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Appendiceal neoplasm

MedGen UID:: 1629
•Concept ID:: C0003614
•: Neoplastic Process

Synonyms:	Appendiceal Neoplasm; Appendiceal Neoplasms; Neoplasm, Appendiceal; Neoplasms, Appendiceal
SNOMED CT:	Neoplasm of appendix (126846004); Appendiceal tumor (126846004); Tumor of appendix (126846004)

Monarch Initiative:	MONDO:0001236

Definition

A benign or malignant neoplasm involving the appendix. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAppendiceal neoplasm

Disease
- Disorder by Site
  - Disorder of gastrointestinal tract
    - Intestinal disorder
      - Cecal disorder
        Cecal neoplasm
        Appendiceal neoplasm
        Appendix cancer
        Appendix carcinoma
        Appendix adenocarcinoma
        Appendix Carcinoma by AJCC v7 Stage
        Appendix Carcinoma by AJCC v8 Stage
        Appendix Mixed Adenoneuroendocrine Carcinoma
        Appendix Neuroendocrine Carcinoma
        Appendix Undifferentiated Carcinoma
        Metastatic Appendix Carcinoma
        Recurrent Appendix Carcinoma
        Refractory Appendix Carcinoma
        Appendix Kaposi Sarcoma
        Appendix Leiomyosarcoma
        Appendix lymphoma
        Appendix Intraepithelial Neoplasia
        Appendix High Grade Intraepithelial Neoplasia
        Appendix Low Grade Intraepithelial Neoplasia
        Appendix Mucinous Neoplasm
        High Grade Appendix Mucinous Neoplasm
        Low Grade Appendix Mucinous Neoplasm
        Stage 0 Low Grade Appendix Mucinous Neoplasm (LAMN) AJCC v8
        Appendix neuroendocrine neoplasm
        Neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade
        Appendix Enterochromaffin Cell Serotonin-Producing Neuroendocrine Tumor
        Appendix L-cell glucagon-like peptide-producing neuroendocrine tumor
        Appendix Neuroendocrine Tumor by AJCC v7 Stage
        Appendix Neuroendocrine Tumor by AJCC v8 Stage
        Appendix neuroendocrine tumor G1
        Appendix Neuroendocrine Tumor G2
        Appendix Neuroendocrine Tumor G3
        Appendix Tubular Carcinoid
        Classic neuroendocrine tumor of appendix
        Goblet cell carcinoma
        Benign neoplasm of appendix
        Appendix adenoma
        Appendix Mucinous Cystadenoma
        Appendix Serrated Lesions and Polyps
        Appendix Traditional Serrated Adenoma
        Appendix Tubular Adenoma
        Appendix Tubulovillous Adenoma
        Appendix villous adenoma
        Appendix leiomyoma
        Appendix Lipoma

Professional guidelines

PubMed

Treatment Variation and Long-Term Outcomes of Low-Grade Appendiceal Neoplasms.

White MG, Bhutiani N, Helmink BA, Taggart M, Foo WC, Mansfield PF, Fournier KF, Scally CP
Ann Surg Oncol 2023 Dec;30(13):8138-8143. Epub 2023 Sep 13 doi: 10.1245/s10434-023-13501-8. PMID: 37702905

Diagnostic and therapeutic laparoscopy in assessment and management of patients with appendiceal neoplasms.

Tan GHC, Shamji T, Mehta A, Chandrakumaran K, Dayal S, Mohamed F, Carr NJ, Rowaiye B, Cecil T, Moran BJ
Int J Hyperthermia 2018 May;34(3):336-340. Epub 2017 Jun 28 doi: 10.1080/02656736.2017.1338363. PMID: 28605985

Mucinous appendiceal neoplasms: Incidence, diagnosis and surgical treatment.

Nutu OA, Marcacuzco Quinto AA, Manrique Municio A, Justo Alonso I, Calvo Pulido J, García-Conde M, Cambra Molero F, Jiménez Romero LC
Cir Esp 2017 Jun-Jul;95(6):321-327. Epub 2017 Jun 24 doi: 10.1016/j.ciresp.2017.05.008. PMID: 28655402

See all (11)

Recent clinical studies

Etiology

Appendiceal neoplasms-A practical guide.

Rossi A, Maloney Patel N
J Surg Oncol 2023 Jun;127(8):1300-1305. doi: 10.1002/jso.27304. PMID: 37222692

Lymph node positive pseudomyxoma peritonei.

Sugarbaker PH, Chang D
Eur J Surg Oncol 2022 Dec;48(12):2369-2377. Epub 2022 Jul 31 doi: 10.1016/j.ejso.2022.07.018. PMID: 35941031

Risk of appendiceal neoplasm after interval appendectomy for complicated appendicitis: A systematic review and meta-analysis.

