro Oncol 2024 Sep 5;26(9):1670-1682. doi: 10.1093/neuonc/noae053. PMID: 38502052Free PMC Article
Association of electrochemical skin conductance with neuropathy in chemotherapy-treated patients.
Mahfouz FM, Park SB, Li T, Timmins HC, Horvath LG, Harrison M, Grimison P, King T, Goldstein D, Mizrahi D
Clin Auton Res 2022 Dec;32(6):497-506. Epub 2022 Sep 21 doi: 10.1007/s10286-022-00895-w. PMID: 36129622Free PMC Article
Optimizing Clinical Screening for Chemotherapy-Induced Peripheral Neuropathy.
McCrary JM, Goldstein D, Trinh T, Timmins HC, Li T, Friedlander M, Bosco A, Harrison M, Maier N, O'Neill S, Park SB
J Pain Symptom Manage 2019 Dec;58(6):1023-1032. Epub 2019 Jul 30 doi: 10.1016/j.jpainsymman.2019.07.021. PMID: 31374367
Optimizing bevacizumab dosing in glioblastoma: less is more.
Ajlan A, Thomas P, Albakr A, Nagpal S, Recht L
J Neurooncol 2017 Oct;135(1):99-105. Epub 2017 Jun 30 doi: 10.1007/s11060-017-2553-2. PMID: 28667595

Clinical prediction guides

Defining the role of surgery for patients with multiple brain metastases.
Ersoy TF, Brainman D, Coras R, Berger B, Weissinger F, Grote A, Simon M
J Neurooncol 2024 Sep;169(2):317-328. Epub 2024 Jun 25 doi: 10.1007/s11060-024-04739-7. PMID: 38916848Free PMC Article
Marizomib for patients with newly diagnosed glioblastoma: A randomized phase 3 trial.
Roth P, Gorlia T, Reijneveld JC, de Vos F, Idbaih A, Frenel JS, Le Rhun E, Sepulveda JM, Perry J, Masucci GL, Freres P, Hirte H, Seidel C, Walenkamp A, Lukacova S, Meijnders P, Blais A, Ducray F, Verschaeve V, Nicholas G, Balana C, Bota DA, Preusser M, Nuyens S, Dhermain F, van den Bent M, O'Callaghan CJ, Vanlancker M, Mason W, Weller M
Neuro Oncol 2024 Sep 5;26(9):1670-1682. doi: 10.1093/neuonc/noae053. PMID: 38502052Free PMC Article
REGOMA-OSS: a large, Italian, multicenter, prospective, observational study evaluating the efficacy and safety of regorafenib in patients with recurrent glioblastoma.
Caccese M, Desideri I, Villani V, Simonelli M, Buglione M, Chiesa S, Franceschi E, Gaviani P, Stasi I, Caserta C, Brugnara S, Lolli I, Bennicelli E, Bini P, Cuccu AS, Scoccianti S, Padovan M, Gori S, Bonetti A, Giordano P, Pellerino A, Gregucci F, Riva N, Cinieri S, Internò V, Santoni M, Pernice G, Dealis C, Stievano L, Paiar F, Magni G, De Salvo GL, Zagonel V, Lombardi G
ESMO Open 2024 Apr;9(4):102943. Epub 2024 Mar 15 doi: 10.1016/j.esmoop.2024.102943. PMID: 38492275Free PMC Article
Patient-Reported Outcome Measures in Chemotherapy-Induced Peripheral Neurotoxicity: Defining Minimal and Clinically Important Changes.
Li T, Timmins HC, Trinh T, Mizrahi D, Harrison M, Horvath LG, Grimison P, Friedlander M, Kiernan MC, King MT, Rutherford C, Goldstein D, Park SB
J Natl Compr Canc Netw 2023 Feb;21(2):125-132.e3. doi: 10.6004/jnccn.2022.7074. PMID: 36791763
Physical activity behaviors in cancer survivors treated with neurotoxic chemotherapy.
Mizrahi D, Goldstein D, Trinh T, Li T, Timmins HC, Harrison M, Marx GM, Hovey EJ, Lewis CR, Friedlander M, Park SB
Asia Pac J Clin Oncol 2023 Feb;19(1):243-249. Epub 2022 Jul 25 doi: 10.1111/ajco.13834. PMID: 35879821Free PMC Article

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