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Metastatic Malignant Neoplasm in the Esophagus

MedGen UID:
146901
Concept ID:
C0686055
Neoplastic Process
Synonyms: Esophageal Metastasis; Metastases to Esophagus; Metastases to the Esophagus; Metastasis to Esophagus; Metastasis to the Esophagus; Metastatic malignant neoplasm of esophagus; Metastatic malignant neoplasm to esophagus; Metastatic Malignant Neoplasm to the Esophagus; Metastatic Neoplasm to the Esophagus; Metastatic Tumor to the Esophagus; Secondary malignant neoplasm of esophagus
SNOMED CT: Secondary malignant neoplasm of esophagus (94286009); Metastatic malignant neoplasm to esophagus (94286009); Metastatic malignant neoplasm of esophagus (94286009)

Definition

A malignant neoplasm that has spread to the esophagus from another organ or system, or from another primary esophageal tumor. The primary esophageal tumor is not in continuity with the metastatic lesion. Representative examples of metastatic cancers to the esophagus include breast and lung metastatic carcinomas and melanomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Esophagus

Professional guidelines

PubMed

Ajani JA, D'Amico TA, Bentrem DJ, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Farjah F, Gerdes H, Gibson M, Grierson P, Hofstetter WL, Ilson DH, Jalal S, Keswani RN, Kim S, Kleinberg LR, Klempner S, Lacy J, Licciardi F, Ly QP, Matkowskyj KA, McNamara M, Miller A, Mukherjee S, Mulcahy MF, Outlaw D, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian NR, Pluchino LA
J Natl Compr Canc Netw 2023 Apr;21(4):393-422. doi: 10.6004/jnccn.2023.0019. PMID: 37015332
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974
Joshi SS, Badgwell BD
CA Cancer J Clin 2021 May;71(3):264-279. Epub 2021 Feb 16 doi: 10.3322/caac.21657. PMID: 33592120Free PMC Article

Recent clinical studies

Etiology

Liu T, Bai Y, Lin X, Li W, Wang J, Zhang X, Pan H, Bai C, Bai L, Cheng Y, Zhang J, Zhong H, Ba Y, Hu W, Xu R, Guo W, Qin S, Yang N, Lu J, Shitara K, Lei M, Li M, Bao N, Chen T, Shen L
Int J Cancer 2023 Feb 15;152(4):749-760. Epub 2022 Oct 31 doi: 10.1002/ijc.34296. PMID: 36121651Free PMC Article
Reed CC, Shaheen NJ
Dig Dis Sci 2018 Aug;63(8):2136-2145. doi: 10.1007/s10620-018-5066-8. PMID: 29671157
Amadi C, Gatenby P
World J Gastroenterol 2017 Jul 28;23(28):5051-5067. doi: 10.3748/wjg.v23.i28.5051. PMID: 28811703Free PMC Article
Hoeppner J, Lordick F, Brunner T, Glatz T, Bronsert P, Röthling N, Schmoor C, Lorenz D, Ell C, Hopt UT, Siewert JR
BMC Cancer 2016 Jul 19;16:503. doi: 10.1186/s12885-016-2564-y. PMID: 27435280Free PMC Article
Aupérin A, Le Péchoux C, Rolland E, Curran WJ, Furuse K, Fournel P, Belderbos J, Clamon G, Ulutin HC, Paulus R, Yamanaka T, Bozonnat MC, Uitterhoeve A, Wang X, Stewart L, Arriagada R, Burdett S, Pignon JP
J Clin Oncol 2010 May 1;28(13):2181-90. Epub 2010 Mar 29 doi: 10.1200/JCO.2009.26.2543. PMID: 20351327

