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Refractory Medulloblastoma

MedGen UID:
1642493
Concept ID:
C4684869
Neoplastic Process

Definition

Medulloblastoma that does not respond to treatment. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Adile AA, Kameda-Smith MM, Bakhshinyan D, Banfield L, Salim SK, Farrokhyar F, Fleming AJ
Syst Rev 2020 Mar 4;9(1):47. doi: 10.1186/s13643-020-01307-8. PMID: 32127049Free PMC Article
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Ruggiero A, Trombatore G, Triarico S, Arena R, Ferrara P, Scalzone M, Pierri F, Riccardi R
Anticancer Drugs 2013 Nov;24(10):1007-19. doi: 10.1097/CAD.0b013e3283650bda. PMID: 23962902

Recent clinical studies

Etiology

Szalontay L, Khakoo Y
Curr Oncol Rep 2020 Jul 9;22(9):90. doi: 10.1007/s11912-020-00953-4. PMID: 32643099
Le Teuff G, Castaneda-Heredia A, Dufour C, Jaspan T, Calmon R, Devos A, McHugh K, Leblond P, Frappaz D, Aerts I, Zwaan CM, Ducassou S, Chastagner P, Verschuur A, Corradini N, Casanova M, Rubie H, Riccardi R, Le Deley MC, Vassal G, Geoerger B; European consortium Innovative Therapies for Children with Cancer (ITCC)
Pediatr Blood Cancer 2020 Jan;67(1):e28032. Epub 2019 Oct 8 doi: 10.1002/pbc.28032. PMID: 31595663
Grill J, Geoerger B, Gesner L, Perek D, Leblond P, Cañete A, Aerts I, Madero L, de Toledo Codina JS, Verlooy J, Estlin E, Cisar L, Breazna A, Dorman A, Bailey S, Nicolin G, Grundy RG, Hargrave D; European Consortium Innovative Therapies for Children with Cancer (ITCC) and the European Society for Paediatric Oncology (SIOPE) brain tumor group
Neuro Oncol 2013 Sep;15(9):1236-43. Epub 2013 Jul 14 doi: 10.1093/neuonc/not097. PMID: 23857707Free PMC Article
Benesch M, Siegler N, Hoff Kv, Lassay L, Kropshofer G, Müller H, Sommer C, Rutkowski S, Fleischhack G, Urban C
Anticancer Drugs 2009 Oct;20(9):794-9. doi: 10.1097/CAD.0b013e32832f4abe. PMID: 19617818
Fouladi M, Nicholson HS, Zhou T, Laningham F, Helton KJ, Holmes E, Cohen K, Speights RA, Wright J, Pollack IF; Children's Oncology Group
Cancer 2007 Dec 1;110(11):2535-41. doi: 10.1002/cncr.23078. PMID: 17932894

Diagnosis

Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I
JAMA Oncol 2023 Dec 1;9(12):1688-1695. doi: 10.1001/jamaoncol.2023.4437. PMID: 37883081Free PMC Article
Frappaz D, Barritault M, Montané L, Laigle-Donadey F, Chinot O, Le Rhun E, Bonneville-Levard A, Hottinger AF, Meyronnet D, Bidaux AS, Garin G, Pérol D
Neuro Oncol 2021 Nov 2;23(11):1949-1960. doi: 10.1093/neuonc/noab087. PMID: 33825892Free PMC Article
Szalontay L, Khakoo Y
Curr Oncol Rep 2020 Jul 9;22(9):90. doi: 10.1007/s11912-020-00953-4. PMID: 32643099
Benesch M, Siegler N, Hoff Kv, Lassay L, Kropshofer G, Müller H, Sommer C, Rutkowski S, Fleischhack G, Urban C
Anticancer Drugs 2009 Oct;20(9):794-9. doi: 10.1097/CAD.0b013e32832f4abe. PMID: 19617818
Vassal G, Boland I, Terrier-Lacombe MJ, Watson AJ, Margison GP, Vénuat AM, Morizet J, Parker F, Lacroix C, Lellouch-Tubiana A, Pierre-Kahn A, Poullain MG, Gouyette A
Clin Cancer Res 1998 Feb;4(2):463-8. PMID: 9516937

