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Neurogenic thoracic outlet syndrome

MedGen UID:
155880
•Concept ID:
C0751549
•
Disease or Syndrome
Synonyms: Neurogenic Thoracic Outlet Syndrome; Thoracic Outlet Syndrome, Neurogenic
SNOMED CT: Neurogenic thoracic outlet syndrome (2040007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0015061
Orphanet: ORPHA100073

Definition

Neurogenic thoracic outlet syndrome (NTOS) is a form of thoracic outlet syndrome (TOS; see this term) that presents with pain, paresthesias and weakness in an upper extremity and is divided into true NTOS and disputed NTOS. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurogenic thoracic outlet syndrome

Professional guidelines

PubMed

Neurogenic thoracic outlet syndrome: When to consider the diagnosis and current management options.
Kam Fai Ho K, Guazzo L, Muller J
Aust J Gen Pract 2023 Sep;52(9):627-632. doi: 10.31128/AJGP-09-22-6571. PMID: 37666785
Thoracic Outlet Syndrome Part II: Consensus on the Management of Neurogenic Thoracic Outlet Syndrome by the European Association of Neurosurgical Societies' Section of Peripheral Nerve Surgery.
Rochkind S, Ferraresi S, Denisova N, Garozzo D, Heinen C, Alimehmeti R, Capone C, Barone DG, Zdunczyk A, Pedro MT, Antoniadis G, Kaiser R, Dubuisson A, Pondaag W, Kretschmer T, Rasulic L, Dengler NF
Neurosurgery 2023 Feb 1;92(2):251-257. Epub 2022 Dec 6 doi: 10.1227/neu.0000000000002232. PMID: 36542350
Physical Therapy Management of Neurogenic Thoracic Outlet Syndrome.
Collins E, Orpin M
Thorac Surg Clin 2021 Feb;31(1):61-69. doi: 10.1016/j.thorsurg.2020.09.003. PMID: 33220772

Recent clinical studies

Etiology

Trans-axillary thoracic outlet decompression.
Goeteyn J, Teijink SBJ, Pesser N, van Sambeek MRHM, van Nuenen BFL, Teijink JAW
Semin Vasc Surg 2024 Mar;37(1):66-73. Epub 2024 Mar 4 doi: 10.1053/j.semvascsurg.2024.02.006. PMID: 38704186
Neurogenic thoracic outlet syndrome: When to consider the diagnosis and current management options.
Kam Fai Ho K, Guazzo L, Muller J
Aust J Gen Pract 2023 Sep;52(9):627-632. doi: 10.31128/AJGP-09-22-6571. PMID: 37666785
Thoracic Outlet Syndrome Part II: Consensus on the Management of Neurogenic Thoracic Outlet Syndrome by the European Association of Neurosurgical Societies' Section of Peripheral Nerve Surgery.
Rochkind S, Ferraresi S, Denisova N, Garozzo D, Heinen C, Alimehmeti R, Capone C, Barone DG, Zdunczyk A, Pedro MT, Antoniadis G, Kaiser R, Dubuisson A, Pondaag W, Kretschmer T, Rasulic L, Dengler NF
Neurosurgery 2023 Feb 1;92(2):251-257. Epub 2022 Dec 6 doi: 10.1227/neu.0000000000002232. PMID: 36542350
Neurogenic Thoracic Outlet Syndrome.
Dengler NF, Pedro MT, Kretschmer T, Heinen C, Rosahl SK, Antoniadis G
Dtsch Arztebl Int 2022 Oct 28;119(43):735-742. doi: 10.3238/arztebl.m2022.0296. PMID: 35978467Free PMC Article
Physical therapy management, surgical treatment, and patient-reported outcomes measures in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome.
Balderman J, Abuirqeba AA, Eichaker L, Pate C, Earley JA, Bottros MM, Jayarajan SN, Thompson RW
J Vasc Surg 2019 Sep;70(3):832-841. Epub 2019 Mar 7 doi: 10.1016/j.jvs.2018.12.027. PMID: 30852035

