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Transthyretin cardiac amyloidosis

MedGen UID:
1615958
Concept ID:
C4531196
Disease or Syndrome
Synonym: TTR cardiac amyloidosis
 
HPO: HP:0031327

Definition

A type of cardiac amyloidosis related to deposition of transthyretin (TTR), which is identified by immunohistochemical staining. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransthyretin cardiac amyloidosis

Professional guidelines

PubMed

Bampatsias D, Wardhere A, Maurer MS
Curr Opin Cardiol 2024 Sep 1;39(5):407-416. Epub 2024 Apr 19 doi: 10.1097/HCO.0000000000001156. PMID: 38652263Free PMC Article
Stern LK, Patel J
Methodist Debakey Cardiovasc J 2022;18(2):59-72. Epub 2022 Mar 14 doi: 10.14797/mdcvj.1050. PMID: 35414852Free PMC Article
Maurer MS, Bokhari S, Damy T, Dorbala S, Drachman BM, Fontana M, Grogan M, Kristen AV, Lousada I, Nativi-Nicolau J, Cristina Quarta C, Rapezzi C, Ruberg FL, Witteles R, Merlini G
Circ Heart Fail 2019 Sep;12(9):e006075. Epub 2019 Sep 4 doi: 10.1161/CIRCHEARTFAILURE.119.006075. PMID: 31480867Free PMC Article

Recent clinical studies

Etiology

Maurer MS, Kale P, Fontana M, Berk JL, Grogan M, Gustafsson F, Hung RR, Gottlieb RL, Damy T, González-Duarte A, Sarswat N, Sekijima Y, Tahara N, Taylor MS, Kubanek M, Donal E, Palecek T, Tsujita K, Tang WHW, Yu WC, Obici L, Simões M, Fernandes F, Poulsen SH, Diemberger I, Perfetto F, Solomon SD, Di Carli M, Badri P, White MT, Chen J, Yureneva E, Sweetser MT, Jay PY, Garg PP, Vest J, Gillmore JD; APOLLO-B Trial Investigators
N Engl J Med 2023 Oct 26;389(17):1553-1565. doi: 10.1056/NEJMoa2300757. PMID: 37888916Free PMC Article
Maurer MS, Bokhari S, Damy T, Dorbala S, Drachman BM, Fontana M, Grogan M, Kristen AV, Lousada I, Nativi-Nicolau J, Cristina Quarta C, Rapezzi C, Ruberg FL, Witteles R, Merlini G
Circ Heart Fail 2019 Sep;12(9):e006075. Epub 2019 Sep 4 doi: 10.1161/CIRCHEARTFAILURE.119.006075. PMID: 31480867Free PMC Article
Mankad AK, Shah KB
Curr Cardiol Rep 2017 Aug 24;19(10):97. doi: 10.1007/s11886-017-0911-5. PMID: 28840452
Grogan M, Scott CG, Kyle RA, Zeldenrust SR, Gertz MA, Lin G, Klarich KW, Miller WL, Maleszewski JJ, Dispenzieri A
J Am Coll Cardiol 2016 Sep 6;68(10):1014-20. doi: 10.1016/j.jacc.2016.06.033. PMID: 27585505
Wechalekar AD, Gillmore JD, Hawkins PN
Lancet 2016 Jun 25;387(10038):2641-2654. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01274-X. PMID: 26719234

Diagnosis

Porcari A, Fontana M, Gillmore JD
Cardiovasc Res 2023 Feb 3;118(18):3517-3535. doi: 10.1093/cvr/cvac119. PMID: 35929637Free PMC Article
Stern LK, Patel J
Methodist Debakey Cardiovasc J 2022;18(2):59-72. Epub 2022 Mar 14 doi: 10.14797/mdcvj.1050. PMID: 35414852Free PMC Article
Rubin J, Maurer MS
Annu Rev Med 2020 Jan 27;71:203-219. doi: 10.1146/annurev-med-052918-020140. PMID: 31986086
Maurer MS, Bokhari S, Damy T, Dorbala S, Drachman BM, Fontana M, Grogan M, Kristen AV, Lousada I, Nativi-Nicolau J, Cristina Quarta C, Rapezzi C, Ruberg FL, Witteles R, Merlini G
Circ Heart Fail 2019 Sep;12(9):e006075. Epub 2019 Sep 4 doi: 10.1161/CIRCHEARTFAILURE.119.006075. PMID: 31480867Free PMC Article
Wechalekar AD, Gillmore JD, Hawkins PN
Lancet 2016 Jun 25;387(10038):2641-2654. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01274-X. PMID: 26719234

