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Pure Erythroid Leukemia

MedGen UID:
1626382
Concept ID:
C4520841
Neoplastic Process
Synonyms: Acute Erythremic Myelosis; Acute Myeloid Leukemia M6b; Di Guglielmo Disease; Di Guglielmo's Disease; Erythremic Myelosis

Definition

Acute erythroid leukemia characterized by the presence of immature erythroid cells in the bone marrow (at least 80% of the cellular component), without evidence of a significant myeloblastic cell population present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPure Erythroid Leukemia

Professional guidelines

PubMed

Reichard KK, Tefferi A, Abdelmagid M, Orazi A, Alexandres C, Haack J, Greipp PT
Blood Cancer J 2022 Nov 2;12(11):147. doi: 10.1038/s41408-022-00746-x. PMID: 36323674Free PMC Article
Boddu P, Benton CB, Wang W, Borthakur G, Khoury JD, Pemmaraju N
Blood Rev 2018 Mar;32(2):96-105. Epub 2017 Sep 18 doi: 10.1016/j.blre.2017.09.002. PMID: 28965757Free PMC Article
Ko PS, Liu YC, Yeh CM, Gau JP, Yu YB, Hsiao LT, Tzeng CH, Chen PM, Chiou TJ, Liu CJ, Liu JH
PLoS One 2017;12(2):e0172029. Epub 2017 Feb 14 doi: 10.1371/journal.pone.0172029. PMID: 28196090Free PMC Article

Recent clinical studies

Etiology

Reinig EF, Greipp PT, Chiu A, Howard MT, Reichard KK
Mod Pathol 2018 May;31(5):705-717. Epub 2018 Jan 12 doi: 10.1038/modpathol.2017.175. PMID: 29327715
Arber DA
Curr Opin Hematol 2017 Mar;24(2):146-151. doi: 10.1097/MOH.0000000000000314. PMID: 27875373
Li H, Hasserjian RP, Kroft SH, Harrington AM, Wheaton SE, Pildain A, Ewalt MD, Gratzinger D, Hosking P, Olteanu H
Am J Clin Pathol 2016 Apr;145(4):538-51. Epub 2016 Apr 22 doi: 10.1093/ajcp/aqw033. PMID: 27124944
Wang SA, Hasserjian RP
Hum Pathol 2012 Feb;43(2):153-64. Epub 2011 Dec 9 doi: 10.1016/j.humpath.2011.08.008. PMID: 22154053
Liu W, Hasserjian RP, Hu Y, Zhang L, Miranda RN, Medeiros LJ, Wang SA
Mod Pathol 2011 Mar;24(3):375-83. Epub 2010 Nov 19 doi: 10.1038/modpathol.2010.194. PMID: 21102413

Diagnosis

Kuusanmäki H, Dufva O, Vähä-Koskela M, Leppä AM, Huuhtanen J, Vänttinen I, Nygren P, Klievink J, Bouhlal J, Pölönen P, Zhang Q, Adnan-Awad S, Mancebo-Pérez C, Saad J, Miettinen J, Javarappa KK, Aakko S, Ruokoranta T, Eldfors S, Heinäniemi M, Theilgaard-Mönch K, Wartiovaara-Kautto U, Keränen M, Porkka K, Konopleva M, Wennerberg K, Kontro M, Heckman CA, Mustjoki S
Blood 2023 Mar 30;141(13):1610-1625. doi: 10.1182/blood.2021011094. PMID: 36508699Free PMC Article
Boddu P, Benton CB, Wang W, Borthakur G, Khoury JD, Pemmaraju N
Blood Rev 2018 Mar;32(2):96-105. Epub 2017 Sep 18 doi: 10.1016/j.blre.2017.09.002. PMID: 28965757Free PMC Article
Wang W, Wang SA, Medeiros LJ, Khoury JD
Am J Hematol 2017 Mar;92(3):292-296. Epub 2017 Feb 3 doi: 10.1002/ajh.24626. PMID: 28006859
Arber DA
Curr Opin Hematol 2017 Mar;24(2):146-151. doi: 10.1097/MOH.0000000000000314. PMID: 27875373
Zuo Z, Polski JM, Kasyan A, Medeiros LJ
Arch Pathol Lab Med 2010 Sep;134(9):1261-70. doi: 10.5858/2009-0350-RA.1. PMID: 20807044