Diagnosis

Ajani JA, D'Amico TA, Bentrem DJ, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Farjah F, Gerdes H, Gibson M, Grierson P, Hofstetter WL, Ilson DH, Jalal S, Keswani RN, Kim S, Kleinberg LR, Klempner S, Lacy J, Licciardi F, Ly QP, Matkowskyj KA, McNamara M, Miller A, Mukherjee S, Mulcahy MF, Outlaw D, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian NR, Pluchino LA
J Natl Compr Canc Netw 2023 Apr;21(4):393-422. doi: 10.6004/jnccn.2023.0019. PMID: 37015332
Joshi SS, Badgwell BD
CA Cancer J Clin 2021 May;71(3):264-279. Epub 2021 Feb 16 doi: 10.3322/caac.21657. PMID: 33592120Free PMC Article
Mönig S, van Hootegem S, Chevallay M, Wijnhoven BPL
Best Pract Res Clin Gastroenterol 2018 Oct-Dec;36-37:91-96. Epub 2018 Nov 24 doi: 10.1016/j.bpg.2018.11.002. PMID: 30551863
Amadi C, Gatenby P
World J Gastroenterol 2017 Jul 28;23(28):5051-5067. doi: 10.3748/wjg.v23.i28.5051. PMID: 28811703Free PMC Article
Van Cutsem E, Sagaert X, Topal B, Haustermans K, Prenen H
Lancet 2016 Nov 26;388(10060):2654-2664. Epub 2016 May 5 doi: 10.1016/S0140-6736(16)30354-3. PMID: 27156933

Therapy

Shah MA, Shitara K, Ajani JA, Bang YJ, Enzinger P, Ilson D, Lordick F, Van Cutsem E, Gallego Plazas J, Huang J, Shen L, Oh SC, Sunpaweravong P, Soo Hoo HF, Turk HM, Oh M, Park JW, Moran D, Bhattacharya P, Arozullah A, Xu RH
Nat Med 2023 Aug;29(8):2133-2141. Epub 2023 Jul 31 doi: 10.1038/s41591-023-02465-7. PMID: 37524953Free PMC Article
Shitara K, Lordick F, Bang YJ, Enzinger P, Ilson D, Shah MA, Van Cutsem E, Xu RH, Aprile G, Xu J, Chao J, Pazo-Cid R, Kang YK, Yang J, Moran D, Bhattacharya P, Arozullah A, Park JW, Oh M, Ajani JA
Lancet 2023 May 20;401(10389):1655-1668. Epub 2023 Apr 15 doi: 10.1016/S0140-6736(23)00620-7. PMID: 37068504
Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555
Högner A, Moehler M
Curr Oncol 2022 Mar 2;29(3):1559-1574. doi: 10.3390/curroncol29030131. PMID: 35323331Free PMC Article
Janjigian YY, Kawazoe A, Yañez P, Li N, Lonardi S, Kolesnik O, Barajas O, Bai Y, Shen L, Tang Y, Wyrwicz LS, Xu J, Shitara K, Qin S, Van Cutsem E, Tabernero J, Li L, Shah S, Bhagia P, Chung HC
Nature 2021 Dec;600(7890):727-730. Epub 2021 Dec 15 doi: 10.1038/s41586-021-04161-3. PMID: 34912120Free PMC Article

Prognosis

Ajani JA, D'Amico TA, Bentrem DJ, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Farjah F, Gerdes H, Gibson M, Grierson P, Hofstetter WL, Ilson DH, Jalal S, Keswani RN, Kim S, Kleinberg LR, Klempner S, Lacy J, Licciardi F, Ly QP, Matkowskyj KA, McNamara M, Miller A, Mukherjee S, Mulcahy MF, Outlaw D, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian NR, Pluchino LA
J Natl Compr Canc Netw 2023 Apr;21(4):393-422. doi: 10.6004/jnccn.2023.0019. PMID: 37015332
Zarrilli G, Galuppini F, Angerilli V, Munari G, Sabbadin M, Lazzarin V, Nicolè L, Biancotti R, Fassan M
Int J Mol Sci 2021 Mar 31;22(7) doi: 10.3390/ijms22073640. PMID: 33807389Free PMC Article
Amadi C, Gatenby P
World J Gastroenterol 2017 Jul 28;23(28):5051-5067. doi: 10.3748/wjg.v23.i28.5051. PMID: 28811703Free PMC Article
Maron SB, Catenacci DV
Surg Oncol Clin N Am 2017 Apr;26(2):293-312. doi: 10.1016/j.soc.2016.10.002. PMID: 28279470Free PMC Article
Gronnier C, Piessen G, Mariette C
J Visc Surg 2012 Feb;149(1):e23-33. Epub 2012 Feb 16 doi: 10.1016/j.jviscsurg.2012.01.003. PMID: 22341763