Therapy

Bampatsias D, Wardhere A, Maurer MS
Curr Opin Cardiol 2024 Sep 1;39(5):407-416. Epub 2024 Apr 19 doi: 10.1097/HCO.0000000000001156. PMID: 38652263Free PMC Article
Maurer MS, Kale P, Fontana M, Berk JL, Grogan M, Gustafsson F, Hung RR, Gottlieb RL, Damy T, González-Duarte A, Sarswat N, Sekijima Y, Tahara N, Taylor MS, Kubanek M, Donal E, Palecek T, Tsujita K, Tang WHW, Yu WC, Obici L, Simões M, Fernandes F, Poulsen SH, Diemberger I, Perfetto F, Solomon SD, Di Carli M, Badri P, White MT, Chen J, Yureneva E, Sweetser MT, Jay PY, Garg PP, Vest J, Gillmore JD; APOLLO-B Trial Investigators
N Engl J Med 2023 Oct 26;389(17):1553-1565. doi: 10.1056/NEJMoa2300757. PMID: 37888916Free PMC Article
Stern LK, Patel J
Methodist Debakey Cardiovasc J 2022;18(2):59-72. Epub 2022 Mar 14 doi: 10.14797/mdcvj.1050. PMID: 35414852Free PMC Article
Griffin JM, Rosenblum H, Maurer MS
Circ Res 2021 May 14;128(10):1554-1575. Epub 2021 May 13 doi: 10.1161/CIRCRESAHA.121.318187. PMID: 33983835Free PMC Article
Rubin J, Maurer MS
Annu Rev Med 2020 Jan 27;71:203-219. doi: 10.1146/annurev-med-052918-020140. PMID: 31986086

Prognosis

Porcari A, Fontana M, Gillmore JD
Cardiovasc Res 2023 Feb 3;118(18):3517-3535. doi: 10.1093/cvr/cvac119. PMID: 35929637Free PMC Article
Stern LK, Patel J
Methodist Debakey Cardiovasc J 2022;18(2):59-72. Epub 2022 Mar 14 doi: 10.14797/mdcvj.1050. PMID: 35414852Free PMC Article
Rubin J, Maurer MS
Annu Rev Med 2020 Jan 27;71:203-219. doi: 10.1146/annurev-med-052918-020140. PMID: 31986086
Yamamoto H, Yokochi T
ESC Heart Fail 2019 Dec;6(6):1128-1139. Epub 2019 Sep 25 doi: 10.1002/ehf2.12518. PMID: 31553132Free PMC Article
Maurer MS, Bokhari S, Damy T, Dorbala S, Drachman BM, Fontana M, Grogan M, Kristen AV, Lousada I, Nativi-Nicolau J, Cristina Quarta C, Rapezzi C, Ruberg FL, Witteles R, Merlini G
Circ Heart Fail 2019 Sep;12(9):e006075. Epub 2019 Sep 4 doi: 10.1161/CIRCHEARTFAILURE.119.006075. PMID: 31480867Free PMC Article

