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Nuclear Cataract Grade 4

MedGen UID:
1623861
•Concept ID:
C4525726
•
Disease or Syndrome

Definition

A stage of nuclear sclerotic cataract marked by severe yellowing and sclerosis of the lens nucleus. (Modified LOCS II) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNuclear Cataract Grade 4

Professional guidelines

PubMed

Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the GEMS-001 clinical trial.
Hernando-Calvo A, Malone E, Day D, Prawira A, Weinreb I, Yang SYC, Wong H, Rodriguez A, Jennings S, Eliason A, Wang L, Spreafico A, Siu LL, Hansen AR
Cancer Med 2023 Oct;12(20):20299-20310. Epub 2023 Oct 11 doi: 10.1002/cam4.6589. PMID: 37818869Free PMC Article
Management of Severely Subluxated Cataracts Using Femtosecond Laser-Assisted Cataract Surgery.
Chee SP, Wong MH, Jap A
Am J Ophthalmol 2017 Jan;173:7-15. Epub 2016 Sep 23 doi: 10.1016/j.ajo.2016.09.021. PMID: 27670621

Recent clinical studies

Etiology

Cataract progression after Nd:YAG laser iridotomy in primary angle-closure suspect eyes.
Chang DS, Jiang Y, Kim JA, Huang S, Munoz B, Aung T, He M, Foster PJ, Friedman D
Br J Ophthalmol 2023 Sep;107(9):1264-1268. Epub 2022 May 2 doi: 10.1136/bjophthalmol-2021-320929. PMID: 35501120
Comparative study between conventional and 4 mm manual small-incision cataract surgery.
Chauhan RA, Agrawal SO, Sawarkar RR, Agrawal S
Indian J Ophthalmol 2022 Nov;70(11):3879-3882. doi: 10.4103/ijo.IJO_1607_22. PMID: 36308119Free PMC Article
Objective assessment of nuclear cataract: comparison of double-pass and Scheimpflug systems.
Lim SA, Hwang J, Hwang KY, Chung SH
J Cataract Refract Surg 2014 May;40(5):716-21. doi: 10.1016/j.jcrs.2013.10.032. PMID: 24767907
23-Gauge transconjunctival pars plana vitrectomy for removal of retained lens fragments.
Baker PS, Spirn MJ, Chiang A, Regillo CD, Ho AC, Vander JF, Kaiser RS
Am J Ophthalmol 2011 Oct;152(4):624-7. Epub 2011 Jul 2 doi: 10.1016/j.ajo.2011.04.003. PMID: 21726843
Diagnostic x-ray exposure and lens opacities: the Beaver Dam Eye Study.
Klein BE, Klein R, Linton KL, Franke T
Am J Public Health 1993 Apr;83(4):588-90. doi: 10.2105/ajph.83.4.588. PMID: 8460743Free PMC Article

Diagnosis

A case report of iridoschisis and cataract: a challenging diagnosis.
Katipoğlu Z, Turan M
Int Ophthalmol 2024 Feb 7;44(1):26. doi: 10.1007/s10792-024-03001-3. PMID: 38326697
New technology using crystalline lens autofluorescence for presbyopia and cataract grading.
Eom Y, Suh YW, Kim SW, Lee YJ, Jeon HS, Lee SY, Lee IH, Song JS, Kim HM
Graefes Arch Clin Exp Ophthalmol 2023 Jul;261(7):1923-1932. Epub 2023 Feb 24 doi: 10.1007/s00417-023-05999-1. PMID: 36826601
Objective assessment of nuclear cataract: comparison of double-pass and Scheimpflug systems.
Lim SA, Hwang J, Hwang KY, Chung SH
J Cataract Refract Surg 2014 May;40(5):716-21. doi: 10.1016/j.jcrs.2013.10.032. PMID: 24767907
Influence of cataract morphology on straylight and contrast sensitivity and its relevance to fitness to drive.
Bal T, Coeckelbergh T, Van Looveren J, Rozema JJ, Tassignon MJ
Ophthalmologica 2011;225(2):105-11. Epub 2010 Sep 24 doi: 10.1159/000317076. PMID: 20881445
Diagnostic x-ray exposure and lens opacities: the Beaver Dam Eye Study.
Klein BE, Klein R, Linton KL, Franke T
Am J Public Health 1993 Apr;83(4):588-90. doi: 10.2105/ajph.83.4.588. PMID: 8460743Free PMC Article

