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Small cerebellar cortex

MedGen UID:
1622266
•Concept ID:
C4531131
•
Finding
HPO: HP:0031423

Definition

Reduced size of the cerebellar cortex. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall cerebellar cortex

Professional guidelines

PubMed

Functional connectivity between the cerebellar vermis and cerebrum distinguishes early treatment response for major depressive episodes in adolescents.
Wang L, Zhao P, Zhang J, Zhang R, Liu J, Duan J, Zhang X, Zhu R, Wang F
J Affect Disord 2023 Oct 15;339:256-263. Epub 2023 Jul 10 doi: 10.1016/j.jad.2023.07.054. PMID: 37437740
Prenatal diagnosis of rhombencephalosynapsis: neuroimaging features and severity of vermian anomaly.
Krajden Haratz K, Oliveira Szejnfeld P, Govindaswamy M, Leibovitz Z, Gindes L, Severino M, Rossi A, Paladini D, Garcia Rodriguez R, Ben-Sira L, Borkowski Tillman T, Gupta R, Lotem G, Raz N, Hamamoto TENK, Kidron D, Arad A, Birnbaum R, Brussilov M, Pomar L, Vial Y, Leventer RJ, McGillivray G, Fink M, Krzeszowski W, Fernandes Moron A, Lev D, Tamarkin M, Shalev J, Har Toov J, Lerman-Sagie T, Malinger G
Ultrasound Obstet Gynecol 2021 Dec;58(6):864-874. doi: 10.1002/uog.23660. PMID: 33942916
Transcranial magnetic stimulation in hereditary ataxias: Diagnostic utility, pathophysiological insight and treatment.
Rodríguez-Labrada R, Velázquez-Pérez L, Ziemann U
Clin Neurophysiol 2018 Aug;129(8):1688-1698. Epub 2018 Jun 15 doi: 10.1016/j.clinph.2018.06.003. PMID: 29940480

Recent clinical studies

Etiology

Etiology of Primary Cerebellar Intracerebral Hemorrhage Based on Topographic Localization.
Incontri D, Marchina S, Andreev A, Wilson M, Wang JY, Lin D, Heistand EC, Carvalho F, Selim M, Lioutas VA
Stroke 2023 Dec;54(12):3074-3080. Epub 2023 Oct 16 doi: 10.1161/STROKEAHA.123.044271. PMID: 37842779Free PMC Article
Neuropathological Features of Gaucher Disease and Gaucher Disease with Parkinsonism.
Furderer ML, Hertz E, Lopez GJ, Sidransky E
Int J Mol Sci 2022 May 23;23(10) doi: 10.3390/ijms23105842. PMID: 35628652Free PMC Article
CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model.
Yshii LM, Gebauer CM, Pignolet B, Mauré E, Quériault C, Pierau M, Saito H, Suzuki N, Brunner-Weinzierl M, Bauer J, Liblau R
Brain 2016 Nov 1;139(11):2923-2934. doi: 10.1093/brain/aww225. PMID: 27604307
Tremor.
Raethjen J, Deuschl G
Curr Opin Neurol 2009 Aug;22(4):400-5. doi: 10.1097/WCO.0b013e32832dc056. PMID: 19553813
Functional neural circuits for mental timekeeping.
Stevens MC, Kiehl KA, Pearlson G, Calhoun VD
Hum Brain Mapp 2007 May;28(5):394-408. doi: 10.1002/hbm.20285. PMID: 16944489Free PMC Article

Diagnosis

MRI of Cerebellar Infarction.
De Cocker LJ, Lövblad KO, Hendrikse J
Eur Neurol 2017;77(3-4):137-146. Epub 2017 Jan 18 doi: 10.1159/000455229. PMID: 28095387
Tremor.
Raethjen J, Deuschl G
Curr Opin Neurol 2009 Aug;22(4):400-5. doi: 10.1097/WCO.0b013e32832dc056. PMID: 19553813
Gluten ataxia.
Hadjivassiliou M, Sanders DS, Woodroofe N, Williamson C, Grünewald RA
Cerebellum 2008;7(3):494-8. doi: 10.1007/s12311-008-0052-x. PMID: 18787912
Anti-CV2 autoantibodies and paraneoplastic neurological syndromes.
Rogemond V, Honnorat J
Clin Rev Allergy Immunol 2000 Aug;19(1):51-9. doi: 10.1385/CRIAI:19:1:51. PMID: 11064826
The mechanism and clinical significance of optokinetic nystagmus.
Dix MR
J Laryngol Otol 1980 Aug;94(8):845-64. doi: 10.1017/s0022215100089611. PMID: 7000938

Therapy

CD8 T-cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer.
Hardwick M, Nolan L, Nicoll JAR, Jogai S, Arriola E, Joseph-Pietras D, Norman J, Ottensmeier CHH, Galea I
Neuropathol Appl Neurobiol 2022 Feb;48(2):e12755. Epub 2021 Aug 8 doi: 10.1111/nan.12755. PMID: 34309064
n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway.
Lee JH, Lin SY, Liu JW, Lin SZ, Harn HJ, Chiou TW
Int J Mol Sci 2021 Jun 13;22(12) doi: 10.3390/ijms22126339. PMID: 34199295Free PMC Article
Update on the pharmacotherapy of cerebellar and central vestibular disorders.
Kalla R, Teufel J, Feil K, Muth C, Strupp M
J Neurol 2016 Apr;263 Suppl 1:S24-9. Epub 2016 Apr 15 doi: 10.1007/s00415-015-7987-x. PMID: 27083881Free PMC Article
The neural basis of human dance.
Brown S, Martinez MJ, Parsons LM
Cereb Cortex 2006 Aug;16(8):1157-67. Epub 2005 Oct 12 doi: 10.1093/cercor/bhj057. PMID: 16221923
Subacute cerebellar degeneration and Eaton-Lambert syndrome with bronchogenic carcinoma. A case report.
Satoyoshi E, Kowa H, Fukunaga N
Neurology 1973 Jul;23(7):764-8. doi: 10.1212/wnl.23.7.764. PMID: 4351327

