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Grade 3 Peripheral Sensory Neuropathy, CTCAE

MedGen UID:
1638067
•Concept ID:
C4686433
•
Finding

Definition

Severe symptoms; limiting self care ADL [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Peripheral Sensory Neuropathy, CTCAE

Recent clinical studies

Etiology

A randomized trial to evaluate the preventive effect of lafutidine on chemotherapy-induced peripheral neuropathy in patients treated with carboplatin and paclitaxel for lung cancer.
Cho K, Saikawa H, Hashimoto T, Katagiri H, Owada Y, Yakuwa K, Fujimura I, Utsumi Y, Akiyama M, Nagashima H, Takahashi F, Maemondo M
Ann Palliat Med 2023 Nov;12(6):1136-1145. Epub 2023 Sep 18 doi: 10.21037/apm-23-90. PMID: 37731302
Patient-Reported Outcome Measures in Chemotherapy-Induced Peripheral Neurotoxicity: Defining Minimal and Clinically Important Changes.
Li T, Timmins HC, Trinh T, Mizrahi D, Harrison M, Horvath LG, Grimison P, Friedlander M, Kiernan MC, King MT, Rutherford C, Goldstein D, Park SB
J Natl Compr Canc Netw 2023 Feb;21(2):125-132.e3. doi: 10.6004/jnccn.2022.7074. PMID: 36791763
Association between Genetic Variants and Peripheral Neuropathy in Patients with NSCLC Treated with First-Line Platinum-Based Therapy.
de Jong C, Herder GJM, van Haarlem SWA, van der Meer FS, van Lindert ASR, Ten Heuvel A, Brouwer J, Egberts TCG, Deneer VHM
Genes (Basel) 2023 Jan 7;14(1) doi: 10.3390/genes14010170. PMID: 36672910Free PMC Article
Effectiveness of Acupuncture Treatment on Chemotherapy-Induced Peripheral Neuropathy: A Pilot, Randomized, Assessor-Blinded, Controlled Trial.
Iravani S, Kazemi Motlagh AH, Emami Razavi SZ, Shahi F, Wang J, Hou L, Sun W, Afshari Fard MR, Aghili M, Karimi M, Rezaeizadeh H, Zhao B
Pain Res Manag 2020;2020:2504674. Epub 2020 Jun 29 doi: 10.1155/2020/2504674. PMID: 32676134Free PMC Article
Evaluation of chemotherapy-induced peripheral neuropathy using current perception threshold and clinical evaluations.
Griffith KA, Couture DJ, Zhu S, Pandya N, Johantgen ME, Cavaletti G, Davenport JM, Tanguay LJ, Choflet A, Milliron T, Glass E, Gambill N, Renn CL, Dorsey SG
Support Care Cancer 2014 May;22(5):1161-9. Epub 2013 Dec 21 doi: 10.1007/s00520-013-2068-0. PMID: 24362842Free PMC Article

