U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal natural killer subset distribution

MedGen UID:
1640812
•Concept ID:
C4703685
•
Finding
HPO: HP:0500033

Definition

Any abnormality in the proportion natural killer subsets relative to the total number of natural killer cells. [from HPO]

Professional guidelines

PubMed

The abnormal distribution of NK cell subsets before HAART treatment may be related to the level of immune reconstitution in HIV patient.
Sun S, Kong W, Cui X, Lin Y, Lu B, Pan Y, Huang J, Hu X
Int Immunopharmacol 2021 Jul;96:107784. Epub 2021 May 24 doi: 10.1016/j.intimp.2021.107784. PMID: 34162148
Terminal Differentiation of CD56(dim)CD16(+) Natural Killer Cells Is Associated with Increase in Natural Killer Cell Frequencies After Antiretroviral Treatment in HIV-1 Infection.
Ahmad F, Tufa DM, Mishra N, Jacobs R, Schmidt RE
AIDS Res Hum Retroviruses 2015 Dec;31(12):1206-12. Epub 2015 Sep 9 doi: 10.1089/aid.2015.0115. PMID: 26352913
Lymphocyte subset distribution and natural killer activity in growth hormone deficiency before and during short-term treatment with growth hormone releasing hormone.
Kiess W, Malozowski S, Gelato M, Butenand O, Doerr H, Crisp B, Eisl E, Maluish A, Belohradsky BH
Clin Immunol Immunopathol 1988 Jul;48(1):85-94. doi: 10.1016/0090-1229(88)90159-6. PMID: 3133146

Recent clinical studies

Etiology

The abnormal distribution of NK cell subsets before HAART treatment may be related to the level of immune reconstitution in HIV patient.
Sun S, Kong W, Cui X, Lin Y, Lu B, Pan Y, Huang J, Hu X
Int Immunopharmacol 2021 Jul;96:107784. Epub 2021 May 24 doi: 10.1016/j.intimp.2021.107784. PMID: 34162148
Increased Serum Interleukin-2 Levels Are Associated with Abnormal Peripheral Blood Natural Killer Cell Levels in Patients with Active Rheumatoid Arthritis.
Li B, Guo Q, Wang Y, Su R, Gao C, Zhao J, Li X, Wang C
Mediators Inflamm 2020;2020:6108342. Epub 2020 Sep 15 doi: 10.1155/2020/6108342. PMID: 33013198Free PMC Article
Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood.
Santilli V, Cagigi A, Guzzo I, Rinaldi S, Mora N, Zotta F, Piazza A, Rossi P, Emma F, Dello Strologo L, Palma P
Pediatr Nephrol 2016 Jun;31(6):1001-10. Epub 2015 Dec 21 doi: 10.1007/s00467-015-3274-4. PMID: 26692023
Terminal Differentiation of CD56(dim)CD16(+) Natural Killer Cells Is Associated with Increase in Natural Killer Cell Frequencies After Antiretroviral Treatment in HIV-1 Infection.
Ahmad F, Tufa DM, Mishra N, Jacobs R, Schmidt RE
AIDS Res Hum Retroviruses 2015 Dec;31(12):1206-12. Epub 2015 Sep 9 doi: 10.1089/aid.2015.0115. PMID: 26352913
Immune function and anti-HTLV-I/II status in anti-HIV-1-negative intravenous drug users receiving methadone.
Klimas NG, Blaney NT, Morgan RO, Chitwood D, Milles K, Lee H, Fletcher MA
Am J Med 1991 Feb;90(2):163-70. PMID: 1671730

Diagnosis

Case Report: Altered NK Cell Compartment and Reduced CXCR4 Chemotactic Response of B Lymphocytes in an Immunodeficient Patient With HPV-Related Disease.
Doria M, Moscato GMF, Di Cesare S, Di Matteo G, Sgrulletti M, Bachelerie F, Marin-Esteban V, Moschese V
Front Immunol 2022;13:799564. Epub 2022 Jan 26 doi: 10.3389/fimmu.2022.799564. PMID: 35154113Free PMC Article
Autoimmune Retinopathy: An Immunologic Cellular-Driven Disorder.
Heckenlively JR, Lundy SK
Adv Exp Med Biol 2018;1074:193-201. doi: 10.1007/978-3-319-75402-4_24. PMID: 29721944
Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood.
Santilli V, Cagigi A, Guzzo I, Rinaldi S, Mora N, Zotta F, Piazza A, Rossi P, Emma F, Dello Strologo L, Palma P
Pediatr Nephrol 2016 Jun;31(6):1001-10. Epub 2015 Dec 21 doi: 10.1007/s00467-015-3274-4. PMID: 26692023
Characteristic immune abnormalities in hemophagocytic lymphohistiocytosis.
Egeler RM, Shapiro R, Loechelt B, Filipovich A
J Pediatr Hematol Oncol 1996 Nov;18(4):340-5. doi: 10.1097/00043426-199611000-00002. PMID: 8888739
Use of whole blood methods in assessment of immune parameters in immunodeficiency states.
Fletcher MA, Baron GC, Ashman MR, Fischl MA, Klimas NG
Diagn Clin Immunol 1987;5(2):69-81. PMID: 3113759