Therapy

Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I
JAMA Oncol 2023 Dec 1;9(12):1688-1695. doi: 10.1001/jamaoncol.2023.4437. PMID: 37883081Free PMC Article
Frappaz D, Barritault M, Montané L, Laigle-Donadey F, Chinot O, Le Rhun E, Bonneville-Levard A, Hottinger AF, Meyronnet D, Bidaux AS, Garin G, Pérol D
Neuro Oncol 2021 Nov 2;23(11):1949-1960. doi: 10.1093/neuonc/noab087. PMID: 33825892Free PMC Article
Szalontay L, Khakoo Y
Curr Oncol Rep 2020 Jul 9;22(9):90. doi: 10.1007/s11912-020-00953-4. PMID: 32643099
Le Teuff G, Castaneda-Heredia A, Dufour C, Jaspan T, Calmon R, Devos A, McHugh K, Leblond P, Frappaz D, Aerts I, Zwaan CM, Ducassou S, Chastagner P, Verschuur A, Corradini N, Casanova M, Rubie H, Riccardi R, Le Deley MC, Vassal G, Geoerger B; European consortium Innovative Therapies for Children with Cancer (ITCC)
Pediatr Blood Cancer 2020 Jan;67(1):e28032. Epub 2019 Oct 8 doi: 10.1002/pbc.28032. PMID: 31595663
Aguilera DG, Goldman S, Fangusaro J
Pediatr Blood Cancer 2011 Mar;56(3):491-4. doi: 10.1002/pbc.22868. PMID: 21072819

Prognosis

Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I
JAMA Oncol 2023 Dec 1;9(12):1688-1695. doi: 10.1001/jamaoncol.2023.4437. PMID: 37883081Free PMC Article
Frappaz D, Barritault M, Montané L, Laigle-Donadey F, Chinot O, Le Rhun E, Bonneville-Levard A, Hottinger AF, Meyronnet D, Bidaux AS, Garin G, Pérol D
Neuro Oncol 2021 Nov 2;23(11):1949-1960. doi: 10.1093/neuonc/noab087. PMID: 33825892Free PMC Article
Szalontay L, Khakoo Y
Curr Oncol Rep 2020 Jul 9;22(9):90. doi: 10.1007/s11912-020-00953-4. PMID: 32643099
Le Teuff G, Castaneda-Heredia A, Dufour C, Jaspan T, Calmon R, Devos A, McHugh K, Leblond P, Frappaz D, Aerts I, Zwaan CM, Ducassou S, Chastagner P, Verschuur A, Corradini N, Casanova M, Rubie H, Riccardi R, Le Deley MC, Vassal G, Geoerger B; European consortium Innovative Therapies for Children with Cancer (ITCC)
Pediatr Blood Cancer 2020 Jan;67(1):e28032. Epub 2019 Oct 8 doi: 10.1002/pbc.28032. PMID: 31595663
Gajjar A, Stewart CF, Ellison DW, Kaste S, Kun LE, Packer RJ, Goldman S, Chintagumpala M, Wallace D, Takebe N, Boyett JM, Gilbertson RJ, Curran T
Clin Cancer Res 2013 Nov 15;19(22):6305-12. Epub 2013 Sep 27 doi: 10.1158/1078-0432.CCR-13-1425. PMID: 24077351Free PMC Article

Clinical prediction guides

Frappaz D, Barritault M, Montané L, Laigle-Donadey F, Chinot O, Le Rhun E, Bonneville-Levard A, Hottinger AF, Meyronnet D, Bidaux AS, Garin G, Pérol D
Neuro Oncol 2021 Nov 2;23(11):1949-1960. doi: 10.1093/neuonc/noab087. PMID: 33825892Free PMC Article
Le Teuff G, Castaneda-Heredia A, Dufour C, Jaspan T, Calmon R, Devos A, McHugh K, Leblond P, Frappaz D, Aerts I, Zwaan CM, Ducassou S, Chastagner P, Verschuur A, Corradini N, Casanova M, Rubie H, Riccardi R, Le Deley MC, Vassal G, Geoerger B; European consortium Innovative Therapies for Children with Cancer (ITCC)
Pediatr Blood Cancer 2020 Jan;67(1):e28032. Epub 2019 Oct 8 doi: 10.1002/pbc.28032. PMID: 31595663
Gajjar A, Stewart CF, Ellison DW, Kaste S, Kun LE, Packer RJ, Goldman S, Chintagumpala M, Wallace D, Takebe N, Boyett JM, Gilbertson RJ, Curran T
Clin Cancer Res 2013 Nov 15;19(22):6305-12. Epub 2013 Sep 27 doi: 10.1158/1078-0432.CCR-13-1425. PMID: 24077351Free PMC Article
Benesch M, Siegler N, Hoff Kv, Lassay L, Kropshofer G, Müller H, Sommer C, Rutkowski S, Fleischhack G, Urban C
Anticancer Drugs 2009 Oct;20(9):794-9. doi: 10.1097/CAD.0b013e32832f4abe. PMID: 19617818
Vassal G, Boland I, Terrier-Lacombe MJ, Watson AJ, Margison GP, Vénuat AM, Morizet J, Parker F, Lacroix C, Lellouch-Tubiana A, Pierre-Kahn A, Poullain MG, Gouyette A
Clin Cancer Res 1998 Feb;4(2):463-8. PMID: 9516937

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