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Recurrent Acute Biphenotypic Leukemia

MedGen UID:
1641256
•Concept ID:
C4067209
•
Neoplastic Process
Synonym: Acute Biphenotypic Leukemia in Relapse

Definition

The reemergence of acute biphenotypic leukemia after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Acute Biphenotypic Leukemia

Recent clinical studies

Etiology

A Case of Acute Mixed Cell Leukemia Resembling AML1-ETO Positive Acute Myeloid Leukemia.
Li R, Wu Y, Zhang X, Wang L, Zhang Y, Xiao H
Clin Lab 2023 Apr 1;69(4) doi: 10.7754/Clin.Lab.2022.220723. PMID: 37057942
Phase 1 study of the histone deacetylase inhibitor entinostat plus clofarabine for poor-risk Philadelphia chromosome-negative (newly diagnosed older adults or adults with relapsed refractory disease) acute lymphoblastic leukemia or biphenotypic leukemia.
Carraway HE, Sawalha Y, Gojo I, Lee MJ, Lee S, Tomita Y, Yuno A, Greer J, Smith BD, Pratz KW, Levis MJ, Gore SD, Ghosh N, Dezern A, Blackford AL, Baer MR, Gore L, Piekarz R, Trepel JB, Karp JE
Leuk Res 2021 Nov;110:106707. Epub 2021 Sep 10 doi: 10.1016/j.leukres.2021.106707. PMID: 34563945Free PMC Article
Allogeneic Hematopoietic Cell Transplantation for Patients with Mixed Phenotype Acute Leukemia.
Munker R, Brazauskas R, Wang HL, de Lima M, Khoury HJ, Gale RP, Maziarz RT, Sandmaier BM, Weisdorf D, Saber W; Center for International Blood and Marrow Transplant Research
Biol Blood Marrow Transplant 2016 Jun;22(6):1024-1029. Epub 2016 Feb 21 doi: 10.1016/j.bbmt.2016.02.013. PMID: 26903380Free PMC Article
Classification of acute leukemias.
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428
FLAG (fludarabine, high-dose cytarabine, and G-CSF) for refractory and high-risk relapsed acute leukemia in children.
McCarthy AJ, Pitcher LA, Hann IM, Oakhill A
Med Pediatr Oncol 1999 Jun;32(6):411-5. doi: 10.1002/(sici)1096-911x(199906)32:6<411::aid-mpo3>3.0.co;2-k. PMID: 10358698

Diagnosis

How to think about acute leukemia of ambiguous lineage.
Weinberg OK
Hematology Am Soc Hematol Educ Program 2024 Dec 6;2024(1):287-292. doi: 10.1182/hematology.2024000554. PMID: 39644014Free PMC Article
Genomic Landscape of Mixed-Phenotype Acute Leukemia.
Hennawi M, Pakasticali N, Tashkandi H, Hussaini M
Int J Mol Sci 2022 Sep 24;23(19) doi: 10.3390/ijms231911259. PMID: 36232559Free PMC Article
How I Diagnose Acute Leukemia of Ambiguous Lineage.
Weinberg OK, Arber DA
Am J Clin Pathol 2022 Jul 1;158(1):27-34. doi: 10.1093/ajcp/aqac070. PMID: 35775438
Relapse of an acute leukemia of mixed lineage as an isolated orbital mass.
Zhou XY, Behdad A
Blood 2017 Aug 17;130(7):953. doi: 10.1182/blood-2017-04-781906. PMID: 28818980
Classification of acute leukemias.
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

Therapy

Phase 1 study of the histone deacetylase inhibitor entinostat plus clofarabine for poor-risk Philadelphia chromosome-negative (newly diagnosed older adults or adults with relapsed refractory disease) acute lymphoblastic leukemia or biphenotypic leukemia.
Carraway HE, Sawalha Y, Gojo I, Lee MJ, Lee S, Tomita Y, Yuno A, Greer J, Smith BD, Pratz KW, Levis MJ, Gore SD, Ghosh N, Dezern A, Blackford AL, Baer MR, Gore L, Piekarz R, Trepel JB, Karp JE
Leuk Res 2021 Nov;110:106707. Epub 2021 Sep 10 doi: 10.1016/j.leukres.2021.106707. PMID: 34563945Free PMC Article
High-dose etoposide and cyclophosphamide in adults and children with primary refractory and multiply relapsed acute leukaemias: The Royal Marsden experience.
Carceller F, Hirsch SG, Khabra K, Petterson T, Malik R, Guerra-García P, Moreno L, Marshall LV, Taj M, Atra A, Ethell M, Potter M, Lancaster D
Leuk Res 2019 Oct;85:106217. Epub 2019 Aug 13 doi: 10.1016/j.leukres.2019.106217. PMID: 31493701
Blinatumomab-induced donor T-cell activation for post-stem cell transplant-relapsed acute CD19-positive biphenotypic leukemia.
Alcharakh M, Yun S, Dong Y, Vincelette ND, Daud M, Manzoor S, Riaz IB, Anwer F
Immunotherapy 2016 Jul;8(8):847-52. doi: 10.2217/imt-2015-0023. PMID: 27381683
Temozolomide and cisplatin in relapsed/refractory acute leukemia.
Seiter K, Katragadda S, Ponce D, Rasul M, Ahmed N
J Hematol Oncol 2009 May 22;2:21. doi: 10.1186/1756-8722-2-21. PMID: 19463179Free PMC Article
Chromosomal translocations involving the MLL gene: molecular mechanisms.
Aplan PD
DNA Repair (Amst) 2006 Sep 8;5(9-10):1265-72. Epub 2006 Jun 21 doi: 10.1016/j.dnarep.2006.05.034. PMID: 16797254Free PMC Article

