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Benign Ovarian Cyst

MedGen UID:
149258
•Concept ID:
C0740364
•
Neoplastic Process
Synonyms: Benign cyst of ovary; Benign Cyst of Ovary; Benign Cyst of the Ovary
SNOMED CT: Benign cyst of ovary (446832006); Benign cyst of ovary (447249001)

Definition

A non-malignant ovarian cyst. [from NCI]

Professional guidelines

PubMed

Borderline ovarian tumors: French guidelines from the CNGOF. Part 1. Epidemiology, biopathology, imaging and biomarkers.
Huchon C, Bourdel N, Abdel Wahab C, Azaïs H, Bendifallah S, Bolze PA, Brun JL, Canlorbe G, Chauvet P, Chereau E, Courbiere B, De La Motte Rouge T, Devouassoux-Shisheboran M, Eymerit-Morin C, Fauvet R, Gauroy E, Gauthier T, Grynberg M, Koskas M, Larouzee E, Lecointre L, Levêque J, Margueritte F, Mathieu D'argent E, Nyangoh-Timoh K, Ouldamer L, Raad J, Raimond E, Ramanah R, Rolland L, Rousset P, Rousset-Jablonski C, Thomassin-Naggara I, Uzan C, Zilliox M, Daraï E
J Gynecol Obstet Hum Reprod 2021 Jan;50(1):101965. Epub 2020 Nov 4 doi: 10.1016/j.jogoh.2020.101965. PMID: 33160106
Is expectant management of sonographically benign adnexal cysts an option in selected asymptomatic premenopausal women?
Alcázar JL, Castillo G, Jurado M, García GL
Hum Reprod 2005 Nov;20(11):3231-4. Epub 2005 Jul 15 doi: 10.1093/humrep/dei206. PMID: 16024535
The value of cyst puncture in the differential diagnosis of benign ovarian tumours.
Vercellini P, Oldani S, Felicetta I, Bramante T, Rognoni MT, Crosignani PG
Hum Reprod 1995 Jun;10(6):1465-9. doi: 10.1093/humrep/10.6.1465. PMID: 7593516

Recent clinical studies

Etiology

Influence of ovarian cysts on ovarian reserve and fertility: A case-control study.
Bareghamyan H, Chopikyan A, Petrosyan M, Shahverdyan N, Harutyunyan A
Int J Gynaecol Obstet 2024 May;165(2):424-430. Epub 2023 Dec 7 doi: 10.1002/ijgo.15284. PMID: 38059670
The safety and effectiveness of elective laparoscopic surgery for benign ovarian cysts during pregnancy-Comparison with emergency surgery.
Samejima K, Takai Y, Matsunaga S, Nagai T, Kikuchi A
J Obstet Gynaecol Res 2022 Oct;48(10):2603-2609. Epub 2022 Jul 26 doi: 10.1111/jog.15357. PMID: 35882386
Short- and Long-Term Complications of Intraoperative Benign Ovarian Cyst Spillage: A Systematic Review and Meta-analysis.
Eisenberg N, Volodarsky-Perel A, Brochu I, Tremblay C, Gorak E, Hudon E, Fortin S, Kogan L, Rivard C
J Minim Invasive Gynecol 2021 May;28(5):957-970. Epub 2020 Dec 3 doi: 10.1016/j.jmig.2020.11.025. PMID: 33279627
A cystectomic technique with low risk of rupture for women with benign ovarian cyst.
Chikazawa K, Imai K, Wang L, Kuwata T, Konno R
J Obstet Gynaecol 2021 Apr;41(3):459-461. Epub 2020 Jun 4 doi: 10.1080/01443615.2020.1755622. PMID: 32496929
Benign epithelial ovarian tumours-cancer precursors or markers for ovarian cancer risk?
Jordan S, Green A, Webb P
Cancer Causes Control 2006 Jun;17(5):623-32. doi: 10.1007/s10552-005-0370-y. PMID: 16633908