Clinical prediction guides

Shitara K, Lordick F, Bang YJ, Enzinger P, Ilson D, Shah MA, Van Cutsem E, Xu RH, Aprile G, Xu J, Chao J, Pazo-Cid R, Kang YK, Yang J, Moran D, Bhattacharya P, Arozullah A, Park JW, Oh M, Ajani JA
Lancet 2023 May 20;401(10389):1655-1668. Epub 2023 Apr 15 doi: 10.1016/S0140-6736(23)00620-7. PMID: 37068504
Moehler M, Högner A, Wagner AD, Obermannova R, Alsina M, Thuss-Patience P, van Laarhoven H, Smyth E
Eur J Cancer 2022 Nov;176:13-29. Epub 2022 Sep 29 doi: 10.1016/j.ejca.2022.08.023. PMID: 36183651
Högner A, Moehler M
Curr Oncol 2022 Mar 2;29(3):1559-1574. doi: 10.3390/curroncol29030131. PMID: 35323331Free PMC Article
Janjigian YY, Shitara K, Moehler M, Garrido M, Salman P, Shen L, Wyrwicz L, Yamaguchi K, Skoczylas T, Campos Bragagnoli A, Liu T, Schenker M, Yanez P, Tehfe M, Kowalyszyn R, Karamouzis MV, Bruges R, Zander T, Pazo-Cid R, Hitre E, Feeney K, Cleary JM, Poulart V, Cullen D, Lei M, Xiao H, Kondo K, Li M, Ajani JA
Lancet 2021 Jul 3;398(10294):27-40. Epub 2021 Jun 5 doi: 10.1016/S0140-6736(21)00797-2. PMID: 34102137Free PMC Article
Tabernero J, Bang YJ, Van Cutsem E, Fuchs CS, Janjigian YY, Bhagia P, Li K, Adelberg D, Qin SK
Future Oncol 2021 Aug;17(22):2847-2855. Epub 2021 May 12 doi: 10.2217/fon-2021-0176. PMID: 33975465Free PMC Article

Recent systematic reviews

Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Codipilly DC, Chandar AK, Singh S, Wani S, Shaheen NJ, Inadomi JM, Chak A, Iyer PG
Gastroenterology 2018 Jun;154(8):2068-2086.e5. Epub 2018 Feb 16 doi: 10.1053/j.gastro.2018.02.022. PMID: 29458154Free PMC Article
Chakravarty PD, McMurran AEL, Banigo A, Shakeel M, Ah-See KW
J Laryngol Otol 2018 Jan;132(1):14-21. Epub 2017 Nov 27 doi: 10.1017/S0022215117002390. PMID: 29173195
Barauna Neto JC, Dedivitis RA, Aires FT, Pfann RZ, Matos LL, Cernea CR
ORL J Otorhinolaryngol Relat Spec 2017;79(4):222-229. Epub 2017 Jul 29 doi: 10.1159/000477970. PMID: 28768272
Chung CS, Lee YC, Wu MS
Best Pract Res Clin Gastroenterol 2015 Dec;29(6):869-83. Epub 2015 Oct 9 doi: 10.1016/j.bpg.2015.09.010. PMID: 26651249

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