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Recurrent BRCA- Associated Ovarian Carcinoma

MedGen UID:
1637849
Concept ID:
C4688332
Neoplastic Process
Synonym: Recurrent BRCA-Mutated Ovarian Carcinoma

Definition

The reemergence of BRCA-associated ovarian carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent BRCA- Associated Ovarian Carcinoma

Professional guidelines

PubMed

Washington CR, Richardson DL, Moore KN
Future Oncol 2019 Oct;15(30):3435-3449. Epub 2019 Sep 3 doi: 10.2217/fon-2019-0271. PMID: 31478762
Matulonis UA
Clin Adv Hematol Oncol 2018 Jun;16(6):426-437. PMID: 30067614
Pignata S, C Cecere S, Du Bois A, Harter P, Heitz F
Ann Oncol 2017 Nov 1;28(suppl_8):viii51-viii56. doi: 10.1093/annonc/mdx441. PMID: 29232464

Recent clinical studies

Etiology

Tutt ANJ, Garber JE, Kaufman B, Viale G, Fumagalli D, Rastogi P, Gelber RD, de Azambuja E, Fielding A, Balmaña J, Domchek SM, Gelmon KA, Hollingsworth SJ, Korde LA, Linderholm B, Bandos H, Senkus E, Suga JM, Shao Z, Pippas AW, Nowecki Z, Huzarski T, Ganz PA, Lucas PC, Baker N, Loibl S, McConnell R, Piccart M, Schmutzler R, Steger GG, Costantino JP, Arahmani A, Wolmark N, McFadden E, Karantza V, Lakhani SR, Yothers G, Campbell C, Geyer CE Jr; OlympiA Clinical Trial Steering Committee and Investigators
N Engl J Med 2021 Jun 24;384(25):2394-2405. Epub 2021 Jun 3 doi: 10.1056/NEJMoa2105215. PMID: 34081848Free PMC Article
González-Martín A, Pothuri B, Vergote I, DePont Christensen R, Graybill W, Mirza MR, McCormick C, Lorusso D, Hoskins P, Freyer G, Baumann K, Jardon K, Redondo A, Moore RG, Vulsteke C, O'Cearbhaill RE, Lund B, Backes F, Barretina-Ginesta P, Haggerty AF, Rubio-Pérez MJ, Shahin MS, Mangili G, Bradley WH, Bruchim I, Sun K, Malinowska IA, Li Y, Gupta D, Monk BJ; PRIMA/ENGOT-OV26/GOG-3012 Investigators
N Engl J Med 2019 Dec 19;381(25):2391-2402. Epub 2019 Sep 28 doi: 10.1056/NEJMoa1910962. PMID: 31562799
Stewart C, Ralyea C, Lockwood S
Semin Oncol Nurs 2019 Apr;35(2):151-156. Epub 2019 Mar 11 doi: 10.1016/j.soncn.2019.02.001. PMID: 30867104
Mittica G, Ghisoni E, Giannone G, Genta S, Aglietta M, Sapino A, Valabrega G
Recent Pat Anticancer Drug Discov 2018;13(4):392-410. doi: 10.2174/1574892813666180305165256. PMID: 29512470
Mirza MR, Monk BJ, Herrstedt J, Oza AM, Mahner S, Redondo A, Fabbro M, Ledermann JA, Lorusso D, Vergote I, Ben-Baruch NE, Marth C, Mądry R, Christensen RD, Berek JS, Dørum A, Tinker AV, du Bois A, González-Martín A, Follana P, Benigno B, Rosenberg P, Gilbert L, Rimel BJ, Buscema J, Balser JP, Agarwal S, Matulonis UA; ENGOT-OV16/NOVA Investigators
N Engl J Med 2016 Dec 1;375(22):2154-2164. Epub 2016 Oct 7 doi: 10.1056/NEJMoa1611310. PMID: 27717299

