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Increased micromegakaryocyte count

MedGen UID:
1626370
•Concept ID:
C4531161
•
Finding
HPO: HP:0031386

Definition

The presence of abnormally high numbers of micromegakaryocytes in the bone marrow. Micromegakaryocytes are mononuclear diploid cells, with a nucleus similar in size to that of a myeloblast or promyelocyte with the cell being less than 30 micrometers in diameter. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased micromegakaryocyte count

Conditions with this feature

Thrombocythemia 3
MedGen UID:
482755
•Concept ID:
C3281125
•
Disease or Syndrome
Thrombocythemia-3 is an autosomal dominant hematologic disorder characterized by increased platelet production resulting in increased numbers of circulating platelets. Thrombocythemia can be associated with thrombotic episodes, such as cerebrovascular events or myocardial infarction (summary by Mead et al., 2012). For a discussion of genetic heterogeneity of thrombocythemia, see THCYT1 (187950).
See: Condition Record
Thrombocythemia 3

Professional guidelines

PubMed

Clinical and morphological criteria for the diagnosis of prefibrotic idiopathic (primary) myelofibrosis.
Thiele J, Kvasnicka HM, Zankovich R, Diehl V
Ann Hematol 2001 Mar;80(3):160-5. doi: 10.1007/s002770000278. PMID: 11320901
Peripheral blood picture in primary hypocellular refractory anemia and idiopathic acquired aplastic anemia: an additional tool for differential diagnosis.
Elghetany MT, Hudnall SD, Gardner FH
Haematologica 1997 Jan-Feb;82(1):21-4. PMID: 9107077

Recent clinical studies

Etiology

New polymorphisms of Xeroderma Pigmentosum DNA repair genes in myelodysplastic syndrome.
Santiago SP, Junior HLR, de Sousa JC, de Paula Borges D, de Oliveira RTG, Farias IR, Costa MB, Maia ARS, da Nóbrega Ito M, Magalhães SMM, Pinheiro RF
Leuk Res 2017 Jul;58:73-82. Epub 2017 Apr 1 doi: 10.1016/j.leukres.2017.03.012. PMID: 28472728
Acute erythroid neoplastic proliferations. A biological study based on 62 patients.
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165
Bone marrow features and clinical findings in chronic myeloid leukemia--a comparative, multicenter, immunohistological and morphometric study on 614 patients.
Thiele J, Kvasnicka HM, Schmitt-Graeff A, Zirbes TK, Birnbaum F, Kressmann C, Melguizo-Grahmann M, Frackenpohl H, Sprungmann C, Leder LD, Diehl V, Zankovich R, Schaefer HE, Niederle N, Fischer R
Leuk Lymphoma 2000 Jan;36(3-4):295-308. doi: 10.3109/10428190009148850. PMID: 10674901
Peripheral blood picture in primary hypocellular refractory anemia and idiopathic acquired aplastic anemia: an additional tool for differential diagnosis.
Elghetany MT, Hudnall SD, Gardner FH
Haematologica 1997 Jan-Feb;82(1):21-4. PMID: 9107077
Megakaryocytopoiesis in bone marrow biopsies of patients with acquired immunodeficiency syndrome (AIDS). An immunohistochemical and morphometric evaluation with special emphasis on myelodysplastic features and precursor cells.
Thiele J, Titius BR, Quitmann H, Fischer R, Salzberger B, Dienemann D, Stein H
Pathol Res Pract 1992 Aug;188(6):722-8. doi: 10.1016/s0344-0338(11)80168-8. PMID: 1437834

Diagnosis

Acute erythroid neoplastic proliferations. A biological study based on 62 patients.
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165
Clinical and morphological criteria for the diagnosis of prefibrotic idiopathic (primary) myelofibrosis.
Thiele J, Kvasnicka HM, Zankovich R, Diehl V
Ann Hematol 2001 Mar;80(3):160-5. doi: 10.1007/s002770000278. PMID: 11320901
Bone marrow features and clinical findings in chronic myeloid leukemia--a comparative, multicenter, immunohistological and morphometric study on 614 patients.
Thiele J, Kvasnicka HM, Schmitt-Graeff A, Zirbes TK, Birnbaum F, Kressmann C, Melguizo-Grahmann M, Frackenpohl H, Sprungmann C, Leder LD, Diehl V, Zankovich R, Schaefer HE, Niederle N, Fischer R
Leuk Lymphoma 2000 Jan;36(3-4):295-308. doi: 10.3109/10428190009148850. PMID: 10674901
3q21 and 3q26 cytogenetic abnormalities in acute myeloblastic leukemia: biological and clinical features.
Testoni N, Borsaru G, Martinelli G, Carboni C, Ruggeri D, Ottaviani E, Pelliconi S, Ricci P, Pastano R, Visani G, Zaccaria A, Tura S
Haematologica 1999 Aug;84(8):690-4. PMID: 10457403
Peripheral blood picture in primary hypocellular refractory anemia and idiopathic acquired aplastic anemia: an additional tool for differential diagnosis.
Elghetany MT, Hudnall SD, Gardner FH
Haematologica 1997 Jan-Feb;82(1):21-4. PMID: 9107077