Clinical prediction guides

Maurer MS, Kale P, Fontana M, Berk JL, Grogan M, Gustafsson F, Hung RR, Gottlieb RL, Damy T, González-Duarte A, Sarswat N, Sekijima Y, Tahara N, Taylor MS, Kubanek M, Donal E, Palecek T, Tsujita K, Tang WHW, Yu WC, Obici L, Simões M, Fernandes F, Poulsen SH, Diemberger I, Perfetto F, Solomon SD, Di Carli M, Badri P, White MT, Chen J, Yureneva E, Sweetser MT, Jay PY, Garg PP, Vest J, Gillmore JD; APOLLO-B Trial Investigators
N Engl J Med 2023 Oct 26;389(17):1553-1565. doi: 10.1056/NEJMoa2300757. PMID: 37888916Free PMC Article
Arana-Achaga X, Goena-Vives C, Villanueva-Benito I, Solla-Ruiz I, Rengel Jimenez A, Gaspar TI, Urreta-Barallobre I, Barge-Caballero G, Seijas-Marcos S, Cabrera E, Garcia-Pavía P, Basurte Elorz MT, Ayestarán NM, Sierra LT, Robledo Iñarritu M, Lozano-Bahamonde A, Escolar-Perez V, Gómez-Ramírez C, Alzola E, Andrés RN, Francisco Matias JL, Limeres Freire J, Armengou Arxe A, Negre Busó M, Piqueras-Flores J, Martínez-Del Río J, Onaindia Gandarias JJ, Rodriguez Sanchez I, Querejeta Iraola R
JACC Cardiovasc Imaging 2023 Dec;16(12):1567-1580. Epub 2023 Jun 28 doi: 10.1016/j.jcmg.2023.05.002. PMID: 37389511
Ioannou A, Massa P, Patel RK, Razvi Y, Porcari A, Rauf MU, Jiang A, Cabras G, Filisetti S, Bolhuis RE, Bandera F, Venneri L, Martinez-Naharro A, Law S, Kotecha T, Virsinskaite R, Knight DS, Emdin M, Petrie A, Lachmann H, Wechelakar A, Petrie M, Hughes A, Freemantle N, Hawkins PN, Whelan C, McMurray JJV, Gillmore JD, Fontana M
Eur Heart J 2023 Aug 14;44(31):2893-2907. doi: 10.1093/eurheartj/ehad347. PMID: 37216684Free PMC Article
Ioannou A, Patel RK, Razvi Y, Porcari A, Sinagra G, Venneri L, Bandera F, Masi A, Williams GE, O'Beara S, Ganesananthan S, Massa P, Knight D, Martinez-Naharro A, Kotecha T, Chacko L, Brown J, Rauf MU, Manisty C, Moon J, Lachmann H, Wechelakar A, Petrie A, Whelan C, Hawkins PN, Gillmore JD, Fontana M
Circulation 2022 Nov 29;146(22):1657-1670. Epub 2022 Nov 3 doi: 10.1161/CIRCULATIONAHA.122.060852. PMID: 36325894Free PMC Article
Grogan M, Scott CG, Kyle RA, Zeldenrust SR, Gertz MA, Lin G, Klarich KW, Miller WL, Maleszewski JJ, Dispenzieri A
J Am Coll Cardiol 2016 Sep 6;68(10):1014-20. doi: 10.1016/j.jacc.2016.06.033. PMID: 27585505

Recent systematic reviews

Ahluwalia N, Roshankar G, Draycott L, Jimenez-Zepeda V, Fine N, Chan D, Han D, Miller RJH
J Nucl Cardiol 2023 Dec;30(6):2464-2476. Epub 2023 May 24 doi: 10.1007/s12350-023-03297-1. PMID: 37226006
Aimo A, Merlo M, Porcari A, Georgiopoulos G, Pagura L, Vergaro G, Sinagra G, Emdin M, Rapezzi C
Eur J Heart Fail 2022 Dec;24(12):2342-2351. Epub 2022 May 16 doi: 10.1002/ejhf.2532. PMID: 35509173Free PMC Article
Ibrahim M, Saint Croix GR, Lacy S, Fattouh M, Barillas-Lara MI, Behrooz L, Mechanic O
Heart Fail Rev 2022 Mar;27(2):517-524. Epub 2021 Jul 16 doi: 10.1007/s10741-021-10143-4. PMID: 34272629
Marques N, Azevedo O, Almeida AR, Bento D, Cruz I, Correia E, Lourenço C, Lopes LR
J Am Heart Assoc 2020 Oct 20;9(19):e016614. Epub 2020 Sep 24 doi: 10.1161/JAHA.120.016614. PMID: 32969287Free PMC Article
Penalver J, Ambrosino M, Jeon HD, Agrawal A, Kanjanahattakij N, Pitteloud M, Stempel J, Amanullah A
Curr Cardiol Rev 2020;16(3):221-230. doi: 10.2174/1573403X15666190722154152. PMID: 31544701Free PMC Article

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