Diagnosis

Think About Klippel-Feil as Causing Neurogenic Thoracic Outlet Syndrome!
Arsicot M, Bordet M
Eur J Vasc Endovasc Surg 2023 Apr;65(4):502. Epub 2022 Dec 24 doi: 10.1016/j.ejvs.2022.12.024. PMID: 36574924
Neurogenic Thoracic Outlet Syndrome.
Dengler NF, Pedro MT, Kretschmer T, Heinen C, Rosahl SK, Antoniadis G
Dtsch Arztebl Int 2022 Oct 28;119(43):735-742. doi: 10.3238/arztebl.m2022.0296. PMID: 35978467Free PMC Article
Physical Therapy Management of Neurogenic Thoracic Outlet Syndrome.
Collins E, Orpin M
Thorac Surg Clin 2021 Feb;31(1):61-69. doi: 10.1016/j.thorsurg.2020.09.003. PMID: 33220772
Thoracic outlet syndrome.
Kuhn JE, Lebus V GF, Bible JE
J Am Acad Orthop Surg 2015 Apr;23(4):222-32. doi: 10.5435/JAAOS-D-13-00215. PMID: 25808686
Etiology of neurogenic thoracic outlet syndrome.
Brantigan CO, Roos DB
Hand Clin 2004 Feb;20(1):17-22. doi: 10.1016/s0749-0712(03)00112-4. PMID: 15005379

Therapy

Thoracic Outlet Syndrome Part II: Consensus on the Management of Neurogenic Thoracic Outlet Syndrome by the European Association of Neurosurgical Societies' Section of Peripheral Nerve Surgery.
Rochkind S, Ferraresi S, Denisova N, Garozzo D, Heinen C, Alimehmeti R, Capone C, Barone DG, Zdunczyk A, Pedro MT, Antoniadis G, Kaiser R, Dubuisson A, Pondaag W, Kretschmer T, Rasulic L, Dengler NF
Neurosurgery 2023 Feb 1;92(2):251-257. Epub 2022 Dec 6 doi: 10.1227/neu.0000000000002232. PMID: 36542350
Neurogenic Thoracic Outlet Syndrome.
Dengler NF, Pedro MT, Kretschmer T, Heinen C, Rosahl SK, Antoniadis G
Dtsch Arztebl Int 2022 Oct 28;119(43):735-742. doi: 10.3238/arztebl.m2022.0296. PMID: 35978467Free PMC Article
Neurogenic Thoracic Outlet Syndrome in Athletes - Nonsurgical Treatment Options.
Warrick A, Davis B
Curr Sports Med Rep 2021 Jun 1;20(6):319-326. doi: 10.1249/JSR.0000000000000854. PMID: 34099610
Physical therapy management, surgical treatment, and patient-reported outcomes measures in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome.
Balderman J, Abuirqeba AA, Eichaker L, Pate C, Earley JA, Bottros MM, Jayarajan SN, Thompson RW
J Vasc Surg 2019 Sep;70(3):832-841. Epub 2019 Mar 7 doi: 10.1016/j.jvs.2018.12.027. PMID: 30852035
Neurogenic thoracic outlet syndrome: surgical versus conservative therapy.
Wilbourn AJ, Porter JM
J Vasc Surg 1992 May;15(5):880-2. doi: 10.1016/0741-5214(92)90731-m. PMID: 1578550

Prognosis

Neurogenic thoracic outlet syndrome and controversies in diagnosis and management.
McIntosh E, Tripathi RK, Ohman JW
Semin Vasc Surg 2024 Mar;37(1):20-25. Epub 2024 Feb 19 doi: 10.1053/j.semvascsurg.2024.02.002. PMID: 38704179
Novel Diagnostic and Treatment Techniques for Neurogenic Thoracic Outlet Syndrome.
Wagner ER, Gottschalk MB, Ahmed AS, Graf AR, Karzon AL
Tech Hand Up Extrem Surg 2023 Jun 1;27(2):100-114. doi: 10.1097/BTH.0000000000000419. PMID: 36515356
How Common Is Thoracic Outlet Syndrome?
Illig KA, Rodriguez-Zoppi E
Thorac Surg Clin 2021 Feb;31(1):11-17. doi: 10.1016/j.thorsurg.2020.09.001. PMID: 33220767
Physical therapy management, surgical treatment, and patient-reported outcomes measures in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome.
Balderman J, Abuirqeba AA, Eichaker L, Pate C, Earley JA, Bottros MM, Jayarajan SN, Thompson RW
J Vasc Surg 2019 Sep;70(3):832-841. Epub 2019 Mar 7 doi: 10.1016/j.jvs.2018.12.027. PMID: 30852035
Thoracic outlet syndrome.
Kuhn JE, Lebus V GF, Bible JE
J Am Acad Orthop Surg 2015 Apr;23(4):222-32. doi: 10.5435/JAAOS-D-13-00215. PMID: 25808686

