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Elevated Human Chorionic Gonadotropin

MedGen UID:
1626442
•Concept ID:
C4526839
•
Finding
Synonyms: Elevated HCG; Elevated Human Chorionicgonadotropin

Definition

A finding indicating elevated concentrations of human chorionic gonadotropin in a sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated Human Chorionic Gonadotropin

Professional guidelines

PubMed

Diagnosis and Management of Placental Mesenchymal Disease. A Review of the Literature.
Colpaert RM, Ramseyer AM, Luu T, Quick CM, Frye LT, Magann EF
Obstet Gynecol Surv 2019 Oct;74(10):611-622. doi: 10.1097/OGX.0000000000000716. PMID: 31670834
Testicular choriocarcinoma: a rare variant that requires a unique treatment approach.
Reilley MJ, Pagliaro LC
Curr Oncol Rep 2015 Feb;17(2):2. doi: 10.1007/s11912-014-0430-0. PMID: 25645112

Recent clinical studies

Etiology

Clinicopathological characteristics and oncologic outcomes of patients with gestational trophoblastic neoplasia manifesting as isolated pulmonary lesions.
Gu Y, Liu Y, Cheng H, Wang W, Xue X, Wan X, Feng F, Yang J, Ren T, Zhao J, Jiang F, Li Y, Xiang Y
Gynecol Oncol 2024 Nov;190:28-34. Epub 2024 Aug 10 doi: 10.1016/j.ygyno.2024.07.686. PMID: 39128338
Precocious puberty due to intracranial germ cell tumors: a case-control study.
Chen H, Ni M, Xu Y, Zhong LY
Endocr Relat Cancer 2022 Oct 1;29(10):581-588. Epub 2022 Sep 2 doi: 10.1530/ERC-21-0381. PMID: 35938923
Diagnosis and Management of Placental Mesenchymal Disease. A Review of the Literature.
Colpaert RM, Ramseyer AM, Luu T, Quick CM, Frye LT, Magann EF
Obstet Gynecol Surv 2019 Oct;74(10):611-622. doi: 10.1097/OGX.0000000000000716. PMID: 31670834
Late Relapses in Stage I Testicular Cancer Patients on Surveillance.
Mortensen MS, Lauritsen J, Kier MG, Bandak M, Appelt AL, Agerbæk M, Holm NV, Kempel MM, von der Maase H, Daugaard G
Eur Urol 2016 Aug;70(2):365-71. Epub 2016 Mar 17 doi: 10.1016/j.eururo.2016.03.016. PMID: 26996661
Elevated second-trimester human chorionic gonadotropin levels in association with poor pregnancy outcome.
Wenstrom KD, Owen J, Boots LR, DuBard MB
Am J Obstet Gynecol 1994 Oct;171(4):1038-41. doi: 10.1016/0002-9378(94)90030-2. PMID: 7524322

Diagnosis

Diagnostic Challenges in Invasive Mole With 18 F-FDG PET/CT.
Minami A, Nakamoto R, Shimamura T, Kitano Y, Nakamoto Y
Clin Nucl Med 2024 Dec 1;49(12):1148-1149. Epub 2024 Jul 22 doi: 10.1097/RLU.0000000000005378. PMID: 39045720
Diagnosis and Management of Placental Mesenchymal Disease. A Review of the Literature.
Colpaert RM, Ramseyer AM, Luu T, Quick CM, Frye LT, Magann EF
Obstet Gynecol Surv 2019 Oct;74(10):611-622. doi: 10.1097/OGX.0000000000000716. PMID: 31670834
Supposed pituitary-production of human chorionic Gonadotropin induced by androgen deprivation therapy.
Yoshimura K, Nakashima Y, Sugiyama K, Kohei N, Takizawa A
Int Braz J Urol 2019 Jan-Feb;45(1):38-44. doi: 10.1590/S1677-5538.IBJU.2017.0654. PMID: 29757577Free PMC Article
Testicular choriocarcinoma: a rare variant that requires a unique treatment approach.
Reilley MJ, Pagliaro LC
Curr Oncol Rep 2015 Feb;17(2):2. doi: 10.1007/s11912-014-0430-0. PMID: 25645112
Pruritus and hyperplacentosis.
Goodlin RC, Anderson JC, Skiles TL
Obstet Gynecol 1985 Sep;66(3 Suppl):36S-38S. PMID: 4022514