Peltrini R, Cantoni V, Green R, Lionetti R, D'Ambra M, Bartolini C, De Luca M, Bracale U, Cuocolo A, Corcione F
Surgeon 2021 Dec;19(6):e549-e558. Epub 2021 Feb 25 doi: 10.1016/j.surge.2021.01.010. PMID: 33640282

A retrospective analysis and literature review of neoplastic appendiceal mucinous lesions.

Matias-García B, Mendoza-Moreno F, Blasco-Martínez A, Busteros-Moraza JI, Diez-Alonso M, Garcia-Moreno Nisa F
BMC Surg 2021 Feb 11;21(1):79. doi: 10.1186/s12893-021-01091-9. PMID: 33573654 Free PMC Article

Outcomes from cytoreduction and hyperthermic intraperitoneal chemotherapy for appendiceal epithelial neoplasms.

Narasimhan V, Pham T, Warrier S, Craig Lynch A, Michael M, Tie J, Ramsay R, Heriot A
ANZ J Surg 2019 Sep;89(9):1035-1040. Epub 2019 Jan 26 doi: 10.1111/ans.14985. PMID: 30685879

See all (85)

Diagnosis

Lymph node positive pseudomyxoma peritonei.

Sugarbaker PH, Chang D
Eur J Surg Oncol 2022 Dec;48(12):2369-2377. Epub 2022 Jul 31 doi: 10.1016/j.ejso.2022.07.018. PMID: 35941031

Appendicitis and beyond: a pictorial review of various appendiceal abnormalities.

Fenwick AKC, Hartery A
Emerg Radiol 2021 Jun;28(3):651-664. Epub 2021 Jan 31 doi: 10.1007/s10140-021-01908-3. PMID: 33517502

Updates in Appendix Pathology: The Precarious Cutting Edge.

Carr NJ
Surg Pathol Clin 2020 Sep;13(3):469-484. Epub 2020 Jul 11 doi: 10.1016/j.path.2020.05.006. PMID: 32773195

Mucinous appendiceal neoplasms with or without pseudomyxoma peritonei: a review.

Soucisse ML, Lansom J, Alshahrani MS, Morris DL
ANZ J Surg 2020 Oct;90(10):1888-1894. Epub 2020 Aug 5 doi: 10.1111/ans.16185. PMID: 32761790

Mucinous appendiceal neoplasms: pathologic classification, clinical implications, imaging spectrum and mimics.

Van Hooser A, Williams TR, Myers DT
Abdom Radiol (NY) 2018 Nov;43(11):2913-2922. doi: 10.1007/s00261-018-1561-9. PMID: 29564494

See all (83)

Therapy

Incidence rate and histology of appendiceal neoplasms in complicated versus uncomplicated appendicitis: A meta-analysis and systematic review.

Solis-Pazmino P, Oka K, La K, Termeie O, Figueroa LA, Pilatuna E, Solis-Pazmino D, Harnegie MP, Cohen J, Barnajian M, Nasseri Y
Langenbecks Arch Surg 2023 Nov 9;408(1):432. doi: 10.1007/s00423-023-03164-0. PMID: 37940770 Free PMC Article

The association between appendicitis severity and patient age with appendiceal neoplasm histology-a population-based study.

Alajääski J, Lietzén E, Grönroos JM, Mecklin JP, Leppäniemi A, Nordström P, Rautio T, Rantanen T, Sand J, Paajanen H, Ollila H, Salminen P
Int J Colorectal Dis 2022 May;37(5):1173-1180. Epub 2022 Apr 26 doi: 10.1007/s00384-022-04132-8. PMID: 35474547 Free PMC Article

Risk of appendiceal neoplasm after interval appendectomy for complicated appendicitis: A systematic review and meta-analysis.

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal and appendiceal peritoneal metastases - The Hong Kong experience and literature review.

Chow FC, Yip J, Foo DC, Wei R, Choi HK, Ng KK, Lo OS
Asian J Surg 2021 Jan;44(1):221-228. Epub 2020 Jun 27 doi: 10.1016/j.asjsur.2020.05.010. PMID: 32605790

Outcomes from cytoreduction and hyperthermic intraperitoneal chemotherapy for appendiceal epithelial neoplasms.

Narasimhan V, Pham T, Warrier S, Craig Lynch A, Michael M, Tie J, Ramsay R, Heriot A
ANZ J Surg 2019 Sep;89(9):1035-1040. Epub 2019 Jan 26 doi: 10.1111/ans.14985. PMID: 30685879

See all (34)

Prognosis

Appendiceal neoplasms-A practical guide.