Diagnosis

Relaxin as a potential diagnostic biomarker for ovarian cancer- A prospective study.
Gkrozou F, Pappa C, Tsonis O, Dimitriou E, Paschopoulos M
Eur J Obstet Gynecol Reprod Biol 2021 May;260:99-104. Epub 2021 Mar 15 doi: 10.1016/j.ejogrb.2021.03.008. PMID: 33752121
Perforation of colon cancer into a benign ovarian cyst.
Walsh S, Evoy D, Cantwell CP, Kroon N, Sheahan K, Gibbons D, McDermott EW
J Obstet Gynaecol 2012 Apr;32(3):316-7. doi: 10.3109/01443615.2011.652699. PMID: 22369421
Benign epithelial ovarian tumours-cancer precursors or markers for ovarian cancer risk?
Jordan S, Green A, Webb P
Cancer Causes Control 2006 Jun;17(5):623-32. doi: 10.1007/s10552-005-0370-y. PMID: 16633908
Suprarenal vena caval thrombosis and pulmonary embolism associated with a benign ovarian cyst.
Razvi K, Al-Katib M, McCall J, Barton DP
J Obstet Gynaecol 2002 Nov;22(6):697-8. doi: 10.1080/014436102762062466. PMID: 12554279
Asymptomatic postmenopausal simple ovarian cyst.
Oyelese Y, Kueck AS, Barter JF, Zalud I
Obstet Gynecol Surv 2002 Dec;57(12):803-9. doi: 10.1097/00006254-200212000-00004. PMID: 12493982

Therapy

The safety and effectiveness of elective laparoscopic surgery for benign ovarian cysts during pregnancy-Comparison with emergency surgery.
Samejima K, Takai Y, Matsunaga S, Nagai T, Kikuchi A
J Obstet Gynaecol Res 2022 Oct;48(10):2603-2609. Epub 2022 Jul 26 doi: 10.1111/jog.15357. PMID: 35882386
Ovarian cyst elevation using a metreurynter for laparoscopic cystectomy of a benign ovarian cyst during pregnancy.
Kotani Y, Murakami K, Yamamoto K, Fujishima R, Yahata T, Yo Y, Shimaoka M, Matsumura N
BMC Pregnancy Childbirth 2021 Apr 23;21(1):321. doi: 10.1186/s12884-021-03774-w. PMID: 33892651Free PMC Article
Relaxin as a potential diagnostic biomarker for ovarian cancer- A prospective study.
Gkrozou F, Pappa C, Tsonis O, Dimitriou E, Paschopoulos M
Eur J Obstet Gynecol Reprod Biol 2021 May;260:99-104. Epub 2021 Mar 15 doi: 10.1016/j.ejogrb.2021.03.008. PMID: 33752121
Short- and Long-Term Complications of Intraoperative Benign Ovarian Cyst Spillage: A Systematic Review and Meta-analysis.
Eisenberg N, Volodarsky-Perel A, Brochu I, Tremblay C, Gorak E, Hudon E, Fortin S, Kogan L, Rivard C
J Minim Invasive Gynecol 2021 May;28(5):957-970. Epub 2020 Dec 3 doi: 10.1016/j.jmig.2020.11.025. PMID: 33279627
A cystectomic technique with low risk of rupture for women with benign ovarian cyst.
Chikazawa K, Imai K, Wang L, Kuwata T, Konno R
J Obstet Gynaecol 2021 Apr;41(3):459-461. Epub 2020 Jun 4 doi: 10.1080/01443615.2020.1755622. PMID: 32496929

Prognosis

Predictive Role of Neutrophil to Lymphocyte Ratio in Adnexal Torsion: A Systematic Review and Meta-Analysis.
Khanzadeh S, Tahernia H, Hernandez J, Sarcone C, Lucke-Wold B, Salimi A, Tabatabaei F
Mediators Inflamm 2022;2022:9680591. Epub 2022 Nov 3 doi: 10.1155/2022/9680591. PMID: 36387932Free PMC Article
Ovarian cyst elevation using a metreurynter for laparoscopic cystectomy of a benign ovarian cyst during pregnancy.
Kotani Y, Murakami K, Yamamoto K, Fujishima R, Yahata T, Yo Y, Shimaoka M, Matsumura N
BMC Pregnancy Childbirth 2021 Apr 23;21(1):321. doi: 10.1186/s12884-021-03774-w. PMID: 33892651Free PMC Article
Relaxin as a potential diagnostic biomarker for ovarian cancer- A prospective study.
Gkrozou F, Pappa C, Tsonis O, Dimitriou E, Paschopoulos M
Eur J Obstet Gynecol Reprod Biol 2021 May;260:99-104. Epub 2021 Mar 15 doi: 10.1016/j.ejogrb.2021.03.008. PMID: 33752121
LncRNAs expression profiling in normal ovary, benign ovarian cyst and malignant epithelial ovarian cancer.
Wang H, Fu Z, Dai C, Cao J, Liu X, Xu J, Lv M, Gu Y, Zhang J, Hua X, Jia G, Xu S, Jia X, Xu P
Sci Rep 2016 Dec 12;6:38983. doi: 10.1038/srep38983. PMID: 27941916Free PMC Article
Benign epithelial ovarian tumours-cancer precursors or markers for ovarian cancer risk?
Jordan S, Green A, Webb P
Cancer Causes Control 2006 Jun;17(5):623-32. doi: 10.1007/s10552-005-0370-y. PMID: 16633908