Diagnosis

González-Martín A, Pothuri B, Vergote I, DePont Christensen R, Graybill W, Mirza MR, McCormick C, Lorusso D, Hoskins P, Freyer G, Baumann K, Jardon K, Redondo A, Moore RG, Vulsteke C, O'Cearbhaill RE, Lund B, Backes F, Barretina-Ginesta P, Haggerty AF, Rubio-Pérez MJ, Shahin MS, Mangili G, Bradley WH, Bruchim I, Sun K, Malinowska IA, Li Y, Gupta D, Monk BJ; PRIMA/ENGOT-OV26/GOG-3012 Investigators
N Engl J Med 2019 Dec 19;381(25):2391-2402. Epub 2019 Sep 28 doi: 10.1056/NEJMoa1910962. PMID: 31562799
Stewart C, Ralyea C, Lockwood S
Semin Oncol Nurs 2019 Apr;35(2):151-156. Epub 2019 Mar 11 doi: 10.1016/j.soncn.2019.02.001. PMID: 30867104
Mittica G, Ghisoni E, Giannone G, Genta S, Aglietta M, Sapino A, Valabrega G
Recent Pat Anticancer Drug Discov 2018;13(4):392-410. doi: 10.2174/1574892813666180305165256. PMID: 29512470
Coleman RL, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Colombo N, Weberpals JI, Clamp A, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Garcia-Donas J, Swisher EM, Floquet A, Konecny GE, McNeish IA, Scott CL, Cameron T, Maloney L, Isaacson J, Goble S, Grace C, Harding TC, Raponi M, Sun J, Lin KK, Giordano H, Ledermann JA; ARIEL3 investigators
Lancet 2017 Oct 28;390(10106):1949-1961. Epub 2017 Sep 12 doi: 10.1016/S0140-6736(17)32440-6. PMID: 28916367Free PMC Article
Mirza MR, Monk BJ, Herrstedt J, Oza AM, Mahner S, Redondo A, Fabbro M, Ledermann JA, Lorusso D, Vergote I, Ben-Baruch NE, Marth C, Mądry R, Christensen RD, Berek JS, Dørum A, Tinker AV, du Bois A, González-Martín A, Follana P, Benigno B, Rosenberg P, Gilbert L, Rimel BJ, Buscema J, Balser JP, Agarwal S, Matulonis UA; ENGOT-OV16/NOVA Investigators
N Engl J Med 2016 Dec 1;375(22):2154-2164. Epub 2016 Oct 7 doi: 10.1056/NEJMoa1611310. PMID: 27717299

Therapy

Tutt ANJ, Garber JE, Kaufman B, Viale G, Fumagalli D, Rastogi P, Gelber RD, de Azambuja E, Fielding A, Balmaña J, Domchek SM, Gelmon KA, Hollingsworth SJ, Korde LA, Linderholm B, Bandos H, Senkus E, Suga JM, Shao Z, Pippas AW, Nowecki Z, Huzarski T, Ganz PA, Lucas PC, Baker N, Loibl S, McConnell R, Piccart M, Schmutzler R, Steger GG, Costantino JP, Arahmani A, Wolmark N, McFadden E, Karantza V, Lakhani SR, Yothers G, Campbell C, Geyer CE Jr; OlympiA Clinical Trial Steering Committee and Investigators
N Engl J Med 2021 Jun 24;384(25):2394-2405. Epub 2021 Jun 3 doi: 10.1056/NEJMoa2105215. PMID: 34081848Free PMC Article
González-Martín A, Pothuri B, Vergote I, DePont Christensen R, Graybill W, Mirza MR, McCormick C, Lorusso D, Hoskins P, Freyer G, Baumann K, Jardon K, Redondo A, Moore RG, Vulsteke C, O'Cearbhaill RE, Lund B, Backes F, Barretina-Ginesta P, Haggerty AF, Rubio-Pérez MJ, Shahin MS, Mangili G, Bradley WH, Bruchim I, Sun K, Malinowska IA, Li Y, Gupta D, Monk BJ; PRIMA/ENGOT-OV26/GOG-3012 Investigators
N Engl J Med 2019 Dec 19;381(25):2391-2402. Epub 2019 Sep 28 doi: 10.1056/NEJMoa1910962. PMID: 31562799
Mittica G, Ghisoni E, Giannone G, Genta S, Aglietta M, Sapino A, Valabrega G
Recent Pat Anticancer Drug Discov 2018;13(4):392-410. doi: 10.2174/1574892813666180305165256. PMID: 29512470
Coleman RL, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Colombo N, Weberpals JI, Clamp A, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Garcia-Donas J, Swisher EM, Floquet A, Konecny GE, McNeish IA, Scott CL, Cameron T, Maloney L, Isaacson J, Goble S, Grace C, Harding TC, Raponi M, Sun J, Lin KK, Giordano H, Ledermann JA; ARIEL3 investigators
Lancet 2017 Oct 28;390(10106):1949-1961. Epub 2017 Sep 12 doi: 10.1016/S0140-6736(17)32440-6. PMID: 28916367Free PMC Article
Mirza MR, Monk BJ, Herrstedt J, Oza AM, Mahner S, Redondo A, Fabbro M, Ledermann JA, Lorusso D, Vergote I, Ben-Baruch NE, Marth C, Mądry R, Christensen RD, Berek JS, Dørum A, Tinker AV, du Bois A, González-Martín A, Follana P, Benigno B, Rosenberg P, Gilbert L, Rimel BJ, Buscema J, Balser JP, Agarwal S, Matulonis UA; ENGOT-OV16/NOVA Investigators
N Engl J Med 2016 Dec 1;375(22):2154-2164. Epub 2016 Oct 7 doi: 10.1056/NEJMoa1611310. PMID: 27717299