Therapy

Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood.
Santilli V, Cagigi A, Guzzo I, Rinaldi S, Mora N, Zotta F, Piazza A, Rossi P, Emma F, Dello Strologo L, Palma P
Pediatr Nephrol 2016 Jun;31(6):1001-10. Epub 2015 Dec 21 doi: 10.1007/s00467-015-3274-4. PMID: 26692023
Terminal Differentiation of CD56(dim)CD16(+) Natural Killer Cells Is Associated with Increase in Natural Killer Cell Frequencies After Antiretroviral Treatment in HIV-1 Infection.
Ahmad F, Tufa DM, Mishra N, Jacobs R, Schmidt RE
AIDS Res Hum Retroviruses 2015 Dec;31(12):1206-12. Epub 2015 Sep 9 doi: 10.1089/aid.2015.0115. PMID: 26352913
Reduction of naive CD4/CD45RA+ T cells in children with biliary atresia before and after liver transplantation.
Pawlowska J, Michalkiewicz J, Czubkowski P, Jankowska I, Teisseyre M, Socha P, Kalicinski P, Socha J
Transplant Proc 2003 Dec;35(8):3026-8. doi: 10.1016/j.transproceed.2003.10.088. PMID: 14697969
Immune function and anti-HTLV-I/II status in anti-HIV-1-negative intravenous drug users receiving methadone.
Klimas NG, Blaney NT, Morgan RO, Chitwood D, Milles K, Lee H, Fletcher MA
Am J Med 1991 Feb;90(2):163-70. PMID: 1671730
Lymphocyte subset distribution and natural killer activity in growth hormone deficiency before and during short-term treatment with growth hormone releasing hormone.
Kiess W, Malozowski S, Gelato M, Butenand O, Doerr H, Crisp B, Eisl E, Maluish A, Belohradsky BH
Clin Immunol Immunopathol 1988 Jul;48(1):85-94. doi: 10.1016/0090-1229(88)90159-6. PMID: 3133146

Prognosis

Inflammatory breast cancer microenvironment repertoire based on DNA methylation data deconvolution reveals actionable targets to enhance the treatment efficacy.
Calanca N, Faldoni FLC, Souza CP, Souza JS, de Souza Alves BE, Soares MBP, Wong DVT, Lima-Junior RCP, Marchi FA, Rainho CA, Rogatto SR
J Transl Med 2024 Aug 5;22(1):735. doi: 10.1186/s12967-024-05553-5. PMID: 39103878Free PMC Article
Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients.
Pascual-Guardia S, Ataya M, Ramírez-Martínez I, Yélamos J, Chalela R, Bellido S, López-Botet M, Gea J
Respir Res 2020 Mar 4;21(1):63. doi: 10.1186/s12931-020-1323-4. PMID: 32131843Free PMC Article
Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood.
Santilli V, Cagigi A, Guzzo I, Rinaldi S, Mora N, Zotta F, Piazza A, Rossi P, Emma F, Dello Strologo L, Palma P
Pediatr Nephrol 2016 Jun;31(6):1001-10. Epub 2015 Dec 21 doi: 10.1007/s00467-015-3274-4. PMID: 26692023
Abnormal distribution of peripheral lymphocyte subsets induced by PDAC modulates overall survival.
Xu YF, Lu Y, Cheng H, Shi S, Xu J, Long J, Liu L, Liu C, Yu X
Pancreatology 2014 Jul-Aug;14(4):295-301. Epub 2014 Jun 11 doi: 10.1016/j.pan.2014.05.797. PMID: 25062880
Immunological evaluation of β-thalassemia major patients receiving oral iron chelator deferasirox.
Aleem A, Shakoor Z, Alsaleh K, Algahtani F, Iqbal Z, Al-Momen A
J Coll Physicians Surg Pak 2014 Jul;24(7):467-71. PMID: 25052967

Clinical prediction guides

Increased Serum Interleukin-2 Levels Are Associated with Abnormal Peripheral Blood Natural Killer Cell Levels in Patients with Active Rheumatoid Arthritis.
Li B, Guo Q, Wang Y, Su R, Gao C, Zhao J, Li X, Wang C
Mediators Inflamm 2020;2020:6108342. Epub 2020 Sep 15 doi: 10.1155/2020/6108342. PMID: 33013198Free PMC Article
Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood.
Santilli V, Cagigi A, Guzzo I, Rinaldi S, Mora N, Zotta F, Piazza A, Rossi P, Emma F, Dello Strologo L, Palma P
Pediatr Nephrol 2016 Jun;31(6):1001-10. Epub 2015 Dec 21 doi: 10.1007/s00467-015-3274-4. PMID: 26692023
Terminal Differentiation of CD56(dim)CD16(+) Natural Killer Cells Is Associated with Increase in Natural Killer Cell Frequencies After Antiretroviral Treatment in HIV-1 Infection.
Ahmad F, Tufa DM, Mishra N, Jacobs R, Schmidt RE
AIDS Res Hum Retroviruses 2015 Dec;31(12):1206-12. Epub 2015 Sep 9 doi: 10.1089/aid.2015.0115. PMID: 26352913
Abnormal distribution of peripheral lymphocyte subsets induced by PDAC modulates overall survival.
Xu YF, Lu Y, Cheng H, Shi S, Xu J, Long J, Liu L, Liu C, Yu X
Pancreatology 2014 Jul-Aug;14(4):295-301. Epub 2014 Jun 11 doi: 10.1016/j.pan.2014.05.797. PMID: 25062880
Reduction of naive CD4/CD45RA+ T cells in children with biliary atresia before and after liver transplantation.
Pawlowska J, Michalkiewicz J, Czubkowski P, Jankowska I, Teisseyre M, Socha P, Kalicinski P, Socha J
Transplant Proc 2003 Dec;35(8):3026-8. doi: 10.1016/j.transproceed.2003.10.088. PMID: 14697969

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...