Clinical prediction guides

Comparison of immunohistochemical characteristics of endometriomas with non-endometriotic benign ovarian cysts.
Cagiran FT, Kali Z, Kirici P, Celik O
Eur Rev Med Pharmacol Sci 2022 Oct;26(20):7594-7599. doi: 10.26355/eurrev_202210_30034. PMID: 36314331
Relaxin as a potential diagnostic biomarker for ovarian cancer- A prospective study.
Gkrozou F, Pappa C, Tsonis O, Dimitriou E, Paschopoulos M
Eur J Obstet Gynecol Reprod Biol 2021 May;260:99-104. Epub 2021 Mar 15 doi: 10.1016/j.ejogrb.2021.03.008. PMID: 33752121
Short- and Long-Term Complications of Intraoperative Benign Ovarian Cyst Spillage: A Systematic Review and Meta-analysis.
Eisenberg N, Volodarsky-Perel A, Brochu I, Tremblay C, Gorak E, Hudon E, Fortin S, Kogan L, Rivard C
J Minim Invasive Gynecol 2021 May;28(5):957-970. Epub 2020 Dec 3 doi: 10.1016/j.jmig.2020.11.025. PMID: 33279627
LncRNAs expression profiling in normal ovary, benign ovarian cyst and malignant epithelial ovarian cancer.
Wang H, Fu Z, Dai C, Cao J, Liu X, Xu J, Lv M, Gu Y, Zhang J, Hua X, Jia G, Xu S, Jia X, Xu P
Sci Rep 2016 Dec 12;6:38983. doi: 10.1038/srep38983. PMID: 27941916Free PMC Article
Demons syndrome revisited: a review of the literature.
Brun JL
Gynecol Oncol 2007 Jun;105(3):796-800. Epub 2007 Apr 11 doi: 10.1016/j.ygyno.2007.01.050. PMID: 17433421

Recent systematic reviews

Predictive Role of Neutrophil to Lymphocyte Ratio in Adnexal Torsion: A Systematic Review and Meta-Analysis.
Khanzadeh S, Tahernia H, Hernandez J, Sarcone C, Lucke-Wold B, Salimi A, Tabatabaei F
Mediators Inflamm 2022;2022:9680591. Epub 2022 Nov 3 doi: 10.1155/2022/9680591. PMID: 36387932Free PMC Article
Short- and Long-Term Complications of Intraoperative Benign Ovarian Cyst Spillage: A Systematic Review and Meta-analysis.
Eisenberg N, Volodarsky-Perel A, Brochu I, Tremblay C, Gorak E, Hudon E, Fortin S, Kogan L, Rivard C
J Minim Invasive Gynecol 2021 May;28(5):957-970. Epub 2020 Dec 3 doi: 10.1016/j.jmig.2020.11.025. PMID: 33279627
The effect of bipolar electrocoagulation during ovarian cystectomy on ovarian reserve: a systematic review.
Pergialiotis V, Prodromidou A, Frountzas M, Bitos K, Perrea D, Doumouchtsis SK
Am J Obstet Gynecol 2015 Nov;213(5):620-8. Epub 2015 Apr 13 doi: 10.1016/j.ajog.2015.04.006. PMID: 25882917
Demons syndrome revisited: a review of the literature.
Brun JL
Gynecol Oncol 2007 Jun;105(3):796-800. Epub 2007 Apr 11 doi: 10.1016/j.ygyno.2007.01.050. PMID: 17433421

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