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Neonatal anemia

MedGen UID:
1530
•Concept ID:
C0002891
•
Disease or Syndrome
Synonyms: Anemia Neonatorum; Anemia, Neonatal; Anemias, Neonatal; Neonatal Anemia; Neonatal Anemias
SNOMED CT: Neonatal anemia (234350007)
 
Monarch Initiative: MONDO:0001240

Definition

The mildest form of erythroblastosis fetalis in which anemia is the chief manifestation. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal anemia

Professional guidelines

PubMed

50 Years Ago in TheJournalofPediatrics: Neonatal Anemia Prevention and Treatment.
Solevåg AL, Andresen JH, Saugstad OD
J Pediatr 2021 Jul;234:211. doi: 10.1016/j.jpeds.2021.03.060. PMID: 34172161
Management and prevention of neonatal anemia: current evidence and guidelines.
von Lindern JS, Lopriore E
Expert Rev Hematol 2014 Apr;7(2):195-202. Epub 2014 Feb 13 doi: 10.1586/17474086.2014.878225. PMID: 24524256
Erythropoietin in the pathogenesis and treatment of neonatal anemia.
Strauss RG
Transfusion 1995 Jan;35(1):68-73. doi: 10.1046/j.1537-2995.1995.35195090667.x. PMID: 7998075

Recent clinical studies

Etiology

What Is New about Transfusions for Preterm Infants? An Update.
Kirpalani H, Whyte RK
Neonatology 2019;115(4):406-410. Epub 2019 Apr 11 doi: 10.1159/000499048. PMID: 30974429
Iron and exclusive breastfeeding.
Tawia S
Breastfeed Rev 2012 Mar;20(1):35-47. PMID: 22724312
Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis.
Gardener H, Spiegelman D, Buka SL
Pediatrics 2011 Aug;128(2):344-55. Epub 2011 Jul 11 doi: 10.1542/peds.2010-1036. PMID: 21746727Free PMC Article
Blood transfusion in newborn.
Mahapatra M, Choudhry VP
Indian J Pediatr 2003 Nov;70(11):909-14. doi: 10.1007/BF02730598. PMID: 14703232
Gamma-thalassaemia.
Stamatoyannopoulos G
Lancet 1971 Jul 24;2(7717):192-3. doi: 10.1016/s0140-6736(71)90900-7. PMID: 4104852

Diagnosis

Diagnosing Anemia in Neonates: An Evidence-Based Approach.
Christensen RD, Bahr TM, Tweddell SM, Ohls RK, Henry E
Neoreviews 2023 Jun 1;24(6):e343-e355. doi: 10.1542/neo.24-6-e343. PMID: 37258503
Neonatal Anemia.
German KR, Juul SE
Curr Pediatr Rev 2023;19(4):388-394. doi: 10.2174/1573396319666221121140627. PMID: 36411551
Severe Neonatal Anemia Due to Spontaneous Massive Fetomaternal Hemorrhage at Term: An Illustrative Case with Suspected Antenatal Diagnosis and Brief Review of Current Knowledge.
Gică N, Botezatu R, Demetrian M, Vayna AM, Cimpoca-Raptis BA, Ciobanu AM, Gica C, Peltecu G, Panaitescu AM
Medicina (Kaunas) 2021 Nov 23;57(12) doi: 10.3390/medicina57121285. PMID: 34946230Free PMC Article
Hemolytic Disease of the Fetus and Newborn: Historical and Current State.
Jackson ME, Baker JM
Clin Lab Med 2021 Mar;41(1):133-151. Epub 2020 Dec 24 doi: 10.1016/j.cll.2020.10.009. PMID: 33494881
Anemia and polycythemia in the newborn.
Kates EH, Kates JS
Pediatr Rev 2007 Jan;28(1):33-4. doi: 10.1542/pir.28-1-33. PMID: 17197458

Therapy

Anemia, Iron Supplementation, and the Brain.
Gisslen T, Rao R, Georgieff MK
Clin Perinatol 2023 Dec;50(4):853-868. Epub 2023 Aug 31 doi: 10.1016/j.clp.2023.07.009. PMID: 37866852Free PMC Article
Red Blood Cell Transfusion Thresholds for Anemia of Prematurity.
Holzapfel LF, Rysavy MA, Bell EF
Neoreviews 2023 Jun 1;24(6):e370-e376. doi: 10.1542/neo.24-6-e370. PMID: 37258497Free PMC Article
Neonatal Anemia.
German KR, Juul SE
Curr Pediatr Rev 2023;19(4):388-394. doi: 10.2174/1573396319666221121140627. PMID: 36411551
50 Years Ago in TheJournalofPediatrics: Neonatal Anemia Prevention and Treatment.
Solevåg AL, Andresen JH, Saugstad OD
J Pediatr 2021 Jul;234:211. doi: 10.1016/j.jpeds.2021.03.060. PMID: 34172161
Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis.
Gardener H, Spiegelman D, Buka SL
Pediatrics 2011 Aug;128(2):344-55. Epub 2011 Jul 11 doi: 10.1542/peds.2010-1036. PMID: 21746727Free PMC Article