Clinical prediction guides

Neurogenic thoracic outlet syndrome and controversies in diagnosis and management.
McIntosh E, Tripathi RK, Ohman JW
Semin Vasc Surg 2024 Mar;37(1):20-25. Epub 2024 Feb 19 doi: 10.1053/j.semvascsurg.2024.02.002. PMID: 38704179
Thoracic Outlet Syndrome Part II: Consensus on the Management of Neurogenic Thoracic Outlet Syndrome by the European Association of Neurosurgical Societies' Section of Peripheral Nerve Surgery.
Rochkind S, Ferraresi S, Denisova N, Garozzo D, Heinen C, Alimehmeti R, Capone C, Barone DG, Zdunczyk A, Pedro MT, Antoniadis G, Kaiser R, Dubuisson A, Pondaag W, Kretschmer T, Rasulic L, Dengler NF
Neurosurgery 2023 Feb 1;92(2):251-257. Epub 2022 Dec 6 doi: 10.1227/neu.0000000000002232. PMID: 36542350
Neurogenic Thoracic Outlet Syndrome.
Dengler NF, Pedro MT, Kretschmer T, Heinen C, Rosahl SK, Antoniadis G
Dtsch Arztebl Int 2022 Oct 28;119(43):735-742. doi: 10.3238/arztebl.m2022.0296. PMID: 35978467Free PMC Article
Physical therapy management, surgical treatment, and patient-reported outcomes measures in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome.
Balderman J, Abuirqeba AA, Eichaker L, Pate C, Earley JA, Bottros MM, Jayarajan SN, Thompson RW
J Vasc Surg 2019 Sep;70(3):832-841. Epub 2019 Mar 7 doi: 10.1016/j.jvs.2018.12.027. PMID: 30852035
Thoracic outlet syndrome.
Kuhn JE, Lebus V GF, Bible JE
J Am Acad Orthop Surg 2015 Apr;23(4):222-32. doi: 10.5435/JAAOS-D-13-00215. PMID: 25808686

Recent systematic reviews

Botulinum toxin injections for the treatment of neurogenic thoracic outlet syndrome: A systematic review.
Woodworth TT, Le A, Miller C, Conger A, Mahan MA, Cushman DM
Muscle Nerve 2024 Jul;70(1):28-35. Epub 2024 Mar 26 doi: 10.1002/mus.28080. PMID: 38529885
Possible role of the botulinum toxin in the management of neurogenic thoracic outlet syndrome: a systematic review.
Fouasson-Chailloux A, Jager T, Daley P, Falcone A, Duysens C, Estoppey D, Merle M, Pomares G
Eur J Phys Rehabil Med 2023 Dec;59(6):706-713. Epub 2023 Sep 22 doi: 10.23736/S1973-9087.23.07815-2. PMID: 37737048Free PMC Article
Considerations for Surgical Treatment of Neurogenic Thoracic Outlet Syndrome: A Meta-Analysis of Patient-Reported Outcomes.
Blondin M, Garner GL, Hones KM, Nichols DS, Cox EA, Chim H
J Hand Surg Am 2023 Jun;48(6):585-594. Epub 2023 Apr 11 doi: 10.1016/j.jhsa.2023.03.005. PMID: 37055338
Thoracic Outlet Syndrome Part II: Consensus on the Management of Neurogenic Thoracic Outlet Syndrome by the European Association of Neurosurgical Societies' Section of Peripheral Nerve Surgery.
Rochkind S, Ferraresi S, Denisova N, Garozzo D, Heinen C, Alimehmeti R, Capone C, Barone DG, Zdunczyk A, Pedro MT, Antoniadis G, Kaiser R, Dubuisson A, Pondaag W, Kretschmer T, Rasulic L, Dengler NF
Neurosurgery 2023 Feb 1;92(2):251-257. Epub 2022 Dec 6 doi: 10.1227/neu.0000000000002232. PMID: 36542350
Outcomes of Surgical Management of Neurogenic Thoracic Outlet Syndrome: A Systematic Review and Bayesian Perspective.
Yin ZG, Gong KT, Zhang JB
J Hand Surg Am 2019 May;44(5):416.e1-416.e17. Epub 2018 Aug 16 doi: 10.1016/j.jhsa.2018.06.120. PMID: 30122304

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