Rossi A, Maloney Patel N
J Surg Oncol 2023 Jun;127(8):1300-1305. doi: 10.1002/jso.27304. PMID: 37222692

Lymph node positive pseudomyxoma peritonei.

Sugarbaker PH, Chang D
Eur J Surg Oncol 2022 Dec;48(12):2369-2377. Epub 2022 Jul 31 doi: 10.1016/j.ejso.2022.07.018. PMID: 35941031

Updates in Appendix Pathology: The Precarious Cutting Edge.

Carr NJ
Surg Pathol Clin 2020 Sep;13(3):469-484. Epub 2020 Jul 11 doi: 10.1016/j.path.2020.05.006. PMID: 32773195

Mucinous appendiceal neoplasms: classification, imaging, and HIPEC.

Bartlett DJ, Thacker PG Jr, Grotz TE, Graham RP, Fletcher JG, VanBuren WM, Iyer VR, Fidler JL, Menias CO, Wasif N, Sheedy SP
Abdom Radiol (NY) 2019 May;44(5):1686-1702. doi: 10.1007/s00261-018-01888-y. PMID: 30610247

Mucinous appendiceal neoplasms: pathologic classification, clinical implications, imaging spectrum and mimics.

Van Hooser A, Williams TR, Myers DT
Abdom Radiol (NY) 2018 Nov;43(11):2913-2922. doi: 10.1007/s00261-018-1561-9. PMID: 29564494

See all (70)

Clinical prediction guides

A retrospective analysis and literature review of neoplastic appendiceal mucinous lesions.

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal and appendiceal peritoneal metastases - The Hong Kong experience and literature review.

Chow FC, Yip J, Foo DC, Wei R, Choi HK, Ng KK, Lo OS
Asian J Surg 2021 Jan;44(1):221-228. Epub 2020 Jun 27 doi: 10.1016/j.asjsur.2020.05.010. PMID: 32605790

Risk factors for appendiceal neoplasm and malignancy among patients with acute appendicitis.

Brunner M, Lapins P, Langheinrich M, Baecker J, Krautz C, Kersting S, Weber GF, Grützmann R, Maak M
Int J Colorectal Dis 2020 Jan;35(1):157-163. Epub 2019 Dec 6 doi: 10.1007/s00384-019-03453-5. PMID: 31811385

Clinical characteristics of appendiceal diverticular disease.

Çakar E, Bayrak S, Çolak Ş, Dal F, Gürbulak B, Bektaş H, Yarıkkaya E, Ferlengez AG
Int J Colorectal Dis 2019 Dec;34(12):2035-2041. Epub 2019 Nov 4 doi: 10.1007/s00384-019-03410-2. PMID: 31686198

Outcomes from cytoreduction and hyperthermic intraperitoneal chemotherapy for appendiceal epithelial neoplasms.

Narasimhan V, Pham T, Warrier S, Craig Lynch A, Michael M, Tie J, Ramsay R, Heriot A
ANZ J Surg 2019 Sep;89(9):1035-1040. Epub 2019 Jan 26 doi: 10.1111/ans.14985. PMID: 30685879

See all (47)

Recent systematic reviews

Incidence rate and histology of appendiceal neoplasms in complicated versus uncomplicated appendicitis: A meta-analysis and systematic review.

Efficacy and safety in the use of intraperitoneal hyperthermia chemotherapy and peritoneal cytoreductive surgery for pseudomyxoma peritonei from appendiceal neoplasm: A systematic review.

Floriano I, Silvinato A, Reis JC, Cafalli C, Bernardo WM
Clinics (Sao Paulo) 2022;77:100039. Epub 2022 May 13 doi: 10.1016/j.clinsp.2022.100039. PMID: 35576869 Free PMC Article

Risk of appendiceal neoplasm after interval appendectomy for complicated appendicitis: A systematic review and meta-analysis.

Acute appendicitis, inflammatory appendiceal mass and the risk of a hidden malignant tumor: a systematic review of the literature.

Teixeira FJR Jr, Couto Netto SDD, Akaishi EH, Utiyama EM, Menegozzo CAM, Rocha MC
World J Emerg Surg 2017;12:12. Epub 2017 Mar 9 doi: 10.1186/s13017-017-0122-9. PMID: 28286544 Free PMC Article

Management of an unexpected appendiceal neoplasm.

Murphy EM, Farquharson SM, Moran BJ
Br J Surg 2006 Jul;93(7):783-92. doi: 10.1002/bjs.5385. PMID: 16775823

See all (5)

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Appendiceal neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

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