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Erythroleukemia

MedGen UID:
1614281
Concept ID:
C4520840
Neoplastic Process
Synonyms: erythroleukemia; Erythroleukemia (Erythroid/Myeloid); Erythroleukemia, Erythroid/Myeloid
 
Monarch Initiative: MONDO:0859598

Definition

Acute erythroid leukemia characterised by the presence of at least 50% erythroid precursors and at least 20% myeloblasts in the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVErythroleukemia

Professional guidelines

PubMed

Boddu P, Benton CB, Wang W, Borthakur G, Khoury JD, Pemmaraju N
Blood Rev 2018 Mar;32(2):96-105. Epub 2017 Sep 18 doi: 10.1016/j.blre.2017.09.002. PMID: 28965757Free PMC Article
Steensma DP
Curr Hematol Malig Rep 2012 Dec;7(4):310-20. doi: 10.1007/s11899-012-0140-3. PMID: 23015360
Santos FP, Bueso-Ramos CE, Ravandi F
Expert Rev Hematol 2010 Dec;3(6):705-18. doi: 10.1586/ehm.10.62. PMID: 21091147

Recent clinical studies

Etiology

Weinberg OK, Arber DA
Curr Oncol Rep 2021 Apr 20;23(6):69. doi: 10.1007/s11912-021-01060-8. PMID: 33876292
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Arber DA
Curr Opin Hematol 2017 Mar;24(2):146-151. doi: 10.1097/MOH.0000000000000314. PMID: 27875373
Vardiman J, Reichard K
Am J Clin Pathol 2015 Jul;144(1):29-43. doi: 10.1309/AJCP58RSMFRHLHHH. PMID: 26071460
Ge Y, Elghetany MT
Lab Hematol 2005;11(1):31-7. doi: 10.1532/LH96.04056. PMID: 15790550

Diagnosis

Kuusanmäki H, Dufva O, Vähä-Koskela M, Leppä AM, Huuhtanen J, Vänttinen I, Nygren P, Klievink J, Bouhlal J, Pölönen P, Zhang Q, Adnan-Awad S, Mancebo-Pérez C, Saad J, Miettinen J, Javarappa KK, Aakko S, Ruokoranta T, Eldfors S, Heinäniemi M, Theilgaard-Mönch K, Wartiovaara-Kautto U, Keränen M, Porkka K, Konopleva M, Wennerberg K, Kontro M, Heckman CA, Mustjoki S
Blood 2023 Mar 30;141(13):1610-1625. doi: 10.1182/blood.2021011094. PMID: 36508699Free PMC Article
Weinberg OK, Arber DA
Curr Oncol Rep 2021 Apr 20;23(6):69. doi: 10.1007/s11912-021-01060-8. PMID: 33876292
Wang W, Wang SA, Medeiros LJ, Khoury JD
Am J Hematol 2017 Mar;92(3):292-296. Epub 2017 Feb 3 doi: 10.1002/ajh.24626. PMID: 28006859
Arber DA
Curr Opin Hematol 2017 Mar;24(2):146-151. doi: 10.1097/MOH.0000000000000314. PMID: 27875373
Elton TS, Selemon H, Elton SM, Parinandi NL
Gene 2013 Dec 10;532(1):1-12. Epub 2012 Dec 14 doi: 10.1016/j.gene.2012.12.009. PMID: 23246696

Therapy

Kuusanmäki H, Dufva O, Vähä-Koskela M, Leppä AM, Huuhtanen J, Vänttinen I, Nygren P, Klievink J, Bouhlal J, Pölönen P, Zhang Q, Adnan-Awad S, Mancebo-Pérez C, Saad J, Miettinen J, Javarappa KK, Aakko S, Ruokoranta T, Eldfors S, Heinäniemi M, Theilgaard-Mönch K, Wartiovaara-Kautto U, Keränen M, Porkka K, Konopleva M, Wennerberg K, Kontro M, Heckman CA, Mustjoki S
Blood 2023 Mar 30;141(13):1610-1625. doi: 10.1182/blood.2021011094. PMID: 36508699Free PMC Article
Creutzig U, Zimmermann M, Dworzak MN, Ritter J, Schellong G, Reinhardt D
Klin Padiatr 2013 May;225 Suppl 1:S79-86. Epub 2013 May 22 doi: 10.1055/s-0033-1337968. PMID: 23700063
Marks PA
Oncogene 2007 Feb 26;26(9):1351-6. doi: 10.1038/sj.onc.1210204. PMID: 17322921
Yoshida M, Matsuyama A, Komatsu Y, Nishino N
Curr Med Chem 2003 Nov;10(22):2351-8. doi: 10.2174/0929867033456602. PMID: 14529478
Gresser I
Med Oncol Tumor Pharmacother 1986;3(3-4):223-30. doi: 10.1007/BF02934998. PMID: 2433551

Prognosis

Kuusanmäki H, Dufva O, Vähä-Koskela M, Leppä AM, Huuhtanen J, Vänttinen I, Nygren P, Klievink J, Bouhlal J, Pölönen P, Zhang Q, Adnan-Awad S, Mancebo-Pérez C, Saad J, Miettinen J, Javarappa KK, Aakko S, Ruokoranta T, Eldfors S, Heinäniemi M, Theilgaard-Mönch K, Wartiovaara-Kautto U, Keränen M, Porkka K, Konopleva M, Wennerberg K, Kontro M, Heckman CA, Mustjoki S
Blood 2023 Mar 30;141(13):1610-1625. doi: 10.1182/blood.2021011094. PMID: 36508699Free PMC Article
Weinberg OK, Arber DA
Curr Oncol Rep 2021 Apr 20;23(6):69. doi: 10.1007/s11912-021-01060-8. PMID: 33876292
Boddu P, Benton CB, Wang W, Borthakur G, Khoury JD, Pemmaraju N
Blood Rev 2018 Mar;32(2):96-105. Epub 2017 Sep 18 doi: 10.1016/j.blre.2017.09.002. PMID: 28965757Free PMC Article
Arber DA
Curr Opin Hematol 2017 Mar;24(2):146-151. doi: 10.1097/MOH.0000000000000314. PMID: 27875373
Zuo Z, Polski JM, Kasyan A, Medeiros LJ
Arch Pathol Lab Med 2010 Sep;134(9):1261-70. doi: 10.5858/2009-0350-RA.1. PMID: 20807044

Clinical prediction guides

Tupta B, Stuehr E, Sumi MP, Sweeny EA, Smith B, Stuehr DJ, Ghosh A
FASEB J 2022 Feb;36(2):e22099. doi: 10.1096/fj.202101237RR. PMID: 34972240Free PMC Article
Patel N, Alkeraye S, Alobeid E, Alshidi T, Helaby R, Abdulwahab F, Shamseldin HE, Alkuraya FS
Clin Genet 2020 Apr;97(4):661-665. Epub 2020 Jan 12 doi: 10.1111/cge.13699. PMID: 31898316
Vardiman J, Reichard K
Am J Clin Pathol 2015 Jul;144(1):29-43. doi: 10.1309/AJCP58RSMFRHLHHH. PMID: 26071460
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165
Simon MC
Proc Soc Exp Biol Med 1993 Feb;202(2):115-21. doi: 10.3181/00379727-202-43519a. PMID: 8424101

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