Therapy

Cataract progression after Nd:YAG laser iridotomy in primary angle-closure suspect eyes.
Chang DS, Jiang Y, Kim JA, Huang S, Munoz B, Aung T, He M, Foster PJ, Friedman D
Br J Ophthalmol 2023 Sep;107(9):1264-1268. Epub 2022 May 2 doi: 10.1136/bjophthalmol-2021-320929. PMID: 35501120
Comparative study between conventional and 4 mm manual small-incision cataract surgery.
Chauhan RA, Agrawal SO, Sawarkar RR, Agrawal S
Indian J Ophthalmol 2022 Nov;70(11):3879-3882. doi: 10.4103/ijo.IJO_1607_22. PMID: 36308119Free PMC Article
23-Gauge transconjunctival pars plana vitrectomy for removal of retained lens fragments.
Baker PS, Spirn MJ, Chiang A, Regillo CD, Ho AC, Vander JF, Kaiser RS
Am J Ophthalmol 2011 Oct;152(4):624-7. Epub 2011 Jul 2 doi: 10.1016/j.ajo.2011.04.003. PMID: 21726843
Statin use and incident nuclear cataract.
Klein BE, Klein R, Lee KE, Grady LM
JAMA 2006 Jun 21;295(23):2752-8. doi: 10.1001/jama.295.23.2752. PMID: 16788130
Diagnostic x-ray exposure and lens opacities: the Beaver Dam Eye Study.
Klein BE, Klein R, Linton KL, Franke T
Am J Public Health 1993 Apr;83(4):588-90. doi: 10.2105/ajph.83.4.588. PMID: 8460743Free PMC Article

Prognosis

The Influence of Cataract on Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO).
Lincke JB, Dysli C, Jaggi D, Fink R, Wolf S, Zinkernagel MS
Transl Vis Sci Technol 2021 Apr 1;10(4):33. doi: 10.1167/tvst.10.4.33. PMID: 34004011Free PMC Article
Objective assessment of nuclear cataract: comparison of double-pass and Scheimpflug systems.
Lim SA, Hwang J, Hwang KY, Chung SH
J Cataract Refract Surg 2014 May;40(5):716-21. doi: 10.1016/j.jcrs.2013.10.032. PMID: 24767907
Myopia and the long-term incidence of cataract and cataract surgery: the Blue Mountains Eye Study.
Kanthan GL, Mitchell P, Rochtchina E, Cumming RG, Wang JJ
Clin Exp Ophthalmol 2014 May-Jun;42(4):347-53. Epub 2013 Oct 11 doi: 10.1111/ceo.12206. PMID: 24024555
23-Gauge transconjunctival pars plana vitrectomy for removal of retained lens fragments.
Baker PS, Spirn MJ, Chiang A, Regillo CD, Ho AC, Vander JF, Kaiser RS
Am J Ophthalmol 2011 Oct;152(4):624-7. Epub 2011 Jul 2 doi: 10.1016/j.ajo.2011.04.003. PMID: 21726843
Myopia and incident cataract and cataract surgery: the blue mountains eye study.
Younan C, Mitchell P, Cumming RG, Rochtchina E, Wang JJ
Invest Ophthalmol Vis Sci 2002 Dec;43(12):3625-32. PMID: 12454028

Clinical prediction guides

Comparative study between conventional and 4 mm manual small-incision cataract surgery.
Chauhan RA, Agrawal SO, Sawarkar RR, Agrawal S
Indian J Ophthalmol 2022 Nov;70(11):3879-3882. doi: 10.4103/ijo.IJO_1607_22. PMID: 36308119Free PMC Article
The Influence of Cataract on Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO).
Lincke JB, Dysli C, Jaggi D, Fink R, Wolf S, Zinkernagel MS
Transl Vis Sci Technol 2021 Apr 1;10(4):33. doi: 10.1167/tvst.10.4.33. PMID: 34004011Free PMC Article
Cataract and quality of life in patients with glaucoma.
Skalicky SE, Martin KR, Fenwick E, Crowston JG, Goldberg I, McCluskey P
Clin Exp Ophthalmol 2015 May-Jun;43(4):335-41. Epub 2014 Oct 30 doi: 10.1111/ceo.12454. PMID: 25294739
Objective assessment of nuclear cataract: comparison of double-pass and Scheimpflug systems.
Lim SA, Hwang J, Hwang KY, Chung SH
J Cataract Refract Surg 2014 May;40(5):716-21. doi: 10.1016/j.jcrs.2013.10.032. PMID: 24767907
Frailty and age-related cataract.
Klein BE, Klein R, Knudtson MD
Ophthalmology 2006 Dec;113(12):2209-12. Epub 2006 Sep 25 doi: 10.1016/j.ophtha.2006.04.035. PMID: 16996595

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