Prognosis

Comparing the selectivity of vowel representations in cortical auditory vs. motor areas: A repetition-suppression study.
Dole M, Vilain C, Haldin C, Baciu M, Cousin E, Lamalle L, Lœvenbruck H, Vilain A, Schwartz JL
Neuropsychologia 2022 Nov 5;176:108392. Epub 2022 Oct 7 doi: 10.1016/j.neuropsychologia.2022.108392. PMID: 36216084
Population coding in the cerebellum: a machine learning perspective.
Shadmehr R
J Neurophysiol 2020 Dec 1;124(6):2022-2051. Epub 2020 Oct 28 doi: 10.1152/jn.00449.2020. PMID: 33112717Free PMC Article
Term MRI for small preterm babies: do parents really want to know and why has nobody asked them?
Pearce R, Baardsnes J
Acta Paediatr 2012 Oct;101(10):1013-5. Epub 2012 Jul 17 doi: 10.1111/j.1651-2227.2012.02767.x. PMID: 22780585
The mysterious microcircuitry of the cerebellar nuclei.
Uusisaari M, De Schutter E
J Physiol 2011 Jul 15;589(Pt 14):3441-57. Epub 2011 Apr 26 doi: 10.1113/jphysiol.2010.201582. PMID: 21521761Free PMC Article
Central nervous system manifestations of chickenpox.
Johnson R, Milbourn PE
Can Med Assoc J 1970 Apr 25;102(8):831-4. PMID: 5445045Free PMC Article

Clinical prediction guides

Comparing the selectivity of vowel representations in cortical auditory vs. motor areas: A repetition-suppression study.
Dole M, Vilain C, Haldin C, Baciu M, Cousin E, Lamalle L, Lœvenbruck H, Vilain A, Schwartz JL
Neuropsychologia 2022 Nov 5;176:108392. Epub 2022 Oct 7 doi: 10.1016/j.neuropsychologia.2022.108392. PMID: 36216084
Neuroimaging Biomarkers in SCA2 Gene Carriers.
Mascalchi M, Vella A
Int J Mol Sci 2020 Feb 4;21(3) doi: 10.3390/ijms21031020. PMID: 32033120Free PMC Article
Neuroimaging Applications in Chronic Ataxias.
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
Tau-reactive neurofibrillary tangles in cerebellar cortex from patients with Alzheimer's disease.
Tabaton M, Cammarata S, Manetto V, Perry G, Mancardi G
Neurosci Lett 1989 Sep 11;103(3):259-62. doi: 10.1016/0304-3940(89)90109-2. PMID: 2478932
The mechanism and clinical significance of optokinetic nystagmus.
Dix MR
J Laryngol Otol 1980 Aug;94(8):845-64. doi: 10.1017/s0022215100089611. PMID: 7000938

Recent systematic reviews

A Systematic Review on Anti-Yo/PCA-1 Antibody: Beyond Cerebellar Ataxia in Middle-Aged Women with Gynecologic Cancer.
Mendes NT, Ronchi NR, Silva GD
Cerebellum 2023 Dec;22(6):1287-1292. Epub 2022 Nov 5 doi: 10.1007/s12311-022-01492-3. PMID: 36334195
Cerebral Cortical Activity Following Non-invasive Cerebellar Stimulation-a Systematic Review of Combined TMS and EEG Studies.
Fernandez L, Rogasch NC, Do M, Clark G, Major BP, Teo WP, Byrne LK, Enticott PG
Cerebellum 2020 Apr;19(2):309-335. doi: 10.1007/s12311-019-01093-7. PMID: 31907864
Pediatric Brain Development in Down Syndrome: A Field in Its Infancy.
Hamner T, Udhnani MD, Osipowicz KZ, Lee NR
J Int Neuropsychol Soc 2018 Oct;24(9):966-976. Epub 2018 May 23 doi: 10.1017/S1355617718000206. PMID: 29789029Free PMC Article
Deep brain and cortical stimulation for epilepsy.
Sprengers M, Vonck K, Carrette E, Marson AG, Boon P
Cochrane Database Syst Rev 2017 Jul 18;7(7):CD008497. doi: 10.1002/14651858.CD008497.pub3. PMID: 28718878Free PMC Article
Neuroimaging predictors of transition to psychosis--a systematic review and meta-analysis.
Smieskova R, Fusar-Poli P, Allen P, Bendfeldt K, Stieglitz RD, Drewe J, Radue EW, McGuire PK, Riecher-Rössler A, Borgwardt SJ
Neurosci Biobehav Rev 2010 Jul;34(8):1207-22. Epub 2010 Feb 6 doi: 10.1016/j.neubiorev.2010.01.016. PMID: 20144653

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