Therapy

Kuusanmäki H, Dufva O, Vähä-Koskela M, Leppä AM, Huuhtanen J, Vänttinen I, Nygren P, Klievink J, Bouhlal J, Pölönen P, Zhang Q, Adnan-Awad S, Mancebo-Pérez C, Saad J, Miettinen J, Javarappa KK, Aakko S, Ruokoranta T, Eldfors S, Heinäniemi M, Theilgaard-Mönch K, Wartiovaara-Kautto U, Keränen M, Porkka K, Konopleva M, Wennerberg K, Kontro M, Heckman CA, Mustjoki S
Blood 2023 Mar 30;141(13):1610-1625. doi: 10.1182/blood.2021011094. PMID: 36508699Free PMC Article
Thakral B, Wang SA
Blood 2017 Sep 28;130(13):1600. doi: 10.1182/blood-2017-07-796466. PMID: 28963106
Sadrzadeh H, Hasserjian R, Fathi AT
Am J Hematol 2013 Mar;88(3):240-1. Epub 2012 May 6 doi: 10.1002/ajh.23224. PMID: 22565525
Xu M, Finn LS, Tsuchiya KD, Thomson B, Pollard J, Rutledge J
Pediatr Dev Pathol 2012 Jan-Feb;15(1):76-8. Epub 2011 Aug 30 doi: 10.2350/11-04-1029-CR.1. PMID: 21877942
Kitagawa J, Hara T, Tsurumi H, Oyama M, Moriwaki H
Intern Med 2009;48(18):1695-8. Epub 2009 Sep 15 doi: 10.2169/internalmedicine.48.1798. PMID: 19755777

Prognosis

Kuusanmäki H, Dufva O, Vähä-Koskela M, Leppä AM, Huuhtanen J, Vänttinen I, Nygren P, Klievink J, Bouhlal J, Pölönen P, Zhang Q, Adnan-Awad S, Mancebo-Pérez C, Saad J, Miettinen J, Javarappa KK, Aakko S, Ruokoranta T, Eldfors S, Heinäniemi M, Theilgaard-Mönch K, Wartiovaara-Kautto U, Keränen M, Porkka K, Konopleva M, Wennerberg K, Kontro M, Heckman CA, Mustjoki S
Blood 2023 Mar 30;141(13):1610-1625. doi: 10.1182/blood.2021011094. PMID: 36508699Free PMC Article
Di Genua C, Nerlov C
Exp Hematol 2021 May;97:6-13. Epub 2021 Feb 16 doi: 10.1016/j.exphem.2021.02.006. PMID: 33600869
Boddu P, Benton CB, Wang W, Borthakur G, Khoury JD, Pemmaraju N
Blood Rev 2018 Mar;32(2):96-105. Epub 2017 Sep 18 doi: 10.1016/j.blre.2017.09.002. PMID: 28965757Free PMC Article
Arber DA
Curr Opin Hematol 2017 Mar;24(2):146-151. doi: 10.1097/MOH.0000000000000314. PMID: 27875373
Zuo Z, Polski JM, Kasyan A, Medeiros LJ
Arch Pathol Lab Med 2010 Sep;134(9):1261-70. doi: 10.5858/2009-0350-RA.1. PMID: 20807044

Clinical prediction guides

Fang H, Wang SA, You MJ, Hu S, Miranda RN, Tang Z, Lin P, Jorgensen JL, Xu J, Thakral B, Schlette EJ, El Hussein S, Bueso-Ramos C, Medeiros LJ, Wang W
Cytometry B Clin Cytom 2022 Nov;102(6):440-447. Epub 2022 Sep 26 doi: 10.1002/cyto.b.22095. PMID: 36156384
Ko PS, Liu YC, Yeh CM, Gau JP, Yu YB, Hsiao LT, Tzeng CH, Chen PM, Chiou TJ, Liu CJ, Liu JH
PLoS One 2017;12(2):e0172029. Epub 2017 Feb 14 doi: 10.1371/journal.pone.0172029. PMID: 28196090Free PMC Article
Yu H, Pinkus JL, Pinkus GS
Appl Immunohistochem Mol Morphol 2016 Jan;24(1):51-6. doi: 10.1097/PAI.0000000000000139. PMID: 25611244
Lessard M, Struski S, Leymarie V, Flandrin G, Lafage-Pochitaloff M, Mozziconacci MJ, Talmant P, Bastard C, Charrin C, Baranger L, Hélias C, Cornillet-Lefebvre P, Mugneret F, Cabrol C, Pagès MP, Fert-Ferret D, Nguyen-Khac F, Quilichini B, Barin C, Berger R; Groupe Francophone de Cytogénétique Hématologique (GFCH)
Cancer Genet Cytogenet 2005 Dec;163(2):113-22. doi: 10.1016/j.cancergencyto.2005.05.006. PMID: 16337853
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165

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