Prognosis

Genomic Landscape of Mixed-Phenotype Acute Leukemia.
Hennawi M, Pakasticali N, Tashkandi H, Hussaini M
Int J Mol Sci 2022 Sep 24;23(19) doi: 10.3390/ijms231911259. PMID: 36232559Free PMC Article
Phase 1 study of the histone deacetylase inhibitor entinostat plus clofarabine for poor-risk Philadelphia chromosome-negative (newly diagnosed older adults or adults with relapsed refractory disease) acute lymphoblastic leukemia or biphenotypic leukemia.
Carraway HE, Sawalha Y, Gojo I, Lee MJ, Lee S, Tomita Y, Yuno A, Greer J, Smith BD, Pratz KW, Levis MJ, Gore SD, Ghosh N, Dezern A, Blackford AL, Baer MR, Gore L, Piekarz R, Trepel JB, Karp JE
Leuk Res 2021 Nov;110:106707. Epub 2021 Sep 10 doi: 10.1016/j.leukres.2021.106707. PMID: 34563945Free PMC Article
Blinatumomab-induced donor T-cell activation for post-stem cell transplant-relapsed acute CD19-positive biphenotypic leukemia.
Alcharakh M, Yun S, Dong Y, Vincelette ND, Daud M, Manzoor S, Riaz IB, Anwer F
Immunotherapy 2016 Jul;8(8):847-52. doi: 10.2217/imt-2015-0023. PMID: 27381683
Monitoring mixed lineage leukemia expression may help identify patients with mixed lineage leukemia--rearranged acute leukemia who are at high risk of relapse after allogeneic hematopoietic stem cell transplantation.
Liu J, Wang Y, Xu LP, Liu DH, Qin YZ, Chang YJ, Liu KY, Huang XJ
Biol Blood Marrow Transplant 2014 Jul;20(7):929-36. Epub 2014 Mar 13 doi: 10.1016/j.bbmt.2014.03.008. PMID: 24631740
Classification of acute leukemias.
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

Clinical prediction guides

A Case of Acute Mixed Cell Leukemia Resembling AML1-ETO Positive Acute Myeloid Leukemia.
Li R, Wu Y, Zhang X, Wang L, Zhang Y, Xiao H
Clin Lab 2023 Apr 1;69(4) doi: 10.7754/Clin.Lab.2022.220723. PMID: 37057942
Genomic and clinical characterization of B/T mixed phenotype acute leukemia reveals recurrent features and T-ALL like mutations.
Mi X, Griffin G, Lee W, Patel S, Ohgami R, Ok CY, Wang S, Geyer JT, Xiao W, Roshal M, Garcia JS, Silverman LB, Sallan SE, Aster JC, Harris MH, Weinberg OK
Am J Hematol 2018 Nov;93(11):1358-1367. Epub 2018 Sep 26 doi: 10.1002/ajh.25256. PMID: 30117174Free PMC Article
Mixed Phenotype Acute Leukemia with t(12;17)(p13;q21)/TAF15-ZNF384 and Other Chromosome Abnormalities.
Yamamoto K, Kawamoto S, Mizutani Y, Yakushijin K, Yamashita T, Nakamachi Y, Kawano S, Hayashi Y, Matsuoka H, Minami H
Cytogenet Genome Res 2016;149(3):165-170. Epub 2016 Sep 9 doi: 10.1159/000448447. PMID: 27607436
Allogeneic Hematopoietic Cell Transplantation for Patients with Mixed Phenotype Acute Leukemia.
Munker R, Brazauskas R, Wang HL, de Lima M, Khoury HJ, Gale RP, Maziarz RT, Sandmaier BM, Weisdorf D, Saber W; Center for International Blood and Marrow Transplant Research
Biol Blood Marrow Transplant 2016 Jun;22(6):1024-1029. Epub 2016 Feb 21 doi: 10.1016/j.bbmt.2016.02.013. PMID: 26903380Free PMC Article
Monitoring mixed lineage leukemia expression may help identify patients with mixed lineage leukemia--rearranged acute leukemia who are at high risk of relapse after allogeneic hematopoietic stem cell transplantation.
Liu J, Wang Y, Xu LP, Liu DH, Qin YZ, Chang YJ, Liu KY, Huang XJ
Biol Blood Marrow Transplant 2014 Jul;20(7):929-36. Epub 2014 Mar 13 doi: 10.1016/j.bbmt.2014.03.008. PMID: 24631740

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