Prognosis

The association between maternal anemia and neonatal anemia: a systematic review and meta-analysis.
Zhao B, Sun M, Wu T, Li J, Shi H, Wei Y
BMC Pregnancy Childbirth 2024 Oct 18;24(1):677. doi: 10.1186/s12884-024-06832-1. PMID: 39425056Free PMC Article
Fetomaternal hemorrhage: evaluation of recurrence within a large integrated healthcare system.
Boller MJ, Moore GS, Hung YY, Ritterman Weintraub ML, Schauer GM
Am J Obstet Gynecol 2021 Nov;225(5):540.e1-540.e8. Epub 2021 May 4 doi: 10.1016/j.ajog.2021.04.257. PMID: 33961809
Neurodevelopmental outcome of extremely low-birth-weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion.
Whyte RK
Semin Perinatol 2012 Aug;36(4):290-3. doi: 10.1053/j.semperi.2012.04.010. PMID: 22818550
Clinico-pathologic conference: fetomaternal transfusion.
Bowers LA, Myers P, Gilbert-Barness E, Pomerance HH
Fetal Pediatr Pathol 2006 Jul-Aug;25(4):199-210. doi: 10.1080/15513810601015746. PMID: 17162527
Sequelae of neonatal jaundice.
Culley P, Powell J, Waterhouse J, Wood B
Br Med J 1970 Aug 15;3(5719):383-6. doi: 10.1136/bmj.3.5719.383. PMID: 5451590Free PMC Article

Clinical prediction guides

The association between maternal anemia and neonatal anemia: a systematic review and meta-analysis.
Zhao B, Sun M, Wu T, Li J, Shi H, Wei Y
BMC Pregnancy Childbirth 2024 Oct 18;24(1):677. doi: 10.1186/s12884-024-06832-1. PMID: 39425056Free PMC Article
What Is New about Transfusions for Preterm Infants? An Update.
Kirpalani H, Whyte RK
Neonatology 2019;115(4):406-410. Epub 2019 Apr 11 doi: 10.1159/000499048. PMID: 30974429
Do transfusions cause necrotizing enterocolitis? The complementary role of randomized trials and observational studies.
Kirpalani H, Zupancic JA
Semin Perinatol 2012 Aug;36(4):269-76. doi: 10.1053/j.semperi.2012.04.007. PMID: 22818547
Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis.
Gardener H, Spiegelman D, Buka SL
Pediatrics 2011 Aug;128(2):344-55. Epub 2011 Jul 11 doi: 10.1542/peds.2010-1036. PMID: 21746727Free PMC Article
Erythropoietin, protein, and iron supplementation and the prevention of anaemia of prematurity.
Bechensteen AG, Hågå P, Halvorsen S, Whitelaw A, Liestøl K, Lindemann R, Grøgaard J, Hellebostad M, Saugstad OD, Grønn M
Arch Dis Child 1993 Jul;69(1 Spec No):19-23. doi: 10.1136/adc.69.1_spec_no.19. PMID: 8346946Free PMC Article

Recent systematic reviews

The association between maternal anemia and neonatal anemia: a systematic review and meta-analysis.
Zhao B, Sun M, Wu T, Li J, Shi H, Wei Y
BMC Pregnancy Childbirth 2024 Oct 18;24(1):677. doi: 10.1186/s12884-024-06832-1. PMID: 39425056Free PMC Article
Perinatal outcome of pregnancy complicated by twin anemia-polycythemia sequence: systematic review and meta-analysis.
Giorgione V, D'antonio F, Manji A, Reed K, Khalil A
Ultrasound Obstet Gynecol 2021 Dec;58(6):813-823. doi: 10.1002/uog.23585. PMID: 33428243
Immunoglobulin for alloimmune hemolytic disease in neonates.
Zwiers C, Scheffer-Rath ME, Lopriore E, de Haas M, Liley HG
Cochrane Database Syst Rev 2018 Mar 18;3(3):CD003313. doi: 10.1002/14651858.CD003313.pub2. PMID: 29551014Free PMC Article
Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants.
Whyte R, Kirpalani H
Cochrane Database Syst Rev 2011 Nov 9;(11):CD000512. doi: 10.1002/14651858.CD000512.pub2. PMID: 22071798
Late umbilical cord-clamping as an intervention for reducing iron deficiency anaemia in term infants in developing and industrialised countries: a systematic review.
van Rheenen P, Brabin BJ
Ann Trop Paediatr 2004 Mar;24(1):3-16. doi: 10.1179/027249304225013286. PMID: 15005961

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