Diagnosis

Patient-Reported Outcome Measures in Chemotherapy-Induced Peripheral Neurotoxicity: Defining Minimal and Clinically Important Changes.
Li T, Timmins HC, Trinh T, Mizrahi D, Harrison M, Horvath LG, Grimison P, Friedlander M, Kiernan MC, King MT, Rutherford C, Goldstein D, Park SB
J Natl Compr Canc Netw 2023 Feb;21(2):125-132.e3. doi: 10.6004/jnccn.2022.7074. PMID: 36791763
Association of electrochemical skin conductance with neuropathy in chemotherapy-treated patients.
Mahfouz FM, Park SB, Li T, Timmins HC, Horvath LG, Harrison M, Grimison P, King T, Goldstein D, Mizrahi D
Clin Auton Res 2022 Dec;32(6):497-506. Epub 2022 Sep 21 doi: 10.1007/s10286-022-00895-w. PMID: 36129622Free PMC Article
Time-dependent discrepancies between physician-assessed and patient-reported oxaliplatin-induced peripheral neuropathy in patients with metastatic colorectal cancer who received mFOLFOX6 plus bevacizumab: a post hoc analysis (WJOG4407GSS2).
Miura Y, Ando M, Yamazaki K, Hironaka S, Boku N, Muro K, Hyodo I
Support Care Cancer 2021 Jul;29(7):3715-3723. Epub 2020 Nov 16 doi: 10.1007/s00520-020-05891-2. PMID: 33200233
Patterns and severity of vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia.
Lavoie Smith EM, Li L, Chiang C, Thomas K, Hutchinson RJ, Wells EM, Ho RH, Skiles J, Chakraborty A, Bridges CM, Renbarger J
J Peripher Nerv Syst 2015 Mar;20(1):37-46. doi: 10.1111/jns.12114. PMID: 25977177Free PMC Article
Evaluation of chemotherapy-induced peripheral neuropathy using current perception threshold and clinical evaluations.
Griffith KA, Couture DJ, Zhu S, Pandya N, Johantgen ME, Cavaletti G, Davenport JM, Tanguay LJ, Choflet A, Milliron T, Glass E, Gambill N, Renn CL, Dorsey SG
Support Care Cancer 2014 May;22(5):1161-9. Epub 2013 Dec 21 doi: 10.1007/s00520-013-2068-0. PMID: 24362842Free PMC Article

Therapy

A randomized trial to evaluate the preventive effect of lafutidine on chemotherapy-induced peripheral neuropathy in patients treated with carboplatin and paclitaxel for lung cancer.
Cho K, Saikawa H, Hashimoto T, Katagiri H, Owada Y, Yakuwa K, Fujimura I, Utsumi Y, Akiyama M, Nagashima H, Takahashi F, Maemondo M
Ann Palliat Med 2023 Nov;12(6):1136-1145. Epub 2023 Sep 18 doi: 10.21037/apm-23-90. PMID: 37731302
Patient-Reported Outcome Measures in Chemotherapy-Induced Peripheral Neurotoxicity: Defining Minimal and Clinically Important Changes.
Li T, Timmins HC, Trinh T, Mizrahi D, Harrison M, Horvath LG, Grimison P, Friedlander M, Kiernan MC, King MT, Rutherford C, Goldstein D, Park SB
J Natl Compr Canc Netw 2023 Feb;21(2):125-132.e3. doi: 10.6004/jnccn.2022.7074. PMID: 36791763
Association between Genetic Variants and Peripheral Neuropathy in Patients with NSCLC Treated with First-Line Platinum-Based Therapy.
de Jong C, Herder GJM, van Haarlem SWA, van der Meer FS, van Lindert ASR, Ten Heuvel A, Brouwer J, Egberts TCG, Deneer VHM
Genes (Basel) 2023 Jan 7;14(1) doi: 10.3390/genes14010170. PMID: 36672910Free PMC Article
Taxane-induced peripheral neuropathy and quality of life in breast cancer patients.
Salehifar E, Janbabaei G, Alipour A, Tabrizi N, Avan R
J Oncol Pharm Pract 2020 Sep;26(6):1421-1428. Epub 2020 Jan 14 doi: 10.1177/1078155219898511. PMID: 31937190
Patterns and severity of vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia.
Lavoie Smith EM, Li L, Chiang C, Thomas K, Hutchinson RJ, Wells EM, Ho RH, Skiles J, Chakraborty A, Bridges CM, Renbarger J
J Peripher Nerv Syst 2015 Mar;20(1):37-46. doi: 10.1111/jns.12114. PMID: 25977177Free PMC Article