Therapy

Elevated HCG and retroperitoneal adenopathy after clomiphene therapy for infertility.
Tiwari RV, Di Jiang M, Jarvi K, Hamilton R
BMJ Case Rep 2022 Apr 26;15(4) doi: 10.1136/bcr-2022-249766. PMID: 35473701Free PMC Article
Supposed pituitary-production of human chorionic Gonadotropin induced by androgen deprivation therapy.
Yoshimura K, Nakashima Y, Sugiyama K, Kohei N, Takizawa A
Int Braz J Urol 2019 Jan-Feb;45(1):38-44. doi: 10.1590/S1677-5538.IBJU.2017.0654. PMID: 29757577Free PMC Article
Low-dose aspirin for pre-eclampsia prevention in twins with elevated human chorionic gonadotropin.
Euser AG, Metz TD, Allshouse AA, Heyborne KD
J Perinatol 2016 Aug;36(8):601-5. Epub 2016 Apr 7 doi: 10.1038/jp.2016.55. PMID: 27054838Free PMC Article
Testicular choriocarcinoma: a rare variant that requires a unique treatment approach.
Reilley MJ, Pagliaro LC
Curr Oncol Rep 2015 Feb;17(2):2. doi: 10.1007/s11912-014-0430-0. PMID: 25645112
Elevated second-trimester human chorionic gonadotropin levels in association with poor pregnancy outcome.
Wenstrom KD, Owen J, Boots LR, DuBard MB
Am J Obstet Gynecol 1994 Oct;171(4):1038-41. doi: 10.1016/0002-9378(94)90030-2. PMID: 7524322

Prognosis

Diagnosis and Management of Placental Mesenchymal Disease. A Review of the Literature.
Colpaert RM, Ramseyer AM, Luu T, Quick CM, Frye LT, Magann EF
Obstet Gynecol Surv 2019 Oct;74(10):611-622. doi: 10.1097/OGX.0000000000000716. PMID: 31670834
Low-dose aspirin for pre-eclampsia prevention in twins with elevated human chorionic gonadotropin.
Euser AG, Metz TD, Allshouse AA, Heyborne KD
J Perinatol 2016 Aug;36(8):601-5. Epub 2016 Apr 7 doi: 10.1038/jp.2016.55. PMID: 27054838Free PMC Article
Testicular choriocarcinoma: a rare variant that requires a unique treatment approach.
Reilley MJ, Pagliaro LC
Curr Oncol Rep 2015 Feb;17(2):2. doi: 10.1007/s11912-014-0430-0. PMID: 25645112
Elevated second-trimester human chorionic gonadotropin levels in association with poor pregnancy outcome.
Wenstrom KD, Owen J, Boots LR, DuBard MB
Am J Obstet Gynecol 1994 Oct;171(4):1038-41. doi: 10.1016/0002-9378(94)90030-2. PMID: 7524322
Abnormal liver enzymes and human chorionic gonadotropin elevation in abdominal testicular seminoma.
Hoard TD, Lewis EL
Urology 1976 May;7(5):512-4. doi: 10.1016/0090-4295(76)90193-x. PMID: 5796

Clinical prediction guides

Clinicopathological characteristics and oncologic outcomes of patients with gestational trophoblastic neoplasia manifesting as isolated pulmonary lesions.
Gu Y, Liu Y, Cheng H, Wang W, Xue X, Wan X, Feng F, Yang J, Ren T, Zhao J, Jiang F, Li Y, Xiang Y
Gynecol Oncol 2024 Nov;190:28-34. Epub 2024 Aug 10 doi: 10.1016/j.ygyno.2024.07.686. PMID: 39128338
Diagnostic Challenges in Invasive Mole With 18 F-FDG PET/CT.
Minami A, Nakamoto R, Shimamura T, Kitano Y, Nakamoto Y
Clin Nucl Med 2024 Dec 1;49(12):1148-1149. Epub 2024 Jul 22 doi: 10.1097/RLU.0000000000005378. PMID: 39045720
Search for morphological indicators that predict implantation by principal component analysis using images of blastocyst.
Mashiko D, Tokoro M, Kojima M, Fukunaga N, Asada Y, Yamagata K
PeerJ 2022;10:e13441. Epub 2022 May 16 doi: 10.7717/peerj.13441. PMID: 35602891Free PMC Article
Supposed pituitary-production of human chorionic Gonadotropin induced by androgen deprivation therapy.
Yoshimura K, Nakashima Y, Sugiyama K, Kohei N, Takizawa A
Int Braz J Urol 2019 Jan-Feb;45(1):38-44. doi: 10.1590/S1677-5538.IBJU.2017.0654. PMID: 29757577Free PMC Article
Low-dose aspirin for pre-eclampsia prevention in twins with elevated human chorionic gonadotropin.
Euser AG, Metz TD, Allshouse AA, Heyborne KD
J Perinatol 2016 Aug;36(8):601-5. Epub 2016 Apr 7 doi: 10.1038/jp.2016.55. PMID: 27054838Free PMC Article

Recent systematic reviews

Systematic review of sonographic findings of placental mesenchymal dysplasia and subsequent pregnancy outcome.
Nayeri UA, West AB, Grossetta Nardini HK, Copel JA, Sfakianaki AK
Ultrasound Obstet Gynecol 2013 Apr;41(4):366-74. doi: 10.1002/uog.12359. PMID: 23239538

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