Therapy

The potential effect of short-course high-dose steroid on the maturation and apoptosis of leukemic cells in a child with acute megakaryoblastic leukemia.
Hiçsönmez G, Cetin M, Okur H, Erdemli E, Gürgey A
Leuk Lymphoma 2003 Jun;44(6):1037-42. doi: 10.1080/1042819031000067954. PMID: 12854906
Therapy-related leukemia: a panmyelosis.
Foucar K, McKenna RW, Bloomfield CD, Bowers TK, Brunning RD
Cancer 1979 Apr;43(4):1285-96. doi: 10.1002/1097-0142(197904)43:4<1285::aid-cncr2820430416>3.0.co;2-j. PMID: 445330

Prognosis

New polymorphisms of Xeroderma Pigmentosum DNA repair genes in myelodysplastic syndrome.
Santiago SP, Junior HLR, de Sousa JC, de Paula Borges D, de Oliveira RTG, Farias IR, Costa MB, Maia ARS, da Nóbrega Ito M, Magalhães SMM, Pinheiro RF
Leuk Res 2017 Jul;58:73-82. Epub 2017 Apr 1 doi: 10.1016/j.leukres.2017.03.012. PMID: 28472728
The potential effect of short-course high-dose steroid on the maturation and apoptosis of leukemic cells in a child with acute megakaryoblastic leukemia.
Hiçsönmez G, Cetin M, Okur H, Erdemli E, Gürgey A
Leuk Lymphoma 2003 Jun;44(6):1037-42. doi: 10.1080/1042819031000067954. PMID: 12854906
3q21 and 3q26 cytogenetic abnormalities in acute myeloblastic leukemia: biological and clinical features.
Testoni N, Borsaru G, Martinelli G, Carboni C, Ruggeri D, Ottaviani E, Pelliconi S, Ricci P, Pastano R, Visani G, Zaccaria A, Tura S
Haematologica 1999 Aug;84(8):690-4. PMID: 10457403
Peripheral blood picture in primary hypocellular refractory anemia and idiopathic acquired aplastic anemia: an additional tool for differential diagnosis.
Elghetany MT, Hudnall SD, Gardner FH
Haematologica 1997 Jan-Feb;82(1):21-4. PMID: 9107077
Fanconi's anaemia, with special reference to erythrokinetic features.
Skikne BS, Lynch SR, Bezwoda WR, Bothwell TH, Bernstein R, Katz J, Kramer S, Zucker M
S Afr Med J 1978 Jan 14;53(2):43-50. PMID: 644412

Clinical prediction guides

New polymorphisms of Xeroderma Pigmentosum DNA repair genes in myelodysplastic syndrome.
Santiago SP, Junior HLR, de Sousa JC, de Paula Borges D, de Oliveira RTG, Farias IR, Costa MB, Maia ARS, da Nóbrega Ito M, Magalhães SMM, Pinheiro RF
Leuk Res 2017 Jul;58:73-82. Epub 2017 Apr 1 doi: 10.1016/j.leukres.2017.03.012. PMID: 28472728
Comparative study of myelodysplastic syndromes and normal bone marrow biopsies with conventional staining and immunocytochemistry.
Das R, Hayer J, Dey P, Garewal G
Anal Quant Cytol Histol 2005 Jun;27(3):152-6. PMID: 16121636
Acute erythroid neoplastic proliferations. A biological study based on 62 patients.
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165
3q21 and 3q26 cytogenetic abnormalities in acute myeloblastic leukemia: biological and clinical features.
Testoni N, Borsaru G, Martinelli G, Carboni C, Ruggeri D, Ottaviani E, Pelliconi S, Ricci P, Pastano R, Visani G, Zaccaria A, Tura S
Haematologica 1999 Aug;84(8):690-4. PMID: 10457403
Inversion of chromosome 3 in a case of chronic myelogenous leukemia with abnormal thrombopoiesis.
Shimazaki C, Fujita N, Nakanishi S, Nishio A, Haruyama H, Nakagawa M, Ijichi H, Nishida K, Misawa S
Cancer Genet Cytogenet 1986 Feb 1;20(1-2):121-7. doi: 10.1016/0165-4608(86)90115-9. PMID: 3455854

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