Prognosis

Association between Genetic Variants and Peripheral Neuropathy in Patients with NSCLC Treated with First-Line Platinum-Based Therapy.
de Jong C, Herder GJM, van Haarlem SWA, van der Meer FS, van Lindert ASR, Ten Heuvel A, Brouwer J, Egberts TCG, Deneer VHM
Genes (Basel) 2023 Jan 7;14(1) doi: 10.3390/genes14010170. PMID: 36672910Free PMC Article
Association of electrochemical skin conductance with neuropathy in chemotherapy-treated patients.
Mahfouz FM, Park SB, Li T, Timmins HC, Horvath LG, Harrison M, Grimison P, King T, Goldstein D, Mizrahi D
Clin Auton Res 2022 Dec;32(6):497-506. Epub 2022 Sep 21 doi: 10.1007/s10286-022-00895-w. PMID: 36129622Free PMC Article
Predictors of the development of nab-paclitaxel-induced peripheral neuropathy in breast cancer patients: post hoc analysis of a prospective, phase II, self-controlled clinical trial.
Kanbayashi Y, Sakaguchi K, Ishikawa T, Tabuchi Y, Takagi R, Yokota I, Katoh N, Takayama K, Taguchi T
Med Oncol 2022 Jul 19;39(10):153. doi: 10.1007/s12032-022-01754-4. PMID: 35852641
Taxane-induced peripheral neuropathy and quality of life in breast cancer patients.
Salehifar E, Janbabaei G, Alipour A, Tabrizi N, Avan R
J Oncol Pharm Pract 2020 Sep;26(6):1421-1428. Epub 2020 Jan 14 doi: 10.1177/1078155219898511. PMID: 31937190
Taxane-induced peripheral neuropathy has good long-term prognosis: a 1- to 13-year evaluation.
Osmani K, Vignes S, Aissi M, Wade F, Milani P, Lévy BI, Kubis N
J Neurol 2012 Sep;259(9):1936-43. Epub 2012 Feb 17 doi: 10.1007/s00415-012-6442-5. PMID: 22349867

Clinical prediction guides

A randomized trial to evaluate the preventive effect of lafutidine on chemotherapy-induced peripheral neuropathy in patients treated with carboplatin and paclitaxel for lung cancer.
Cho K, Saikawa H, Hashimoto T, Katagiri H, Owada Y, Yakuwa K, Fujimura I, Utsumi Y, Akiyama M, Nagashima H, Takahashi F, Maemondo M
Ann Palliat Med 2023 Nov;12(6):1136-1145. Epub 2023 Sep 18 doi: 10.21037/apm-23-90. PMID: 37731302
Patient-Reported Outcome Measures in Chemotherapy-Induced Peripheral Neurotoxicity: Defining Minimal and Clinically Important Changes.
Li T, Timmins HC, Trinh T, Mizrahi D, Harrison M, Horvath LG, Grimison P, Friedlander M, Kiernan MC, King MT, Rutherford C, Goldstein D, Park SB
J Natl Compr Canc Netw 2023 Feb;21(2):125-132.e3. doi: 10.6004/jnccn.2022.7074. PMID: 36791763
Association between Genetic Variants and Peripheral Neuropathy in Patients with NSCLC Treated with First-Line Platinum-Based Therapy.
de Jong C, Herder GJM, van Haarlem SWA, van der Meer FS, van Lindert ASR, Ten Heuvel A, Brouwer J, Egberts TCG, Deneer VHM
Genes (Basel) 2023 Jan 7;14(1) doi: 10.3390/genes14010170. PMID: 36672910Free PMC Article
Association of electrochemical skin conductance with neuropathy in chemotherapy-treated patients.
Mahfouz FM, Park SB, Li T, Timmins HC, Horvath LG, Harrison M, Grimison P, King T, Goldstein D, Mizrahi D
Clin Auton Res 2022 Dec;32(6):497-506. Epub 2022 Sep 21 doi: 10.1007/s10286-022-00895-w. PMID: 36129622Free PMC Article
Predictors of the development of nab-paclitaxel-induced peripheral neuropathy in breast cancer patients: post hoc analysis of a prospective, phase II, self-controlled clinical trial.
Kanbayashi Y, Sakaguchi K, Ishikawa T, Tabuchi Y, Takagi R, Yokota I, Katoh N, Takayama K, Taguchi T
Med Oncol 2022 Jul 19;39(10):153. doi: 10.1007/s12032-022-01754-4. PMID: 35852641

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