Prognosis

Shah JB, Pueschl D, Wubbenhorst B, Fan M, Pluta J, D'Andrea K, Hubert AP, Shilan JS, Zhou W, Kraya AA, Llop Guevara A, Ruan C, Serra V, Balmaña J, Feldman M, Morin PJ, Nayak A, Maxwell KN, Domchek SM, Nathanson KL
Nat Commun 2022 Nov 7;13(1):6728. doi: 10.1038/s41467-022-34523-y. PMID: 36344544Free PMC Article
Wang YA, Jian JW, Hung CF, Peng HP, Yang CF, Cheng HS, Yang AS
BMC Cancer 2018 Mar 22;18(1):315. doi: 10.1186/s12885-018-4229-5. PMID: 29566657Free PMC Article
Mittica G, Ghisoni E, Giannone G, Genta S, Aglietta M, Sapino A, Valabrega G
Recent Pat Anticancer Drug Discov 2018;13(4):392-410. doi: 10.2174/1574892813666180305165256. PMID: 29512470
Ray-Coquard I
Future Oncol 2017 Oct;13(23s):17-21. Epub 2017 Oct 11 doi: 10.2217/fon-2017-0318. PMID: 29020822
Coleman RL, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Colombo N, Weberpals JI, Clamp A, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Garcia-Donas J, Swisher EM, Floquet A, Konecny GE, McNeish IA, Scott CL, Cameron T, Maloney L, Isaacson J, Goble S, Grace C, Harding TC, Raponi M, Sun J, Lin KK, Giordano H, Ledermann JA; ARIEL3 investigators
Lancet 2017 Oct 28;390(10106):1949-1961. Epub 2017 Sep 12 doi: 10.1016/S0140-6736(17)32440-6. PMID: 28916367Free PMC Article

Clinical prediction guides

Shah JB, Pueschl D, Wubbenhorst B, Fan M, Pluta J, D'Andrea K, Hubert AP, Shilan JS, Zhou W, Kraya AA, Llop Guevara A, Ruan C, Serra V, Balmaña J, Feldman M, Morin PJ, Nayak A, Maxwell KN, Domchek SM, Nathanson KL
Nat Commun 2022 Nov 7;13(1):6728. doi: 10.1038/s41467-022-34523-y. PMID: 36344544Free PMC Article
Paik ES, Heo EJ, Choi CH, Kim JH, Kim JW, Kim YM, Park SY, Lee JW, Kim JW, Kim BG
Cancer Sci 2021 Dec;112(12):5055-5067. Epub 2021 Oct 25 doi: 10.1111/cas.15166. PMID: 34657357Free PMC Article
Li A, Xie R, Zhi Q, Deng Y, Wu Y, Li W, Yang L, Jiao Z, Luo J, Zi Y, Sun G, Zhang J, Shi Y, Liu J
Gynecol Oncol 2018 Oct;151(1):145-152. Epub 2018 Aug 2 doi: 10.1016/j.ygyno.2018.07.024. PMID: 30078507
Mittica G, Ghisoni E, Giannone G, Genta S, Aglietta M, Sapino A, Valabrega G
Recent Pat Anticancer Drug Discov 2018;13(4):392-410. doi: 10.2174/1574892813666180305165256. PMID: 29512470
Ray-Coquard I
Future Oncol 2017 Oct;13(23s):17-21. Epub 2017 Oct 11 doi: 10.2217/fon-2017-0318. PMID: 29020822

Recent systematic reviews

Batalini F, DaSilva LL, Campoverde L, Comini ACM, Carvalho BM, Nogueira W, Silveira H, Ernst BJ, Mina LA
Chin Clin Oncol 2023 Jun;12(3):21. Epub 2023 May 15 doi: 10.21037/cco-22-114. PMID: 37211773
Huber D, Seitz S, Kast K, Emons G, Ortmann O
Arch Gynecol Obstet 2020 Sep;302(3):715-720. Epub 2020 Jul 27 doi: 10.1007/s00404-020-05690-4. PMID: 32719921Free PMC Article
Ruscito I, Bellati F, Ray-Coquard I, Mirza MR, du Bois A, Gasparri ML, Costanzi F, De Marco MP, Nuti M, Caserta D, Pignata S, Dorigo O, Sehouli J, Braicu EI
Cancer Treat Rev 2020 Jul;87:102040. Epub 2020 May 26 doi: 10.1016/j.ctrv.2020.102040. PMID: 32485510
Co M, Liu T, Leung J, Li CH, Tse T, Wong M, Kwong A
Clin Breast Cancer 2020 Jun;20(3):e244-e250. Epub 2019 Aug 22 doi: 10.1016/j.clbc.2019.07.014. PMID: 32144082
Van der Hoeven NMA, Van Wijk K, Bonfrer SE, Beltman JJ, Louwe LA, De Kroon CD, Van Asperen CJ, Gaarenstroom KN
Clin Oncol (R Coll Radiol) 2018 Aug;30(8):463-471. Epub 2018 Apr 22 doi: 10.1016/j.clon.2018.03.036. PMID: 29691126

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